Data for (Study ST003430)

(Analysis AN005633)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
aCD 101 NA 1.0591 1.1069 1.1189 1.0449 0.9748 NA 0.8506 NA 0.8448 NA NA
aCD 161 1.0414 0.7322 0.8309 0.9665 1.2066 0.9697 0.8649 1.6623 0.9405 0.9452 1.0781 0.3666
Acetic PAR 1.4885 1.0506 0.1040 0.5804 3.4991 0.6349 0.1771 0.3997 0.3678 0.2512 2.7025 2.1183
Acetyl-CoA 408 2.2517 2.1571 2.4921 1.7307 1.5291 0.0003 0.0004 0.0003 0.0005 0.0003 NA NA
Acetyl-CoA 461 2.3101 2.2058 2.5389 1.7639 1.5588 0.0002 0.0003 0.0006 0.0001 0.0003 0.0002 NA
Acetyl-CoA 79 2.4700 2.4733 2.8168 1.8855 1.7410 0.0005 0.0011 0.0006 0.0009 0.0009 0.0005 0.0004
Alanine NEG PAR 2.1788 1.9912 2.0179 2.1743 2.4570 0.1272 0.1138 0.1140 0.1453 0.1821 0.0270 0.0584
Arginine 131 0.6402 0.6930 0.7338 0.7101 0.8127 1.3323 1.3137 1.3315 1.3403 1.4086 0.4970 0.9936
Arginine 156 0.6256 0.6787 0.7186 0.6968 0.7915 1.3442 1.3261 1.3420 1.3598 1.4263 0.4929 0.9851
Ascorbic acid 157 1.8389 1.7931 1.6721 2.1658 2.4074 0.2716 0.3351 0.2678 0.1678 0.2273 0.5779 0.7301
Ascorbic acid 79 0.1536 NA 0.4368 0.6823 0.9023 1.3607 1.5671 0.8735 0.6643 0.9044 0.5909 0.4644
Asparagine 113 1.6192 1.6347 1.7551 1.5792 1.6916 0.5814 0.5725 0.5751 0.5807 0.6334 0.0506 0.1261
Aspartic 115 1.4937 1.5176 1.4916 1.5451 1.4991 0.7058 0.6950 0.6828 0.7102 0.7058 0.1338 0.2775
Aspartic 88 1.4489 1.4711 1.4519 1.5004 1.4310 0.7513 0.7399 0.7108 0.7339 0.7490 0.1376 0.3124
Butyric PAR 1.9428 1.5780 1.6738 1.8370 2.2476 0.3199 0.2865 0.2656 0.4138 0.2589 0.5516 0.9661
Butyryl-CoA 408 1.8420 0.5482 0.2860 3.2498 6.6774 0.0060 0.0027 0.0048 0.0049 0.0066 0.0013 0.0022
Butyryl-CoA 79 1.9064 0.5164 0.3145 3.0600 6.6227 0.0133 0.0124 0.0079 0.0106 0.0105 0.0060 0.0048
C75 209 1.4039 1.8827 1.3125 1.8558 1.9311 0.4336 0.5473 0.4431 0.2441 0.5466 0.7098 1.8375
Citric 111 NA NA NA NA NA NA NA 2.2165 NA NA 0.3640 0.0127
Citric 173 2.4234 2.4580 2.5716 1.9884 1.7412 0.0130 0.0129 0.0096 0.0136 0.0095 0.0011 0.0029
Citrulline 131 1.1948 1.1729 1.2172 1.0786 1.1782 1.0954 1.1540 1.0377 1.0686 0.7438 0.0509 0.0970
Coenzyme A 408 2.3481 2.4638 2.4962 2.2293 2.0864 0.0017 0.0011 0.0013 0.0019 0.0017 0.0004 0.0004
Coenzyme A 79 2.3433 2.4184 2.5311 2.2585 2.0765 0.0015 0.0020 0.0019 0.0033 0.0027 0.0012 0.0012
Cysteine PARENT 1.3160 1.7379 1.2525 1.7559 2.1228 0.6161 0.3026 0.6337 0.5249 0.7028 0.0684 2.2364
Cystine 120 0.0614 0.1182 0.0818 0.0891 0.1496 1.8816 1.8961 1.8777 1.9058 2.0500 0.1917 0.4729
Cystine 74 0.0620 0.1217 0.0799 0.0905 0.1504 1.8675 1.8992 1.8584 1.8945 2.0838 0.1971 0.4531
FAD 408 2.3273 2.1973 2.1957 2.2733 2.3197 0.0040 0.0050 0.0035 0.0046 0.0031 0.0006 NA
FAD 79 2.4313 2.1663 2.2224 2.2793 2.3472 0.0026 0.0028 0.0029 0.0036 0.0029 0.0009 0.0005
Folic 311 0.2051 0.2727 0.2583 0.3094 0.3657 1.5340 1.6002 1.5474 1.5645 1.4159 1.7098 3.6756
Formic PARENT 0.8312 0.6746 1.1180 1.2617 1.0711 0.9509 0.7841 1.0786 0.7557 0.9257 1.6383 3.5362
Fumaric 71 2.3756 2.0081 2.2199 2.1123 2.3777 0.0547 0.0491 0.0848 0.0607 0.0397 0.0262 0.0696
Glucose 59 0.2341 0.2992 0.2855 0.3182 0.3478 1.5590 1.5888 1.6062 1.5252 1.6289 1.2494 2.6768
Glucose 71 0.2161 0.2746 0.2615 0.2940 0.3206 1.5537 1.5895 1.6002 1.5154 1.6394 1.3593 2.9489
Glutamic acid 102 1.5484 1.5856 1.5498 1.5482 1.4968 0.6981 0.7026 0.6841 0.6965 0.5982 0.0948 0.2119
Glutamic acid 128 1.6822 1.7533 1.7034 1.6765 1.6424 0.5804 0.5987 0.5474 0.5798 0.4763 0.0628 0.1487
GSSG 179 2.3025 1.4874 1.4323 2.5074 3.2598 0.0086 0.0067 0.0068 0.0057 0.0122 0.0015 NA
GSSG 306 2.4870 1.5816 1.3935 2.6027 3.2401 0.0056 0.0050 0.0041 0.0065 0.0096 0.0010 0.0006
HEPES 107 1.0078 1.0563 0.9205 0.9907 1.0460 0.6726 0.7279 0.6317 0.6030 0.3198 3.5075 7.0071
HEPES 80 1.0099 1.0447 0.9612 0.9807 1.0279 0.6717 0.7081 0.6496 0.6006 0.3150 3.4809 7.0942
HMG-CoA 408 2.3018 2.1961 2.1177 2.7155 2.3723 0.0025 0.0035 0.0035 0.0027 0.0027 0.0015 0.0065
HMG-CoA 426 1.4449 1.3828 1.3957 1.7641 1.4496 0.0020 0.0015 0.0024 NA 0.0015 0.0014 NA
Ketoglutaric 101 2.0827 1.8764 1.9099 2.0531 2.2200 0.2647 0.2551 0.2562 0.2984 0.1948 0.0141 0.0139
Ketoglutaric 57 1.8771 1.7295 1.7960 1.8761 1.9666 0.3995 0.4280 0.4193 0.3966 0.3822 0.0671 0.0769
Lactic 71 1.2522 0.8764 1.1800 1.0180 1.4050 1.0119 0.8496 0.9556 1.0374 0.6085 0.0067 NA
Lactic 87 1.3317 0.9277 1.2415 1.0888 1.5016 1.0672 0.9245 1.0329 1.1207 0.6462 0.0053 0.0007
Lauroyl-CoA 408 1.7284 0.7841 0.5415 4.2008 4.5845 0.1178 0.1080 0.1043 0.1309 0.0896 0.1637 0.0930
Malic 115 2.3244 2.0908 2.2359 2.1889 2.3839 0.0626 0.0647 0.0600 0.0706 0.0374 0.0022 0.0020
Malic 71 2.3475 2.0451 2.2392 2.1677 2.4060 0.0599 0.0586 0.0553 0.0612 0.0368 0.0022 0.0037
Malonic 59 3.8465 1.0115 3.5398 0.0086 0.0088 0.0531 0.0114 0.0407 0.0037 0.0027 0.0028 0.0035
Malonyl-CoA 408 3.1978 2.2892 4.1203 0.1747 0.1510 0.0004 0.0006 0.0007 0.0004 0.0006 0.0003 0.0004
Malonyl-CoA 426 1.8959 1.3589 2.4152 0.1082 0.0965 0.0001 0.0002 NA 0.0001 0.0001 NA 0.0001
Methylcrotonyl-CoA 408 2.2035 1.8702 1.9885 1.9001 1.9290 0.0046 0.0043 0.0058 0.0075 0.0040 0.0027 NA
Methylcrotonyl-CoA 79 2.4666 2.2523 2.2276 2.1815 2.2168 0.0055 0.0068 0.0089 0.0053 0.0062 0.0037 0.0038
myo-Inositol 161 1.9319 1.8162 1.7114 1.7028 1.7251 0.4052 0.4055 0.4128 0.4129 0.4034 0.2170 0.5492
Myristic PAR 1.7905 1.1515 1.2066 1.7217 2.3140 0.4458 0.3724 0.3412 0.5022 0.6750 0.4705 0.9085
Myristoyl-CoA 408 1.8116 0.9453 0.6790 4.4245 4.5523 0.0303 0.0290 0.0321 0.0297 0.0365 0.0324 0.0279
NAD+ 273 1.2016 1.0952 1.0966 1.0696 1.1336 0.0000 0.0000 NA NA 0.0002 NA NA
NAD+ 540 2.4430 2.2493 2.2725 2.1963 2.2850 0.0001 0.0001 0.0001 0.0002 0.0002 0.0000 0.0001
NADH 335 1.0831 0.8374 0.9263 1.1361 0.8510 NA NA NA NA NA NA NA
NADH 408 2.5478 1.9329 2.2410 2.5548 1.9580 0.0004 0.0003 0.0003 0.0003 0.0003 0.0003 0.0006
NADPH 328 1.2489 1.0697 1.1738 0.4264 0.5834 NA NA NA NA NA NA NA
NADPH 408 2.9333 2.4527 2.6852 0.9986 1.3860 0.0013 0.0013 0.0012 0.0011 0.0010 0.0012 0.0014
Octanoyl-CoA 79 1.8031 1.8565 2.4585 2.0617 1.9334 0.2284 0.3352 0.4051 0.0742 0.2457 0.0723 0.0148
Oleoyl-CoA (18:1) 79 2.1876 1.9090 2.1897 3.3924 2.2387 0.0048 0.0037 0.0056 0.0048 0.0046 0.0023 0.0025
Oxaloacetic 87 2.2883 1.0920 2.7916 2.0209 2.0680 0.1505 0.2096 0.1907 0.3019 0.1200 0.0470 0.0327
Palmitic PAR 1.7908 1.2043 1.5045 1.7801 1.7258 0.5442 0.4235 0.4612 0.6362 0.7494 0.0751 0.0866
Palmitoleic PAR 2.3032 1.3955 1.8347 1.8278 1.7957 0.2789 0.2388 0.2235 0.3352 0.4326 0.0503 0.0634
Palmitoleyl-CoA (16:1) 79 1.8977 1.3949 1.4223 4.0019 3.7206 0.0080 0.0103 0.0132 0.0078 0.0161 0.0103 0.0064
Palmitoyl-CoA (16:0) 79 1.8216 1.0369 0.7996 4.4256 4.5343 0.0077 0.0102 0.0077 0.0083 0.0083 0.0047 0.0057
Pemetrexed 297 0.7663 0.8662 0.5836 0.5397 0.5034 1.1491 1.0034 1.1679 0.7505 1.3919 0.7541 0.7990
Pemetrexed 321 1.3187 NA 0.6124 1.2439 NA 0.9899 0.5473 0.6400 0.9158 1.1138 0.4999 NA
Penicillin G 289 0.3459 0.4725 0.4419 0.5045 0.6052 1.5450 1.5536 1.6168 1.5930 1.9365 0.0003 0.0002
Phenol Red 195 0.1471 0.2092 0.1774 0.2396 0.2962 1.5593 1.5935 1.6462 1.5841 1.4697 2.7933 2.7926
Phenol Red 93 0.1416 0.2045 0.1813 0.2426 0.2929 1.6084 1.6289 1.6311 1.6349 1.5054 1.4165 2.9361
Phenylalanine 147 1.2250 1.2499 1.2860 1.2381 1.3020 0.7679 0.7682 0.7594 0.7386 0.9015 0.8875 1.8523
Phenylalanine 72 1.1976 1.2209 1.2593 1.2064 1.2689 0.7440 0.7409 0.7500 0.7307 0.8679 1.8683 1.9196
Propionic PARENT 1.5361 1.2781 1.5765 1.3932 1.3581 0.6395 0.7712 0.2642 0.5541 0.2974 2.1851 0.0272
Propionyl-CoA 408 2.5199 2.3781 2.5633 2.0026 1.5392 0.0229 0.0356 0.0321 0.0315 0.0396 0.0141 0.0807
Pyruvic 32 1.5021 1.0108 1.1778 1.5463 2.4594 0.5484 0.4806 0.4345 0.7409 0.4646 1.0587 2.0789
Riboflavin 243 1.0637 1.0108 1.0952 1.0668 1.1082 1.0611 1.2592 1.0827 1.1242 0.7436 0.5330 1.0720
Stearic PAR 1.6598 1.2201 1.3933 1.4960 1.3707 0.6559 0.6549 0.6224 0.7066 0.8231 0.2037 0.3258
Succinic 73 3.4640 1.3533 3.5162 0.2925 0.4181 0.0575 0.0434 0.0569 0.0343 0.0239 0.0068 0.0052
Succinic 99 3.5735 1.2289 3.3928 0.2657 0.3739 0.0568 0.0411 0.0533 0.0327 0.0219 0.0100 0.0084
Succinyl-CoA 408 2.6516 2.4571 3.0575 1.7615 1.0572 0.0055 0.0035 0.0035 0.0077 0.0047 0.0034 0.0034
Taurine 80 2.3245 2.2349 2.2637 2.2681 2.2655 0.0485 0.0433 0.0477 0.0454 0.0223 0.0010 0.0015
Uric 124 0.3449 0.3441 0.3374 0.3000 0.4591 1.7187 2.0367 1.7242 1.6610 1.6377 0.0023 0.0046
Uric 96 0.3213 0.3159 0.3051 0.2998 0.3797 1.6320 1.9038 1.5767 1.5934 1.3828 NA NA
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Factors:

F1Sample source:BT-474 breast cancer cells | Sample Type:Intracellular | Drug Treatment:10 nM GSK214069
F2Sample source:BT-474 breast cancer cells | Sample Type:Intracellular | Drug Treatment:200 nM GSK214069
F3Sample source:BT-474 breast cancer cells | Sample Type:Intracellular | Drug Treatment:500 nM GSK214069
F4Sample source:BT-474 breast cancer cells | Sample Type:Intracellular | Drug Treatment:50 nM GSK214069
F5Sample source:BT-474 breast cancer cells | Sample Type:Intracellular | Drug Treatment:Control
F6Sample source:BT-474 breast cancer cells | Sample Type:Medium | Drug Treatment:10 nM GSK214069
F7Sample source:BT-474 breast cancer cells | Sample Type:Medium | Drug Treatment:200 nM GSK214069
F8Sample source:BT-474 breast cancer cells | Sample Type:Medium | Drug Treatment:500 nM GSK214069
F9Sample source:BT-474 breast cancer cells | Sample Type:Medium | Drug Treatment:50 nM GSK214069
F10Sample source:BT-474 breast cancer cells | Sample Type:Medium | Drug Treatment:Control
F11Sample source:NA | Sample Type:NA | Drug Treatment:NA
F12Sample source:NA | Sample Type:QC | Drug Treatment:NA
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