Data for (Study ST003459)
(Analysis AN005683)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 1-Methyladenosine | 0.7484 | 1.5139 | 0.9741 | NA | 1.0504 | 0.8311 | 0.8342 |
| 1-Methylhistidine | 1.2273 | 1.7672 | 0.7348 | NA | 0.5499 | 1.0229 | 0.5089 |
| 2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid | 0.4040 | 1.8404 | 0.6014 | NA | 1.1319 | 1.1376 | 0.7135 |
| 2-Amino-3-methoxybenzoic acid | 0.7008 | 1.1892 | 0.7246 | NA | 1.0255 | 1.3123 | 0.9718 |
| 3^-Adenosine monophosphate (3^-AMP) | 0.6896 | 1.2954 | 1.0536 | NA | 0.9653 | 0.9856 | 1.0318 |
| 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol | 0.6994 | 1.3627 | 0.8762 | NA | 0.7315 | 1.3503 | 0.9319 |
| 3-Aminoisobutanoic acid | 0.4510 | 1.1398 | 1.0891 | NA | 0.8270 | 1.4684 | 1.0627 |
| 4-[2-(1H-indol-3-yl)ethyl]morpholine-3,5-dione | 0.3072 | 1.5303 | 0.6578 | NA | 1.3299 | 1.0808 | 1.0112 |
| 4-Amino-3-hydroxybenzoic acid | 1.3417 | 1.0250 | 1.1640 | NA | 1.3016 | 0.5679 | 0.5211 |
| 4-Guanidinobutyric acid | 0.2863 | 1.1852 | 2.3634 | NA | 1.0104 | 0.6522 | 0.7912 |
| 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one | 0.5212 | 1.0058 | 0.9329 | NA | 1.0996 | 1.3568 | 1.0892 |
| 5-Methyltryptophan | 0.2794 | 1.0773 | 0.8454 | NA | 1.5063 | 1.3189 | 0.9121 |
| Acetylcarnitine | 0.9122 | 1.6563 | 1.9755 | NA | 0.7924 | 0.4539 | 0.2715 |
| Acetyl-β-methylcholine | 0.7790 | 1.9596 | 1.5862 | NA | 0.0357 | 0.7347 | 1.0686 |
| Adenosine | 0.9446 | 1.0090 | 0.6978 | NA | 1.0117 | 1.2492 | 1.0161 |
| Alanine | 0.6106 | 1.0701 | 1.0757 | NA | 1.0843 | 1.1328 | 1.0605 |
| ALK | 0.7521 | 1.0509 | 0.3732 | NA | 1.7940 | 1.0337 | 0.7859 |
| Allopurinol | 0.8346 | 0.8630 | 0.9085 | NA | 1.1012 | 1.1045 | 1.2205 |
| Arginine | 0.2428 | 0.9175 | 0.6142 | NA | 1.5471 | 1.3410 | 1.3214 |
| Asparagine | 0.4630 | 1.1344 | 0.6043 | NA | 1.1973 | 1.5329 | 0.9590 |
| Aspartame | 0.3731 | 0.9864 | 0.5108 | NA | 1.7407 | 1.2365 | 1.0401 |
| Betaine | 0.5452 | 1.2274 | 1.1065 | NA | 0.7635 | 0.9873 | 1.5290 |
| Butyrylcarnitine | 0.4837 | 1.1746 | 2.0050 | NA | 1.2339 | 0.6905 | 0.5515 |
| Carnitine | 0.6642 | 1.3976 | 1.3122 | NA | 0.5993 | 1.1913 | 0.8845 |
| Carnosine | 0.3023 | 1.1100 | 0.9250 | NA | 1.1964 | 1.3751 | 1.0966 |
| Choline | 0.8813 | 1.0774 | 1.0341 | NA | 1.1442 | 0.9401 | 0.9086 |
| CMP | 0.7101 | 1.1799 | 1.0529 | NA | 0.9101 | 1.2526 | 0.8768 |
| Creatine | 1.1704 | 1.3425 | 1.2056 | NA | 0.5756 | 1.0372 | 0.6269 |
| Cytidine | 1.3453 | 0.9241 | 0.5980 | NA | 0.6311 | 1.4220 | 0.9719 |
| Deoxycytidine | 0.4924 | 1.2514 | 0.6638 | NA | 0.3011 | 2.1244 | 1.1105 |
| Deoxyinosine | 0.2347 | 1.4360 | 0.7704 | NA | 0.1127 | 2.4788 | 0.8799 |
| Ecgonine | 0.7795 | 1.6212 | 1.3746 | NA | 0.3334 | 1.2194 | 0.6873 |
| Ethylmalonic acid/Glutamic acid | 0.8400 | 1.0495 | 1.0546 | NA | 1.1004 | 0.8937 | 1.1007 |
| FLK_1 | 0.3275 | 1.3846 | 0.4605 | NA | 1.6385 | 1.1641 | 0.8532 |
| FLK_2 | 0.4390 | 2.3688 | 0.4716 | NA | 0.7835 | 1.1602 | 0.5265 |
| FNK | 0.7469 | 0.6084 | 1.3644 | NA | 0.8258 | 1.9075 | 0.5175 |
| GLK | 0.4201 | 1.4118 | 0.5673 | NA | 1.5137 | 1.1345 | 0.7926 |
| Glucosamine/ Galactosamine | 0.2795 | 0.5503 | 0.6108 | NA | 1.8207 | 1.0090 | 1.8431 |
| Glutamine | 0.6122 | 0.8670 | 0.8724 | NA | 1.3852 | 1.0653 | 1.2214 |
| Glutathione | 0.2790 | 0.3864 | 1.1388 | NA | 2.1429 | 0.7159 | 1.4957 |
| Glycine | 0.7910 | 1.0569 | 0.9647 | NA | 0.9690 | 1.1869 | 1.0303 |
| Glycylproline | 0.7592 | 1.5049 | 0.9474 | NA | 0.8122 | 1.0741 | 0.8520 |
| Guanidoacetic acid | 0.8959 | 2.7003 | 0.5238 | NA | 0.6538 | 0.5139 | 0.4577 |
| Guanosine | 0.3972 | 1.4509 | 0.6214 | NA | 0.6296 | 2.1134 | 0.5904 |
| Histidine | 0.8074 | 1.5344 | 1.2331 | NA | 0.7223 | 0.8816 | 0.8393 |
| Homoarginine | 0.3666 | 1.2089 | 1.0470 | NA | 0.9410 | 1.4492 | 0.9986 |
| Hypoxanthine | 0.9476 | 1.0487 | 1.0146 | NA | 0.9118 | 1.0604 | 1.0274 |
| Imidazoleacetic acid | 0.8977 | 1.1709 | 1.2917 | NA | 0.9364 | 1.0221 | 0.6722 |
| Indole-3-acrylic acid | 0.5425 | 1.3718 | 0.8057 | NA | 1.0131 | 1.2752 | 0.9241 |
| Inosine | 0.7333 | 0.9473 | 0.8979 | NA | 1.0716 | 1.1609 | 1.2182 |
| Isoleucine | 0.5387 | 1.2938 | 0.8077 | NA | 0.9437 | 1.3563 | 1.0156 |
| Isovalerylcarnitine/ 2-Methylbutyroylcarnitine | 0.4036 | 1.3401 | 1.3720 | NA | 0.7303 | 1.3402 | 0.8758 |
| Ketamine | 1.1583 | 0.7201 | 0.5828 | NA | 1.0095 | 1.1990 | 1.3014 |
| L-Ergothioneine | 0.8456 | 0.8398 | 0.7316 | NA | 1.6176 | 1.0867 | 0.7489 |
| Leucine | 0.5162 | 1.4005 | 0.7717 | NA | 0.9385 | 1.3385 | 0.9699 |
| Leucylproline | 0.3257 | 1.4759 | 0.6579 | NA | 1.1861 | 1.4052 | 0.8182 |
| LLK | 0.3117 | 1.4398 | 0.4831 | NA | 1.5384 | 1.2857 | 0.7494 |
| Lysine | 0.5355 | 1.3545 | 0.9072 | NA | 0.8644 | 1.3622 | 0.9374 |
| Methionine | 0.5544 | 1.2853 | 0.8350 | NA | 0.9744 | 1.3053 | 1.0058 |
| Methionine sulfoxide | 0.4374 | 1.8461 | 0.7639 | NA | 0.4320 | 1.6466 | 0.7532 |
| N1-Methyl-2-pyridone-5-carboxamide | 1.6118 | 1.1094 | 1.2495 | NA | 1.0107 | 0.5058 | 0.4335 |
| N2-Acetyllysine | 0.5179 | 1.3392 | 1.5603 | NA | 0.9910 | 0.8184 | 0.8843 |
| N2-neopentyl-5-methyl-1,3,4-thiadiazol-2-amine | 0.8287 | 0.8427 | 0.7480 | NA | 1.6484 | 1.0439 | 0.7671 |
| N3,N4-Dimethyl-L-arginine | 0.4450 | 1.5836 | 1.0020 | NA | 0.3802 | 1.6624 | 0.9029 |
| N8-Acetylspermidine | 1.2283 | 2.3739 | 0.5975 | NA | 0.4932 | 0.7464 | 0.2802 |
| N-Acetylarginine | 0.3372 | 1.3628 | 1.2511 | NA | 0.6887 | 1.3477 | 1.1004 |
| N-Acetylglutamic acid | 0.7789 | 3.6924 | 0.4046 | NA | 0.1895 | 0.3672 | 0.2248 |
| N-Acetylglutamine | 0.9493 | 1.1764 | 1.1340 | NA | 1.1682 | 0.7346 | 0.8280 |
| N-Acetylhistidine | 1.2075 | 1.4541 | 1.1702 | NA | 0.7387 | 0.6199 | 0.8028 |
| N-Acetylmannosamine | 0.7103 | 1.2594 | 1.2629 | NA | 0.9383 | 0.9576 | 0.9164 |
| N-Acetylmethionine | 0.3344 | 0.9903 | 0.5233 | NA | 2.0189 | 0.9960 | 1.0239 |
| N-Acetylornithine | 1.0470 | 1.3190 | 1.2537 | NA | 0.6667 | 0.8262 | 0.9343 |
| Nicotinamide riboside | 0.5966 | 1.2364 | 0.9950 | NA | 1.0163 | 0.9667 | 1.2503 |
| Nicotine amide | 0.7106 | 1.0376 | 1.0286 | NA | 1.0658 | 1.0714 | 1.1242 |
| Nicotinic acid | 0.6838 | 1.2558 | 1.4165 | NA | 1.0820 | 0.8762 | 0.7196 |
| Nα-({1,3,4-trihydroxy-5-[(N-methylvalyl)amino]cyclohexyl}carbonyl)phenylalaninamide | 0.7241 | 1.6412 | 0.2688 | NA | 1.2158 | 1.2346 | 0.6437 |
| O-Acetylserine | 0.3290 | 0.9395 | 0.6638 | NA | 1.4555 | 1.4023 | 1.1679 |
| Ornithine | 0.5213 | 1.4294 | 0.9725 | NA | 0.6973 | 1.4086 | 0.9519 |
| Phosphocholine | 0.8444 | 1.6434 | 1.3090 | NA | 0.6466 | 0.8086 | 0.7671 |
| Proline | 0.6703 | 1.2470 | 0.9827 | NA | 0.8901 | 1.2088 | 0.9957 |
| Prolylleucine | 0.3104 | 1.7770 | 0.6206 | NA | 1.0935 | 1.2771 | 0.7688 |
| Propionylcarnitine | 0.2595 | 2.1141 | 1.6378 | NA | 0.1648 | 1.2638 | 0.6259 |
| Pyrogallol | 0.2620 | 0.5459 | 0.4927 | NA | 1.8288 | 1.4117 | 1.4428 |
| Pyroglutamic acid | 0.5891 | 1.2036 | 1.0276 | NA | 1.0234 | 1.2592 | 0.8721 |
| Riboflavin | 0.5142 | 1.7860 | 0.7000 | NA | 0.7867 | 1.3081 | 0.7732 |
| S-Adenosylhomocysteine | 0.9334 | 0.8879 | 0.7638 | NA | 1.3178 | 1.1395 | 0.8648 |
| Spermine | 0.5846 | 1.5875 | 0.8212 | NA | 0.6177 | 1.4909 | 0.8045 |
| Sugar alcohol (C6) | 0.2091 | 0.5166 | 0.4467 | NA | 1.7717 | 1.0572 | 2.1472 |
| tert-Butyl N-[1-(aminocarbonyl)-3-methylbutyl]carbamate | 0.3428 | 1.6228 | 0.4757 | NA | 1.3039 | 1.2516 | 0.8295 |
| Thiamine | 0.6195 | 1.1643 | 0.7251 | NA | 1.2249 | 1.0784 | 1.1587 |
| Tiglic acid | 0.5869 | 1.3093 | 0.9641 | NA | 0.8973 | 1.2102 | 1.0310 |
| Tolycaine | 0.4167 | 1.6325 | 0.4656 | NA | 1.3472 | 1.2046 | 0.7331 |
| Trigonelline | 0.4170 | 1.1027 | 1.8785 | NA | 0.9746 | 0.6518 | 1.2600 |
| Trimethylamine N-Oxide | 0.8608 | 0.6188 | 0.1645 | NA | 1.8387 | 0.8466 | 1.6156 |
| Tryptophan | 0.5294 | 1.3551 | 0.7403 | NA | 1.0436 | 1.2900 | 0.9688 |
| Tyrosine | 0.3983 | 1.0899 | 0.6031 | NA | 1.2703 | 1.4169 | 1.1630 |
| Tyrosylalanine_1 | 0.3653 | 1.6568 | 0.6209 | NA | 1.1242 | 1.2637 | 0.8325 |
| Tyrosylalanine_2 | 0.4156 | 1.2607 | 0.6804 | NA | 1.4456 | 1.1681 | 0.9328 |
| Urocanic acid | 1.6516 | 1.7960 | 1.5509 | NA | 0.3265 | 0.3458 | 0.2893 |
| Valine | 0.6915 | 1.2720 | 0.9967 | NA | 0.8729 | 1.1713 | 0.9930 |
| VLK | 0.3754 | 1.9289 | 0.5143 | NA | 1.1229 | 1.2155 | 0.6288 |
| Xylazine | 0.6010 | 0.7661 | 0.4157 | NA | 1.3596 | 1.0523 | 1.8790 |
| α-Aspartylphenylalanine_1 | 0.3516 | 1.4916 | 0.5551 | NA | 1.3748 | 1.2381 | 0.8368 |
| α-Aspartylphenylalanine_2 | 0.3948 | 1.0284 | 0.6360 | NA | 1.4812 | 1.3072 | 1.0820 |
| γ-Aminobutyric acid | 0.5849 | 1.4136 | 1.1187 | NA | 0.7582 | 1.2048 | 0.9326 |
| Υ-Glutamylcysteine | 0.0962 | 0.4690 | 0.6752 | NA | 2.4977 | 0.9689 | 1.2825 |
Factors:
| F1 | Sample source:Liver | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Liver | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Liver | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Liver | Group:QC |
| F5 | Sample source:Liver | Group:Sham / 12C-Serin |
| F6 | Sample source:Liver | Group:Sham / 13C-Serin |
| F7 | Sample source:Liver | Group:Sham / Vehicle |
