Data for (Study ST002858)
(Analysis AN004685)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 10-Formyltetrahydrofolate | 1.0754 | 0.8789 | 0.9114 | 0.9393 | 0.8950 | 1.0344 | 1.1881 |
| 1-3-Bisphosphoglycerate | 0.9384 | 0.9487 | 1.0429 | 1.0962 | 0.9356 | 0.9784 | 1.0589 |
| 2^,3^-Cyclic CMP | 1.1025 | 0.9071 | 1.0140 | 0.9867 | 1.0240 | 0.9349 | 1.0073 |
| 2/3-Phospho-D-glycerate | 1.1097 | 0.9110 | 0.7090 | 1.6659 | 0.5369 | 1.3433 | 0.5969 |
| 2-Aminomuconate | 0.9123 | 0.8250 | 1.0149 | 1.0406 | 1.1689 | 1.0776 | 0.9587 |
| 2-Hydroxyglutarate | 1.0470 | 0.9149 | 0.9914 | 0.9847 | 0.9442 | 1.0407 | 1.0392 |
| 2-Oxoglutarate | 1.1776 | 0.8516 | 0.9837 | 0.9647 | 0.9401 | 1.0262 | 0.9951 |
| 3D-(3-5/4)-Trihydroxycyclohexane-1-2-dione | 1.0177 | 1.0638 | 1.0775 | 1.0614 | 1.0097 | 0.8741 | 0.9311 |
| 3-Methyldioxyindole | 0.7038 | 1.6029 | 0.7498 | 0.5356 | 1.4678 | 0.8401 | 1.2305 |
| 3-Phospho-D-glyceroyl phosphate | 0.9384 | 0.9487 | 1.0429 | 1.0962 | 0.9356 | 0.9784 | 1.0589 |
| 3-Sulfino-L-alanine | 1.1227 | 0.7457 | 1.0389 | 1.1400 | 0.9122 | 1.0905 | 0.9012 |
| 3-Sulfocatechol | 0.8241 | 1.2826 | 1.2863 | 1.0344 | 1.0014 | 0.7838 | 0.8678 |
| 5-Hydroxyindoleacetate | 0.9416 | 0.9794 | 0.9900 | 1.0518 | 1.0658 | 0.9773 | 1.0156 |
| 5-Hydroxyisourate | 1.0548 | 0.9618 | 1.0298 | 1.0315 | 0.9614 | 0.9612 | 0.9900 |
| 5-L-Glutamyl-taurine | 1.1887 | 0.7207 | 1.1697 | 1.1155 | 0.9093 | 0.9502 | 0.8975 |
| 6-Hydroxykynurenic acid | 1.3111 | 1.3296 | 0.8979 | 0.6612 | 0.9151 | 0.9370 | 0.9870 |
| 6-Phospho-D-gluconate | 1.0844 | 0.8259 | 0.9523 | 1.0040 | 0.8473 | 1.0508 | 1.1330 |
| Adenine | 1.1404 | 0.8721 | 1.2141 | 0.7897 | 1.1338 | 0.9064 | 0.8800 |
| Argininosuccinate | 0.9383 | 1.4331 | 1.0497 | 0.7586 | 1.1685 | 1.0597 | 0.7152 |
| Ascorbate | 0.5747 | 2.4492 | 0.8471 | 0.7573 | 0.8591 | 0.8572 | 0.9490 |
| ATP | 0.9350 | 1.3324 | 1.0091 | 1.0171 | 0.9512 | 1.0066 | 0.8679 |
| Carnosine | 1.5442 | 0.9256 | 1.1251 | 0.8752 | NA | 0.8202 | 0.8064 |
| Citrate | 0.9100 | 1.1557 | 0.9495 | 1.0168 | 0.9195 | 1.0334 | 1.0450 |
| CTP | 0.8795 | 0.9436 | 1.0248 | 1.0606 | 1.0537 | 1.0494 | 1.0002 |
| Cys-Gly | 0.6635 | 2.2434 | 0.8126 | 0.8100 | 0.8642 | 1.0043 | 0.7797 |
| D-4--Phosphopantothenate | 0.9916 | 0.9533 | 0.9885 | 0.9840 | 1.3030 | 1.1483 | 0.7317 |
| dAMP | 1.0202 | 1.0017 | 0.8509 | 0.7748 | 1.5239 | 1.0807 | 0.7845 |
| D-Arabitol/Xylitol/Ribitol | 0.9521 | 1.8190 | 0.9541 | 0.9051 | 0.8990 | 0.8649 | 0.7787 |
| dCMP | 0.9477 | 0.9248 | 1.1371 | 1.0754 | 1.0421 | 1.0567 | 0.8188 |
| Dehydroascorbate | 0.9268 | 1.0349 | 1.0090 | 1.0543 | 0.9693 | 0.9977 | 1.0257 |
| D-Fructose 1-6-bisphosphate | 0.8636 | 1.1020 | 1.0802 | 1.1254 | 1.0188 | 1.1802 | 0.8189 |
| D-Glucose | 0.9729 | 0.9657 | 1.0547 | 1.0742 | 1.0185 | 0.9644 | 0.9638 |
| D-Glyceraldehyde 3-phosphate/Glycerone phosphate | 1.2554 | 0.6799 | 1.0595 | 0.7717 | 0.8949 | 1.2279 | 0.8881 |
| D-Hexose-phosphate | 0.9948 | 1.0525 | 1.0228 | 1.0673 | 0.9401 | 0.9777 | 0.9648 |
| D-Rhamnose | 0.8914 | 1.0189 | 0.9540 | 1.0080 | 1.0941 | 1.0334 | 1.0262 |
| FA(10:0) | 0.9388 | 0.9471 | 0.9723 | 1.0568 | 1.0352 | 0.9981 | 1.0596 |
| FA(12:0) | 1.0783 | 0.9803 | 0.8188 | 1.1470 | 0.8387 | 1.0451 | 1.0936 |
| FA(14:0) | 1.1657 | 1.0403 | 0.7724 | 1.0889 | 0.7230 | 1.1247 | 1.0641 |
| FA(14:1) | 1.0518 | 1.0366 | 0.7436 | 1.2099 | 0.7313 | 1.0959 | 1.1429 |
| FA(16:0) | 1.0697 | 0.9680 | 0.8571 | 1.1302 | 0.8546 | 1.0474 | 1.0700 |
| FA(16:1) | 1.2134 | 1.0102 | 0.7051 | 1.1394 | 0.6518 | 1.2016 | 1.0486 |
| FA(18:0) | 1.0882 | 0.9643 | 0.8269 | 1.1564 | 0.8842 | 1.0179 | 1.0710 |
| FA(18:1) | 1.0842 | 0.9417 | 0.8268 | 1.1583 | 0.8324 | 1.0356 | 1.1142 |
| FA(18:2) | 1.1455 | 0.9246 | 0.7618 | 1.1442 | 0.8141 | 1.0758 | 1.1153 |
| FA(18:3) | 1.1793 | 0.8717 | 0.7491 | 1.2287 | 0.7961 | 1.0665 | 1.0945 |
| FA(20:3) | 1.1083 | 1.0319 | 0.7395 | 1.1329 | 0.8665 | 1.1036 | 1.0345 |
| FA(20:4) | 1.1548 | 1.1808 | 0.7243 | 0.9324 | 0.6964 | 1.1517 | 1.1291 |
| FA(20:5) | 1.1086 | 1.0177 | 0.6047 | 1.0413 | 0.7434 | 0.9892 | 1.4595 |
| FA(22:5) | 1.2636 | 1.1836 | 0.6045 | 1.0516 | 0.6641 | 1.0952 | 1.1451 |
| FA(22:6) | 1.0605 | 0.9543 | 0.7384 | 1.2225 | 0.8702 | 1.0383 | 1.1369 |
| FA(4:0) | 0.8958 | 0.8202 | 1.0845 | 1.0632 | 1.2948 | 0.8514 | 1.0179 |
| FA(5:0) | 0.9898 | 1.0046 | 0.9155 | 1.1080 | 1.0322 | 0.9673 | 1.0191 |
| FA(6:0) | 0.9064 | 0.9786 | 0.9104 | 1.0991 | 0.9189 | 1.1435 | 1.0476 |
| FA(7:0) | 0.9816 | 0.9728 | 1.0106 | 0.9864 | 1.0285 | 1.0295 | 0.9856 |
| FA(8:0) | 0.6616 | 0.6307 | 1.4683 | 1.5031 | 1.4060 | 0.5340 | 0.9131 |
| FA(9:0) | 0.9894 | 0.9516 | 1.0517 | 1.0072 | 1.0114 | 1.0193 | 0.9608 |
| Fumarate | 1.0492 | 1.3336 | 0.9014 | 0.9477 | 0.9761 | 0.9365 | 0.9258 |
| Glycerol 3-phosphate | 1.0228 | 0.8580 | 1.1233 | 1.0252 | 1.0313 | 0.9773 | 0.9372 |
| glycine | 0.9303 | 0.9522 | 0.9815 | 1.0051 | 1.0851 | 1.0119 | 1.0395 |
| Glycolate | 1.0353 | 0.9857 | 0.9777 | 1.0067 | 0.9767 | 1.0212 | 0.9900 |
| Homocarnosine | 0.8437 | 1.1863 | 1.0104 | 0.9691 | 1.0089 | 1.0494 | 0.9632 |
| Hydroxyindole-acetylglycine | 1.1521 | 0.8787 | 1.0451 | 0.9794 | 0.8852 | 1.0345 | 0.9642 |
| Indole | 1.0148 | 0.8000 | 1.1065 | 0.9411 | 1.0681 | 0.9565 | 1.0576 |
| Indole-3-acetate | 0.9839 | 0.8099 | 1.0631 | 1.0608 | 1.0416 | 0.8410 | 1.1735 |
| Indolepyruvate | 0.9659 | 0.8706 | 1.1718 | 0.8975 | 1.0946 | 0.9504 | 1.0064 |
| Indoxyl | 0.8330 | 1.0354 | 1.0358 | 0.6022 | 1.2913 | 1.1406 | 1.0232 |
| Lactate | 0.9453 | 1.0009 | 0.9226 | 0.9944 | 1.1164 | 1.0301 | 1.0123 |
| L-aspartate | 0.9959 | 1.0938 | 0.8810 | 0.9704 | 1.0335 | 1.0014 | 1.0478 |
| L-Cysteate | 0.8494 | 0.9314 | 0.9203 | 1.0250 | 1.1312 | 1.0663 | 1.0909 |
| L-cysteine | 1.0458 | 0.9551 | 1.1413 | 0.9731 | 1.0111 | 0.9352 | 0.9185 |
| L-cystine | 1.0561 | 0.8604 | 1.1242 | 1.0146 | 1.0469 | 0.9263 | 0.9475 |
| L-histidine | 1.0175 | 0.8922 | 1.0981 | 0.9576 | 0.9920 | 1.0194 | 0.9815 |
| L-serine | 0.9225 | 0.9370 | 1.0088 | 1.0471 | 1.0681 | 1.0363 | 0.9896 |
| L-threonine | 0.9608 | 0.9817 | 1.0502 | 0.9725 | 1.0679 | 1.0009 | 0.9674 |
| Malate | 1.1267 | 0.8169 | 0.9541 | 1.0383 | 1.0363 | 1.0185 | 0.9778 |
| Maltose/Sucrose | 0.4782 | 0.9062 | 0.5491 | 0.3056 | 0.3126 | 1.8855 | 2.2159 |
| Mannitol/Sorbitol/Glucitol/Iditol | 0.9168 | 1.3880 | 0.6979 | 0.7352 | 2.0650 | 0.5826 | 0.8603 |
| N-Acetylneuraminate | 0.9757 | 1.5115 | 0.9591 | 0.9718 | 0.9543 | 0.8637 | 0.8836 |
| NAD+ | 0.8405 | 0.6411 | 1.1360 | 1.1013 | 1.1576 | 1.0516 | 1.1382 |
| NADH | 0.9275 | 0.8847 | 0.9287 | 1.2510 | 1.3290 | 1.0163 | 0.7212 |
| N-formyl kynurenine | 0.7953 | 1.0152 | 1.1476 | 0.9315 | 1.2955 | 1.0464 | 0.8154 |
| N-Glycoloyl-neuraminate | 0.9266 | 0.9958 | 1.0737 | 0.9164 | 1.0860 | 1.0722 | 0.9231 |
| N-Methylethanolamine phosphate | 1.0671 | 0.8697 | 1.0444 | 1.0106 | 0.9676 | 0.9880 | 1.0141 |
| N-Succinyl-L-glutamate 5-semialdehyde | 0.9258 | 1.0916 | 0.9593 | 0.9374 | 1.0601 | 1.0568 | 0.9887 |
| Oxaloacetate | 0.8954 | 1.1245 | 0.9311 | 1.0338 | 0.9652 | 1.0235 | 1.0618 |
| Pantetheine 4--phosphate | 1.0909 | 0.9416 | 1.0064 | 1.1216 | 0.9165 | 0.8684 | 1.0460 |
| Pantothenate | 1.0430 | 0.9420 | 0.9682 | 0.9841 | 1.0719 | 0.9632 | 1.0199 |
| Phosphate | 0.8203 | 0.8441 | 1.2602 | 1.2225 | 1.0868 | 0.8496 | 0.9516 |
| Phosphocreatine | 1.1560 | 0.7337 | 1.2829 | 1.1709 | 0.9874 | 0.8681 | 0.7835 |
| Phosphoethanolamine | 0.8839 | 0.7238 | 1.0651 | 1.0621 | 1.0674 | 1.1390 | 1.0150 |
| Pyridoxamine 5^-phosphate | 0.9664 | 1.2458 | 0.9209 | 1.2425 | 0.9124 | 0.9589 | 0.8274 |
| Pyruvate | 0.9122 | 0.9955 | 1.0407 | 1.0241 | 1.1255 | 0.9766 | 0.9556 |
| Quinolinic acid | 1.0055 | 0.9911 | 1.0700 | 0.9293 | 1.0379 | 0.9847 | 0.9680 |
| Ribose/Ribulose/Arabinose/Xylose/Xylulose | 0.9231 | 1.0414 | 1.1815 | 1.0621 | 1.0006 | 0.9112 | 0.9078 |
| (S)(+)-Allantoin | 1.0264 | 0.8700 | 0.8359 | 1.2210 | 1.3425 | 0.9286 | 0.8683 |
| S-Glutathionyl-L-cysteine | 0.9436 | 0.9363 | 0.9851 | 1.0896 | 1.0480 | 1.1035 | 0.9062 |
| Sphinganine 1-phosphate | 0.9726 | 0.9397 | 0.8945 | 1.0477 | 0.9461 | 1.1311 | 1.0540 |
| Sphingosine 1-phosphate | 0.9795 | 0.9276 | 0.9661 | 1.0060 | 1.0173 | 1.0392 | 1.0501 |
| Succinate | 1.1114 | 0.9059 | 0.9885 | 0.9911 | 0.9621 | 1.0116 | 0.9944 |
| Tetrahydrofolate | 1.1428 | 1.1402 | 0.9761 | 0.9626 | 0.8567 | 0.8786 | 1.0511 |
| Thiocysteine | 1.0490 | 0.9952 | 1.0893 | 1.0890 | 1.0618 | 0.9215 | 0.8286 |
| Thymidine | 0.9064 | 0.8958 | 1.1578 | 1.0262 | 1.1165 | 0.7924 | 1.1073 |
| UDP | 1.0152 | 1.0021 | 0.9806 | 1.0323 | 0.9559 | 0.9974 | 1.0170 |
| UDP-glucose | 1.0229 | 1.1804 | 1.1301 | 0.6784 | 1.0242 | 1.0328 | 0.9137 |
| UDP-N-acetyl-D-glucosamine | 0.8388 | 0.9140 | 1.1006 | 1.0583 | 1.1902 | 0.9779 | 0.9451 |
| Uracil | 1.0114 | 1.0002 | 1.1521 | 1.1186 | 0.8726 | 0.8121 | 1.0393 |
| Urate | 0.9960 | 0.9616 | 1.0224 | 1.0478 | 0.9791 | 0.9518 | 1.0395 |
Factors:
| F1 | TIMEPOINT:FU1 |
| F2 | TIMEPOINT:FU12 |
| F3 | TIMEPOINT:FU3 |
| F4 | TIMEPOINT:FU6 |
| F5 | TIMEPOINT:FU9 |
| F6 | TIMEPOINT:REND |
| F7 | TIMEPOINT:START |