Data for (Study ST003203)
(Analysis AN005253)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1-Met-His | 0.6114 | 0.9171 | 1.2053 | 0.8559 | 1.0394 | 1.0394 | 1.3298 | 1.2839 | 1.0481 | 1.1005 | 0.7744 | 0.8254 |
3-Met-His | 0.8582 | 1.1034 | 1.4304 | 0.4904 | 1.0626 | 1.1280 | 0.8174 | 1.2874 | 0.6130 | 1.9617 | 0.6948 | 0.7356 |
5-AVA | 1.1111 | 0.6436 | 0.7250 | 0.6895 | 1.2451 | 0.7171 | 2.3475 | 1.0205 | 0.6007 | 1.0067 | 0.7355 | 0.7171 |
AABA | 0.9612 | 0.9406 | 1.0068 | 0.9734 | 1.0644 | 1.0458 | 0.9712 | 1.0106 | 0.9399 | 1.1177 | 1.0127 | 1.0468 |
Ac-Orn | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
ADMA | 0.9155 | 0.8957 | 1.3356 | 1.0208 | 1.0981 | 1.0681 | 0.8180 | 1.2574 | 0.5543 | 0.9380 | 1.1357 | 1.3233 |
Ala | 1.1342 | 0.9092 | 1.7887 | 0.4469 | 1.4475 | 0.9449 | 0.8683 | 0.9426 | 0.4796 | 2.1976 | 0.6459 | 0.6956 |
alpha-AAA | NA | NA | NA | 1.2097 | 0.4839 | 2.5000 | NA | 0.1075 | 0.2151 | 0.3763 | NA | 0.6989 |
Anserine | 0.7347 | 0.7143 | 1.3469 | 0.7321 | 0.6122 | 0.6786 | 1.3095 | 0.8839 | 0.6429 | 3.8304 | 0.7262 | 0.8571 |
Arg | 1.3182 | 0.9027 | 1.9563 | 0.8256 | 1.1886 | 0.8081 | 0.8078 | 0.8071 | 0.5982 | 1.3877 | 0.3877 | 0.4709 |
Asn | 0.9231 | 0.8395 | 1.4449 | 0.6687 | 1.0843 | 1.0352 | 1.0791 | 1.3544 | 0.5772 | 1.3505 | 0.8715 | 1.2510 |
Asp | 1.0105 | 0.7770 | 1.5146 | 0.7459 | 1.2426 | 0.9063 | 1.3088 | 0.9757 | 0.6385 | 1.1995 | 0.8180 | 0.8657 |
BABA | 1.1637 | 1.0454 | 1.2219 | 0.8010 | 1.1637 | 0.9232 | 0.9503 | 1.1811 | 0.8451 | 1.0182 | 0.8689 | 0.9571 |
Betaine | 0.5615 | 1.8160 | 1.0396 | 1.0082 | 0.9178 | 1.5366 | 1.0763 | 0.5984 | 0.6463 | 0.8434 | 0.9637 | 0.9812 |
c4-OH-Pro | NA | NA | NA | NA | NA | 0.6000 | NA | 2.0000 | NA | NA | 0.4000 | NA |
Carnosine | 0.9729 | 1.0188 | 1.0236 | 0.9823 | 1.0080 | 1.0188 | 0.9815 | 0.9948 | 0.9785 | 1.0188 | 0.9861 | 1.0700 |
Cit | 1.3502 | 1.1050 | 1.9401 | 0.8751 | 1.0055 | 0.7061 | 1.2668 | 0.8288 | 0.5481 | 0.9405 | 0.5929 | 0.7662 |
Creatinine | 0.9928 | 0.7068 | 1.1887 | 0.8439 | 1.1254 | 1.0697 | 0.9316 | 1.1361 | 0.9288 | 1.3229 | 0.9471 | 1.0064 |
Cys | 0.9531 | 1.0204 | 1.8764 | 0.8791 | 0.7401 | 0.8896 | 0.9517 | 1.7007 | 0.5611 | 1.0728 | 0.8438 | 0.8896 |
Cystine | 0.8002 | 0.8989 | 0.8891 | 1.2101 | 1.1854 | 1.0718 | 1.1525 | 1.0891 | 0.9220 | 1.0891 | 0.9681 | 0.6742 |
DOPA | 0.9883 | 0.9745 | 1.0000 | 0.9881 | 1.0052 | 1.0063 | 0.9856 | 1.0555 | 0.9291 | 0.9511 | 1.0300 | 1.1758 |
Gln | 0.7812 | 0.3529 | 1.7206 | 0.6690 | 1.6550 | 0.9581 | 0.7825 | 1.5220 | 0.8245 | 1.3631 | 0.7862 | 1.1117 |
Glu | 1.1418 | 0.6494 | 1.4946 | 0.7857 | 1.2471 | 1.0824 | 0.9628 | 1.1299 | 0.7165 | 1.2605 | 0.7699 | 1.0268 |
Gly | 0.8545 | 0.7344 | 1.5944 | 1.0163 | 1.0760 | 0.6195 | 0.8594 | 0.8782 | 1.3660 | 0.8890 | 1.0159 | 0.7161 |
HArg | 0.8422 | 1.0719 | 1.2506 | 1.0719 | 1.3101 | 1.1017 | 1.0521 | 0.8933 | 0.8536 | 1.1613 | 0.7940 | 0.6253 |
HCys | 0.8934 | 0.9250 | 0.9500 | 1.0369 | 0.8657 | 0.8063 | 1.0221 | 0.8030 | 1.6765 | 0.9284 | 0.9016 | 0.7747 |
His | 0.9742 | 0.8355 | 1.3202 | 1.0832 | 1.1526 | 1.0096 | 0.9333 | 0.9600 | 0.9250 | 1.0118 | 0.9107 | 0.8732 |
Ile | 0.9847 | 0.9016 | 1.5272 | 0.8035 | 1.1150 | 0.6917 | 1.4024 | 1.0405 | 0.7586 | 0.9429 | 0.8030 | 0.9054 |
Kynurenine | 0.9728 | 1.0160 | 1.0278 | 1.0491 | 1.0609 | 0.9896 | 0.9591 | 1.0047 | 0.8962 | 1.0840 | 1.0623 | 0.9071 |
Leu | 1.0797 | 0.9634 | 1.1968 | 0.8425 | 1.1130 | 0.8135 | 1.2217 | 1.0023 | 0.7516 | 1.0857 | 0.9368 | 1.0039 |
Lys | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Met | 0.9979 | 0.9992 | 0.9975 | 0.9982 | 0.9943 | 1.0051 | 1.0021 | 1.0096 | 0.9989 | 0.9947 | 0.9994 | 1.0089 |
Met-SO | 1.0290 | 0.8812 | 1.2014 | 0.8950 | 1.0848 | 0.9236 | 1.0599 | 1.0290 | 0.8805 | 1.0852 | 0.9186 | 1.1015 |
Nitro-Tyr | NA | 0.5714 | NA | NA | NA | NA | NA | NA | NA | NA | 1.1429 | NA |
Orn | 0.2599 | 2.8408 | 3.0089 | 0.4928 | 0.4335 | NA | 0.1730 | 0.1932 | NA | 0.0329 | 0.2474 | NA |
PAG | 0.6552 | 1.0567 | 1.2718 | 0.8094 | 1.0567 | 0.9667 | 0.8693 | 0.6407 | 0.6445 | 1.1241 | 1.3826 | 1.8885 |
Phe | 1.2340 | 0.5859 | 1.7719 | 0.6316 | 1.3917 | 0.9970 | 1.1634 | 0.8009 | 0.1953 | 2.1002 | 0.3860 | 0.5979 |
PheAlaBetaine | 0.6807 | 1.3765 | 1.0588 | 0.8824 | 1.0588 | 1.0588 | 1.0588 | 1.0588 | 1.0588 | 1.3235 | 0.8603 | 0.6618 |
Pro | 1.0269 | 0.9872 | 1.3730 | 0.8379 | 1.1535 | 0.8707 | 1.2770 | 1.0564 | 0.6055 | 1.2052 | 0.7896 | 0.9644 |
ProBetaine | 0.9245 | 0.9338 | 1.0286 | 1.1021 | 0.9139 | 0.9407 | 0.9793 | 0.9683 | 1.2644 | 1.0593 | 0.9149 | 0.8834 |
Sarcosine | 0.8936 | 0.9207 | 1.0436 | 0.8562 | 1.2501 | 0.9020 | 0.9914 | 1.2046 | 0.8815 | 1.2993 | 0.9073 | 1.1444 |
SDMA | 1.0369 | 0.7828 | 1.2809 | 0.7828 | 1.4232 | 0.7828 | 1.3758 | 1.0674 | 0.6167 | 1.2809 | 0.7591 | 1.0674 |
Ser | 1.1218 | 1.0413 | 2.0635 | 0.8021 | 1.0926 | 0.6978 | 1.3937 | 0.9202 | 0.5076 | 0.9626 | 0.5962 | 0.6997 |
t4-OH-Pro | 0.8932 | 0.7626 | 1.0781 | 0.7504 | 1.0260 | 1.3661 | 0.8594 | 1.1362 | 0.8399 | 1.4401 | 1.0829 | 1.0998 |
Taurine | 1.0144 | 0.2701 | 1.4705 | 0.7166 | 1.5020 | 1.0542 | 0.6508 | 1.2978 | 0.8411 | 1.8364 | 0.8701 | 1.0128 |
Thr | 1.1193 | 0.9308 | 1.9516 | 0.7364 | 1.1762 | 0.6532 | 1.3565 | 1.0572 | 0.4602 | 1.1248 | 0.6487 | 0.8579 |
TMAO | 0.8815 | 0.8354 | 0.7870 | 0.8736 | 1.1904 | 0.7718 | 1.1252 | 1.1641 | 1.1012 | 1.1005 | 1.0475 | 1.1450 |
Trigonelline | 0.6954 | 0.7484 | 1.0039 | 1.1255 | 0.9965 | 1.3226 | 1.0283 | 0.8869 | 0.8989 | 0.8355 | 1.2283 | 1.1655 |
Trp | 1.0392 | 0.5248 | 2.1507 | 1.0706 | 1.1753 | 0.7402 | 1.0896 | 0.8590 | 0.4374 | 1.4355 | 0.6539 | 1.0250 |
TrpBetaine | 0.9728 | 0.8630 | 1.3072 | 0.6561 | 1.1299 | 1.1350 | 1.2177 | 0.7182 | 1.0207 | 0.6473 | 0.9754 | 0.9488 |
Tyr | 1.1330 | 0.9523 | 1.5948 | 0.7910 | 1.1779 | 0.7360 | 1.4091 | 1.0437 | 0.5108 | 1.1400 | 0.6962 | 0.8763 |
Val | 1.0760 | 0.6862 | 1.8068 | 0.5682 | 1.4300 | 0.6059 | 1.4472 | 0.9890 | 0.2383 | 1.3783 | 0.7231 | 0.8015 |
Factors:
F1 | Sample source:Tear | Study Arm:1 | Timepoint:Week 10 | PZC (< 660 ug/L):N |
F2 | Sample source:Tear | Study Arm:1 | Timepoint:Week 10 | PZC (< 660 ug/L):Y |
F3 | Sample source:Tear | Study Arm:1 | Timepoint:Week 18 | PZC (< 660 ug/L):N |
F4 | Sample source:Tear | Study Arm:1 | Timepoint:Week 18 | PZC (< 660 ug/L):Y |
F5 | Sample source:Tear | Study Arm:1 | Timepoint:Week 2 | PZC (< 660 ug/L):N |
F6 | Sample source:Tear | Study Arm:1 | Timepoint:Week 2 | PZC (< 660 ug/L):Y |
F7 | Sample source:Tear | Study Arm:2 | Timepoint:Week 10 | PZC (< 660 ug/L):N |
F8 | Sample source:Tear | Study Arm:2 | Timepoint:Week 10 | PZC (< 660 ug/L):Y |
F9 | Sample source:Tear | Study Arm:2 | Timepoint:Week 18 | PZC (< 660 ug/L):N |
F10 | Sample source:Tear | Study Arm:2 | Timepoint:Week 18 | PZC (< 660 ug/L):Y |
F11 | Sample source:Tear | Study Arm:2 | Timepoint:Week 2 | PZC (< 660 ug/L):N |
F12 | Sample source:Tear | Study Arm:2 | Timepoint:Week 2 | PZC (< 660 ug/L):Y |