Data for (Study ST003112)
(Analysis AN005111)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 1-Methyladenosine | 1.1545 | 0.9886 | 0.8331 |
| 1-Methylnicotinamide | 0.9752 | 1.1563 | 0.8466 |
| 2DG | NA | NA | NA |
| 2DGP | 2.4705 | 0.1295 | 0.1549 |
| 2-Hydroxycaproic acid | 1.1898 | 0.7474 | 1.0732 |
| 2-Hydroxyvaleric acid | 0.9855 | 1.0125 | 1.0024 |
| 3-Hydroxymethylglutaric acid | 1.0549 | 0.9019 | 1.0503 |
| 3-Indolepropionic acid | 1.0575 | 0.9320 | 1.0122 |
| 3-Methylhistidine | 0.8664 | 0.9598 | 1.2028 |
| 3-Phosphoglyceric acid | 0.9887 | 0.8409 | 1.1988 |
| 4-Acetamidobutanoic acid | NA | NA | NA |
| 4-Hydroxyproline | NA | NA | NA |
| 4-Pyridoxic acid | 1.0364 | 0.9053 | 1.0681 |
| 4-Trimethylammoniobutanoic acid | 1.3438 | 0.7389 | 0.9035 |
| 5-Thymidylic acid | NA | NA | NA |
| 6-Phosphogluconic acid | 0.6727 | 0.9701 | 1.4167 |
| 6-Phosphonoglucono-D-lactone | NA | NA | NA |
| Acetylcholine | 0.9853 | 1.1750 | 0.8130 |
| Acetyl-CoA | 1.0739 | 0.9459 | 0.9769 |
| Acetylcysteine | NA | NA | NA |
| Adenine | 0.9892 | 0.9785 | 1.0377 |
| Adenosine | 0.9342 | 1.0387 | 1.0316 |
| Adenosine monophosphate | 0.9228 | 0.9036 | 1.2025 |
| Adenosine triphosphate | 0.7575 | 0.7699 | 1.5514 |
| ADP | 0.9933 | 0.8113 | 1.2280 |
| ADP-glucose | 0.9775 | 0.8719 | 1.1757 |
| AICAR | 1.2130 | 0.7430 | 1.0514 |
| Allantoin | 1.1292 | 0.8479 | 1.0267 |
| Aminoadipic acid | 0.9584 | 0.8439 | 1.2307 |
| Argininosuccinic acid | 1.1566 | 0.8731 | 0.9653 |
| Ascorbic acid | NA | NA | NA |
| Asymmetric dimethylarginine | 1.1163 | 1.0163 | 0.8454 |
| Betaine | 0.8496 | 1.0303 | 1.1402 |
| Butyrylcarnitine | 1.0748 | 0.8766 | 1.0567 |
| Caprylic acid | 1.4428 | 0.3800 | 1.2068 |
| Carnosine | 1.3328 | 0.9333 | 0.6896 |
| CDP | 1.0098 | 1.1369 | 0.7946 |
| CDP-Ethanolamine | 1.0326 | 0.9526 | 1.0172 |
| Choline | 1.2561 | 0.9554 | 0.7532 |
| cis-Aconitic acid | 1.1707 | 0.8845 | 0.9356 |
| Citicoline | 1.0415 | 0.9514 | 1.0082 |
| Citric acid | 1.1241 | 0.8637 | 1.0143 |
| Citrulline | 1.0622 | 0.9088 | 1.0338 |
| Coenzyme A | 0.9404 | 0.9461 | 1.1325 |
| Creatine | 1.0220 | 0.9794 | 0.9983 |
| Creatinine | 1.0141 | 0.9403 | 1.0532 |
| Cyclic AMP | 1.0602 | 0.9479 | 1.0006 |
| Cytidine | 0.9175 | 0.8765 | 1.2403 |
| Cytidine monophosphate | 1.0367 | 0.9616 | 1.0020 |
| Cytidine triphosphate | NA | NA | NA |
| Cytosine | 1.0257 | 0.7980 | 1.2056 |
| D-2-Hydroxyglutaric acid | 1.0532 | 0.9090 | 1.0441 |
| dCDP | NA | NA | NA |
| dCMP | NA | NA | NA |
| dCTP | NA | NA | NA |
| Deoxyadenosine | 0.9389 | 0.8700 | 1.2229 |
| Deoxyadenosine monophosphate | NA | NA | NA |
| Deoxyadenosine triphosphate | NA | NA | NA |
| Deoxyinosine | 1.6020 | 0.4631 | 0.9240 |
| Deoxyribose 5-phosphate | 1.0638 | 1.0266 | 0.7818 |
| Deoxyuridine | 1.0877 | 0.7966 | 1.1351 |
| D-Erythrose 4-phosphate | NA | NA | NA |
| D-Fructose | 0.8526 | 1.1577 | 0.9880 |
| D-Glucose | 0.7778 | 0.9116 | 1.3624 |
| D-Glucuronic acid | 1.7463 | 0.5840 | 0.2006 |
| D-Glyceraldehyde 3-phosphate | 1.6620 | 0.7662 | 0.5004 |
| D-Ribose | 1.0076 | 0.9767 | 1.0183 |
| D-Ribose 5-phosphate | 1.0271 | 0.9245 | 1.0565 |
| D-Ribulose | 0.9340 | 1.0423 | 1.0276 |
| D-Ribulose 5-phosphate | 1.1704 | 0.8914 | 0.9280 |
| D-Sedoheptulose 7-phosphate | 0.9332 | 1.2282 | 0.8117 |
| FAD | 0.9280 | 1.1165 | 0.9675 |
| Flavin Mononucleotide | NA | NA | NA |
| "Fructose 1,6-bisphosphate" | 1.3042 | 0.5266 | 1.1974 |
| Fructose 6-phosphate | 1.0963 | 0.8427 | 1.0712 |
| Fumaric acid | 1.0072 | 0.8488 | 1.1680 |
| Galactonic acid | 0.6249 | 1.1511 | 1.2614 |
| GDP-glucose | 0.9659 | 0.9108 | 1.1439 |
| Gluconic acid | 0.5559 | 1.3308 | 1.1322 |
| Glucosamine | NA | NA | NA |
| Glucosamine 6-phosphate | 0.9457 | 0.9993 | 1.0641 |
| Glucose 6-phosphate | 0.8034 | 0.7974 | 1.4657 |
| Glutathione | 0.9889 | 0.9451 | 1.0770 |
| Glycerol 3-phosphate | 0.8536 | 1.2258 | 0.9073 |
| Glycerophosphocholine | 1.0130 | 0.9446 | 1.0495 |
| Glycine | 1.0857 | 0.9231 | 0.9897 |
| Guanidoacetic acid | 1.0475 | 0.9103 | 1.0493 |
| Guanine | 1.0590 | 1.0727 | 0.8464 |
| Guanosine | 1.0747 | 1.0310 | 0.8767 |
| Guanosine diphosphate | 0.9355 | 0.7489 | 1.3682 |
| Guanosine monophosphate | 1.0029 | 0.8604 | 1.1595 |
| Guanosine triphosphate | 0.6817 | 0.7447 | 1.6693 |
| Hexanoylcarnitine | 1.1409 | 0.8139 | 1.0527 |
| Hippuric acid | 0.9342 | 0.6389 | 1.4979 |
| Homocysteine | NA | NA | NA |
| Hypotaurine | 1.0623 | 0.9081 | 1.0345 |
| Hypoxanthine | 0.9598 | 1.0181 | 1.0257 |
| IDP | NA | NA | NA |
| Imidazoleacetic acid | 1.1702 | 0.8439 | 0.9835 |
| Indole | NA | NA | NA |
| Indolelactic acid | NA | NA | NA |
| Indoxyl sulfate | 0.9798 | 0.7286 | 1.3402 |
| Inosine | 1.1502 | 1.0472 | 0.7697 |
| Inosinic acid | 1.1319 | 0.8270 | 1.0479 |
| Isovalerylcarnitine | 1.2212 | 0.8354 | 0.9340 |
| Kynurenic acid | 1.1550 | 0.8883 | 0.9495 |
| L-Acetylcarnitine | 1.0957 | 0.9399 | 0.9585 |
| L-Alanine | 1.0316 | 0.9287 | 1.0463 |
| L-Arginine | 1.1546 | 0.9627 | 0.8631 |
| L-Asparagine | 1.0365 | 0.9738 | 0.9880 |
| L-Aspartic acid | 1.0403 | 0.9941 | 0.9599 |
| L-Carnitine | 1.0155 | 0.9239 | 1.0707 |
| L-Cystathionine | 1.1518 | 0.9533 | 0.8774 |
| L-Cysteine | NA | NA | NA |
| L-Cystine | 1.3142 | 0.9676 | 0.6712 |
| L-Dihydroorotic acid | NA | NA | NA |
| L-Glutamic acid | 1.0221 | 0.9368 | 1.0480 |
| L-Glutamine | 1.0663 | 0.9502 | 0.9808 |
| L-Glyceric acid | 0.9779 | 0.9656 | 1.0659 |
| L-Histidine | 1.0327 | 0.9697 | 0.9972 |
| L-Homoserine | 1.0147 | 0.9641 | 1.0247 |
| L-Isoleucine | 0.8142 | 1.2483 | 0.9270 |
| L-Kynurenine | NA | NA | NA |
| L-Lactic acid | 1.0712 | 0.9375 | 0.9898 |
| L-Leucine | 1.0419 | 0.9785 | 0.9762 |
| L-Lysine | 1.1352 | 0.9991 | 0.8433 |
| L-Methionine | 1.1161 | 0.8707 | 1.0154 |
| L-Palmitoylcarnitine | NA | NA | NA |
| L-Phenylalanine | 1.2112 | 0.8798 | 0.8938 |
| L-Pipecolic acid | 0.8079 | 0.9718 | 1.2570 |
| L-Proline | 0.8382 | 0.9669 | 1.2274 |
| L-Serine | 1.1780 | 0.8868 | 0.9245 |
| L-Threonine | 0.9770 | 0.9976 | 1.0297 |
| L-Tryptophan | 1.1440 | 0.9066 | 0.9410 |
| L-Tyrosine | 1.1378 | 0.8603 | 1.0023 |
| L-Valine | 0.9750 | 0.9603 | 1.0755 |
| Malic acid | 1.0181 | 0.8948 | 1.1016 |
| Myoinositol | 0.9680 | 0.9884 | 1.0509 |
| N6-Acetyl-L-lysine | 1.3682 | 0.7950 | 0.8096 |
| "N6,N6,N6-Trimethyl-L-lysine" | 0.9825 | 0.9515 | 1.0770 |
| N-Acetylasparagine | 0.8596 | 0.9882 | 1.1776 |
| N-Acetylaspartylglutamic acid | 1.1794 | 0.8894 | 0.9197 |
| N-Acetyl-D-glucosamine | 1.1407 | 0.8591 | 1.0003 |
| N-Acetyl-glucosamine 1-phosphate | 1.1056 | 0.8359 | 1.0683 |
| N-Acetylglutamic acid | 1.0986 | 0.8981 | 1.0039 |
| N-Acetylglutamine | 1.3860 | 0.6154 | 0.9984 |
| N-Acetyl-L-alanine | 1.1474 | 0.9336 | 0.9055 |
| N-Acetyl-L-aspartic acid | 1.0342 | 0.9427 | 1.0269 |
| N-Acetyl-L-methionine | 1.0229 | 1.1100 | 0.8450 |
| N-Acetylornithine | 1.0262 | 0.8560 | 1.1374 |
| N-Acetylputrescine | NA | NA | NA |
| N-acetyltryptophan | 1.2207 | 0.7080 | 0.8150 |
| NAD | 0.9560 | 0.7484 | 1.3449 |
| NADH | 1.1970 | 0.7343 | 1.2015 |
| NADP | 0.8179 | 0.6826 | 1.5828 |
| NADPH | 0.8147 | 0.8909 | 1.3435 |
| N-Formyl-L-methionine | 1.0117 | 0.8719 | 1.1358 |
| Niacinamide | 0.9150 | 1.1426 | 0.9328 |
| Nicotinamide riboside | 1.0714 | 0.9376 | 0.9896 |
| Nicotinamide ribotide | 0.9766 | 0.8371 | 1.2173 |
| Nicotinic acid | NA | NA | NA |
| Nicotinic acid adenine dinucleotide | NA | NA | NA |
| Nicotinic acid mononucleotide | NA | NA | NA |
| O-Phosphoethanolamine | 0.9446 | 0.9327 | 1.1432 |
| Ornithine | 0.7335 | 1.5479 | 0.6718 |
| Orotic acid | 0.8550 | 0.9341 | 1.2460 |
| Oxalacetic acid | NA | NA | NA |
| Oxidized glutathione | 1.0549 | 1.1161 | 0.8005 |
| Oxoglutaric acid | 0.8086 | 0.6799 | 1.5968 |
| Palmitic acid | NA | NA | NA |
| Pantothenic acid | 1.7384 | 0.5461 | 0.6680 |
| Phosphocreatine | 1.0636 | 1.0890 | 0.8220 |
| Phosphoenolpyruvic acid | 0.9772 | 0.7867 | 1.2755 |
| Phosphorylcholine | 0.8659 | 1.0104 | 1.1443 |
| Phosphoserine | 0.9516 | 0.9926 | 1.0651 |
| Propionylcarnitine | 1.0927 | 0.8226 | 1.0988 |
| Purine | 1.0876 | 1.0077 | 0.8889 |
| Pyridoxine | NA | NA | NA |
| Pyroglutamic acid | 1.0183 | 0.9962 | 0.9830 |
| Pyruvic acid | 1.0194 | 0.7422 | 1.2782 |
| Riboflavin | 1.0907 | 0.8561 | 1.0621 |
| S-Adenosylhomocysteine | 0.8979 | 1.0199 | 1.0959 |
| S-Adenosylmethionine | 1.0341 | 0.9702 | 0.9949 |
| "Sedoheptulose 1,7-bisphosphate" | 1.0685 | 0.8744 | 1.0666 |
| Succinic acid | 0.9668 | 1.0360 | 0.9968 |
| Succinyl-CoA | NA | NA | NA |
| Taurine | 1.0513 | 0.9580 | 0.9891 |
| Thiamine | 0.9783 | 1.0147 | 1.0081 |
| Thiamine monophosphate | 1.0876 | 1.0438 | 0.8467 |
| Thymidine | 1.1561 | 0.7893 | 1.0637 |
| Thymidine 5^-triphosphate | NA | NA | NA |
| Thymine | 1.1972 | 0.8232 | 0.9762 |
| Uracil | 1.1787 | 0.8690 | 0.9443 |
| Ureidopropionic acid | 1.0019 | 0.9772 | 1.0244 |
| Ureidosuccinic acid | 1.0002 | 0.8647 | 1.1576 |
| Uric acid | 0.9448 | 0.9155 | 1.1630 |
| Uridine | 1.0420 | 0.9655 | 0.9913 |
| Uridine 5^-diphosphate | 1.5494 | 0.6628 | 0.7524 |
| Uridine 5^-monophosphate | 1.1571 | 0.8658 | 0.9732 |
| Uridine diphosphate glucose | 0.9348 | 0.9401 | 1.1459 |
| Uridine diphosphate glucuronic acid | 0.8820 | 0.8638 | 1.2965 |
| Uridine diphosphate-N-acetylglucosamine | 1.1071 | 0.8875 | 1.0063 |
| Uridine triphosphate | NA | NA | NA |
| Urocanic acid | 1.0798 | 0.8623 | 1.0675 |
| Xanthine | 0.9088 | 1.1342 | 0.9499 |
Factors:
| F1 | Sample source:Brain | Genotype:C9orf72 | Treatment:2DG |
| F2 | Sample source:Brain | Genotype:C9orf72 | Treatment:Saline |
| F3 | Sample source:Brain | Genotype:WT | Treatment:Saline |
