Data for (Study ST003405)

(Analysis AN005588)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4F5F6F7F8F9F10
12-Hydroxydodecanoic acid 0.9967 0.9915 1.0567 0.9982 0.9899 0.9830 0.9790 1.0406 0.9843 0.9800
1-Methylhistidine 1.0035 0.9896 0.9759 0.9908 0.9987 1.0013 1.0049 1.0053 1.0155 1.0145
3-Hydroxymethylglutarate 1.0150 0.9935 0.9816 0.9961 1.0140 0.9965 1.0059 0.9879 0.9996 1.0099
3-Phosphoglycerate 1.0475 1.0005 0.9903 0.9928 1.0238 0.9984 0.9964 0.9678 0.9928 0.9897
3-Sulfinoalanine 1.0158 1.0066 0.9790 1.0122 1.0325 0.9744 0.9880 0.9696 1.0044 1.0176
4-Guanidinobutanoic acid 1.0159 1.0037 0.9938 1.0045 1.0059 1.0026 0.9961 0.9751 1.0031 0.9993
4-Hydroxyproline 0.9690 0.9924 0.9748 0.9977 1.0027 0.9806 1.0053 1.0155 1.0302 1.0319
4-Pyridoxic acid 1.0229 1.0122 0.9915 1.0018 1.0214 0.9347 1.0246 0.9971 1.0001 0.9937
5^-Methylthioadenosine 0.8972 1.0016 0.9944 1.0129 1.0091 1.0219 1.0128 1.0066 1.0269 1.0166
6-Phosphogluconic acid 1.0062 0.9698 1.0081 0.9723 1.0040 0.9811 0.9911 1.0462 1.0139 1.0072
Acetyl-CoA 1.0277 0.9982 0.9614 0.9942 1.0082 1.0041 1.0023 0.9937 1.0031 1.0070
Adenine 0.9985 0.9875 0.9933 0.9987 0.9987 1.0052 0.9991 1.0060 1.0094 1.0034
Adenosine diphosphate 1.0195 0.9958 0.9953 0.9970 1.0185 1.0016 0.9852 0.9956 0.9982 0.9932
Adenosine monophosphate 1.0020 0.9873 0.9785 0.9926 1.0041 1.0086 1.0021 1.0080 1.0030 1.0138
Adenosine triphosphate 1.0074 0.9929 1.0083 0.9938 1.0170 0.9874 0.9929 1.0045 1.0009 0.9948
Ala-gln 1.0045 0.9635 0.9372 0.9732 0.9959 1.0268 0.9937 1.0225 1.0459 1.0367
Alanine 0.9936 0.9876 0.9758 0.9919 0.9951 1.0039 1.0047 1.0137 1.0153 1.0184
Ala-pro 1.0283 0.9858 0.9495 0.9800 0.9939 1.0229 1.0143 0.9937 1.0107 1.0209
Alkyl-PC(p-16:0) 0.9990 1.0100 0.9955 0.9922 1.0009 0.9922 1.0026 1.0088 1.0050 0.9937
Alkyl-PC(p-18:0/18:1) 0.9747 0.9869 0.9816 0.9942 0.9739 1.0108 1.0231 1.0167 1.0140 1.0241
Alkyl-PE(p-18:0/20:4) 0.9770 1.0015 1.0069 1.0005 0.9852 0.9943 1.0005 1.0216 1.0045 1.0079
Allantoic acid 0.9973 0.9870 0.9916 1.0219 1.0125 1.0009 1.0339 0.9827 0.9966 0.9755
Allantoin 1.0154 0.9999 0.9812 1.0030 1.0033 0.9984 1.0143 0.9800 1.0049 0.9997
Aminoadipic acid 0.9683 0.9528 0.9393 0.9526 0.9661 1.0476 1.0421 1.0414 1.0427 1.0472
Arginine 1.0037 0.9947 0.9891 0.9961 1.0041 0.9937 1.0033 1.0045 1.0063 1.0043
Asparagine 0.9812 0.9725 0.9786 0.9857 0.9929 1.0008 1.0044 1.0315 1.0243 1.0281
Aspartic acid 1.0201 1.0072 1.0050 1.0141 1.0238 0.9787 0.9838 0.9772 0.9974 0.9927
Asp-glu 1.0084 0.9669 0.9414 0.9707 1.0019 1.0234 1.0226 1.0090 1.0300 1.0257
Asymmetric dimethylarginine 1.0144 0.9901 0.9725 0.9926 1.0084 0.9979 1.0052 0.9983 1.0128 1.0078
Betaine 1.0002 0.9914 0.9846 0.9924 0.9984 1.0058 1.0097 0.9989 1.0089 1.0096
Butanal 1.0199 1.0026 1.0087 0.9964 1.0039 0.9882 0.9954 0.9971 0.9972 0.9907
Butyrylcholine 0.9920 0.9814 0.9647 0.9747 1.0013 1.0074 1.0243 1.0039 1.0252 1.0251
Carnitine 1.0068 0.9978 0.9961 1.0019 1.0109 0.9905 1.0009 0.9919 1.0019 1.0014
CDP-ethanolamine 0.9982 1.0005 1.0374 0.9953 1.0470 0.9457 0.9759 1.0166 0.9828 1.0006
Cer(18:1;O2/16:0) 0.9616 1.0360 1.0488 1.0496 0.9764 0.9747 0.9769 0.9863 0.9954 0.9941
Choline 0.9836 0.9909 1.0225 0.9970 1.0206 0.9740 0.9908 1.0117 0.9980 1.0108
Citrulline 1.0049 0.9915 0.9843 0.9994 1.0014 0.9991 0.9953 1.0033 1.0091 1.0117
Creatine 1.0065 0.9981 0.9972 0.9983 1.0009 1.0027 1.0008 0.9953 1.0000 1.0003
Creatinine 1.0057 0.9986 0.9856 0.9987 1.0029 0.9989 1.0068 0.9949 1.0056 1.0024
Cys-gly 1.0271 1.0079 0.9897 1.0015 1.0135 0.9960 1.0068 0.9803 0.9901 0.9872
Cystathionine 0.9217 0.8973 0.8770 0.8961 0.9150 1.0968 1.0966 1.0874 1.1003 1.1117
Cystine 0.9974 1.0185 0.9541 0.9616 0.9793 1.0093 1.0100 0.9927 1.0393 1.0378
Cytidine diphosphate 1.0127 0.9908 1.0061 0.9939 1.0174 0.9971 0.9919 0.9959 1.0026 0.9916
Cytidine monophosphate 1.0005 0.9854 0.9975 1.0023 1.0267 0.9862 0.9877 0.9897 1.0090 1.0151
Dihydroxyacetone phosphate 1.0025 0.9877 0.9954 1.0015 1.0133 0.9861 0.9824 1.0208 1.0054 1.0050
Dimethylysine 1.0102 0.9904 0.9692 0.9919 1.0085 0.9955 1.0119 1.0000 1.0110 1.0114
Folic acid 1.0136 1.0023 0.9868 0.9988 1.0185 0.9857 1.0105 0.9852 1.0028 0.9958
Fructose 6-phosphate 0.9895 0.9736 1.0177 0.9887 1.0221 0.9749 0.9823 1.0302 1.0065 1.0146
Gamma-glutamylalanine 1.0053 0.9810 0.9544 0.9899 0.9936 1.0178 0.9988 1.0035 1.0244 1.0314
Gamma-glutamylcysteine 0.9856 0.9830 0.9630 0.9835 0.9861 0.9873 1.0039 1.0393 1.0253 1.0430
GDP-mannose 1.0162 0.9875 0.9922 0.9892 1.0157 1.0053 0.9975 0.9984 1.0021 0.9960
Glucose 6-phosphate 0.9832 0.9715 1.0297 0.9863 1.0171 0.9651 0.9765 1.0550 1.0082 1.0074
Glu-glu 1.0380 0.9877 0.9742 0.9932 1.0063 1.0101 1.0033 0.9810 1.0059 1.0004
Glutamate 1.0085 0.9952 0.9954 1.0008 1.0029 1.0040 0.9982 0.9945 1.0016 0.9990
Glutamine 0.9993 0.9978 0.9944 0.9987 1.0025 0.9905 0.9963 1.0065 1.0045 1.0095
Glutathione 1.0165 1.0016 0.9944 1.0024 1.0121 1.0016 1.0025 0.9863 0.9943 0.9884
Gly-asp 1.0241 0.9888 0.9681 0.9899 1.0003 1.0096 1.0037 0.9939 1.0091 1.0125
Glyceraldehyde 3-p 1.0383 0.9717 0.9788 0.9934 1.0011 1.0284 0.9926 0.9931 1.0064 0.9961
Glycerol 3-phosphate 0.9842 0.9728 0.9952 0.9896 1.0099 0.9805 0.9925 1.0356 1.0182 1.0214
Glycerophosphocholine 1.0075 0.9943 1.0005 0.9952 1.0064 0.9992 0.9967 0.9985 0.9991 1.0026
Glycine 1.0056 0.9865 0.9687 0.9901 0.9967 1.0107 1.0065 1.0053 1.0143 1.0158
Gly-glu 1.0165 0.9797 0.9684 0.9894 0.9944 1.0140 0.9963 1.0108 1.0188 1.0117
Histidine 0.9989 0.9863 0.9787 0.9921 0.9956 0.9955 1.0054 1.0181 1.0113 1.0182
Homo-arginine 1.0119 0.9886 0.9755 0.9919 1.0039 0.9956 1.0057 1.0041 1.0164 1.0064
Hypotaurine 1.0162 1.0020 0.9874 0.9993 1.0070 1.0073 1.0097 0.9678 1.0032 1.0001
Indoleacetaldehyde 1.0328 1.0052 0.9865 1.0028 1.0197 0.9804 1.0007 0.9782 1.0014 0.9923
Indoleacetic acid 1.0245 1.0164 0.9972 1.0127 1.0219 0.9720 1.0028 0.9690 0.9958 0.9876
Indoleacrylic acid 1.0020 0.9862 0.9774 0.9910 0.9981 0.9997 1.0033 1.0111 1.0139 1.0174
Inosine 0.9598 0.9823 1.0000 1.0112 1.0358 0.9614 1.0144 1.0036 1.0190 1.0126
Isoleucine 1.0026 0.9916 0.9857 0.9947 1.0020 0.9971 1.0022 1.0054 1.0090 1.0098
Itaconic acid 1.0134 0.9932 0.9971 0.9912 1.0013 1.0072 0.9943 0.9980 1.0036 1.0008
Kynurenine 1.0050 0.9815 0.9635 0.9862 0.9996 1.0039 1.0057 1.0104 1.0197 1.0245
Lactose 1.0254 0.9909 0.9867 0.9832 1.0202 0.9929 1.0052 0.9929 1.0064 0.9961
Leucine 1.0017 0.9922 0.9862 0.9954 0.9998 0.9968 1.0017 1.0059 1.0095 1.0109
LPC(15:0/0:0) 0.9858 1.0189 0.9937 1.0033 0.9966 0.9884 1.0075 1.0022 1.0010 1.0025
LPC(16:0/0:0) 0.9940 1.0090 1.0006 1.0012 1.0039 0.9945 1.0008 0.9996 0.9971 0.9994
LPC(18:1) 0.9984 1.0034 0.9981 1.0018 1.0049 0.9973 1.0008 1.0010 0.9960 0.9984
LPE(16:0/0:0) 0.9944 1.0208 0.9885 1.0126 1.0008 0.9873 1.0054 0.9940 0.9954 1.0008
LPE(18:1) 1.0359 1.0000 1.0020 1.0009 1.0001 1.0082 0.9815 0.9981 0.9855 0.9878
Lysine 1.0095 0.9930 0.9823 0.9952 1.0076 0.9913 1.0051 1.0027 1.0094 1.0039
Maltol 0.9774 1.0091 0.9901 1.0030 0.9984 0.9985 1.0134 0.9889 1.0113 1.0098
Methionine 0.9999 0.9889 0.9846 0.9933 0.9996 0.9986 1.0015 1.0094 1.0112 1.0130
Methionine sulfoxide 1.0050 0.9923 0.9833 0.9952 1.0011 0.9977 1.0005 1.0025 1.0087 1.0138
N2-acetyllysine 1.0908 0.9851 0.9311 0.9599 0.9822 0.9401 1.0092 0.9563 1.0635 1.0819
N6-acetyllysine 1.0252 1.0082 0.9588 0.9686 0.9975 1.0182 1.0088 1.0011 1.0083 1.0054
N6-methyllysine 1.0157 0.9860 0.9939 0.9899 1.0115 0.9994 1.0002 1.0011 0.9993 1.0031
N-acetylaspartate 1.0107 0.9947 0.9943 0.9804 0.9954 1.0137 1.0077 0.9952 1.0033 1.0045
N-acetylglucosamine 1.0054 0.9760 0.9921 0.9859 1.0046 1.0052 1.0080 1.0036 1.0071 1.0120
N-acetylglutamine 0.9921 0.9704 0.9679 0.9636 0.9790 1.0322 1.0273 1.0282 1.0213 1.0179
N-acetylmethionine 1.0315 0.9994 0.9493 0.9823 0.9862 1.0173 1.0156 0.9835 1.0173 1.0176
N-acetylneuraminate 1.0082 0.9931 0.9954 0.9959 0.9956 1.0045 1.0091 0.9969 1.0043 0.9971
N-acetylornithine 1.0021 0.9854 0.9759 0.9933 0.9984 0.9961 1.0020 1.0119 1.0163 1.0184
N-acetylphenylalanine 0.9872 1.0030 0.9890 1.0103 1.0197 0.9863 0.9971 1.0127 0.9953 0.9994
N-acetylputrescine 1.0165 0.9916 0.9700 0.9901 0.9976 0.9976 1.0005 1.0161 0.9990 1.0209
NAD 1.0165 0.9917 0.9945 0.9923 1.0107 1.0014 0.9953 1.0004 1.0010 0.9960
NADH 1.0169 0.9896 0.9841 0.9924 1.0027 1.0068 1.0023 0.9950 1.0062 1.0039
NADP 1.0083 0.9771 0.9924 0.9871 1.0239 1.0004 1.0002 0.9996 0.9993 1.0117
NADPH 0.9904 0.9911 1.0021 1.0029 1.0102 0.9716 0.9985 1.0120 1.0151 1.0061
Nicotinamide 0.9849 1.0099 0.9960 1.0069 0.9929 0.9957 1.0123 0.9963 1.0049 1.0003
N-methylglutamic acid 1.0112 0.9907 0.9796 0.9996 1.0037 1.0064 1.0029 0.9881 1.0100 1.0079
Ophthalmic acid 1.0142 0.9816 1.0047 0.9975 1.0020 0.9845 0.9791 1.0326 0.9972 1.0066
Ornithine 1.0164 0.9918 0.9830 0.9986 1.0126 0.9877 0.9969 0.9983 1.0084 1.0063
Oxidized glutathione 1.0337 1.0040 0.9986 1.0033 1.0247 0.9875 0.9950 0.9808 0.9898 0.9826
Pantothenic acid 1.0029 1.0046 1.0138 1.0084 1.0087 0.9922 0.9931 0.9858 0.9973 0.9931
PC(18:0/20:4) 0.9935 1.0020 1.0075 1.0037 0.9999 0.9953 0.9965 1.0040 0.9987 0.9988
PE(16:0/18:1) 0.9876 1.0020 0.9944 1.0065 0.9925 1.0012 1.0045 0.9986 1.0089 1.0038
PE(16:0/20:4) 0.9979 1.0145 0.9931 1.0168 1.0038 0.9942 0.9985 0.9860 0.9985 0.9967
Phenylalanine 0.9980 0.9911 0.9836 0.9939 0.9980 0.9989 1.0031 1.0090 1.0110 1.0134
Phosphocreatine 1.0017 0.9893 0.9886 0.9909 1.0017 0.9993 1.0088 1.0033 1.0089 1.0075
Phosphoenolpyruvate 1.0623 1.0112 0.9836 0.9946 1.0413 1.0084 0.9945 0.9474 0.9768 0.9800
Phosphoethanolamine 0.9773 0.9890 1.1142 0.9945 1.0562 0.9159 0.9519 1.0568 0.9597 0.9845
Phosphoserine 0.9429 0.9320 1.0045 0.9783 0.9931 0.9902 1.0002 1.0760 1.0391 1.0438
Picolinic acid 0.9976 0.9896 1.0003 0.9919 1.0016 1.0183 0.9912 0.9950 1.0074 1.0072
Pro-gly 1.0155 0.9846 0.9645 0.9864 0.9848 1.0224 1.0109 1.0016 1.0137 1.0156
Proline 0.9993 0.9946 0.9889 0.9984 1.0010 1.0019 1.0031 0.9981 1.0071 1.0075
PS(16:0/18:1) 0.9749 1.0206 1.0018 1.0106 0.9768 1.0012 1.0036 1.0005 1.0102 0.9998
Pyridoxal 1.0197 0.9902 0.9812 0.9926 1.0159 1.0021 1.0059 0.9901 1.0043 0.9980
Pyridoxine 1.0005 1.0023 0.9870 0.9993 0.9995 1.0003 1.0084 0.9920 1.0078 1.0029
Pyroglutamate 1.0038 1.0019 0.9848 0.9978 0.9982 1.0011 1.0124 0.9924 1.0061 1.0015
Riboflavin 1.0086 1.0108 0.9760 1.0073 1.0004 1.0006 1.0069 0.9865 1.0029 1.0001
Ribulose 5-phosphate 0.9797 0.9673 0.9988 1.0023 1.0063 0.9877 0.9839 1.0446 1.0236 1.0058
Saccharopine 0.9399 0.9237 0.9011 0.9380 0.9510 1.0780 1.0559 1.0857 1.0635 1.0630
S-adenosylhomocysteine 1.0225 0.9969 0.9739 0.9939 1.0109 1.0026 1.0006 0.9894 1.0038 1.0055
S-adenosylmethionine 1.0210 0.9913 0.9825 0.9985 0.9999 1.0113 0.9940 0.9922 1.0042 1.0052
Serine 0.9989 0.9894 0.9859 0.9951 1.0024 0.9911 0.9966 1.0124 1.0123 1.0160
SM(18:1;O2/18:1) 0.9954 1.0032 1.0206 1.0137 1.0051 0.9892 0.9976 0.9891 0.9857 1.0005
Sphinganine 0.9609 1.0314 0.9774 1.0068 0.9462 1.0251 1.0227 0.9936 1.0152 1.0206
Sphingosine 1.0299 1.0165 0.9697 1.0099 0.9957 1.0229 1.0079 0.9546 0.9930 0.9998
Taurine 1.0136 1.0070 0.9864 1.0038 1.0050 1.0081 1.0117 0.9646 1.0032 0.9964
Thiamine pyrophosphate 1.0564 0.9892 0.9694 0.9974 1.0088 1.0031 0.9931 1.0105 0.9301 1.0420
Threonine 0.9942 0.9923 0.9814 0.9952 0.9960 0.9967 1.0040 1.0101 1.0134 1.0166
TMAO 1.0308 1.0163 1.0185 1.0234 1.0354 0.9660 0.9672 0.9797 0.9839 0.9787
Trimethyllysine 1.0170 0.9904 0.9652 0.9895 1.0052 0.9991 1.0074 0.9987 1.0158 1.0119
Tryptophan 1.0008 0.9872 0.9805 0.9919 0.9989 0.9996 1.0024 1.0100 1.0127 1.0159
Tyrosine 0.9981 0.9902 0.9837 0.9932 0.9982 0.9994 1.0023 1.0097 1.0117 1.0136
UDP-glucose 1.0066 0.9992 0.9872 0.9979 1.0026 1.0040 1.0045 0.9919 1.0035 1.0028
Urate 1.0827 0.9855 0.9656 1.0292 1.0054 0.9891 1.0070 0.9656 0.9957 0.9741
Uridine monophosphate 1.0173 1.0106 1.0264 0.9880 1.0184 0.9612 0.9939 1.0286 0.9813 0.9742
Uridine triphosphate 1.0140 0.9947 1.0155 0.9971 1.0299 0.9744 0.9879 1.0000 0.9956 0.9909
Valine 1.0002 0.9906 0.9870 0.9964 0.9991 0.9976 1.0023 1.0072 1.0081 1.0115
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Sample source:U2OS Osteosarcoma Cell Line | ATF4:KO | Treatment_time:0
F2Sample source:U2OS Osteosarcoma Cell Line | ATF4:KO | Treatment_time:0.5
F3Sample source:U2OS Osteosarcoma Cell Line | ATF4:KO | Treatment_time:24
F4Sample source:U2OS Osteosarcoma Cell Line | ATF4:KO | Treatment_time:4
F5Sample source:U2OS Osteosarcoma Cell Line | ATF4:KO | Treatment_time:8
F6Sample source:U2OS Osteosarcoma Cell Line | ATF4:WT | Treatment_time:0
F7Sample source:U2OS Osteosarcoma Cell Line | ATF4:WT | Treatment_time:0.5
F8Sample source:U2OS Osteosarcoma Cell Line | ATF4:WT | Treatment_time:24
F9Sample source:U2OS Osteosarcoma Cell Line | ATF4:WT | Treatment_time:4
F10Sample source:U2OS Osteosarcoma Cell Line | ATF4:WT | Treatment_time:8
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