Data for (Study ST003347)

(Analysis AN005482)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Metabolite	F1	F2	F3	F4	F5	F6
2/3-phosphoglycerate	1.2538	0.8720	1.0715	0.6207	1.2327	0.9747
2-aminoadipic acid	1.6894	0.8638	0.6074	1.3453	0.9121	0.7910
2-hydroxyglutarate	1.1088	0.9534	0.6999	1.2834	1.1034	0.9255
2-ketoglutarate	0.6727	0.9253	0.5223	0.3902	1.2723	1.6086
3-phosphoserine	0.6413	1.4832	0.6053	1.6015	0.5679	1.0504
acetylcarnitine	1.6312	0.5915	0.9594	1.4120	1.2796	0.5632
acetylcholine	1.7675	0.6479	0.4935	1.7014	0.7924	0.7987
adenosine	0.4645	0.4786	1.6387	0.7317	0.3941	1.6462
ADP	1.6089	0.7600	0.5480	0.8144	1.4943	0.8872
ADP-ribose	0.2040	1.0607	0.9949	0.8515	1.4408	1.2241
alanine	0.7044	0.6775	0.5610	1.1392	1.1847	1.3666
AMP	0.6054	1.4125	1.3204	0.2779	0.9804	1.2017
arginine	1.0802	0.8604	0.6656	1.2863	1.0438	1.0318
argininosuccinate	0.2071	2.0449	1.2586	0.5246	1.2025	0.8811
asparagine	0.4529	0.4132	0.5441	0.2625	0.7387	2.2943
aspartate	0.3735	1.5806	1.3581	0.4164	0.2781	1.4967
aspartylglucosamine	1.4498	0.8276	0.5152	1.4794	1.3796	0.6743
ATP	0.3385	1.3118	1.1889	0.6978	0.3900	1.5365
beta-alanine	1.0206	1.1374	0.5809	2.0233	0.6597	0.7890
beta-citrylglutamic acid	0.3158	1.9190	1.2562	0.2999	0.2660	1.4715
betaine	0.4255	1.1427	1.2067	0.3157	1.3429	1.2832
butyrylcarnitine	1.6355	0.8688	0.6814	0.6728	1.6405	0.7505
cAMP	0.3013	2.1770	0.7469	1.1007	2.0400	0.3171
carnitinamide	0.5297	1.1140	0.8944	0.8724	1.3924	1.0985
carnitine	1.7002	0.3587	1.2778	0.9198	0.6469	1.0483
carnosine	0.3278	2.0973	1.3857	0.3380	0.2837	1.2838
CDP	1.1364	0.6713	1.2125	1.2491	0.9162	0.9072
choline	1.9471	0.8479	0.4114	1.0791	0.9996	0.8574
cis-aconitate	1.6616	1.0290	1.3066	0.2868	0.9477	0.8842
citicoline	1.4199	0.7958	0.6294	1.1450	1.1695	0.9202
citrate	1.2283	0.3989	0.4167	2.2177	0.6947	1.0218
citrulline	0.9852	1.4698	1.4169	0.2468	0.3252	1.2780
CMP-acetylneuraminic acid	1.2582	0.6994	0.5710	1.6728	1.3223	0.7381
creatine	1.1153	0.9023	0.7559	1.4190	0.9828	0.9123
creatinine	1.2670	0.7673	0.6170	1.5987	0.8228	0.9636
cyclic ADP-ribose	1.4653	0.6120	0.7741	1.5375	0.8873	0.8618
Cys-Gly	1.6690	0.7677	0.4446	1.5965	0.7692	0.8765
cystathionine	1.3364	1.4050	1.5604	0.5966	0.5763	0.7626
cytidine	0.2810	1.1878	0.4247	1.7698	0.9388	1.1990
cytosine	0.2559	1.2917	0.5291	1.7000	0.8252	1.1991
dihydroorotate	1.6809	2.0004	0.7101	1.3474	0.3983	0.4315
dihydroxyacetone phosphate	1.3810	1.0994	0.9407	0.3526	0.8253	1.2005
dimethylarginine	1.3542	0.9154	0.4554	1.2056	0.9495	1.0599
dimethyllysine	0.5314	1.1780	2.8688	0.5981	0.5491	0.6373
dTTP	0.9903	0.6758	1.0988	0.3573	1.1718	1.3922
fructose 6-Phosphate	0.4184	1.2988	1.1115	0.3757	0.8989	1.4484
fumarate	1.1372	0.8968	0.7098	1.5492	0.7516	0.9777
GABA	1.1623	0.7513	0.7287	1.3505	1.2242	0.8915
GDP	1.0894	0.8232	0.8289	1.5824	0.9781	0.8490
GDP-glucose	0.6586	2.3520	1.3205	0.3958	0.9794	0.6469
gluconate	0.9016	1.4338	0.6636	0.2347	1.6005	1.0829
glucose	1.1756	1.0980	0.9361	0.9704	0.9039	0.9580
glucose 6-phosphate	0.7800	0.7790	1.5538	0.6981	1.1449	1.0221
glucuronic acid	1.6525	1.2611	0.8517	0.2922	1.3509	0.7959
glutamate	1.0926	0.8623	0.6862	1.5263	1.1586	0.8370
glutamine	1.1950	0.9049	0.7270	1.2639	1.1541	0.8775
glutamylproline	1.0992	0.7985	0.6268	1.3686	1.1029	1.0020
glutathione	1.3760	0.8095	0.5072	1.6056	0.9451	0.8783
glyceraldehyde 3-phosphate	0.7052	0.9177	2.3586	0.5116	0.7485	0.8792
glycerol 3-phosphate	0.5128	0.3262	1.7105	0.4211	0.4238	1.8028
glycerophosphoethanolamine	1.5070	0.7439	0.9433	1.3911	0.7469	0.8339
glycerophosphoinositol	0.8823	1.7838	1.5581	0.4375	1.6974	0.3204
glycerylphosphorylcholine	0.3636	1.5153	0.4006	2.0593	1.2520	0.7046
glycine	1.0422	0.7190	0.6061	1.3654	0.8181	1.2246
glycylglycine	1.3576	0.7172	0.6415	1.2705	1.2311	0.8910
GMP	0.5891	1.6109	1.1966	0.4424	0.3684	1.3963
GTP	1.4395	0.7509	0.8463	1.2644	1.1320	0.7835
guanidinobutyrate	0.5655	1.5541	0.9077	0.5763	1.3971	0.9996
guanine	1.6315	0.9274	0.5235	0.8193	0.8924	1.1029
guanosine	1.0959	0.8598	0.5832	1.5893	0.9982	0.9368
histidine	0.8715	0.6683	1.4218	1.0132	0.8717	1.0767
homoarginine	0.6984	0.6074	2.6514	0.6904	0.8109	0.7707
homocitrulline	0.3344	2.2524	0.8009	0.8705	0.3812	1.1803
hydroxyphenyllactate	1.4121	0.6964	0.7089	1.8133	0.7935	0.7879
hydroxyproline	1.1509	1.0705	0.6609	0.9143	1.3623	0.9206
hydroxytrimethyllysine	0.8539	0.9343	2.3300	0.7779	0.6261	0.7390
hypotaurine	0.8270	1.3523	0.6938	2.1233	0.7393	0.6322
hypoxanthine	1.2110	1.0236	1.1949	1.4249	0.9336	0.6060
IMP	0.5175	1.1490	0.9550	0.7837	1.0867	1.2690
inosine	0.4350	2.0774	1.4226	0.3070	0.7044	1.0269
isoleucine	0.5320	0.3718	2.2871	0.6415	0.4960	1.3358
isovalerylcarnitine C5	0.7912	1.3132	0.9228	0.4874	1.2393	1.1231
ketoleucine+ketoisoleucine	0.5606	0.8256	0.4396	1.3576	1.4535	1.1816
ketovaline	1.0107	0.8607	1.1985	1.3568	0.6961	0.9386
kynurenine	0.6156	1.5636	0.7922	0.3037	1.6761	1.0244
lactate	1.0158	1.2122	2.1350	0.2830	0.4371	0.9584
lanthionine	1.0265	0.5639	0.5678	0.7840	2.5016	0.7781
leucine	0.5311	0.3358	2.5739	0.6327	0.5033	1.2116
lysine	1.0151	0.8704	0.5140	1.6835	1.2100	0.8535
malate	1.1778	0.9401	0.8711	1.0406	0.9491	1.0107
methionine	1.0935	0.9626	0.5704	1.2396	1.3789	0.8775
methionine sulfoxide	1.3859	0.7356	0.5648	1.2370	1.5512	0.7627
methyllysine	0.5061	1.3691	0.9015	0.8945	1.4273	0.9507
myo-inositol	0.7718	1.4360	1.3442	0.9641	1.6051	0.4393
N-acetylarginine	1.3756	0.9416	0.7989	1.3582	1.0176	0.7541
N-acetylaspartate	0.4652	0.3565	1.9121	1.3677	1.9977	0.4504
N-acetylaspartylglutamate	0.7917	1.2135	0.8742	1.0213	0.8595	1.1199
N-acetylglutamate	1.1070	0.8560	0.5127	1.5718	0.9255	1.0135
N-acetylneuramic acid	1.2988	1.0587	0.6118	1.7311	1.1200	0.5898
N-acetylornithine	1.3594	0.9550	0.7830	1.4673	1.1153	0.6600
N-acetylserine	0.4932	0.3224	2.5089	0.8012	0.4314	1.2215
NAD	1.1696	0.7685	0.6158	1.2317	0.8877	1.1634
NADP	0.7109	1.1535	1.4364	0.8763	0.5161	1.1534
NADPH	0.3266	1.1137	1.2091	0.4459	1.8762	1.0142
N-carbamoylaspartate	1.4919	0.4749	0.7532	0.7187	1.0820	1.2397
N-carbamoylglutamate	1.2866	1.0378	0.6977	1.3471	0.9488	0.8410
nicotinamide riboside	1.5032	0.8117	0.6846	1.5763	0.7978	0.8132
noradrenaline	1.1235	0.7763	0.5832	1.9253	1.0674	0.7622
ophthalmic acid	1.6145	0.5577	0.5184	2.2837	0.5295	0.7481
ornithine	1.2643	0.6796	0.5464	1.4308	1.0147	1.0321
orotate	1.0205	0.4374	1.0173	1.4724	1.0165	1.0179
orotidine	0.7779	0.8840	0.6262	1.4907	0.8929	1.1642
oxidized glutathione	0.7888	1.5004	0.9697	0.5387	0.6995	1.2515
pantothenate	0.4635	1.1707	1.1312	1.7191	0.3591	1.0782
phenylalanine	0.5207	0.3637	2.2140	0.6257	0.5395	1.3682
phosphocholine	1.4652	0.8646	0.4061	1.6746	1.2875	0.6509
phosphocreatine	0.7459	0.5390	0.4120	1.3238	0.7129	1.6331
proline	1.3203	1.0137	0.6046	1.5067	1.0109	0.7719
propionylcarnitine	0.5169	0.6852	0.6363	0.7630	2.0440	1.1773
propionylcholine	0.4566	0.6964	0.6160	2.3615	1.3864	0.7416
pyridoxine	1.2916	0.8043	0.5876	1.7652	0.9876	0.7819
pyroglutamic acid	1.0547	0.9005	1.1801	1.2704	0.4728	1.0608
pyruvate	1.3549	0.5972	1.1860	0.5824	0.5642	1.3577
S-(2-succinyl)cysteine	0.7884	0.8253	1.2928	0.4647	1.3448	1.1420
S-(2-Succinyl)glutathione	1.2618	0.6576	1.3630	1.6668	0.9633	0.5437
S-adenosylhomocysteine	1.2676	1.0982	0.6670	1.1530	1.2061	0.8041
S-adenosylmethionine	1.3131	0.6920	0.5041	0.5742	1.6445	1.1360
sarcosine	1.0021	1.0141	1.0084	1.1284	1.0140	0.9165
sedoheptulose 7-phosphate	0.7551	1.3046	0.7383	1.3414	1.1396	0.8343
serine	1.5121	0.8878	0.5691	1.6580	1.0008	0.6861
succinate	1.1594	0.7241	1.0264	1.2325	0.9214	0.9680
succinyladenosine	2.0255	1.1895	0.7463	0.4697	0.7962	0.8511
taurine	0.4592	0.2815	1.1867	0.5928	1.6545	1.4127
thiamine	1.0968	0.4487	0.9877	1.0599	2.2997	0.5536
threonine	1.4256	0.9675	0.4316	1.1718	1.1115	0.9460
trimethyllysine	0.9437	0.9680	0.7159	1.2114	0.9135	1.1238
tryptophan	0.6426	0.4305	1.4309	0.6517	0.6569	1.5937
tyrosine	1.5731	1.1885	0.7010	0.5975	1.1418	0.8991
UDP-GlcNac	0.9313	0.8026	1.3568	1.2907	0.8671	0.8757
UDP-glucose	0.2421	1.5252	1.4885	0.3686	0.5546	1.4105
UMP	0.3972	1.9260	1.5130	0.5826	0.4050	1.0881
uric acid	0.9635	1.5167	0.9629	1.1768	0.8354	0.7724
uridine	0.3845	1.2734	1.2504	0.4452	1.6862	0.9802
UTP	0.7164	1.0133	1.5231	0.9433	0.5879	1.1080
valine	1.5073	0.8572	0.6758	1.0819	1.1569	0.8604
valine-d8	1.8592	0.5817	0.5866	1.5255	0.9335	0.7567
xanthine	0.2688	1.0057	1.4655	1.1565	1.0716	1.0160

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1	Sample source:Skin | Genotype:A3V/R337X | Sex:F
F2	Sample source:Skin | Genotype:M26L/R396H | Sex:F
F3	Sample source:Skin | Genotype:M26L/R396H | Sex:M
F4	Sample source:Skin | Genotype:R309H/c.1191+5G->C | Sex:F
F5	Sample source:Skin | Genotype:Wildtype | Sex:F
F6	Sample source:Skin | Genotype:Wildtype | Sex:M