Data for (Study ST002984)

(Analysis AN004903)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5
1-Methyluracil 1.0847 1.0492 0.8644 1.0029 1.0466
2,3-Dihydroxybenzoate 1.2144 1.4880 1.1791 0.5272 0.7036
2,3-Diphosphoglycerate NA 0.0022 0.7183 5.6209 0.0320
2,6-Pyridinedicarboxylic acid 0.3481 0.4185 1.0475 1.6875 1.1366
2-C-Methyl-D-erythritol 4-phosphate 1.0419 0.7777 1.3166 0.8158 1.1246
2-Deoxy-D-ribose 5-phosphate 0.8007 0.8147 1.5935 0.7312 1.0784
2-Deoxy-glucose_6-phosphate 1.2946 1.3437 0.6061 1.3323 0.4378
2-Furoic acid 1.0844 0.9487 1.0620 1.0926 0.8517
2-Hydroxyglutaric_Acid 1.1102 0.7392 1.0054 1.0061 1.2319
2-Hydroxyhippuric acid 1.4987 0.7360 0.7371 1.5956 0.4329
2-Hydroxyisovaleric acid 0.8111 0.8851 1.0268 0.8570 1.3460
2-Hydroxyphenylacetic acid 0.9593 0.9844 1.0394 1.0335 0.9592
2-Isopropylmalic acid 0.9169 0.5958 1.3764 0.9274 1.1321
2-Methyl-3-Hydroxybutyric acid 0.7989 0.8906 1.0416 0.8263 1.3658
2-Methylbenzoic acid 1.3153 0.7170 1.1382 0.9134 1.1335
2-Methyl citrate 1.0381 0.6747 1.0962 1.2363 0.9869
2-Methylhippuric acid 1.0935 0.6746 0.9236 1.1394 1.2435
2-Oxobutyrate 0.6409 0.5717 1.0601 0.5537 1.9511
2-oxoglutarate 0.6126 0.4897 1.1432 1.0853 1.5192
2-Phosphoglycolate 0.0541 0.4543 1.6774 1.6893 0.2124
2-Picolinic acid 0.5209 1.0682 1.1612 1.0106 0.9730
2-Succinyl Cysteine 0.7207 0.3822 1.1212 1.4910 1.1528
3,4-Dihydroxymandelic acid 1.9328 0.1934 2.0511 0.7873 0.4531
3-Hydroxymethylglutaric acid 0.8868 0.7861 1.0396 1.0881 1.1558
3-Hydroxyphenylacetic acid 0.7749 0.8499 1.4009 0.7047 1.2091
3-Indoleacetic Acid 1.3264 0.7431 0.9118 1.4174 0.7541
3-Methyl-2-oxopentanoate 1.0689 1.0653 1.0097 0.8363 1.0697
3-Methyladipic acid 0.8099 1.7543 0.4663 0.9432 0.6224
3-Methyl-L-His 0.7348 0.5533 1.8382 0.8384 0.9750
3-Methylthiopropionate 0.6921 0.7545 0.7057 1.6454 0.6453
3-Phospho-D-glycerate + 2-Phospho-D-glycerate 1.1526 1.1300 1.7055 0.6452 0.4461
4-Hydroxybenzoic acid 0.8816 0.7428 1.0624 1.1992 1.0586
4-Hydroxyphenylacetic acid 0.7846 0.8283 1.3901 0.7288 1.2384
4-Hydroxyphenyllactic acid 0.7543 0.6198 1.1174 1.1842 1.2194
4-Hydroxyphenylpyruvic acid 1.0568 0.9510 1.3704 0.5032 1.3148
4-Hydroxyproline 1.0218 0.9810 1.1190 1.3127 0.5380
4-Methylbenzoic acid 1.0301 0.9641 1.0779 1.0185 0.9426
4-Phospho-D-erythronate 1.2569 1.0409 0.7175 1.1950 0.5631
5-Dehydroquinic acid 0.7626 0.6993 1.1269 1.0433 1.2757
5-Keto-gluconate 0.3615 0.2205 0.5376 2.6477 0.7764
Acetoacetate 0.8205 0.6408 0.6314 1.5431 0.7272
Acetyl-glycine 1.1923 0.9962 1.0556 1.0616 0.7932
Adipic acid 1.2145 1.1091 0.8987 0.9798 0.9006
ADP 0.5674 0.3984 1.7413 1.6872 0.4130
ADP-ribose 0.5591 0.9120 1.2141 0.6790 1.2975
Ala-Ala 0.6525 0.7083 2.1582 0.4944 0.9075
Allatoin 1.2010 0.8182 0.7962 1.2849 0.9931
alpha-HMB 0.9161 0.7843 0.8512 1.1211 1.2952
AMP 1.4144 0.8336 1.2223 NA 0.8372
Ascorbic_acid 0.4398 0.2404 0.7671 2.0887 1.0890
Aspartic acid 0.7551 0.8168 0.9963 0.9865 1.3409
Asp-Asp-Gly 0.7671 0.4923 1.1276 1.5738 0.9062
Asp-Asp-Ser 1.3872 0.5958 0.9833 1.2150 0.6298
Azelaic acid 0.3809 0.3003 0.3626 0.3022 3.5102
Benzoic acid 0.8984 1.0971 1.2144 0.8654 0.8754
beta-hydroxy-beta-methylbutyrate (HMB) 0.7821 0.7617 1.1654 0.7455 1.4788
beta-Hydroxybutyrate 1.2755 0.9937 0.9213 0.7177 1.2235
beta-hydroxy-iso-butyrate 1.3786 0.9654 0.9898 0.6810 1.2507
beta-Keto-iso-valeric acid 0.8495 1.1046 1.0099 0.9563 1.1272
Butyrate 0.9705 1.1275 0.9317 0.8354 1.1241
Caproic acid 1.0563 0.9872 0.9555 1.0600 0.9647
Carbamoyl-DL-aspartic_acid 1.1365 0.5172 0.9855 1.1591 0.8492
cis-Aconitate 1.2743 0.8357 1.0643 1.0266 0.9638
Citicoline 1.3522 0.9189 1.0344 0.9053 0.9445
Citraconic acid 1.1991 0.7659 1.1474 0.9753 1.0530
Citrate 1.0782 0.9569 1.0753 1.0567 0.8728
CMP 1.7935 1.8891 0.8298 0.3545 0.5335
Creatine_phosphate 4.2859 0.6385 0.5196 0.2171 0.2654
cTMP 1.2730 1.1861 1.0473 0.8116 0.6738
cyclic FMN 1.6229 0.4813 0.8444 1.6699 0.4568
Cys-Gly 1.0079 0.5170 1.8136 1.0219 0.8859
Cysteic_acid 1.0234 0.9943 0.8911 1.1089 0.9809
Cystine 1.0274 0.7782 1.2128 0.9343 1.1003
D-4^-Phosphopantothenate 1.9044 1.1425 0.9373 0.6892 0.6655
Deoxyuridine 1.6776 0.8058 0.4064 1.7029 0.4282
dGDP 0.5727 0.3918 1.7453 1.6932 0.4075
D-Glucarate 1.0934 1.0467 1.0744 0.8773 0.9681
D-Glucopyranuronate 0.4864 0.2953 0.7734 1.9755 1.0701
D-(+)-Glucosamine 1.0790 0.9297 1.1096 0.7785 1.1842
D-Glucosamine 1-phosphate 1.1003 0.8580 0.7138 1.2800 1.0830
D-Glucose 0.8120 1.0883 0.9788 0.8251 1.2094
D-Glucuronate 0.4906 0.3077 0.7807 2.0045 1.1031
D-Glyceric_acid 0.8522 1.5046 0.9816 0.7746 0.7647
dGMP 0.6346 0.4854 1.5971 1.5218 0.5653
Dihydroorotate 0.2618 0.2201 2.8956 0.2521 0.9354
Dihydrooroticacid NA 0.0153 2.0070 0.0094 0.8183
Dihydrouracil 0.4573 0.4870 1.5740 1.0553 1.1981
Dimethylallyl pyrophosphate 0.2963 0.3708 1.4356 NA 0.6928
DL-Glyceraldehyde-3-phosphate 0.7050 0.7481 1.0865 1.1682 1.1920
DL-Homocysteic acid 0.3259 0.2506 0.7055 2.5220 0.6835
Enanthic acid 1.0737 0.9693 0.9650 1.0206 1.0121
Ergothioneine 1.5184 0.6356 1.1308 1.2198 0.7912
Erythose 0.5855 0.9677 1.0426 0.9963 1.1915
Ethanolamine Phosphate 3.1824 0.9075 1.2746 0.2663 0.6374
Ferulic acid 0.7940 1.2169 0.6408 1.0828 1.0784
Formyl-L-methionine 1.0935 0.7328 1.0807 1.1908 0.9623
Fructose1,6-diphosphate 1.1644 0.9019 0.7460 1.5572 0.3366
Fructose-6-Phosphate 0.8608 1.1669 1.6813 0.3725 0.9058
Fumarate 1.1277 0.8183 1.0716 1.0109 1.0623
Galactose-1-Phosphate 1.3539 1.1578 0.9314 0.6884 1.0778
gamma-Ala-Lys 0.3224 0.1433 0.3127 0.2361 3.8401
gamma-Glu-Abu 0.2696 0.4350 0.7520 2.4028 0.6394
gamma-Glu-Ala 0.6407 0.8683 1.4776 0.8441 1.0160
gamma-Glu-Arg 1.0775 0.8561 0.5454 1.5366 0.9734
gamma-Glu-Citrulline 1.2800 0.8744 0.7768 1.4920 0.6773
gamma-Glu-Cys 1.1800 0.5641 1.1610 1.1195 1.1136
gamma-Glu-Gln 1.2692 1.0725 0.8353 1.1502 0.7868
gamma-Glu-Glu 0.6768 0.3632 0.9736 1.7951 0.9976
gamma-Glu-Gly 0.8329 0.7237 0.8836 1.2324 1.2441
gamma-Glu-His 0.9049 0.9624 0.9182 1.0703 1.0891
gamma-Glu-homoCys 1.6439 0.2573 1.1942 1.5042 0.7757
gamma-Glu-homoCys-Gly 0.1066 0.1181 3.4165 0.0995 0.9005
gamma-Glu-Leu 0.8757 0.5925 1.0701 1.2322 1.1866
gamma-Glu-Lys 1.0689 0.9760 0.9839 0.9837 1.0296
gamma-Glu-Met 0.0777 0.0964 0.7807 2.2949 1.2062
gamma-Glu-Phe 0.6265 0.3144 1.3183 1.3415 1.2460
gamma-Glu-Ser 0.8677 0.8323 0.8818 1.2750 1.0584
gamma-Glu-Taurine 0.8111 0.4747 0.9875 1.6718 0.9346
gamma-Glu-Thr 0.8863 0.7348 0.7634 1.6859 0.8130
gamma-Glu-Trp 1.0479 0.3883 1.1162 1.4007 1.1006
gamma-Glu-Tyr 0.7935 0.4159 1.1014 1.5787 1.0011
gamma-Glu-Val 0.8381 0.6568 0.9314 1.3054 1.1870
GDP-D-mannose NA 0.7647 0.7943 NA 1.7350
Gentisic acid 1.4944 1.4554 1.1780 0.5454 0.6194
Glu-Asp 0.8721 0.6888 1.1278 1.2381 1.0148
Glucose-1-Phosphate 1.9769 1.2517 0.8304 0.7873 0.6695
Glucose-6-Phosphate 0.6507 0.9558 1.8720 0.3691 0.7510
Glutaconic acid 1.0501 0.6784 0.9865 1.0991 1.2423
Glutamic acid 0.7332 0.8041 1.1229 1.0007 1.2228
Glutaric acid 0.7792 0.8594 0.7957 1.1905 1.2508
Glutathione_oxidized form 0.2915 0.3877 0.2514 NA 1.4696
Glutathione, reduced 1.0168 0.6389 1.4867 1.0182 0.8940
glyceraldehyde 3-phosphate/Dihidroxyacetophosphate 0.6912 1.1113 0.7211 1.6645 0.4642
Glycerol 2-phosphate 1.1632 1.2304 0.7631 1.2621 0.6026
Glycerol_3-phosphate 1.1503 1.2195 0.7693 1.2704 0.6054
Gly-Gly 0.8709 1.0531 0.9818 0.9208 1.1069
Gly-Leu 0.7419 0.6494 1.2819 1.1334 1.0846
Homocystine 1.0236 1.2907 0.4901 1.6398 0.2590
Homovanillic acid 0.7598 0.6222 1.1163 1.1652 1.2367
Hypotaurine 0.9627 1.0910 0.7683 1.3713 0.7252
Iso-citrate 0.9194 0.8662 1.0937 1.1147 0.9657
Isopentenyl pyrophosphate NA 0.2250 1.4271 NA 0.3672
Itaconic acid 1.0775 0.6948 0.9653 1.1213 1.2071
keto-isocaproic acid (4-Methyl-2-oxopentanoate) 1.0693 1.0647 1.0119 0.8354 1.0689
Ketoleucine (3-Methyl-2-oxovaleric acid) 0.9426 0.8829 1.1965 0.6819 1.3235
Lactate 0.9476 1.0327 0.9340 0.9906 1.0640
Lanthionine 0.1528 0.3655 2.9935 0.2024 0.9718
L-Ascorbic acid 2-sulfate 0.9831 0.9093 1.2126 1.0679 0.8211
L-Cysteine_S-sulfate 1.0528 0.7787 1.1644 1.0477 1.0077
L-Cysteinesulfinic acid 0.8816 0.7807 1.0658 0.9035 1.3473
Leucinic acid 0.8566 0.7678 0.8645 1.2584 1.1727
Leu-Leu-Tyr 1.1999 0.5610 1.1618 1.1599 0.9735
Levulinic acid 1.4421 0.9939 0.9600 1.0338 0.8023
L-Homocysteic acid 1.1488 0.7735 1.0611 1.3432 0.7372
L-Threonic acid 1.0760 1.0920 0.8652 NA 0.5116
Malate 1.2620 0.7818 1.0364 1.1014 0.9736
Maltitol/Lactitol 1.2227 0.8852 0.9691 1.0950 0.9494
Mandelic acid 0.8553 0.8537 1.2632 0.9570 1.1605
MES (IS) 1.0554 1.1159 0.8873 1.0571 0.8908
Methionine Sulfoxide 0.9384 0.8695 0.9513 1.2241 0.9713
Mevalonate 1.5204 1.0206 1.1356 0.7853 0.8416
N-Acetyl-a-D-glucosamine_1-phosphate 1.1602 1.8659 0.7285 0.3202 0.8499
N-Acetylaspartate 1.1189 0.8424 1.0249 1.3079 0.7493
N-Acetyl-Asp-Glu 0.9329 0.7450 1.2674 0.8993 1.1670
N-Acetyl-D-glucosamine_6-phosphate 1.6068 1.1299 1.2443 0.5781 0.4128
N-Acetyl-D-mannosamine 1.0377 1.0899 0.6399 1.4106 0.7512
N-Acetyl-L-glutamic_Acid 1.4109 0.7836 1.0252 1.1433 0.8658
N-Acetylneuraminic_acid 0.8310 0.8702 0.8888 1.3455 0.9456
Nicotinic_Acid 0.3771 0.4229 1.0318 1.7183 1.0988
N-Methyl-Arg 0.9544 0.9137 1.0224 1.0763 1.0103
N-α-Acetyl-L-methionine_sulfoxide 0.5282 0.4941 1.0112 1.6414 0.3573
O-Acetyl-L-serine 0.7249 0.8048 1.1205 1.0083 1.2197
O-Phospho-L-serine 0.5484 0.8161 1.3166 0.9304 1.1814
Ophthalmic Acid 0.6887 0.7036 1.6220 1.3448 0.4683
Orotic_acid 0.7755 0.6675 1.0266 1.5701 0.8089
Orthophosphate 0.8858 1.0666 1.3110 0.6651 1.0463
O-Succinyl-L-homoserine 1.2811 0.6359 1.0261 1.1582 1.0760
Phenylpyruvic acid 0.7685 0.6223 1.1067 1.2069 1.1948
Phosphoenolpyruvate 1.4107 0.9138 1.1468 0.7125 1.0850
PLP (pyridoxal-5^-phosphate) 1.4171 0.4706 0.6429 1.8570 0.2723
p-Toluenesulfonic acid 0.9232 0.6130 0.5308 2.3875 0.3711
Pyroglutamic acid 0.8694 1.1644 0.7963 1.3140 0.7225
Pyrophosphate 0.6250 0.7229 1.2609 1.5177 0.6587
Pyruvate 0.8982 0.8427 1.0708 0.8547 1.3197
Quinolinate 0.3449 0.4176 1.0451 1.6914 1.1371
Ribose5-phosphate + Ribulose5-phosphate + D-Xylulose_5-phosphate 1.2690 1.1216 1.0441 0.9095 0.7830
Sebacic acid 0.6128 0.5109 0.6509 0.6288 2.5048
Sedoheptulose_7-phosphate NA 0.7675 1.6925 0.1728 0.1705
Succinate 0.8928 0.9529 1.0544 1.0536 0.9882
Succinic anhydride 0.8251 0.9383 1.0924 1.0499 1.0026
Sucrose 0.5451 0.4923 0.6901 1.0842 2.0023
Tartaric acid 4.1533 0.5239 0.7709 0.8973 0.4135
Taurine 1.1820 1.1940 0.8702 1.0340 0.7866
Terephthalic acid 1.2189 0.8516 0.9869 1.2034 0.8486
Thiosulfate 0.7110 0.6605 1.3100 0.9830 1.2290
Thiotaurine 0.5290 0.4904 0.7413 2.3894 0.4813
trans-2-Butenoic acid 1.6580 0.8834 0.9845 1.1641 0.2462
trans-Aconiticacid 1.2327 0.7556 1.0625 1.0275 1.0748
Tyrosol 1.0288 1.0291 0.9182 1.1531 0.8620
UDP-N-acetylgalactosamine 0.2198 0.5251 1.6448 0.6817 1.5275
UMP 0.6382 1.3981 1.7027 0.3737 0.2312
Uric_acid 1.0649 0.9079 1.1352 0.9311 1.0171
Urocanic acid 0.9030 0.8516 1.2207 0.9460 1.0540
Xanthine 0.7533 0.4639 1.2901 1.1684 1.2416
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Factors:

F1Symotons:asymptomatic
F2Symotons:mild
F3Symotons:moderate
F4Symotons:Negative
F5Symotons:severe
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