Data for (Study ST003457)
(Analysis AN005679)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 1-Methyladenosine | 1.2472 | 0.9762 | 0.7949 | NA | 1.1490 | 0.8784 | 0.8707 |
| 2,2,6,6-Tetramethyl-4-piperidinol | 0.9660 | 1.0668 | 0.9442 | NA | 1.0729 | 0.9381 | 0.9974 |
| 2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid | 0.4902 | 1.2287 | 1.3799 | NA | 0.3130 | 1.4873 | 1.2612 |
| 2,6-Dimethylpyrazine | 0.9728 | 0.9381 | 0.9997 | NA | 1.1225 | 0.9932 | 0.9650 |
| 2-Amino-3-methoxybenzoic acid | 1.2006 | 0.8337 | 0.9572 | NA | 1.0103 | 1.0136 | 0.9653 |
| 2-Amino-4-methylpyrimidine | 1.1008 | 1.0351 | 0.9984 | NA | 0.9347 | 0.8756 | 1.0734 |
| 3-Methylhistidine | 1.0351 | 0.9230 | 0.9381 | NA | 0.8346 | 1.4166 | 0.7829 |
| 3-Methylxanthine | 0.8058 | 0.9021 | 0.7673 | NA | 1.2536 | 1.0809 | 1.1761 |
| 4,4^-dimethoxy[1,1^-biphenyl]-2-carbonitrile | 0.5883 | 1.2512 | 0.9895 | NA | 0.7369 | 1.2821 | 1.1992 |
| 4-Guanidinobutyric acid | 0.9733 | 0.9857 | 0.9439 | NA | 1.0612 | 0.9301 | 1.1224 |
| 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one | 1.3793 | 0.7700 | 1.5840 | NA | 0.7067 | 1.1057 | 0.4671 |
| Acetylcarnitine | 0.9266 | 0.8515 | 0.9428 | NA | 1.1253 | 1.0391 | 1.1338 |
| Adenine | 0.6046 | 0.9542 | 0.5665 | NA | 1.4227 | 0.8973 | 1.5950 |
| Adenosine | 1.4530 | 1.1583 | 1.7908 | NA | 0.4378 | 0.6279 | 0.6400 |
| Alanine | 0.4477 | 1.0090 | 0.8748 | NA | 1.3364 | 1.0225 | 1.3711 |
| Alanyltyrosine | 0.3975 | 1.4715 | 1.3224 | NA | 0.4031 | 1.0138 | 1.6298 |
| Allopurinol | 0.9784 | 0.9506 | 1.0260 | NA | 1.0330 | 1.0228 | 0.9943 |
| AMP | 2.0715 | 1.2875 | 1.5153 | NA | 0.3339 | 0.3437 | 0.4358 |
| Anserine | 1.0452 | 0.9428 | 0.8538 | NA | 1.1272 | 1.0533 | 0.9214 |
| Arginine | 0.9029 | 1.1066 | 1.2367 | NA | 0.8763 | 0.9671 | 0.9596 |
| Asparagine | 0.4602 | 1.0910 | 1.1217 | NA | 1.0062 | 1.1987 | 1.2034 |
| Aspartame | 0.3008 | 1.5271 | 1.2976 | NA | 0.2706 | 1.2463 | 1.5761 |
| Betaine | 0.6326 | 0.9307 | 0.9024 | NA | 1.2051 | 0.7399 | 1.7530 |
| Butyrylcarnitine | 0.9068 | 0.5707 | 1.0630 | NA | 1.0368 | 1.0439 | 1.5261 |
| Carnitine | 0.9334 | 1.0646 | 1.0196 | NA | 0.9624 | 0.9913 | 1.0448 |
| Carnosine | 1.2833 | 0.9515 | 0.9599 | NA | 0.9820 | 0.9369 | 0.8353 |
| Choline | 0.7550 | 1.1041 | 0.9960 | NA | 1.0623 | 1.0518 | 1.0399 |
| Clomazone | 1.6320 | 0.4956 | 0.7282 | NA | 0.7760 | 1.1387 | 1.2153 |
| Creatine | 0.9889 | 0.9743 | 0.9832 | NA | 1.0233 | 0.9932 | 1.0439 |
| Cytidine | 1.1947 | 1.0627 | 0.8446 | NA | 0.9379 | 1.0143 | 0.8760 |
| Cytosine | 1.1404 | 1.0637 | 0.8931 | NA | 0.9412 | 1.0176 | 0.8899 |
| Deoxycytidine | 1.1147 | 0.8852 | 0.8309 | NA | 1.1178 | 1.0910 | 0.8909 |
| Ecgonine | 0.6542 | 1.2041 | 1.1694 | NA | 0.7632 | 1.0842 | 1.2230 |
| Glucosamine/ Galactosamine | 1.5890 | 0.7053 | 1.4712 | NA | 0.6835 | 1.0670 | 0.4691 |
| Glutaric acid | 0.8076 | 1.0704 | 1.0746 | NA | 1.0060 | 1.0424 | 1.0236 |
| Glycine | 1.1298 | 1.1562 | 0.7194 | NA | 1.2869 | 1.0980 | 0.3860 |
| Guanosine | 1.4604 | 0.9129 | 1.5366 | NA | 0.5670 | 0.7960 | 0.8150 |
| Guanosine monophosphate (GMP) | 2.4276 | 1.0600 | 2.0400 | NA | 0.1281 | 0.1710 | 0.2443 |
| Histidine | 1.0415 | 0.9842 | 0.9415 | NA | 1.0156 | 0.9776 | 1.0333 |
| Hypotaurine | 1.2041 | 1.0901 | 1.2848 | NA | 0.8793 | 0.7020 | 0.8813 |
| Hypoxanthine | 0.9304 | 1.0069 | 0.8740 | NA | 1.1043 | 1.0050 | 1.0637 |
| IMP | 2.6818 | 1.0360 | 2.1568 | NA | 0.0242 | 0.0959 | 0.0595 |
| Inosine | 0.9762 | 0.9487 | 1.0427 | NA | 1.0332 | 1.0140 | 0.9946 |
| Isoleucine | 0.7059 | 0.9949 | 1.0349 | NA | 1.0585 | 1.0232 | 1.2552 |
| Isovalerylcarnitine/ 2-Methylbutyroylcarnitine | 0.6574 | 1.1520 | 0.7316 | NA | 0.7699 | 1.5083 | 1.1516 |
| Ketamine | 0.7587 | 0.9705 | 0.9977 | NA | 0.9819 | 1.1257 | 1.2199 |
| L-Ergothioneine | 1.5068 | 1.2332 | 0.9960 | NA | 0.9347 | 0.3471 | 0.9749 |
| Leucine | 0.6930 | 1.1039 | 1.1105 | NA | 0.7889 | 1.1655 | 1.2212 |
| Leucylalanine | 0.2350 | 1.3961 | 1.4770 | NA | 0.2786 | 1.0166 | 1.9547 |
| LLK | 0.2951 | 1.5487 | 0.8007 | NA | 0.3696 | 1.2736 | 1.8834 |
| Lysine | 0.9923 | 1.0902 | 1.2941 | NA | 0.8369 | 0.9801 | 0.8401 |
| Methionine | 0.6943 | 1.0051 | 1.0915 | NA | 0.9498 | 1.0839 | 1.2644 |
| Methionine sulfoxide | 0.4918 | 0.9476 | 0.7646 | NA | 1.0820 | 1.3123 | 1.4571 |
| N1-Methyl-2-pyridone-5-carboxamide | 2.7959 | 1.2062 | 0.4722 | NA | 0.4678 | 0.3165 | 0.4792 |
| N6,N6,N6-Trimethyl-L-lysine | 0.9177 | 1.2532 | 1.2536 | NA | 0.6638 | 1.0200 | 0.9401 |
| N-Acetylornithine | 0.6981 | 0.8430 | 1.0038 | NA | 1.1866 | 1.0520 | 1.2899 |
| Nicotinamide riboside | 0.9070 | 1.1910 | 0.9763 | NA | 0.7265 | 1.1461 | 1.0628 |
| Nicotine amide | 0.9595 | 1.0235 | 0.9690 | NA | 1.0593 | 0.9590 | 1.0293 |
| Oxidized glutathione | 0.6689 | 0.5015 | 0.8991 | NA | 1.4076 | 1.3828 | 1.1532 |
| Pantothenic acid | 0.9947 | 1.1641 | 1.2042 | NA | 0.7622 | 1.0421 | 0.8450 |
| Phosphocholine | 1.0314 | 0.9741 | 0.9396 | NA | 1.0303 | 0.9915 | 1.0241 |
| Proline | 0.8883 | 1.0652 | 1.1726 | NA | 0.9230 | 1.0070 | 0.9828 |
| Prolylleucine_1 | 0.9419 | 0.8988 | 1.0510 | NA | 1.0852 | 0.9869 | 1.0653 |
| Prolylleucine_2 | 0.9518 | 0.9612 | 0.9920 | NA | 1.0323 | 1.0451 | 1.0208 |
| Propionylcarnitine | 0.5325 | 0.8668 | 1.3229 | NA | 0.9238 | 1.1232 | 1.4152 |
| Purine | 0.5540 | 1.7381 | 0.6481 | NA | 0.9896 | 0.9481 | 1.0455 |
| Pyridoxamine | 0.6385 | 0.7712 | 0.7054 | NA | 1.5516 | 1.0179 | 1.3222 |
| Pyroglutamic acid | 0.9171 | 1.0360 | 1.0258 | NA | 0.9582 | 1.0590 | 1.0137 |
| Riboflavin | 0.6370 | 0.7917 | 0.6903 | NA | 1.0685 | 1.8322 | 0.8706 |
| S-Adenosylhomocysteine | 0.9256 | 0.7664 | 0.8915 | NA | 1.1872 | 1.1318 | 1.0938 |
| S-Adenosylmethionine | 0.6738 | 0.7971 | 0.6267 | NA | 1.3692 | 1.0707 | 1.4921 |
| Spermine | 0.9129 | 1.1514 | 1.1734 | NA | 0.7037 | 1.1872 | 0.8864 |
| tert-Butyl N-[1-(aminocarbonyl)-3-methylbutyl]carbamate | 0.6008 | 1.0878 | 1.1889 | NA | 0.5674 | 1.3953 | 1.2761 |
| Thiamine | 0.9738 | 0.9130 | 0.9151 | NA | 1.0262 | 1.1044 | 1.0617 |
| Tiglic acid | 0.7383 | 1.1455 | 1.0884 | NA | 0.8957 | 1.0084 | 1.1943 |
| Tiglylcarnitine | 0.6177 | 1.0233 | 0.8311 | NA | 1.0859 | 1.1341 | 1.3542 |
| Trimethylamine N-Oxide | 1.1106 | 0.7939 | 0.5935 | NA | 1.3594 | 0.7801 | 1.3479 |
| Tryptophan | 0.6857 | 1.1621 | 1.1991 | NA | 0.8508 | 1.0739 | 1.1041 |
| Tyrosine | 0.7133 | 0.9704 | 1.1908 | NA | 0.9905 | 1.1337 | 1.0653 |
| VLK | 1.2248 | 0.3231 | 1.5476 | NA | 0.4676 | 1.9612 | 0.4836 |
| Xanthosine | 0.8449 | 1.1129 | 1.0916 | NA | 1.0058 | 0.9854 | 0.9763 |
| γ-Aminobutyric acid | 0.9427 | 0.9982 | 0.7138 | NA | 1.1091 | 1.1063 | 1.0776 |
Factors:
| F1 | Sample source:Heart | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Heart | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Heart | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Heart | Group:QC |
| F5 | Sample source:Heart | Group:Sham / 12C-Serin |
| F6 | Sample source:Heart | Group:Sham / 13C-Serin |
| F7 | Sample source:Heart | Group:Sham / Vehicle |
