Data for (Study ST003460)
(Analysis AN005685)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 1-Methyladenine | 2.4659 | 2.0750 | 1.2474 | NA | 0.0333 | 0.0292 | 0.0307 |
| 1-Methyladenosine | 0.4661 | 0.7831 | 0.2997 | NA | 2.0707 | 0.9266 | 1.1381 |
| 2-Amino-4-methylpyrimidine | 1.3604 | 1.1102 | 0.8539 | NA | 0.7265 | 0.9069 | 0.9587 |
| 2-Aminoadipic acid | 0.6529 | 1.8579 | 1.2525 | NA | 0.4683 | 1.1654 | 0.6390 |
| 2-Methylbutyroylcarnitine | 0.3604 | 1.0317 | 0.4557 | NA | 1.0310 | 1.6271 | 1.2960 |
| 2-Picolinic acid | 0.7323 | 1.4269 | 1.0133 | NA | 0.9803 | 0.6661 | 1.2503 |
| 3^-Adenosine monophosphate (3^-AMP) | 0.0017 | 0.1395 | 0.0263 | NA | 3.1170 | 0.5126 | 1.9546 |
| 3-Hydroxy-2-methyl-4-pyrone | 2.4565 | 0.4580 | 1.4880 | NA | 0.5153 | 0.7064 | 0.4930 |
| 3-Hydroxyhippuric acid | 1.0213 | 0.4752 | 0.4377 | NA | 1.6377 | 0.7842 | 1.4836 |
| 3-Methylhistidine | 0.9891 | 0.9458 | 0.6316 | NA | 0.8765 | 1.4545 | 0.8911 |
| 3-Ureidopropionic acid | 0.6631 | 1.7483 | 0.8859 | NA | 0.6866 | 0.9586 | 1.0005 |
| 4,8-Dihydroxyquinoline-2-carboxylic acid | 2.1960 | 0.8192 | 0.3556 | NA | 1.6536 | 0.2423 | 0.2149 |
| 4-Amino-3-hydroxybenzoic acid_1 | 2.4408 | 1.2707 | 0.4688 | NA | 0.4872 | 0.4245 | 0.5231 |
| 4-Amino-3-hydroxybenzoic acid_2 | 2.1273 | 2.7559 | 0.4939 | NA | 0.0586 | 0.0335 | 0.0370 |
| 4-Guanidinobutyric acid | 0.6419 | 0.9536 | 0.8408 | NA | 2.0310 | 0.4823 | 0.9609 |
| 4-Indolecarbaldehyde | 0.4350 | 1.1601 | 0.6018 | NA | 1.1305 | 1.2617 | 1.2824 |
| 4-pyridoxic acid | 1.2821 | 1.0131 | 0.5265 | NA | 1.2754 | 0.7823 | 0.8452 |
| 5,6-Dihydrothymine | 1.2925 | 1.4487 | 0.8478 | NA | 0.5245 | 1.0384 | 0.6962 |
| 5-Aminolevulinic acid | 0.4375 | 0.7182 | 0.5462 | NA | 2.0470 | 0.8696 | 1.2060 |
| 5-Hydroxyindole-3-acetic acid | 1.3878 | 1.1605 | 0.8998 | NA | 0.9893 | 0.7751 | 0.6497 |
| 6-Methoxyquinoline | 0.7994 | 0.9224 | 0.7896 | NA | 1.1193 | 1.0946 | 1.2260 |
| 7-Methylguanine | 1.8806 | 1.0884 | 0.6275 | NA | 0.9984 | 0.5604 | 0.5446 |
| Acetyl-L-carnitine | 1.2635 | 0.6448 | 0.5429 | NA | 1.0277 | 1.1852 | 1.1429 |
| Acetyl-β-methylcholine | 0.8966 | 0.9207 | 0.7979 | NA | 1.1120 | 1.0685 | 1.1378 |
| Acipimox | 1.9425 | 1.0356 | 0.7369 | NA | 0.8228 | 0.6116 | 0.6254 |
| Adenosine | 0.0430 | 0.3045 | 0.1362 | NA | 2.0231 | 0.6012 | 2.9467 |
| Alanine | 0.4066 | 1.0359 | 0.7018 | NA | 1.2211 | 1.2414 | 1.3255 |
| Allantoin | 2.0006 | 1.0580 | 0.6695 | NA | 0.7479 | 0.6577 | 0.6014 |
| Allopurinol | 0.0029 | 0.4658 | 0.4289 | NA | 2.1805 | 0.4146 | 2.6290 |
| Betaine | 0.7005 | 0.9955 | 0.7175 | NA | 1.1505 | 0.9442 | 1.4673 |
| Butorphanol | 3.8132 | 1.0113 | 0.8495 | NA | 0.0002 | 0.0005 | 0.0001 |
| Butyrylcarnitine | 0.6036 | 0.7408 | 0.3751 | NA | 1.3255 | 1.4432 | 1.2659 |
| Carnitine | 0.5937 | 1.0925 | 0.5844 | NA | 1.6009 | 0.9173 | 1.0045 |
| Choline | 0.7103 | 1.4281 | 0.9982 | NA | 0.7629 | 1.0978 | 1.0024 |
| Clomazone_1 | 2.0404 | 0.4321 | 0.4763 | NA | 0.7401 | 0.9016 | 1.1969 |
| Clomazone_2 | 1.9407 | 0.5675 | 0.5309 | NA | 0.7806 | 0.9161 | 1.0396 |
| Corticosterone | 1.0573 | 1.2204 | 0.9673 | NA | 0.5241 | 1.0837 | 1.1745 |
| Creatine | 1.2676 | 1.1413 | 0.8945 | NA | 0.7314 | 0.9935 | 0.8920 |
| Creatinine | 1.5579 | 1.0085 | 0.6468 | NA | 1.0397 | 0.7912 | 0.7057 |
| Cytidine | 0.5667 | 0.7224 | 0.5346 | NA | 1.2758 | 1.4539 | 1.2853 |
| Daidzein | 0.1718 | 1.5461 | 1.0852 | NA | 1.8209 | 0.5081 | 0.8806 |
| Deoxycytidine | 1.0045 | 0.5621 | 0.3364 | NA | 1.0290 | 1.5437 | 1.2567 |
| Deschloroketamine | 1.0781 | 0.9450 | 0.7947 | NA | 0.7716 | 1.0703 | 1.3167 |
| Desoxycortone | 2.2353 | 1.1769 | 1.4575 | NA | 0.1027 | 0.5785 | 0.5703 |
| DL-Carnitine | 0.6020 | 1.1021 | 0.5819 | NA | 1.5968 | 0.9225 | 0.9808 |
| Ecgonine | 0.9454 | 1.0730 | 0.7034 | NA | 0.7613 | 1.2494 | 1.1590 |
| Esketamine | 0.9228 | 1.0202 | 0.8412 | NA | 0.8834 | 1.0870 | 1.2214 |
| Galactosamine | 0.8092 | 0.5434 | 0.1549 | NA | 1.6598 | 1.0401 | 1.4934 |
| Glutamic acid | 1.1103 | 1.2495 | 0.6099 | NA | 0.8996 | 1.0904 | 0.7937 |
| Glycine | 0.9548 | 1.0064 | 0.8581 | NA | 1.0421 | 1.1441 | 0.8981 |
| Guanosine | 0.0420 | 0.3092 | 0.2008 | NA | 1.6034 | 0.5967 | 3.4643 |
| Hippuric acid | 0.3039 | 0.3013 | 0.0721 | NA | 2.7532 | 0.8785 | 1.3029 |
| Histidine | 1.3379 | 1.1084 | 0.8849 | NA | 0.7356 | 0.8998 | 0.9677 |
| Homocarnosine | 1.3068 | 1.1954 | 0.6804 | NA | 0.8686 | 1.0932 | 0.5943 |
| Homocitrulline | 0.4048 | 0.9044 | 0.7202 | NA | 1.2270 | 1.2080 | 1.5277 |
| Indole-3-acetic acid | 1.1983 | 1.3283 | 0.6735 | NA | 0.8383 | 0.9032 | 0.8603 |
| Indole-3-carboxyaldehyde | 0.6812 | 1.5255 | 0.7344 | NA | 0.9133 | 0.9939 | 1.0252 |
| Indole-3-lactic acid | 1.3787 | 1.2423 | 1.1047 | NA | 0.5853 | 0.8886 | 0.8036 |
| Indole-3-methyl acetate | 0.2655 | 0.2918 | 0.0846 | NA | 1.5534 | 1.4009 | 2.2616 |
| Inosine | 0.0181 | 0.4828 | 0.4270 | NA | 2.2974 | 0.3989 | 2.4524 |
| Isoleucine | 0.4932 | 1.2852 | 0.7220 | NA | 0.9622 | 1.1065 | 1.3891 |
| Kynurenic acid/ Indole-3-glyoxylic acid | 0.9830 | 0.9943 | 0.4371 | NA | 1.6671 | 0.6876 | 0.9326 |
| Kynurenine | 0.8314 | 1.1862 | 0.7080 | NA | 0.7613 | 1.2436 | 1.1647 |
| Leucine | 0.5902 | 1.3463 | 0.7978 | NA | 0.8895 | 1.0536 | 1.2952 |
| Lysine | 0.7363 | 1.1075 | 0.8635 | NA | 1.1113 | 1.0561 | 1.0761 |
| Methionine | 0.4143 | 0.9256 | 0.5863 | NA | 1.1600 | 1.3895 | 1.4233 |
| Methionine sulfoxide | 0.5269 | 0.8023 | 0.7185 | NA | 1.2698 | 1.2574 | 1.3791 |
| N1-Methyl-2-pyridone-5-carboxamide | 2.6337 | 1.1138 | 0.4558 | NA | 0.4951 | 0.4103 | 0.4923 |
| N2-Acetyllysine | 1.4188 | 1.0393 | 0.4868 | NA | 1.3523 | 0.5877 | 0.8113 |
| N3,N4-Dimethyl-L-arginine | 0.7142 | 1.0455 | 0.7882 | NA | 1.3011 | 1.0495 | 0.9940 |
| N6,N6,N6-Trimethyl-L-lysine | 1.5700 | 1.1234 | 1.1716 | NA | 0.9251 | 0.6394 | 0.5417 |
| N8-Acetylspermidine | 1.2757 | 1.1069 | 0.9748 | NA | 1.2415 | 0.7395 | 0.5319 |
| N-Acetylalanine | 1.0036 | 1.2480 | 0.7593 | NA | 0.7849 | 1.0378 | 1.0614 |
| N-Acetylarginine | 0.9906 | 1.0737 | 0.4327 | NA | 1.4870 | 0.7701 | 0.9497 |
| N-Acetylglucosamine | 1.6642 | 1.7854 | 1.4944 | NA | 0.4353 | 0.3393 | 0.3714 |
| N-Acetylglutamic acid | 1.5436 | 2.1997 | 0.4240 | NA | 0.3647 | 0.5670 | 0.4840 |
| N-Acetylglutamine | 2.0504 | 1.4255 | 0.7053 | NA | 0.6940 | 0.3971 | 0.4404 |
| N-Acetylglycine | 2.4479 | 0.8702 | 0.8450 | NA | 0.1909 | 0.8982 | 0.5604 |
| N-Acetylhistamine | 2.6286 | 1.6033 | 0.8662 | NA | 0.2089 | 0.2688 | 0.1431 |
| N-Acetylhistidine | 2.8303 | 1.4124 | 0.4452 | NA | 0.3266 | 0.2298 | 0.3044 |
| N-Acetylneuraminic acid | 2.4700 | 2.1409 | 1.1266 | NA | 0.0509 | 0.0244 | 0.0007 |
| N-Acetylornithine | 0.4987 | 0.8479 | 0.6233 | NA | 1.2898 | 1.1248 | 1.5695 |
| N-Acetylphenylalanine | 0.1551 | 0.1751 | 0.0742 | NA | 2.3017 | 1.4364 | 1.5261 |
| N-AcetylProline | 2.4200 | 0.9327 | 0.3161 | NA | 0.7332 | 0.6999 | 0.4081 |
| N-Acetyltryptophan | 0.5746 | 0.8875 | 0.5598 | NA | 1.1421 | 1.3087 | 1.4097 |
| N-Acetyltyrosine | 3.0196 | 0.9692 | 0.5178 | NA | 0.3077 | 0.3955 | 0.3988 |
| Nicotinamide N-oxide | 0.4572 | 0.3064 | 0.1834 | NA | 2.1673 | 0.9059 | 1.7620 |
| Nicotine amide | 0.4172 | 1.0155 | 0.7165 | NA | 1.2604 | 1.0999 | 1.4650 |
| Nicotinic acid | 1.5563 | 2.5566 | 1.9620 | NA | 0.0516 | 0.0800 | 0.0327 |
| N-Isovalerylglycine | 1.3567 | 0.9257 | 0.5361 | NA | 0.9785 | 0.9743 | 0.9956 |
| N-Methylhydantoin | 0.6618 | 1.6996 | 0.9277 | NA | 0.6861 | 0.9678 | 1.0277 |
| Norketamine | 1.4307 | 0.8357 | 0.8406 | NA | 0.9548 | 0.8849 | 0.9649 |
| O-Acetylserine | 3.1158 | 0.6765 | 0.3766 | NA | 0.4609 | 0.4426 | 0.4879 |
| Octanoylcarnitine | 0.7397 | 0.5381 | 0.3137 | NA | 0.9906 | 1.7588 | 1.4214 |
| Pantothenic acid | 0.7203 | 1.6989 | 1.2240 | NA | 0.7323 | 0.8309 | 0.8742 |
| Phosphocholine | 2.0691 | 1.1260 | 0.9612 | NA | 0.7126 | 0.4351 | 0.5689 |
| Pipecolinic acid | 0.8441 | 0.9891 | 0.6502 | NA | 1.1716 | 1.0305 | 1.1862 |
| Proline | 0.4716 | 1.0539 | 0.8149 | NA | 1.0786 | 1.3177 | 1.2277 |
| Prolylleucine | 1.8084 | 0.8108 | 0.6533 | NA | 1.3065 | 0.5817 | 0.5545 |
| Propionylcarnitine | 0.4440 | 1.0723 | 0.3778 | NA | 1.3615 | 1.3073 | 1.1679 |
| Pyroglutamic acid | 0.8235 | 1.4120 | 1.2683 | NA | 0.6801 | 1.0632 | 0.8494 |
| Serine | 1.0700 | 0.7516 | 0.5231 | NA | 1.1935 | 1.1145 | 1.1453 |
| Serotonin | 0.8803 | 0.8931 | 0.7197 | NA | 1.1010 | 1.0832 | 1.2434 |
| Taurine | 1.7904 | 0.9436 | 0.7992 | NA | 0.6690 | 0.8348 | 0.8169 |
| Thiamine | 0.4510 | 0.8868 | 0.6863 | NA | 1.9774 | 0.8201 | 1.0288 |
| Threonine | 0.6702 | 1.0362 | 0.6770 | NA | 0.9842 | 1.2271 | 1.3250 |
| Trigonelline | 0.6270 | 1.0811 | 0.8470 | NA | 1.5271 | 0.6376 | 1.2717 |
| Trimethylamine N-Oxide | 1.3992 | 0.3958 | 0.1222 | NA | 2.4960 | 0.4205 | 0.6366 |
| Tryptophan | 0.3959 | 1.1828 | 0.5802 | NA | 1.1089 | 1.3100 | 1.2831 |
| Tyrosine | 0.5421 | 1.1966 | 0.6731 | NA | 1.0757 | 1.1921 | 1.2092 |
| Urocanic acid | 1.3214 | 2.8073 | 1.8156 | NA | 0.0554 | 0.1148 | 0.0578 |
| Valine | 0.6182 | 1.2748 | 0.7596 | NA | 0.9310 | 1.1108 | 1.2473 |
| Vanillyl alcohol | 1.0809 | 1.1908 | 0.4201 | NA | 0.8704 | 1.2303 | 0.8900 |
| Xanthosine | 0.0876 | 0.7986 | 0.5927 | NA | 2.1284 | 0.6126 | 1.7685 |
| Xylazine | 0.9778 | 0.9973 | 0.8392 | NA | 0.8079 | 1.0582 | 1.3189 |
| δ-Valerolactam | 2.5998 | 1.5724 | 0.6734 | NA | 0.1706 | 0.3952 | 0.2338 |
Factors:
| F1 | Sample source:Serum | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Serum | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Serum | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Serum | Group:QC |
| F5 | Sample source:Serum | Group:Sham / 12C-Serin |
| F6 | Sample source:Serum | Group:Sham / 13C-Serin |
| F7 | Sample source:Serum | Group:Sham / Vehicle |
