Data for (Study ST003286)

(Analysis AN005383)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15	F16	F17	F18	F19	F20	F21	F22	F23	F24	F25	F26	F27
Acetate	0.3740	0.7587	0.7193	0.6323	2.3726	2.3788	1.0306	2.5256	1.9707	0.2440	0.5318	1.7404	0.4529	2.1681	1.9426	0.8172	2.9216	1.2708	0.0799	0.0667	0.0959	0.3199	0.3128	0.2500	0.3044	0.3374	0.3811
Alanine	0.6451	0.5954	0.5716	1.1226	1.2245	1.0902	1.4416	1.2667	1.2419	1.0685	0.3485	1.2316	0.9164	1.2985	0.8588	0.7828	1.4336	0.9096	0.5347	0.4885	0.5135	1.4060	1.3197	1.1501	1.1207	1.0507	1.3681
Arginine	0.7903	1.8040	0.7184	1.0967	1.4367	1.2251	1.4354	1.5810	0.9425	0.3625	0.3180	0.4942	1.3616	1.0848	1.3176	1.2152	1.2836	0.7342	0.9345	0.8296	0.8290	0.9299	0.9856	0.8195	1.0277	0.7783	0.6639
Aspartate	1.6412	1.4637	0.9226	3.0537	1.3133	2.4335	2.1148	2.0997	2.1286	0.3752	0.1983	0.3830	0.5725	0.7207	0.9318	1.1650	0.7647	0.7911	0.4699	0.4372	0.2982	0.6474	0.4230	0.4116	0.3970	0.4937	0.3488
Choline	1.9631	2.3484	1.7766	2.2325	2.5387	1.5991	1.8389	1.7846	1.3694	0.2475	0.2398	0.2907	0.6382	0.3354	0.3624	0.5667	0.2694	0.5622	0.5902	0.6572	0.7459	1.0813	0.6629	0.5657	0.5562	0.5759	0.6010
Cystine	1.2536	1.2895	1.1904	1.4539	1.0025	1.1003	1.5780	1.0260	1.0787	0.7205	0.4766	1.3206	1.3504	0.7365	1.3944	1.4826	0.7082	0.9309	0.7336	0.8295	0.6891	0.8680	0.9942	0.6469	0.6886	0.6195	0.8368
Formate	0.3337	0.6566	0.4061	0.7575	3.7863	0.5721	0.3716	0.4691	0.5634	2.7076	0.5550	1.6428	0.6479	1.9361	2.0934	1.1529	2.1930	1.9925	0.5188	0.3967	0.4847	0.4430	0.5508	0.4350	0.4586	0.4099	0.4646
Fumarate	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.7777	0.7777	1.6950	1.2031	0.8973	0.6381	0.3058	0.8309	0.4188	1.3892	1.3560	1.3095	0.8575	0.9970	1.1100	1.2430	1.1965	0.9970
Glucose	1.0010	0.7625	0.9792	0.8305	0.6452	0.8866	0.7803	0.6649	0.7649	1.0966	0.9867	1.0812	1.0886	1.0363	1.0918	1.0318	1.0974	1.0645	1.1219	1.1302	1.1278	1.1338	1.1200	1.1337	1.0870	1.1155	1.1402
Glutamate	0.4584	0.5325	0.5177	1.2718	1.5609	1.4144	1.1490	1.1141	0.6013	0.8414	0.7596	1.5490	1.0046	1.4199	1.8723	1.1688	1.3613	0.8751	0.8163	0.8601	0.9019	0.9498	1.0613	0.7882	0.6117	0.6558	0.8827
Glutamine	0.5408	0.3235	0.2222	0.9535	0.2614	0.3854	1.1339	0.5325	1.0462	1.3907	1.3928	0.9836	1.2623	0.9507	1.2235	1.3565	1.0470	1.3320	1.2261	1.2028	1.1517	1.2177	1.2697	1.0666	1.0485	1.2106	1.2681
Glycine	0.7205	0.8831	0.6549	1.9055	1.6018	1.5917	1.2678	1.3361	1.3694	0.6160	0.3049	1.0760	1.8893	0.2970	0.7289	1.6596	0.8210	1.0480	0.4877	0.6550	0.5594	0.8857	0.4836	0.6084	0.6737	1.5676	1.3074
Histidine	0.7260	0.6725	0.6262	0.5154	0.7275	0.5585	0.6979	0.6584	0.6289	0.9415	0.6178	1.3100	1.1801	0.9898	1.2243	1.3990	1.1909	1.3755	1.3114	0.9781	1.2147	1.3872	1.3708	1.1649	1.2787	1.0555	1.1982
Isoleucine	0.4632	0.7047	0.5144	0.9197	0.6330	0.9835	0.7700	0.8213	0.8583	1.0791	0.8506	0.8484	1.1963	0.9015	1.1068	1.4118	1.0680	1.3583	1.3097	1.1368	1.2082	1.2217	1.3270	1.0695	1.2148	1.0283	0.9954
Lactate	0.3120	0.4418	0.2892	0.7238	1.8759	1.7172	0.8359	1.2311	0.9331	0.5098	0.5521	0.6170	0.9520	2.5366	2.5187	0.7450	2.5221	0.6472	0.7835	0.7498	0.7599	0.7854	0.8529	0.7914	0.7842	0.7323	0.8001
Leucine	0.8742	0.7758	0.7412	1.0496	1.1494	0.7437	0.7627	0.8171	0.8934	1.0937	0.8049	0.8481	1.1549	1.1219	1.2691	1.3252	1.1973	1.3480	0.5460	0.5428	0.5207	1.3873	1.3315	1.0618	1.3085	1.2162	1.1152
Lysine	0.4161	0.4564	0.5367	0.8500	0.7276	0.5630	0.8578	1.1225	0.7423	1.0313	0.7822	0.8636	1.0973	0.9173	1.2668	1.3666	1.0794	0.8076	1.4320	1.3057	1.2956	1.2119	1.2285	1.1978	1.2743	1.3665	1.2031
Methionine	2.1375	1.8435	0.3840	0.9677	1.1241	0.8388	0.6327	0.8548	0.7818	0.8391	0.7912	1.0937	0.8305	0.8094	0.8190	1.3678	0.9341	0.9360	1.2531	0.9574	1.0148	1.0974	1.0075	0.8066	1.0747	0.9581	0.8447
myo-Inositol	0.8738	1.3471	0.8507	0.5902	1.0261	1.0407	1.0361	1.1594	1.0626	0.9407	0.3963	0.7323	1.0808	0.6118	0.7474	0.6980	0.5265	0.5954	1.4491	1.5012	0.9796	1.3056	1.2217	1.2030	1.1645	1.2374	1.6222
Nicotinurate	0.5600	0.6957	0.2617	0.8960	0.5434	0.9098	0.6255	0.7319	0.4785	1.6328	0.9415	1.5117	1.0877	1.1494	1.4614	1.2136	1.0325	1.1925	1.1153	1.2843	1.1039	1.2469	1.1746	1.0780	1.0227	1.0991	0.9496
Phenylalanine	0.8036	1.3688	1.1199	0.9778	1.0680	0.9337	0.7258	0.9211	0.7015	1.1204	0.8433	1.0467	0.9588	0.9257	1.0270	1.2480	0.9040	1.1859	1.1345	1.0434	1.0527	1.0817	1.0879	0.9055	0.9630	0.8301	1.0214
Pyroglutamate	0.6867	0.7226	1.5041	0.8204	1.0406	1.2580	1.2652	1.3305	0.7164	0.8586	0.7956	0.8578	0.9477	0.9777	1.0537	1.0010	1.1576	1.0543	1.1615	0.9844	1.0160	0.8573	1.1977	0.7651	1.0612	1.0287	0.8797
Pyruvate	2.9320	1.1040	0.6789	1.9970	1.2212	0.9848	3.3436	1.1866	2.1046	0.1913	0.6561	1.3275	0.3805	1.5724	1.4789	0.3011	1.4231	1.4461	0.1730	0.1573	0.1897	0.3687	0.3871	0.3213	0.3995	0.3374	0.3363
Serine	0.5657	0.5382	0.4471	1.3279	0.9528	1.3035	1.1640	1.3185	1.2615	0.4923	0.1693	0.2226	1.1331	0.3878	0.5248	1.0778	0.2613	1.5689	1.5498	1.4319	1.3913	1.3591	2.3145	0.6380	0.7680	1.1371	1.6930
Threonine	0.5428	0.9500	0.5856	1.1519	1.2011	0.5934	0.8416	0.7781	1.0111	0.6370	0.2826	0.6946	1.4424	0.1918	0.3265	2.1597	0.1795	0.3507	1.6507	1.4206	1.5831	1.5542	1.1100	1.3211	1.6568	1.4807	1.3024
Tryptophan	0.9791	1.2806	0.7063	0.9492	1.1517	0.6484	0.9038	0.6546	0.7063	1.4899	1.4538	1.1336	0.8465	0.8888	0.7960	1.0751	0.7051	0.8826	1.0695	0.9605	1.3616	1.0358	1.2439	0.9966	1.0333	1.1629	0.8845
Tyrosine	0.5157	0.6203	0.3956	1.1263	1.3704	1.3537	0.9173	1.2704	1.0030	0.9232	0.6010	0.8981	1.1253	0.8876	1.0141	1.3462	1.0692	1.3310	1.0881	1.0484	0.9884	1.0705	1.1375	0.9593	0.9736	1.0082	0.9575
Valine	1.5602	1.4988	1.3693	0.8497	0.6937	0.5498	0.6468	0.6152	0.6783	1.2469	0.7089	1.0771	1.1140	0.8828	0.8602	1.0981	0.8823	1.2375	1.1941	0.9990	1.0715	1.1522	1.1197	0.9749	1.0212	0.9649	0.9332

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Factors:

F1	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab
F2	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab
F3	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment
F4	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab
F5	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab
F6	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment
F7	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab
F8	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab
F9	Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment
F10	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab
F11	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab
F12	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment
F13	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab
F14	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab
F15	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment
F16	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab
F17	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab
F18	Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment
F19	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab
F20	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab
F21	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment
F22	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab
F23	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab
F24	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment
F25	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab
F26	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab
F27	Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment