Data for (Study ST002846)
(Analysis AN004664)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 1,3-bisphospho-D-glycerate | 0.8287 | 0.8015 | 1.1804 |
| 1-methylnicotinamide+ | 1.0808 | 0.8238 | 1.0954 |
| 1-phenylethylamine | 0.9656 | 1.2106 | 0.8238 |
| 2,3-bisphospho-D-glycerate | NA | 1.0109 | 0.9891 |
| 2- / 3-phosphoglycerate | 0.4505 | 1.9255 | 0.6240 |
| 2-aminobutanoate / 2-aminoisobutanoate | NA | NA | NA |
| 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine | 1.0168 | NA | 0.9497 |
| 2-HG | 0.6972 | 1.5742 | 0.7287 |
| 2-hydroxybutanoic acid | 0.9145 | 0.9081 | 1.1773 |
| 2-keto-isovaleric acid | 1.2476 | 0.7359 | 1.0743 |
| 2-ketovaleric acid | 1.3977 | 0.9450 | 0.6573 |
| 2-oxoadipic acid | NA | NA | NA |
| 2-oxobutanoic acid | NA | NA | NA |
| 3,4-dihydroxymandelic acid | NA | NA | NA |
| 3,4-dihydroxyphenylpropanoate | NA | NA | NA |
| 3- / 4 -hydroxybutanoic acid | 1.2351 | 0.9188 | 0.8461 |
| 3- / 4-hydroxyphenylacetic acid / vanillin / | 0.7749 | 1.0282 | 1.1969 |
| 3- / 7-methylguanine | 0.6576 | 1.3429 | 0.9996 |
| 3-aminoisobutanoate | 1.2945 | 0.9559 | 0.7496 |
| 3-hydroxy-anthranilic acid | NA | NA | NA |
| 3-hydroxykynurenine | 0.5931 | 1.5016 | 1.1088 |
| 3-hydroxypropanoic acid | NA | NA | NA |
| 3-methoxytyramine | NA | NA | NA |
| 3-phosphohydroxypyruvic acid | NA | NA | NA |
| 3-phospho-serine | 0.3509 | 1.9417 | 0.7074 |
| 3-ureidopropionic acid | NA | NA | NA |
| 4-hydroxyphenylpyruvic acid | 0.5897 | 1.6373 | 0.7272 |
| 4-hydroxyproline / 5-aminolevulinate / N-acetyl-b-alanine | NA | 1.0000 | NA |
| 4-phosphopantothenate | 1.9471 | 0.3681 | 0.8424 |
| 4-trimethylammoniobutanoate+ | 0.5737 | 1.5455 | 0.8808 |
| 5,6-dihydroxyindole | NA | NA | 1.0000 |
| 5-methylcytosine | 0.8683 | 0.9869 | 1.1448 |
| 5-methyl-THF | NA | NA | NA |
| 5^-methylthioadenosine | 0.2905 | 1.9738 | 0.7358 |
| 6-aminocaproic acid | NA | NA | NA |
| 6-methylnicotinamide | 1.0811 | NA | 0.7567 |
| 6-O-methylguanine | NA | NA | 1.0000 |
| 6-phosphogluconic acid | 0.8019 | 1.6745 | 0.5236 |
| 6-phosphoglucono-D-lactone | 0.8363 | 0.9388 | 1.1380 |
| acetoacetic acid | NA | NA | NA |
| acetylcholine+ | 0.7626 | 1.5305 | 0.7069 |
| acetyl-CoA | 1.3960 | NA | 0.8680 |
| aconitic acid | 0.3816 | 1.5197 | 0.6864 |
| adenine | 0.3353 | 1.7792 | 0.8855 |
| adenosine | 0.7291 | 1.2263 | 1.0447 |
| adenylosuccinate | 0.5353 | 0.7366 | 1.4957 |
| ADP / dGDP | 0.4251 | 1.6837 | 0.8912 |
| ADP-D-glucose | NA | NA | NA |
| agmatine | 1.0616 | 0.4131 | 1.5252 |
| AICA ribonucleotide | NA | 1.0000 | NA |
| a-KG | 0.9915 | 1.0758 | 0.7052 |
| alanine | 0.6508 | 1.5622 | 0.7869 |
| alanine methyl ester | 0.9101 | 1.2277 | 0.8622 |
| allantoin | 0.7978 | 1.2247 | 0.9776 |
| AMP / dGMP | 0.5746 | 1.4986 | 0.9268 |
| anandamide | 1.1640 | 1.4582 | 0.5333 |
| arginine | 0.9784 | 0.6844 | 1.3372 |
| ascorbic acid | NA | NA | NA |
| asparagine | 0.7339 | 1.3656 | 0.9005 |
| aspartic acid | 0.6368 | 1.4780 | 0.8853 |
| ATP / dGTP | 0.4257 | 1.5534 | 1.0209 |
| b-alanine | 0.1413 | 2.3895 | 0.4692 |
| betaine | 0.5321 | 1.5095 | 0.9584 |
| butyric acid | 1.2582 | 0.7676 | 1.0388 |
| butyric acid(iso) | 1.7633 | 0.1391 | 0.3342 |
| carbamoyl phosphate | NA | NA | NA |
| carnitine+ | 0.6185 | 1.5534 | 0.8281 |
| CDP | 0.4339 | 1.7781 | 0.7880 |
| CDP-choline | 0.6150 | 0.8571 | 1.5279 |
| cGMP | NA | NA | NA |
| choline+ | 0.8020 | 1.2005 | 0.9974 |
| citraconic acid | 0.7829 | 0.8890 | 1.3281 |
| citramalic acid | 0.7936 | 1.1761 | 1.0303 |
| citrate / citrate(iso) | 0.1986 | 2.1994 | 0.6020 |
| citrulline | NA | NA | 1.0000 |
| CMP | 0.7844 | 1.1413 | 1.0742 |
| cortisol | 1.1310 | 1.1047 | 0.7294 |
| creatine | 0.2674 | 2.3120 | 0.4206 |
| creatinine | 0.6213 | 1.5571 | 0.8216 |
| CTP | 0.2883 | 1.8958 | 0.8160 |
| cystathionine | 0.4105 | 1.9821 | 0.6074 |
| cysteine | NA | 1.0000 | NA |
| cysteine-S-sulfate | 0.9989 | NA | 1.0011 |
| cystine | 1.7275 | 0.1216 | 1.1509 |
| cytidine | 1.7352 | 0.2948 | 0.9700 |
| cytosine | 0.7932 | 0.9138 | 1.2930 |
| dADP | NA | 1.0000 | NA |
| dAMP | NA | 0.9280 | 1.0720 |
| D-arabinono-1,4-lactone | 0.8927 | NA | 1.4294 |
| dATP | NA | 1.0000 | NA |
| dCDP | 0.0577 | 1.8753 | 0.1470 |
| dCMP | 0.3620 | 1.9867 | 0.6513 |
| dCTP | 0.1590 | 2.2996 | 0.5414 |
| dehydroascorbic acid | 0.9719 | 1.0281 | NA |
| deoxyguanosine | NA | NA | NA |
| deoxyinosine | 0.2317 | 0.2773 | 1.7569 |
| deoxyuridine | 0.6891 | 1.4345 | 0.8764 |
| D-erythrose-4-phosphate | NA | NA | NA |
| D-galactonic acid / D-gluconic acid | 0.3192 | 1.9090 | 0.7718 |
| D-galactosamine/glucosamine-1-phosphate | NA | NA | NA |
| D-galactosamine/glucosamine-6-phosphate | 0.7614 | 1.8029 | 0.4357 |
| dihydroorotate | 1.0605 | NA | 0.8791 |
| dimethylglycine | NA | 1.5617 | 0.4383 |
| DL-DOPA | NA | NA | NA |
| DOPAC | 1.0453 | 1.4696 | 0.6025 |
| DOPAL | 1.1714 | 0.9583 | 0.8703 |
| dopamine | 1.1192 | 1.1218 | 0.7590 |
| dopamine quinone | NA | 0.5149 | 1.7277 |
| DOPEG | 1.1630 | 0.9617 | 0.8753 |
| DOPET | 1.0556 | 0.4412 | 1.5032 |
| D-ribose-1/5-phosphate / D-ribulose 5-phosphate | 0.2482 | 2.1734 | 0.5784 |
| D-sedoheptulose-7-phosphate | 0.4874 | 1.9579 | 0.5547 |
| dTMP | NA | NA | NA |
| dTTP | 0.0705 | 1.2324 | NA |
| dUMP | NA | NA | NA |
| dUTP | NA | NA | NA |
| epinephrine | 1.0541 | 0.5673 | 1.3786 |
| ethyl acetate | 0.8195 | 1.0642 | 1.1163 |
| F-1,6/2,6-DP | 0.4610 | 1.8344 | 0.7046 |
| F1P | 0.6489 | 0.8499 | 1.2004 |
| F6P / G1P / G6P | 0.6977 | 1.6492 | 0.6530 |
| FAD | NA | NA | 1.0000 |
| FMN | NA | NA | NA |
| folic acid | 0.9990 | 0.9957 | 1.0052 |
| fructose / mannose | 1.0776 | 0.9491 | 0.9733 |
| fumaric acid | 0.2542 | 1.9590 | 0.5737 |
| GABA | 0.3938 | 2.0643 | 0.5418 |
| galactosamine / glucosamine | 1.9908 | 0.2542 | 0.7550 |
| galactose / glucose | 1.2382 | 0.7996 | 0.9623 |
| GalNAC/GlcNAC/ManNAC | 1.1577 | 0.4576 | 1.3847 |
| GAP / DHAP | 0.3115 | 2.2514 | 0.4371 |
| GDP | 0.5177 | 1.4060 | 1.0763 |
| GDP-L-fucose | 0.6207 | 1.5295 | 0.8498 |
| glucono-lactone | 1.4739 | 0.8248 | 0.7013 |
| glutaconic acid | 1.0332 | 0.9091 | 1.0577 |
| glutamine | 0.8055 | 1.3070 | 0.8876 |
| glutaminic acid | 0.5368 | 1.7257 | 0.7375 |
| glutathione | 0.3529 | 1.9636 | 0.6835 |
| glutathione disulfide | 0.6186 | 1.4465 | 0.9348 |
| glyceraldehyde | 1.2820 | 0.3640 | 0.7540 |
| glyceric acid | 2.0604 | 0.3276 | 0.6120 |
| glycerol 2/3-phosphate | 0.5128 | 1.8147 | 0.6726 |
| glycine | 0.7881 | 1.4200 | 0.7919 |
| glycylglycine | NA | NA | NA |
| GMP | 0.5532 | 1.3447 | 1.1021 |
| GTP | 0.3153 | 1.6656 | 1.0191 |
| guanidine | 1.6231 | 0.3721 | 0.8478 |
| guanidinoacetate | NA | 1.0000 | NA |
| guanine | 0.5626 | 0.6213 | 1.8161 |
| guanosine | 0.9058 | 0.4937 | 1.6004 |
| gulonic-lactone | 1.1426 | 0.7457 | 1.1117 |
| histamine | NA | NA | NA |
| histidine | 0.8582 | 1.0903 | 1.0515 |
| homocysteine | 1.2328 | NA | 0.3015 |
| homoserine / theronine | 0.8101 | 1.2793 | 0.9106 |
| homovanillic acid | 1.6089 | 0.8165 | 0.8791 |
| hydroxyphenyllactic acid | 0.5061 | 1.6152 | 0.8787 |
| hypoxanthine | 1.1494 | 0.3661 | 1.4845 |
| IDA | 1.0102 | 1.1593 | 0.8305 |
| IDP | NA | NA | 1.0000 |
| imidazole-4-acetate | 0.3910 | 2.9697 | 0.8574 |
| IMP | 0.5265 | 1.2041 | 1.2694 |
| inosine | 0.5848 | 0.9359 | 1.3410 |
| isonictinic acid | 1.1348 | NA | 0.7303 |
| itaconic acid | 0.9385 | 1.1518 | 0.9097 |
| kynurenic acid | 0.6460 | 0.8032 | 1.4623 |
| kynurenine | 0.7666 | 1.3472 | 0.8863 |
| lactic acid | 0.8801 | 1.1493 | 0.9706 |
| L-arginino-succinate | 0.6167 | 1.5316 | 0.8517 |
| L-cysteic acid | NA | NA | NA |
| leucine / leucine(iso) | 1.1395 | 1.0162 | 0.8444 |
| levulinic acid | 0.8666 | 1.1337 | 0.9997 |
| L-NMMA | 0.4609 | 1.7945 | 0.7446 |
| L-tyrosine methyl ester | 0.7582 | 0.9814 | 1.1953 |
| lysine | 0.6252 | 1.5732 | 0.8016 |
| maleic acid | 0.5750 | 1.7262 | 0.8803 |
| malic acid | 0.4904 | 1.6413 | 0.7738 |
| malonyl-CoA | 1.0961 | 0.6302 | 1.0888 |
| mesaconic acid | NA | NA | NA |
| methionine | 0.9160 | 1.0519 | 1.0321 |
| methyl acetoacetate | NA | NA | NA |
| methylglyoxal | NA | NA | NA |
| methylmalonic acid | 0.7403 | 1.0304 | 1.2294 |
| mevalonic acid | 1.1524 | 0.8699 | 0.9777 |
| N1/N8-acetylspermidine | 0.5662 | 1.6000 | 0.5014 |
| N-acetylaspartic acid | 0.7575 | 0.8477 | 1.3948 |
| N-acetylaspartylglutamic acid | 0.1985 | 1.8257 | 0.5751 |
| N-acetyl-DL-alanine | 0.8196 | 1.2127 | 0.9677 |
| N-acetyl-DL-serine | 2.2458 | 0.2289 | 0.5253 |
| N-acetyl-dopamine | NA | NA | NA |
| N-acetylglucosamine 1/6-phosphate | 0.7092 | 1.4378 | 0.8530 |
| N-acetyl-L-glutamic acid | NA | 1.0000 | NA |
| NAD+ | 0.5245 | 1.6927 | 0.7828 |
| NADH | NA | NA | NA |
| NADP+ | 0.4526 | 1.6858 | 0.8616 |
| NADPH | 0.3643 | 1.9575 | 0.5709 |
| N-carbamoyl-L-aspartate | NA | 1.4803 | 0.0393 |
| nebularine | 0.2317 | 0.2766 | 1.7571 |
| nicotinamide | 0.6960 | 1.2774 | 1.0266 |
| nicotinamide riboside+ | NA | NA | NA |
| nicotinic acid | 1.1431 | 1.0978 | 0.7592 |
| N-methyltryptamine | NA | 1.0967 | 0.9033 |
| NMN | 0.3860 | 1.8200 | 0.7939 |
| norepinephrine | 0.9417 | 1.8089 | 0.5384 |
| O-acetyl-L-serine | 0.7006 | 1.3223 | 0.9770 |
| octopamine | 0.8499 | 1.1737 | 0.9764 |
| ornithine | 0.0944 | 2.7454 | 0.1601 |
| orotic acid | 0.4733 | 0.5626 | 1.7007 |
| orotidylic acid | NA | NA | 1.0000 |
| oxalacetic acid | NA | NA | 1.0000 |
| pantothenic acid | 1.3627 | 0.8251 | 0.8122 |
| phenethylamine | NA | NA | NA |
| phenylalanine | 0.7850 | 1.2529 | 0.9621 |
| phenylephrine / synephrine | 0.9403 | 0.7090 | 1.3507 |
| phosphocreatine | 0.3406 | 2.1406 | 0.5188 |
| phosphoenolpyruvate | 0.4507 | 1.9996 | 0.5497 |
| phosphorylcholine+ | 0.3859 | 2.0223 | 0.5918 |
| picolinic acid | 1.2490 | 0.8141 | 0.9370 |
| proline | 1.4116 | 0.7746 | 0.8137 |
| propionic acid | 1.0000 | NA | NA |
| PRPP | NA | NA | NA |
| pseudouridine | 1.3026 | 0.8161 | 0.8813 |
| putrescine | 0.8432 | 1.0912 | 1.0885 |
| pyridoxine | NA | NA | NA |
| pyroglutamic acid | 1.1439 | 0.9533 | 0.7822 |
| pyrroline hydroxycarboxylic acid | 0.7785 | 1.3232 | 0.8984 |
| pyruvic acid | 1.0683 | 1.0726 | 0.8591 |
| quinolinic acid | 0.5773 | 2.6895 | 0.7187 |
| (S)-4-hydroxymandelonitrile | 0.5945 | 1.4059 | 0.9996 |
| S-adenosyl-L-homocysteine | NA | NA | NA |
| S-adenosyl-L-methionine+ | 0.2014 | 2.3470 | 0.4515 |
| S-adenosylmethioninamine+ | 0.9652 | 1.1421 | 0.4665 |
| SAICAR | NA | 1.0000 | NA |
| sarcosine | 0.9223 | 1.3835 | 0.5414 |
| serine | 0.8017 | 1.2433 | 0.9550 |
| serotonin | 1.4203 | 0.9776 | 0.6020 |
| sorbitol / galactitol / L-iditol / manitol | 1.1087 | 0.9457 | 0.9456 |
| spermidine | 0.6433 | 0.5926 | 1.7641 |
| spermine | 1.2087 | 0.5333 | 1.1413 |
| succinic acid | 0.8550 | 1.1674 | 0.9776 |
| succinic semialdehyde | NA | NA | NA |
| succinyl-CoA | 0.3126 | 1.4586 | 0.7132 |
| taurine | 1.0053 | 1.2474 | 0.7473 |
| thiamine+ | NA | NA | NA |
| thymidine | 1.1917 | 0.4725 | 1.3359 |
| thymine | 1.0223 | 1.1240 | 0.8538 |
| tryptamine | 0.9743 | 1.1883 | 0.5376 |
| tryptophan | 0.7494 | 1.3360 | 0.9146 |
| tyramine | 0.7814 | 1.1480 | 1.0706 |
| tyrosine | 1.1076 | 0.9822 | 0.9102 |
| UDP | 0.4018 | 1.8832 | 0.7150 |
| UDP-D-glucose | 0.5365 | 1.6965 | 0.7670 |
| UDP-N-acetyl-galactosamine/UDP-N-acetyl-glucosamine | 0.6783 | 1.4997 | 0.8220 |
| UMP | 0.5063 | 1.8067 | 0.6870 |
| uracil | 0.8184 | 1.2430 | 0.9386 |
| urea | 0.4471 | 1.7610 | 0.7919 |
| uric acid | 1.0124 | 1.1776 | 0.8100 |
| uridine | 1.2378 | 0.2466 | 1.5156 |
| UTP | 0.3815 | 1.9240 | 0.6945 |
| valine | 1.3068 | 1.0194 | 0.6738 |
| xanthine | 1.0953 | 0.6834 | 1.2213 |
| xanthosine | 1.0000 | NA | NA |
| xanthurenic acid | 1.0000 | NA | NA |
| XMP | 0.3700 | 1.7106 | 0.6825 |
| y-glutamylcysteine | NA | NA | NA |
Factors:
| F1 | genotype:ApoE-KO | treatment:no treatment |
| F2 | genotype:wild-type | treatment:IL-4 |
| F3 | genotype:wild-type | treatment:no treatment |
