Data for (Study ST002878)
(Analysis AN004715)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-trimethyllysine | 1.2714 | 0.9751 | 0.9928 | 1.1677 | 0.9852 | 0.9542 | 1.1635 | 0.9931 | 0.9841 | 0.9686 | 0.9452 | 0.8554 |
5^-methylthioadenosine | 0.3961 | 0.4268 | 0.4550 | 0.5956 | 0.6337 | 0.8767 | 0.8998 | 1.0996 | 1.1519 | 0.9951 | 1.3348 | 1.5683 |
acetyl-carnitine | 1.0471 | 0.8300 | 0.8302 | 0.8906 | 0.8266 | 0.8631 | 1.0667 | 0.9630 | 1.1161 | 0.9472 | 1.1152 | 1.1055 |
adenine | 0.3912 | 0.4301 | 0.3877 | 0.3231 | 0.5201 | 0.5278 | 1.1633 | 1.3578 | 1.2128 | 1.1406 | 1.3225 | 1.2709 |
adenosine | 0.5690 | 0.8597 | 0.6229 | 0.6146 | 0.6068 | 0.7914 | 1.1376 | 1.3370 | 1.0981 | 1.0097 | 1.1148 | 0.9649 |
AIR | 0.0499 | 1.2768 | 1.4247 | 1.2810 | 1.5601 | 1.4672 | 0.0190 | 1.0397 | 1.0984 | 1.0423 | 1.0774 | 1.0475 |
alanine | 0.5289 | 0.6692 | 0.6559 | 0.6010 | 0.7005 | 0.8082 | 1.0219 | 1.1493 | 1.1507 | 1.1028 | 1.2338 | 1.2482 |
arginine | 0.4940 | 0.5925 | 0.6165 | 0.5574 | 0.6718 | 0.6425 | 1.0395 | 1.1940 | 1.0162 | 1.2793 | 1.2576 | 1.2617 |
asparagine | 0.6028 | 0.4576 | 0.6224 | 0.4335 | 0.8126 | 1.1007 | 0.9447 | 0.8885 | 0.8956 | 0.8564 | 1.3338 | 1.9727 |
betaine | 0.8081 | 0.7757 | 0.7913 | 0.8319 | 0.7574 | 0.8351 | 1.1615 | 1.1040 | 1.0646 | 1.1348 | 1.0383 | 1.0287 |
carnitine | 0.9680 | 0.9007 | 0.9261 | 0.9697 | 0.9453 | 1.0501 | 1.0274 | 1.0161 | 0.9862 | 1.0171 | 1.0121 | 1.0516 |
CDP-choline | 0.2968 | 0.6948 | 0.8987 | 0.5390 | 1.0568 | 1.1141 | 0.5028 | 1.1534 | 1.0992 | 0.9151 | 1.3730 | 1.3938 |
choline | 0.0227 | 0.0337 | 0.0216 | 0.0352 | 0.0283 | 0.0053 | 1.5872 | 1.2317 | 1.1261 | 1.5207 | 1.2817 | 1.2296 |
citrulline | 0.6884 | 0.9611 | 1.3028 | 0.9759 | 1.4406 | 1.3736 | 0.9545 | 0.9810 | 0.9289 | 0.8887 | 0.9458 | 0.9856 |
creatine | 0.7226 | 0.6928 | 0.7009 | 0.7254 | 0.7132 | 0.8472 | 1.1339 | 1.1271 | 1.1036 | 1.1107 | 1.1463 | 1.0898 |
creatinine | 0.6779 | 0.6421 | 0.9645 | 0.5638 | 1.1964 | 1.3405 | 1.0177 | 0.9797 | 0.9989 | 0.9797 | 1.0356 | 1.2821 |
cystathionine | 0.1148 | 0.1731 | 0.2275 | 0.0912 | 0.4656 | 0.0979 | 1.4991 | 1.2034 | 1.1664 | 1.2498 | 1.3437 | 1.1150 |
cysteine-glutathione disulfide | 0.0645 | 0.0416 | 0.0599 | 0.0647 | 0.0610 | 0.0732 | 1.7565 | 1.1246 | 0.6722 | 1.0543 | 1.7364 | 2.1890 |
dihydrourocanate | 0.3127 | 0.5141 | 0.6747 | 0.5304 | 0.6394 | 0.7559 | 1.3172 | 1.1878 | 1.1386 | 1.1607 | 1.1379 | 1.2033 |
gamma-butyrobetaine | 0.7423 | 0.6664 | 0.6870 | 0.7157 | 0.6911 | 0.7953 | 1.1550 | 1.1130 | 1.0919 | 1.1081 | 1.1203 | 1.1675 |
glycerophosphocholine | 0.8271 | 0.4777 | 0.5004 | 0.4886 | 0.5259 | 0.5714 | 1.5892 | 1.1400 | 1.1221 | 1.0719 | 1.0423 | 1.1871 |
glycine | 0.6844 | 0.6963 | 0.7458 | 0.9058 | 0.7083 | 0.7551 | 0.8876 | 1.1351 | 1.0671 | 0.9936 | 1.2347 | 1.3151 |
guanine | 0.6388 | 0.4742 | 0.4122 | 0.4568 | 0.4106 | 0.3664 | 1.4175 | 1.2388 | 1.0652 | 1.3655 | 1.0974 | 0.9650 |
histamine | 0.1631 | 0.1939 | 0.2123 | 0.2170 | 0.2255 | 0.3318 | 0.9452 | 1.3125 | 1.2984 | 1.2120 | 1.5875 | 1.9957 |
hypoxanthine | 1.1800 | 0.7671 | 0.4967 | 0.7376 | 0.7562 | 0.8843 | 1.7828 | 1.0649 | 0.7957 | 0.9244 | 0.8399 | 1.0550 |
imidazoleacetate | 0.4368 | 0.3472 | 0.4944 | 0.3619 | 0.5377 | 0.8172 | 0.8000 | 1.1916 | 1.2481 | 0.9663 | 1.3628 | 1.7742 |
imidazolepyruvate | 2.2270 | 0.1858 | 0.3087 | 0.2266 | 0.3098 | 0.3237 | 1.8130 | 0.9964 | 0.7873 | 1.1784 | 0.6806 | 1.1191 |
kynurenic acid | 0.6050 | 0.7019 | 1.1182 | 0.8193 | 1.4780 | 1.2817 | 0.8840 | 0.7956 | 0.9211 | 0.9099 | 1.0208 | 1.4719 |
kynurenine | 0.5701 | 0.5662 | 0.7021 | 0.5535 | 0.7363 | 0.6753 | 0.9046 | 1.1795 | 1.2385 | 1.0662 | 1.3738 | 1.2403 |
L-2-aminobutyric acid | 1.0356 | 0.4813 | 0.4533 | 0.6477 | 1.1754 | 0.5428 | 1.4036 | 1.0438 | 1.1616 | 1.0926 | 1.0737 | 0.9593 |
leucine / isoleucine | 0.4544 | 0.6601 | 0.8077 | 0.5955 | 0.8194 | 0.8441 | 0.7381 | 1.2478 | 1.0302 | 1.2388 | 1.2544 | 1.3014 |
lysine | 0.3773 | 0.5373 | 0.5923 | 0.4969 | 0.6935 | 0.7546 | 0.9043 | 1.1455 | 1.1163 | 1.1163 | 1.3708 | 1.4812 |
methionine | 0.4953 | 0.4359 | 0.5117 | 0.4189 | 0.5030 | 0.4866 | 1.1365 | 1.2457 | 1.1469 | 1.2721 | 1.2718 | 1.3182 |
methioninesulfoxide | 0.1007 | 0.1843 | 0.1552 | 0.1521 | 0.1639 | NA | 0.8783 | 0.9789 | 1.1002 | 1.8435 | 1.3619 | 2.5935 |
NAD+ | 0.6305 | 0.4295 | 0.3951 | 0.4454 | 0.4023 | 0.4015 | 1.4581 | 1.0422 | 1.0782 | 1.1556 | 1.1096 | 1.1059 |
NADP+ | 0.8722 | 0.7317 | 0.5861 | 0.8907 | 0.4758 | 0.6350 | 1.2117 | 1.1307 | 1.1287 | 1.0836 | 1.0710 | 0.9395 |
nicotinamide | 1.2271 | 1.0231 | 1.0082 | 0.9681 | 0.9464 | 1.0500 | 0.8432 | 1.1585 | 0.9119 | 1.2605 | 0.9177 | 0.8104 |
N-trimethyllysine | 0.0741 | 0.1574 | 0.1842 | 0.1184 | 0.4318 | 0.0024 | 0.8367 | 2.4511 | 1.4677 | 2.4581 | 3.2329 | 0.3358 |
ornithine | 0.5675 | 0.9637 | 1.0695 | 0.9165 | 1.0209 | 0.9952 | 0.9139 | 1.0400 | 0.9606 | 1.0634 | 1.0711 | 1.1608 |
phenylalanine | 0.7108 | 0.6328 | 0.7242 | 0.7049 | 0.6261 | 0.8503 | 0.9503 | 1.1880 | 0.9199 | 1.2382 | 1.2146 | 1.2694 |
phosphocholine | 0.6343 | 0.4914 | 0.4632 | 0.5052 | 0.3998 | 0.4483 | 1.5402 | 1.2443 | 1.1427 | 1.2559 | 1.0943 | 1.0710 |
proline | 0.5307 | 0.4911 | 0.5976 | 0.4767 | 0.6347 | 0.7019 | 0.9418 | 1.1941 | 1.1700 | 1.1085 | 1.3146 | 1.4114 |
propionyl-carnitine | 1.3105 | 0.7488 | 0.7864 | 0.8756 | 0.9407 | 1.1042 | 1.2725 | 0.9005 | 0.9052 | 0.8823 | 0.9922 | 1.1578 |
riboflavin | 0.9461 | 0.7817 | 0.6968 | 0.7479 | 0.8431 | 0.8973 | 1.1260 | 0.9621 | 0.8712 | 0.9810 | 1.1001 | 1.2226 |
S-adenosyl-methionine | 0.6555 | 0.7726 | 0.8796 | 0.7386 | 1.0901 | 1.0312 | 0.8097 | 0.8961 | 1.0604 | 0.8983 | 1.2148 | 1.4648 |
sarcosine | 0.3656 | 0.4014 | 0.7095 | 0.3889 | 0.7233 | 0.6512 | 0.7560 | 1.1054 | 1.0236 | 0.8148 | 1.5774 | 1.4128 |
serine | 0.8639 | 0.6881 | 0.6936 | 0.7617 | 0.7890 | 0.7755 | 1.6431 | 1.0993 | 0.7518 | 1.2312 | 0.9272 | 0.9789 |
threonine | 0.7523 | 0.4204 | 0.4526 | 0.4084 | 0.4339 | 0.4968 | 1.4697 | 1.2076 | 1.1011 | 1.1892 | 1.1690 | 1.2042 |
urocanate | 0.2572 | 0.6617 | 0.6126 | 0.7974 | 1.5982 | 0.8895 | 0.8550 | 0.7571 | 1.4685 | 0.9192 | 2.2592 | 0.2806 |
valine | 0.8326 | 0.7179 | 0.6727 | 0.7471 | 0.5360 | 0.5491 | 0.8002 | 1.1454 | 1.3182 | 1.2085 | 1.0470 | 1.4248 |
Factors:
F1 | Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes |
F2 | Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour |
F3 | Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours |
F4 | Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes |
F5 | Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours |
F6 | Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours |
F7 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes |
F8 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour |
F9 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours |
F10 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes |
F11 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours |
F12 | Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours |