Data for (Study ST003297)
(Analysis AN005401)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 |
---|---|---|---|---|---|
1,3-BPG | 0.4831 | 2.1667 | 0.0677 | 0.0223 | 1.0890 |
2-2-Dimethyl Succinic acid | 0.5126 | 0.6276 | 1.4105 | 1.3864 | 1.2276 |
2,3-BPG | 0.2714 | 2.1643 | 0.0044 | 0.0045 | 0.0037 |
2/3-Phosphoglyceric acid | 1.1629 | 1.7704 | 0.6107 | 0.6679 | 1.3419 |
2-3-Pyridinedicarboxylic acid | 0.3803 | 0.5160 | 3.2892 | 0.4864 | NA |
2-Aminoadipic acid | 0.7616 | 1.2202 | 0.9197 | 0.9080 | 1.9656 |
2-Deoxyadenosine | NA | 0.0051 | 0.9861 | 0.9892 | 1.4803 |
2-Deoxyadenosine 5-diphosphate | 0.3207 | 0.0164 | 1.2265 | 1.8194 | 1.8307 |
2-Deoxyadenosine 5-monophosphate | 0.2891 | 1.3554 | NA | NA | NA |
2-Deoxyadenosine 5-triphosphate | 1.0367 | 1.0006 | 0.9933 | 0.9756 | 0.9630 |
2-Deoxycytidine | 0.1133 | 0.1475 | 1.3030 | 1.2991 | 2.0363 |
2-Deoxycytidine 5-diphosphate | 1.2767 | 1.1613 | 0.0052 | 0.0053 | 0.2369 |
2-Deoxycytidine 5-monophosphate | 0.9640 | 1.0360 | NA | NA | NA |
2-Deoxyguanosine | NA | 0.0107 | 1.2955 | 1.0086 | 1.1625 |
2-Deoxyinosine | 0.6367 | 2.0737 | 0.4126 | 0.6775 | 1.0880 |
2-Deoxy-ribose | NA | 0.6632 | NA | NA | 1.3368 |
2-Deoxyribose 5-phosphate | 1.0413 | 1.0696 | 0.0017 | NA | NA |
2-Deoxyuridine | 0.1778 | 0.0894 | 1.7680 | 0.9793 | 2.8404 |
2-Deoxyuridine 5-triphosphate | 0.9590 | 0.9325 | 1.0610 | 1.0440 | 1.0212 |
2-Isopropylmalic acid | 0.6186 | 0.9777 | 1.1846 | 1.0905 | 1.7711 |
4-Hydroxyglutamic acid | 0.4648 | 0.8749 | 1.3031 | 1.0389 | 3.0107 |
4-Hydroxyphenyl-pyruvic acid | 0.3885 | 0.5417 | 1.8912 | 1.0768 | 0.2353 |
4-Pyridoxic acid | 0.1679 | 0.3156 | 1.5652 | 1.4005 | 1.4999 |
5-Deoxy-5-(methylthio)adenosine | 1.2715 | 1.2597 | 0.7467 | 0.7654 | 0.7404 |
5-Hydroxy-3-indoleacetic acid | 0.9421 | 0.5819 | 1.3743 | 1.1561 | 0.1242 |
5-Methylcytosine | 1.3524 | 2.0213 | 0.0091 | 0.0044 | 0.0353 |
Acetoacetate | NA | NA | NA | NA | NA |
Aceto-acetyl CoA Isovaleryl-CoA | 1.2145 | 1.3306 | 0.1909 | 0.6133 | 0.2169 |
Acetyl-CoA | 1.3619 | 1.5399 | 0.5753 | 0.5964 | 0.5592 |
Adenine | 0.9150 | 0.8662 | 0.9556 | 1.2163 | 1.2389 |
Adenosine | 1.5109 | 1.9412 | 0.1040 | 0.1001 | 0.0041 |
Adenosine 3-5-cyclic monophosphate | 0.3553 | 0.6233 | 1.2523 | 1.2297 | 1.1722 |
Adenosine 5-diphosphate | 1.9253 | 1.6819 | 0.0034 | 0.0018 | 0.0003 |
Adenosine 5-monophosphate | 1.0634 | 0.9366 | NA | NA | NA |
Adenosine 5-triphosphate | 2.0689 | 1.4657 | 0.4481 | 0.1783 | 0.0340 |
Adenylosuccinic acid | 2.9303 | 3.2896 | 0.4901 | 0.3168 | 0.4953 |
Adipic acid | 0.3291 | 0.4058 | 1.7365 | 1.7171 | 1.3166 |
AICAR | NA | 0.0438 | 1.1489 | 0.9983 | 0.9275 |
AICAR-P | 1.4761 | 1.8698 | 0.0940 | 0.4662 | 0.1067 |
Alanine/Sarcosine | 1.3600 | 1.3400 | 0.7951 | 0.6580 | 0.0811 |
Allantoin | 0.2404 | 0.5797 | 1.3554 | 1.5524 | 1.0594 |
alpha-D-Glucose-1-phosphate | 1.0341 | 1.2970 | 0.0064 | 0.0069 | NA |
alpha-D(+)Mannose 1-phosphate | 1.5089 | 2.5851 | 0.1864 | 0.1759 | 0.1670 |
alpha-Ketoglutaric acid | 0.9143 | 0.9530 | 1.1712 | 1.0137 | 0.6867 |
Arabinose-5-phosphate | 0.6958 | 1.5554 | 0.1360 | NA | NA |
Arginine | NA | 0.0093 | NA | NA | 1.3302 |
Asparagine | 2.0469 | 1.6212 | 0.2504 | 0.0861 | 0.0040 |
Aspartic Acid | 1.0914 | 2.1706 | 0.4708 | 0.2858 | 0.1179 |
beta-Nicotinamide adenine dinucleotide | 1.0860 | 0.9140 | NA | NA | NA |
b-Hydroxy Butyric acid | 1.9570 | 0.2522 | 0.4692 | 1.3322 | 0.0657 |
Butyryl-CoA Isobutyryl-CoA | 1.2938 | 0.9238 | 0.5958 | 1.0696 | 1.6568 |
Carnitine | 0.5816 | 1.2092 | NA | NA | NA |
Carnosine | 1.0526 | 1.0565 | 0.9390 | 0.9454 | 1.0382 |
cis-Aconitic acid | 1.6026 | 1.2464 | 0.5278 | 0.4481 | 0.0093 |
Citramalic acid | 1.8749 | 1.5335 | 0.4206 | 0.4081 | 0.4810 |
Citric acid / Isocitric acid | 1.1696 | 0.7504 | 1.3382 | 0.8490 | 0.3871 |
Citrulline | 1.3656 | 0.9469 | 1.0901 | 0.6530 | 0.0004 |
Coenzyme A | 0.8821 | 1.1046 | 1.1478 | 0.8674 | 1.1679 |
Creatine | 1.8498 | 2.2227 | 0.0484 | 0.0363 | 0.0576 |
Creatine phosphate | 0.1879 | 0.3737 | 2.1654 | 0.9456 | 1.7345 |
Creatinine | 0.9579 | 1.4716 | 0.7391 | 0.7982 | 1.0844 |
Cystathionine | 0.5759 | 0.4660 | 10.5810 | NA | NA |
Cystine | 0.0365 | 0.0228 | 1.2584 | 1.4225 | 5.0029 |
Cytidine | 1.0508 | 1.7460 | 0.0456 | 0.0217 | 0.6316 |
Cytidine 5-diphosphate | 1.0428 | 0.9572 | NA | NA | NA |
Cytidine 5-monophosphate | 0.8938 | 1.1062 | NA | NA | NA |
Cytidine 5-triphosphate | 1.8210 | 1.3691 | 0.8296 | 0.1461 | 0.0048 |
Cytosine | 1.3295 | 1.4304 | 0.0272 | 0.0196 | 0.0139 |
Deoxycytidine 5-triphosphate | 1.2279 | 1.2044 | 0.9717 | 0.6592 | 0.6208 |
Deoxythymidine 5-triphosphate | 1.5128 | 1.4037 | 0.6129 | 0.5491 | 0.5289 |
Dihydroorotic acid | 0.8863 | 1.5024 | 0.5721 | 0.3252 | 0.2667 |
Dihydroxyacetone phosphate | 1.3847 | 2.5737 | 0.0720 | 0.0696 | 0.1005 |
Disaccharide | 0.0366 | 0.2490 | 1.2282 | 1.4005 | 1.4133 |
Erythro-Dihydrosphingosine | 1.4246 | 1.5924 | 0.2820 | 0.0310 | 0.3900 |
Erythrose 4-phosphate | 0.9707 | 1.0244 | NA | NA | NA |
Flavin adenine dinucleotide | 1.0172 | 1.0186 | 0.9884 | 0.9952 | 1.0153 |
Fructose 1,6-biphosphate | 0.6126 | 1.6059 | 0.0150 | 0.0263 | 0.0120 |
Fructose 6-phosphate | 0.7507 | 1.2493 | NA | NA | NA |
Galactonic acid | 0.8042 | 2.0439 | 0.4700 | 0.4614 | 0.5204 |
Galactosamine | 1.6340 | 1.9628 | 0.4489 | 0.3801 | 0.0725 |
gamma-Glu-Cys | 1.8260 | 2.2557 | 0.0429 | 0.0398 | 0.0139 |
Gluconic acid | 0.5990 | 1.6835 | 0.7718 | 0.8085 | 1.0535 |
Glucose 6-phosphate | 1.8067 | 2.3211 | 0.0223 | 0.0143 | 0.0134 |
Glutamic acid | 1.3069 | 1.6054 | 0.7180 | 0.4941 | 0.2534 |
Glutamine | 1.1815 | 1.5003 | 0.6091 | 0.6401 | 1.4138 |
Glutathione (oxidized) | 1.2886 | 2.1090 | 0.2736 | 0.1511 | 0.0770 |
Glutathione (reduced) | 1.3241 | 1.8307 | 0.0105 | 0.0071 | 0.0206 |
Glyceraldehyde 3-phosphate | 1.1356 | 1.6299 | 0.7344 | 0.6293 | 0.6009 |
Glyceric acid | 0.1292 | 0.2310 | 1.5829 | 1.3907 | 1.7173 |
Guanine | 1.6346 | 2.3354 | 0.0808 | 0.1037 | 0.0731 |
Guanosine | 1.2512 | 2.5552 | 0.1693 | 0.1636 | 0.1639 |
Guanosine 5-diphosphate | 1.9007 | 1.7540 | 0.0453 | 0.0602 | 0.0778 |
Guanosine 5-triphosphate | 1.9247 | 1.3954 | 0.5656 | 0.2782 | 0.0166 |
Hexoses | 0.1263 | 0.2489 | 1.6500 | 1.7221 | 2.5159 |
Histidine | 1.2770 | 1.0969 | 0.8317 | 0.8045 | 0.9394 |
Homocitrate | 0.1598 | 0.4102 | 1.4229 | 1.5034 | 2.1182 |
Homocysteine | 0.0306 | 0.1893 | 2.0640 | 2.3896 | 0.1768 |
Homocystine | 1.0433 | 1.1557 | 0.9265 | 0.8935 | 0.8859 |
Homoserine | 1.1334 | 1.3345 | 0.4440 | 0.6303 | 0.5812 |
Hydroxyglutaric acid | 0.6636 | 0.9076 | 1.2806 | 1.0451 | 1.3759 |
Hypotaurine | 0.6924 | 1.3076 | NA | NA | NA |
Hypoxanthine | 1.1538 | 1.6040 | 0.1698 | 0.0423 | 2.9239 |
Inosine | 1.8234 | 2.1967 | 0.0682 | 0.0667 | 0.0696 |
Inosine 5-diphosphate | 1.7907 | 1.6054 | 0.0464 | 0.0284 | 0.0045 |
Inosine 5-monophosphate | 1.1365 | 1.2971 | 0.7976 | 0.8003 | 0.8113 |
Inosine 5-triphosphate | 1.9629 | 1.3139 | 0.5431 | 0.3111 | 0.2148 |
Isoleucine | 0.7303 | 0.6710 | 1.2907 | 1.1099 | 2.0991 |
Isopentenyl pyrophosphate | 0.5321 | 0.3277 | 1.0743 | 2.8219 | 0.1511 |
Isopentyl acetate | 1.3565 | 0.8779 | 1.2873 | 0.6143 | 0.2337 |
Itaconic acid | NA | NA | NA | NA | NA |
Ketovaleric acid | 0.3380 | 0.3550 | 1.7048 | 1.6023 | 0.9997 |
Kynurenine | 0.7158 | 0.6134 | 1.1409 | 1.2684 | 1.3219 |
Lactic acid | 0.4347 | 0.5115 | 1.7291 | 1.4418 | 0.2975 |
Leucine | 0.7263 | 0.6779 | 1.2545 | 1.1433 | 2.1881 |
Maleic acid | 2.1115 | 0.1622 | 1.5001 | 0.0341 | 0.0287 |
Malic acid | 0.7661 | 1.7668 | 0.9611 | 0.6111 | 0.3690 |
Malonic acid | 1.9272 | 0.2259 | 1.4617 | 0.7942 | 0.5143 |
Malonyl-CoA Hydroxybutyryl-CoA | 1.6622 | 1.2761 | 0.3545 | 1.0818 | 0.1169 |
Methionine | 0.9360 | 0.9497 | 1.0841 | 0.9507 | 1.4770 |
m-Hydroxybenzoic acid | 0.5310 | 0.6000 | 0.6693 | 0.0262 | 12.6317 |
N-Acetyl-alpha-D-glucosamine 1-phosphate | 2.1899 | 1.1301 | 0.0722 | 0.0201 | 0.0287 |
N-Acetylaspartic acid | 1.3334 | 0.8931 | 0.6862 | 1.1874 | 0.3993 |
N-Acetyl-D-glucosamine 6-phosphate | 1.3106 | 2.2603 | 0.0291 | 0.0231 | 0.0046 |
N-Acetylglutamic acid | 1.3366 | 1.3462 | 0.0584 | 0.0532 | 0.0412 |
N-Acetylneuraminic acid | 1.5090 | 1.0011 | 0.7937 | 0.7223 | 0.8435 |
N-Carbamoyl-DL-aspartic acid | 0.9708 | 2.7778 | 0.2278 | 0.1765 | 0.0826 |
N-Carbamyl-L-glutamic acid | 0.3122 | 0.6495 | 1.4687 | 1.2430 | 2.1560 |
N-Formyl-L-Tyrosine | 1.2227 | 1.0357 | 0.5208 | 0.3768 | 3.1607 |
Nicotinamide | 0.2376 | 0.2111 | 0.7671 | 1.0256 | 9.4138 |
Nicotinic acid | 1.4608 | 0.7924 | 0.9664 | 0.9410 | 0.2749 |
Nicotinic acid mononucleotide | 0.9462 | 0.6063 | 3.6162 | 0.4335 | 0.0215 |
o-Hydroxybenzoic acid | 0.8540 | 0.9902 | 1.1549 | 1.0174 | 0.9011 |
O-Hydroxy hippuric acid | 1.8497 | 1.5601 | 0.0335 | 0.4342 | NA |
O-Phospho-L-Serine | 1.3138 | 1.3903 | 0.0257 | 0.0250 | 0.0231 |
O-Phosphorylethanolamine | 0.8728 | 0.9520 | 1.0824 | 1.0806 | 1.0734 |
Orotic acid | 1.0977 | 2.0809 | 0.1572 | 0.1834 | NA |
O-Succinyl-L-homoserine | 0.9831 | 1.9980 | 0.2871 | 0.6626 | 0.6684 |
Pantothenic acid | 0.9027 | 0.8752 | 1.1171 | 1.0215 | 1.5011 |
Pentose Alcohol | 0.2067 | 0.2649 | 1.6202 | 1.1361 | 0.9888 |
Pentoses | 0.0139 | 0.0400 | 1.4592 | 1.4901 | 2.1113 |
Phenylalanine | 0.7614 | 0.6640 | 1.2707 | 1.1641 | 1.8391 |
Phenylpyruvic acid | 0.4306 | 0.4532 | 1.8544 | 1.3546 | 0.4437 |
Phosphoenolpyruvic acid | NA | NA | 1.0219 | 0.9737 | NA |
p-Hydroxybenzoic acid | 0.3960 | 0.4547 | 1.3324 | 1.9383 | 0.1147 |
Proline | 2.0521 | 1.4922 | 0.3214 | 0.1705 | 0.2594 |
Propionyl- CoA | 1.8290 | 0.2461 | 1.4429 | 0.6538 | 0.1444 |
Pyridoxal | 0.1891 | 0.2522 | 2.0840 | 1.5274 | 0.6838 |
Pyridoxal 5 phosphate | 1.3010 | 1.4736 | 0.6374 | 0.7370 | 1.0349 |
Pyridoxamine | 1.0650 | 0.9870 | 0.9852 | 0.9731 | 0.9385 |
Pyridoxine | 0.1580 | 0.2219 | 1.7583 | 1.6285 | 2.3995 |
Pyroglutamic acid | 0.1665 | 0.2546 | 1.6873 | 1.5255 | 2.1139 |
Pyruvic acid | 0.1548 | 0.3261 | 1.0967 | 1.7018 | 5.3242 |
Quinic acid | NA | NA | 0.0053 | 2.4566 | 0.0763 |
Riboflavin | 0.1916 | 0.2166 | 1.7229 | 1.6851 | 2.1027 |
Ribose 5-phosphate | 0.8001 | 1.5737 | 0.8318 | 0.7182 | 0.7007 |
Ribulose 5-phosphate | 0.9691 | 1.6113 | 0.0786 | 0.0165 | NA |
S-5-Adenosyl-L-homocysteine | 1.5081 | 1.6142 | 0.4884 | 0.4768 | 0.4748 |
Salicylic Acid | 0.8540 | 0.9902 | 1.1549 | 1.0174 | 0.9011 |
Sedoheptulose-7-phosphate | 1.0016 | 0.9984 | NA | NA | NA |
Serine | 1.5109 | 1.6227 | 0.4702 | 0.4080 | 0.9291 |
Succinic acid | 0.3009 | 0.4300 | 1.5794 | 1.4373 | 1.9005 |
Taurine | 1.6358 | 2.4486 | 0.0462 | 0.0219 | 0.0853 |
Taurocholic acid | 0.1618 | 0.2058 | 1.6970 | 1.7185 | 2.3022 |
Thiamine | 0.7721 | 0.7962 | 1.2125 | 1.1729 | 1.2776 |
Threonine | 1.6659 | 1.5937 | 0.4550 | 0.3866 | 0.3931 |
Thymidine | 0.2595 | 0.3184 | 1.6049 | 1.0835 | 2.3114 |
Thymidine 5-diphosphate | 1.0317 | 0.9661 | NA | NA | NA |
Thymidine 5-monophosphate | 0.9316 | 1.0260 | 1.0185 | 1.0197 | 1.0256 |
Thymine | 0.0729 | 0.1172 | 1.4811 | 1.1565 | 0.7943 |
trans-4-Hydroxy-L-proline | 1.4620 | 1.6482 | 0.3405 | 0.3641 | 0.0470 |
trans-Aconitic acid | 1.0277 | 1.0454 | 1.0246 | 1.0003 | 0.5124 |
Tryptophan | 1.1335 | 0.8950 | 1.0200 | 0.8880 | 1.3815 |
Tyrosine | 0.9075 | 0.8002 | 1.1628 | 1.0423 | 1.5223 |
UDP-Glucose / UDP-Galactose | 1.9372 | 2.1512 | 0.0362 | 0.0359 | 0.0366 |
UDP-Glucuronic Acid | 0.8090 | 1.1910 | NA | NA | NA |
UDP-NAc Glucosamine | 1.9833 | 0.6278 | 0.0000 | 0.0000 | 0.0000 |
Uracil | 0.2171 | 0.2447 | 1.8783 | 1.5773 | 1.4962 |
Uric acid | 0.2568 | 0.3368 | 1.8709 | 1.5169 | 1.1118 |
Uridine | 1.1237 | 2.2144 | 0.4460 | 0.3093 | 0.4403 |
Uridine 5-diphosphate | 1.0247 | 0.9753 | NA | NA | NA |
Uridine 5-monophosphate | 1.6088 | 2.2325 | 0.1497 | 0.1508 | 0.1485 |
Uridine 5-triphosphate | 1.3773 | 0.9489 | 1.2074 | 0.2637 | 0.0014 |
Valine | 1.0151 | 0.8496 | 1.0682 | 0.9760 | 1.5462 |
Xanthine | 0.9991 | 1.1480 | 0.2949 | 0.6231 | 6.6091 |
Xanthosine | 0.4314 | 0.6266 | 1.1783 | 1.2063 | 0.9535 |
Xylulose-5-phosphate | 0.8735 | 1.8504 | 0.1900 | 0.0788 | NA |
Factors:
F1 | Sample source:Cell lysate | Genotype:PD-L1 KO |
F2 | Sample source:Cell lysate | Genotype:Wild-type |
F3 | Sample source:Conditioned media | Genotype:PD-L1 KO |
F4 | Sample source:Conditioned media | Genotype:Wild-type |
F5 | Sample source:Culture media | Genotype:N/A |