Data for (Study ST003249)
(Analysis AN005322)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 1,3-bisphospho-D-glycerate | 1.1432 | 0.8568 | NA |
| 1-methylnicotinamide+ | NA | NA | NA |
| 1-phenylethylamine | 0.6906 | 1.3094 | NA |
| 2,3-bisphospho-D-glycerate | 1.2064 | 0.5872 | NA |
| 2- / 3-phosphoglycerate | 1.3546 | 0.8056 | 0.6795 |
| 2-aminobutanoate / 2-/3-aminoisobutanoate | 0.7939 | 1.3373 | 0.8688 |
| 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine | NA | NA | NA |
| 2-HG | 0.3133 | 2.1417 | 0.0901 |
| 2-hydroxybutanoic acid | NA | 0.8968 | 1.2064 |
| 2-keto-3-deoxy-d-gluconic acid | NA | NA | NA |
| 2-keto-isovaleric acid | NA | NA | NA |
| 2-ketovaleric acid | NA | 0.7414 | 1.2586 |
| 2-oxoadipic acid | NA | NA | NA |
| 2-oxobutanoic acid | NA | NA | NA |
| 3,4-dihydroxymandelic acid | NA | NA | NA |
| 3,4-dihydroxyphenylpropanoate | NA | NA | NA |
| 3- / 4-hydroxyphenylacetic acid | 0.3123 | 0.9045 | 1.8786 |
| 3- / 7-methylguanine | 1.2022 | 1.1553 | 0.2848 |
| 3-hydroxy-anthranilic acid | NA | NA | NA |
| 3-hydroxybutanoic acid | NA | NA | NA |
| 3-hydroxykynurenine | NA | NA | NA |
| 3-hydroxypropanoic acid | 0.7822 | 1.4465 | 0.5426 |
| 3-methoxytyramine | NA | NA | NA |
| 3-phosphohydroxypyruvic acid | NA | NA | NA |
| 3-phospho-serine | 1.1688 | 0.1558 | NA |
| 3-ureidopropionic acid | NA | NA | NA |
| 4-hydroxybutanoic acid | 0.6664 | 1.3406 | 0.9858 |
| 4-hydroxyphenylpyruvic acid | NA | 0.7216 | 1.2784 |
| 4-hydroxyproline / 5-aminolevulinate | 0.8879 | 1.1121 | NA |
| 5-aminopentanoic acid | NA | NA | NA |
| 5^-deoxyadenosine | NA | NA | NA |
| 5-HIAA | NA | NA | NA |
| 5-methylcytosine | NA | NA | NA |
| 5-methyl-THF | NA | NA | NA |
| 5^-methylthioadenosine | NA | NA | NA |
| 6-aminohexanoate | NA | NA | NA |
| 6-O-methylguanine | NA | NA | NA |
| 6-phosphogluconic acid | 1.1506 | 0.8994 | 0.9752 |
| 6-phosphoglucono-D-lactone | NA | NA | NA |
| acetoacetic acid | NA | NA | NA |
| acetoin - | NA | NA | NA |
| acetylcarnitine+ | 1.1794 | 0.8206 | NA |
| acetylcholine+ | 1.0161 | 0.9839 | NA |
| acetyl-CoA | NA | NA | NA |
| aconitic acid | 1.5504 | 0.9348 | 0.0296 |
| acrylic acid | 1.2232 | 1.4718 | 0.0691 |
| adenine | NA | NA | NA |
| adenosine | 0.9569 | 1.0539 | NA |
| adenylosuccinate | 1.3924 | 0.9019 | NA |
| ADP / dGDP | 1.2703 | 1.2075 | 0.0445 |
| ADP-D-glucose | 0.8224 | 1.1184 | NA |
| agmatine | 1.3424 | 0.8916 | 0.1895 |
| AICA ribonucleotide | NA | NA | NA |
| a-KG | 1.3596 | 0.9204 | 0.1600 |
| alanine | 0.8638 | 1.1362 | NA |
| alanine methyl ester | NA | NA | NA |
| allantoin | 0.9236 | 1.0764 | NA |
| AMP / dGMP | 0.5889 | 1.5842 | 0.6536 |
| anandamide | 1.4166 | 0.5834 | NA |
| arginine | 1.0144 | 0.9856 | NA |
| ascorbic acid | 1.6823 | 0.0902 | NA |
| asparagine | 1.0025 | 0.9975 | NA |
| aspartic acid | 1.5743 | 0.8291 | 0.1363 |
| ATP / dGTP | 1.9627 | 0.2022 | 0.0108 |
| b-alanine | 1.4578 | 0.8341 | 0.1240 |
| betaine+ | 1.1022 | 1.3761 | 0.0435 |
| bilirubin | NA | NA | NA |
| biotin | 0.5967 | 1.4494 | 0.5044 |
| butyric acid | 0.7982 | 1.2018 | NA |
| butyric acid(iso) | 1.0550 | 0.8899 | NA |
| caffeic acid | 0.6729 | 1.3271 | NA |
| cAMP(2^,3^) / cAMP(3^,5^) | NA | NA | NA |
| carbamoyl phosphate | 0.9596 | 1.4175 | 0.2459 |
| carnitine+ | 1.0850 | 1.4049 | 0.0202 |
| cCMP(2^,3^-) | 0.9898 | 1.0081 | NA |
| CDP | NA | 1.0000 | NA |
| CDP-choline+ | 0.3915 | 1.4564 | NA |
| cGMP | NA | NA | NA |
| choline+ | 1.1011 | 1.3953 | 0.0070 |
| citraconic acid | 1.0102 | 1.0824 | 0.7223 |
| citramalic acid | 1.0819 | 1.1879 | 0.4603 |
| citrate / citrate(iso) | 1.2305 | 0.9340 | 0.6710 |
| citrulline | 1.1156 | 1.3015 | 0.1658 |
| CMP | 0.6786 | 1.5574 | 0.0561 |
| Coenzyme A + | NA | 1.0000 | NA |
| cortisol | NA | 1.0000 | NA |
| creatine | 1.0210 | 1.4753 | 0.0074 |
| creatinine | 0.7837 | 1.2163 | NA |
| CTP | 1.0000 | NA | NA |
| cystathionine | 0.7055 | 1.2208 | NA |
| cysteine | 1.2483 | 0.8403 | 0.8228 |
| cysteine-S-sulfate | 0.7637 | 1.2363 | NA |
| cystine | 1.0243 | 1.3210 | 0.1247 |
| cytidine | 0.6350 | 1.2920 | NA |
| cytosine | 1.3191 | 0.8443 | 0.5097 |
| dADP | NA | NA | NA |
| dAMP | NA | 1.0000 | NA |
| D-arabinono-1,4-lactone | 1.0445 | 0.9466 | NA |
| dATP | NA | NA | NA |
| dCDP | NA | NA | NA |
| dCMP | NA | NA | NA |
| dCTP | NA | NA | NA |
| dehydroascorbic acid | 1.3934 | 0.9395 | 0.0015 |
| deoxyadenosine | 1.1825 | 0.9017 | 0.8316 |
| deoxycarnitine+ | 0.9012 | 1.0988 | NA |
| deoxycytidine | 0.9145 | 1.0570 | NA |
| deoxyguanosine | NA | NA | NA |
| deoxyinosine | NA | NA | NA |
| deoxyuridine | 1.0397 | 1.0964 | 0.7279 |
| D-erythrose-4-phosphate | NA | NA | 1.0000 |
| D-galactonic acid / D-gluconic acid | 1.1102 | 1.0745 | 0.6306 |
| D-galactosamine/glucosamine-1/6-phosphate | 1.1530 | 1.0945 | 0.3046 |
| D-glucuronolactone | 0.8016 | 1.1653 | NA |
| dihydroorotate | 0.7324 | 1.3979 | 0.7393 |
| dimethylglycine | 0.8487 | 1.1513 | NA |
| DL-DOPA | NA | NA | NA |
| DOPAC | NA | NA | NA |
| dopamine | NA | NA | NA |
| D-ribose-1/5-phosphate / D-ribulose 5-phosphate | 0.9373 | 1.0627 | NA |
| D-sedoheptulose | 1.0236 | 1.3382 | 0.1192 |
| D-sedoheptulose-7-phosphate | 1.1660 | 0.7191 | 1.1785 |
| dTMP | NA | NA | NA |
| dTTP | 1.0000 | NA | NA |
| dUMP | NA | NA | NA |
| dUTP | NA | NA | NA |
| epinephrine / normetanephrine | 1.0524 | 1.0196 | 0.8558 |
| ethyl acetate | 1.1116 | 0.8884 | NA |
| F-1,6/2,6-DP | 1.0422 | 0.9578 | NA |
| F1P | 0.9408 | 1.2618 | 0.8566 |
| F6P / G1P / G6P | 1.3885 | 0.5421 | 1.1388 |
| FAD | 1.0251 | 0.9874 | NA |
| FMN | NA | NA | NA |
| folate | 1.0643 | 0.9678 | NA |
| fructose / mannose | 0.8273 | 1.1727 | NA |
| fumaric acid | 0.8013 | 1.2384 | NA |
| GABA | 1.1773 | 1.1289 | 0.0815 |
| galactosamine / glucosamine / mannosamine | 0.9598 | 0.8751 | 1.3301 |
| galactose / glucose | 0.7888 | 1.2112 | NA |
| GalNAC / GlcNAC | 1.1415 | 0.9346 | 0.8732 |
| GAP / DHAP | 1.1174 | 0.8826 | NA |
| GDP | 1.1436 | 0.8923 | NA |
| GDP-L-fucose | 0.7312 | 1.2688 | NA |
| geranyl-PP | NA | NA | NA |
| glucono-lactone | NA | NA | NA |
| glutaconic acid | 1.4010 | 0.9172 | 0.0454 |
| glutamate | 0.8241 | 1.6518 | 0.0483 |
| glutamine | 1.2202 | 1.2639 | 0.0317 |
| glutathione | 1.0210 | 1.0548 | 0.8483 |
| glutathione disulfide | 1.0496 | 1.1411 | 0.6185 |
| glyceraldehyde | NA | NA | NA |
| glyceric acid | 1.0217 | 1.1672 | 0.4335 |
| glycerol 2/3-phosphate | 0.2700 | 2.1587 | 0.1426 |
| glycine | 0.8004 | 1.1996 | NA |
| glycylglycine | NA | NA | NA |
| glyoxylic acid | NA | NA | NA |
| GMP | 0.4023 | 1.6603 | 0.0269 |
| GTP | 1.7520 | 0.0599 | NA |
| guanidine | 0.7715 | 1.5904 | 0.2762 |
| guanidinoacetate | 0.9560 | 1.5398 | 0.0084 |
| guanine | 0.4456 | 1.9664 | 0.1760 |
| guanosine | NA | 1.0000 | NA |
| gulonic-lactone | NA | NA | NA |
| histamine | 1.0682 | 0.8635 | NA |
| histidine | 1.0239 | 1.1303 | 0.6916 |
| homocysteine | 0.2945 | 1.2352 | NA |
| homocystine | NA | NA | NA |
| homogentisic acid | NA | NA | NA |
| homoserine / threonine / allothreonine | 0.8768 | 1.1232 | NA |
| hydroxyphenyllactic acid / HVA | 0.8246 | 1.6470 | 0.0568 |
| hydroxypyruvic acid | NA | NA | NA |
| hypoxanthine | 0.4449 | 1.7202 | 0.0093 |
| IDP | NA | NA | NA |
| imidazole-4-acetate | 0.9745 | 1.0212 | NA |
| IMP | 0.3739 | 2.0232 | 0.0074 |
| inosine | 0.3899 | 1.4576 | NA |
| isonictinic acid | NA | NA | NA |
| isopentenyl pyrophosphate | NA | NA | NA |
| itaconic acid | 1.3788 | 1.0018 | 0.2387 |
| kynurenic acid | 1.0781 | 1.2994 | 0.2971 |
| kynurenine | 0.9090 | 1.0910 | NA |
| lactic acid | 0.7813 | 1.1750 | NA |
| lactose / maltose / sucrose | NA | 1.0000 | NA |
| L-arginino-succinate | 1.0146 | 0.9854 | NA |
| L-cysteic acid | NA | NA | NA |
| leucine / leucine(iso) / norleucine | 0.9774 | 1.0169 | NA |
| levulinic acid | NA | NA | NA |
| lipoamide | NA | 1.0000 | NA |
| L-NMMA | 0.7781 | 1.1776 | NA |
| L-tyrosine methyl ester | 0.9974 | 1.0021 | NA |
| lysine | 0.8754 | 1.1246 | NA |
| maleic acid | 0.9753 | 1.0247 | NA |
| malic acid | 1.0898 | 0.9102 | NA |
| malonic acid | 0.9172 | 1.3162 | 0.5333 |
| malonyl-CoA | NA | NA | NA |
| mandelic acid / vanillin | NA | NA | NA |
| ManNAC | 0.8506 | 1.4455 | 0.3580 |
| mesaconic acid | 0.6789 | 1.5530 | 0.3043 |
| methionine | 0.8798 | 1.1202 | NA |
| methyl acetoacetate | NA | 0.7262 | 1.5477 |
| methylglyoxal | 0.9436 | 1.3675 | 0.3496 |
| methylmalonic acid | 0.7911 | 1.2696 | 0.7572 |
| mevalonic acid | 0.9072 | 1.0767 | 1.0483 |
| N1-acetylspermine | 0.9043 | 0.8490 | 1.4934 |
| N1/N8-acetylspermidine | 0.7497 | 1.2503 | NA |
| N-acetylaspartic acid | 1.1619 | 0.8381 | NA |
| N-acetylaspartylglutamic acid | NA | 1.0000 | NA |
| N-acetyl-b-alanine | NA | 1.1608 | 0.6783 |
| N-acetyl-DL-alanine | 0.3945 | 0.8889 | 1.9388 |
| N-acetyl-DL-serine / O-acetyl-L-serine | 1.0102 | 1.0132 | 0.9532 |
| N-acetylglucosamine 1/6-phosphate | 1.1567 | 0.7650 | NA |
| N-acetylglycine | NA | NA | NA |
| N-acetyl-L-glutamic acid | NA | NA | NA |
| NAD+ | 0.8459 | 1.1541 | NA |
| NADH | 0.0529 | 1.3788 | NA |
| NADP+ | 0.9078 | 1.1383 | NA |
| NADPH | NA | NA | 1.0000 |
| N-carbamoyl-L-aspartate | 1.0000 | NA | NA |
| nebularine | NA | NA | NA |
| N-formyl-L-methionine | 1.0000 | NA | NA |
| nicotinamide | NA | NA | NA |
| nicotinamide riboside+ | 0.0756 | 2.3210 | 0.0308 |
| nicotinic acid | NA | NA | NA |
| N-methyl-alanine | NA | NA | NA |
| N-methylaspartic acid | 0.8114 | 1.6677 | 0.0418 |
| N-methyltryptamine | NA | NA | NA |
| NMN | NA | NA | NA |
| norepinephrine / pyridoxine | 0.6451 | 1.1420 | NA |
| octopamine | NA | NA | NA |
| ornithine | 0.9781 | 1.5061 | 0.0315 |
| orotic acid | NA | 1.0000 | NA |
| orotidylic acid | NA | NA | NA |
| O-succinyl-homoserine | 1.0344 | 0.8738 | 1.2180 |
| oxalacetic acid | 1.0068 | 0.9966 | NA |
| pantothenic acid | 0.9584 | 1.3590 | 0.0271 |
| phenethylamine | NA | NA | NA |
| phenylalanine | 0.9693 | 1.0245 | NA |
| phenylephrine / synephrine | NA | NA | NA |
| phenylethanolamine | NA | NA | NA |
| phosphocreatine | 1.9187 | 0.1207 | 0.0025 |
| phosphoenolpyruvate | NA | NA | NA |
| phosphorylcholine+ | 1.4045 | 0.8750 | 0.4410 |
| picolinic acid | NA | NA | NA |
| proline | 0.8380 | 1.1620 | NA |
| propionic acid | NA | NA | NA |
| PRPP | NA | NA | NA |
| pseudouridine | 0.9668 | 1.3474 | 0.0576 |
| purine | NA | NA | NA |
| putrescine | 1.3716 | 0.6284 | NA |
| pyridoxal | NA | NA | NA |
| pyroglutamic acid | 0.8206 | 1.1794 | NA |
| pyrroline hydroxycarboxylic acid | 0.8648 | 1.1352 | NA |
| pyruvic acid | 0.9443 | 1.0557 | NA |
| quinolinic acid | NA | NA | NA |
| S-adenosyl-L-homocysteine | NA | 1.0000 | NA |
| S-adenosyl-L-methionine+ | 0.9127 | 1.1091 | NA |
| S-adenosylmethioninamine+ | 1.0094 | 0.9906 | NA |
| SAICAR | NA | NA | NA |
| sarcosine | 1.0924 | 0.8069 | 0.8656 |
| serine | 1.0109 | 1.1082 | 0.2849 |
| serotonin | 0.9283 | 1.0717 | NA |
| sorbitol / galactitol / L-iditol / manitol | 0.7973 | 1.2027 | NA |
| spermidine | 1.0123 | 0.9877 | NA |
| spermine | 1.0113 | 0.9887 | NA |
| succinic acid | 0.7592 | 1.6851 | 0.1113 |
| succinic semialdehyde | NA | NA | NA |
| succinyl-CoA | NA | NA | NA |
| taurine | 1.2309 | 1.2681 | 0.0021 |
| thiamine+ | 0.8269 | 1.4920 | 0.0432 |
| thiamine diphosphate+ | 1.0607 | 0.9162 | 1.0461 |
| thiamine phosphate+ | 0.9063 | 1.1103 | 0.9724 |
| thymidine | 0.1983 | 1.6681 | NA |
| thymine | NA | NA | NA |
| tryptamine | NA | NA | NA |
| tryptophan | 0.8665 | 1.1602 | NA |
| tyramine | NA | NA | NA |
| tyrosine | 0.9465 | 1.0535 | NA |
| UDP | 1.1375 | 0.7937 | NA |
| UDP-D-galactose / UDP-D-glucose | 1.0739 | 0.9261 | NA |
| UDP-N-acetyl-galactosamine/UDP-N-acetyl-glucosamine | 1.2100 | 0.7200 | NA |
| UMP | 1.5119 | 0.4881 | NA |
| uracil | 0.8277 | 1.1723 | NA |
| uracil 5-carboxylic acid | NA | NA | NA |
| urea | 0.6658 | 1.3342 | NA |
| uric acid | 0.9052 | 1.2592 | 0.0132 |
| uridine | 0.7458 | 1.3528 | 0.1546 |
| UTP | 1.0000 | NA | NA |
| valine / norvaline | 0.7901 | 1.2099 | NA |
| vitamin B2 | NA | 1.0000 | NA |
| xanthine | 0.9785 | 1.5199 | 0.0032 |
| xanthosine | 0.6385 | 1.1807 | NA |
| xanthurenic acid | NA | NA | NA |
| XMP | 0.4123 | 1.4060 | 1.0463 |
| xylitol / arabitol / ribito | 0.7926 | 1.1659 | NA |
| y-glutamylcysteine | 0.9588 | 1.3183 | 0.4458 |
Factors:
| F1 | Genotype:HET | Sample source:Microglia |
| F2 | Genotype:KO | Sample source:Microglia |
| F3 | Genotype:N/A | Sample source:Plasma |
