Data for (Study ST003256)
(Analysis AN005338)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PC 16:0/20:4;O | 0.0011 | 0.0017 | 0.0022 | 0.0003 | 0.0003 | 0.0004 | 1.1776 | 0.8568 | 1.4052 | 1.3183 | 0.7951 | 1.3989 | 2.5035 | 1.8302 | 1.1166 | 0.7838 | 2.6393 | 1.9864 |
| PC 16:0/20:4;O2 | 0.0012 | 0.0020 | 0.0027 | 0.0000 | 0.0001 | 0.0002 | 0.2951 | 0.6965 | 1.1443 | 1.0326 | 0.4956 | 2.6082 | 3.2378 | 2.1329 | 0.8128 | 1.0476 | 2.2844 | 1.4406 |
| PC 16:0/20:4;O3 | 0.0004 | 0.0023 | 0.0022 | 0.0001 | 0.0001 | 0.0001 | 0.1833 | 0.4988 | 0.6364 | 0.4944 | 0.1521 | 1.6054 | 2.6716 | 2.4923 | 0.2123 | 1.1287 | 3.4297 | 3.1738 |
| PC 16:0/22:4;O | 0.0009 | 0.0025 | 0.0021 | 0.0002 | 0.0002 | 0.0003 | 0.7758 | 1.1504 | 1.2552 | 0.8619 | 0.8831 | 1.1525 | 2.2808 | 1.7372 | 1.3886 | 0.9866 | 2.5226 | 1.7271 |
| PC 18:0/20:4;O | 0.0009 | 0.0013 | 0.0016 | 0.0001 | 0.0001 | 0.0001 | 1.2325 | 0.7827 | 1.2014 | 1.1848 | 1.1552 | 1.3518 | 2.2904 | 1.8830 | 1.3915 | 0.8386 | 2.6522 | 1.9225 |
| PC 18:0/20:4;O2 | 0.0023 | 0.0028 | 0.0030 | 0.0002 | 0.0002 | 0.0002 | 0.5420 | 0.9637 | 1.4706 | 1.1432 | 0.8859 | 2.3992 | 2.5163 | 1.6452 | 0.9892 | 1.1049 | 1.9577 | 1.2579 |
| PC 18:0/20:4;O3 | 0.0008 | 0.0018 | 0.0041 | NA | 0.0001 | 0.0001 | 0.1903 | 0.5162 | 0.7365 | 0.6640 | 0.6400 | 1.6536 | 3.5814 | 2.1758 | 0.2964 | 1.3043 | 2.7026 | 1.0436 |
| PC 18:0/22:4;O | 0.0014 | 0.0013 | 0.0015 | 0.0005 | 0.0004 | 0.0006 | 1.0312 | 1.6220 | 2.2002 | 1.6641 | 0.8740 | 1.5188 | 1.6427 | 1.3827 | 0.9388 | 0.8458 | 1.8501 | 1.1579 |
| PC 18:1/20:4;O | 0.0009 | 0.0015 | 0.0017 | 0.0003 | 0.0002 | 0.0003 | 0.9595 | 0.8223 | 1.1023 | 1.1047 | 0.7229 | 1.5155 | 2.7876 | 2.2501 | 0.8989 | 0.7873 | 2.6100 | 2.3242 |
| PC 18:1/20:4;O2 | 0.0013 | 0.0022 | 0.0022 | 0.0001 | 0.0001 | 0.0001 | 0.2720 | 0.7144 | 1.1095 | 0.8049 | 0.4770 | 2.5126 | 3.1749 | 2.0489 | 0.7024 | 1.0892 | 2.6001 | 1.4488 |
| PE 16:0/20:4;O | 1.1294 | 1.6677 | 1.8461 | 0.3947 | 0.4550 | 0.4027 | 0.5627 | 0.7844 | 0.7784 | 0.9398 | 0.5127 | 1.3724 | 1.2296 | 1.0712 | 0.6658 | 1.3720 | 1.4945 | 1.2274 |
| PE 16:0/20:4;O2 | 1.1374 | 2.0203 | 1.7278 | 0.3138 | 0.3079 | 0.1584 | 0.4140 | 0.7757 | 0.9749 | 0.3753 | 0.4198 | 1.4011 | 1.1853 | 0.5000 | 0.3589 | 2.0950 | 1.8303 | 0.8519 |
| PE 16:0/20:4;O3 | 0.4619 | 2.7141 | 2.9210 | 0.0591 | 0.1993 | 0.1470 | 0.1782 | 0.2193 | 0.1763 | 0.1696 | 0.1463 | 2.1284 | 1.6732 | 0.9114 | 0.3253 | 2.0209 | 2.1437 | 1.1049 |
| PE 16:0/22:4;O | 1.6041 | 1.9601 | 3.1666 | 0.3824 | 0.6456 | 0.5366 | 0.2458 | 0.5918 | 0.4784 | 0.3314 | 0.1675 | 2.0547 | 0.9183 | 0.4274 | 0.2916 | 1.9228 | 1.0070 | 0.4734 |
| PE 16:0/22:4;O2* | 1.6665 | NA | NA | 0.3958 | NA | 0.4425 | 1.2288 | NA | 1.2466 | NA | NA | NA | NA | NA | NA | 1.0679 | NA | 1.4259 |
| PE 16:0/22:4;O3* | 0.4261 | 2.6879 | 3.0513 | 0.0573 | 0.1568 | 0.1128 | 0.1491 | 0.1673 | 0.3320 | 0.2042 | 0.0676 | 1.6980 | 1.6139 | 1.0815 | 0.4149 | 1.2681 | 2.2700 | 1.2699 |
| PE 18:0/20:4;O | 1.2901 | 1.8245 | 1.9794 | 0.3480 | 0.3678 | 0.3655 | 0.7433 | 0.7959 | 0.6596 | 0.6469 | 0.4229 | 1.4143 | 1.2764 | 0.9371 | 0.6402 | 1.3912 | 1.5265 | 1.0761 |
| PE 18:0/20:4;O2 | 0.8694 | 1.3582 | 1.6309 | 0.2370 | 0.3290 | 0.2599 | 0.9755 | 0.8343 | 0.9698 | 0.9838 | 0.7540 | 1.3598 | 1.4047 | 0.9688 | 0.7075 | 1.2793 | 1.6017 | 1.1298 |
| PE 18:0/20:4;O3 | 0.5048 | 2.4551 | 2.6420 | 0.0543 | 0.0819 | 0.0771 | 0.1781 | 0.3274 | 0.1796 | 0.1636 | 0.1196 | 2.0124 | 1.7768 | 1.0222 | 0.3272 | 2.1108 | 2.2871 | 1.2254 |
| PE 18:0/22:4;O | 1.5653 | 1.4420 | 1.6069 | 0.6403 | 0.6146 | 0.6174 | 1.6868 | 1.1432 | 1.1389 | 1.2314 | 0.3513 | 0.9494 | 0.7545 | 0.5356 | 0.5223 | 0.9983 | 0.9224 | 0.6348 |
| PE 18:0/22:4;O2* | 0.8504 | 2.2282 | 2.6042 | 0.0462 | 0.1237 | 0.0655 | 0.3474 | 0.6460 | 0.3718 | 0.3145 | 0.3022 | 1.9975 | 1.4794 | 0.8118 | 0.3920 | 1.8134 | 1.8363 | 0.9838 |
| PE 18:0/22:4;O3* | 0.6448 | 2.8681 | 2.6844 | 0.0683 | 0.1173 | 0.1017 | 0.1684 | 0.3070 | 0.1769 | 0.1471 | 0.1611 | 1.8541 | 1.7222 | 1.3290 | 0.2717 | 1.7771 | 2.1639 | 1.5150 |
| PE 18:1/20:4;O | 0.6014 | 1.4524 | 1.6278 | 0.2142 | 0.3260 | 0.2730 | 0.4755 | 0.6797 | 0.7097 | 0.6921 | 0.5297 | 1.7457 | 1.6928 | 1.1408 | 0.7082 | 1.5811 | 1.8247 | 1.2815 |
| PE 18:1/20:4;O2 | 1.3599 | 2.2134 | 2.8477 | 0.0454 | 0.0583 | 0.0448 | 0.4585 | 0.6443 | 0.4256 | 0.5619 | 0.4329 | 1.9025 | 1.2051 | 0.7061 | 0.5181 | 1.6965 | 1.4263 | 0.8076 |
| PE 18:1/20:4;O3 | 0.3896 | 2.1405 | 1.9803 | 0.0412 | 0.1257 | 0.0790 | 0.1926 | 0.2407 | 0.1890 | 0.1399 | 0.0820 | 2.1461 | 2.1406 | 1.4305 | 0.4496 | 1.8422 | 2.7071 | 1.4988 |
| PI 16:0/20:4;O | 1.0204 | 1.9875 | 1.5961 | 0.4141 | 0.5586 | 0.5910 | NA | 0.2856 | NA | NA | NA | 1.5344 | NA | NA | NA | 1.0123 | NA | NA |
| PI 16:0/20:4;O2 | 0.6874 | 1.8381 | 0.8383 | 0.2869 | 0.5207 | NA | NA | 0.4443 | NA | NA | NA | 1.6058 | NA | NA | NA | NA | NA | NA |
| PI 16:0/20:4;O3 | 0.9635 | 1.3018 | 1.4622 | 0.7690 | 0.2944 | 0.3755 | NA | 0.4817 | NA | NA | NA | 1.4479 | NA | NA | NA | 1.3350 | NA | NA |
| PI 16:0/22:4;O | NA | 1.0500 | NA | 0.2893 | 0.3447 | 0.3339 | NA | 1.8999 | NA | NA | NA | 2.3692 | NA | NA | NA | 0.5022 | NA | NA |
| PI 18:0/20:4;O | 0.8850 | 1.9021 | 2.2154 | 0.1246 | 0.1423 | 0.1367 | NA | 0.6575 | NA | NA | NA | 1.5916 | NA | NA | NA | 1.3447 | NA | NA |
| PI 18:0/20:4;O2 | 1.0156 | 2.1799 | 2.1261 | 0.0623 | 0.1041 | 0.0785 | NA | 0.5740 | NA | NA | NA | 1.6581 | NA | NA | NA | 1.2013 | NA | NA |
| PI 18:0/20:4;O3 | 0.5098 | 2.4190 | 2.3477 | 0.0243 | 0.0401 | 0.0329 | NA | 0.3576 | NA | NA | NA | 1.8427 | NA | NA | NA | 1.4259 | NA | NA |
| PI 18:0/22:4;O | 1.1206 | 1.9024 | 1.7914 | 0.1535 | 0.1380 | 0.1095 | NA | 0.7330 | NA | NA | NA | 1.5825 | NA | NA | NA | 1.4691 | NA | NA |
| PI 18:0/22:4;O2* | 0.6045 | 2.1545 | 2.1280 | 0.1005 | 0.1240 | 0.0493 | NA | 0.5792 | NA | NA | NA | 1.7306 | NA | NA | NA | 1.2297 | NA | NA |
| PI 18:0/22:4;O3* | 0.5755 | 2.2182 | 2.1299 | 0.0293 | 0.0234 | 0.0279 | NA | 0.3624 | NA | NA | NA | 1.9763 | NA | NA | NA | 1.6571 | NA | NA |
| PI 18:1/20:4;O | 0.8351 | 1.9233 | 1.9567 | 0.3072 | 0.2428 | 0.2549 | NA | 0.6344 | NA | NA | NA | 1.5552 | NA | NA | NA | 1.2905 | NA | NA |
| PI 18:1/20:4;O2 | 1.2152 | 1.2373 | 1.6692 | 0.0686 | 0.2977 | 0.5852 | NA | 0.8685 | NA | NA | NA | 0.8518 | NA | NA | NA | 1.5856 | NA | NA |
| PI 18:1/20:4;O3 | 0.7178 | 2.3299 | 2.2856 | 0.0398 | 0.1317 | 0.0618 | NA | 0.5194 | NA | NA | NA | 1.6067 | NA | NA | NA | 0.9872 | NA | NA |
Factors:
| F1 | Sample source:Breast cancer cells | Genotype:shCtrl | Treatment:DMSO | Treatment Time:2 h |
| F2 | Sample source:Breast cancer cells | Genotype:shCtrl | Treatment:RSL3 (10 µM) | Treatment Time:2 h |
| F3 | Sample source:Breast cancer cells | Genotype:shCtrl | Treatment:RSL3 (1 µM) | Treatment Time:2 h |
| F4 | Sample source:Breast cancer cells | Genotype:shZeb1 | Treatment:DMSO | Treatment Time:2 h |
| F5 | Sample source:Breast cancer cells | Genotype:shZeb1 | Treatment:RSL3 (10 µM) | Treatment Time:2 h |
| F6 | Sample source:Breast cancer cells | Genotype:shZeb1 | Treatment:RSL3 (1 µM) | Treatment Time:2 h |
| F7 | Sample source:Breast cancer cells | Genotype:WT | Treatment:DMSO | Treatment Time:24 h |
| F8 | Sample source:Breast cancer cells | Genotype:WT | Treatment:DMSO | Treatment Time:2 h |
| F9 | Sample source:Breast cancer cells | Genotype:WT | Treatment:DMSO | Treatment Time:4 h |
| F10 | Sample source:Breast cancer cells | Genotype:WT | Treatment:DMSO | Treatment Time:6 h |
| F11 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (10 µM) | Treatment Time:24 h |
| F12 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (10 µM) | Treatment Time:2 h |
| F13 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (10 µM) | Treatment Time:4 h |
| F14 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (10 µM) | Treatment Time:6 h |
| F15 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (1 µM) | Treatment Time:24 h |
| F16 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (1 µM) | Treatment Time:2 h |
| F17 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (1 µM) | Treatment Time:4 h |
| F18 | Sample source:Breast cancer cells | Genotype:WT | Treatment:RSL3 (1 µM) | Treatment Time:6 h |
