Data for (Study ST003484)
(Analysis AN005722)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-Aminomuconate | 1.9679 | 0.2498 | 0.4736 | 1.0386 | 0.6380 | 1.5566 | 0.7900 | 0.6000 | 0.7965 | 0.6257 | 0.6572 | 0.9196 | 1.6249 | 0.4686 | 0.9070 | 2.1617 | 0.2535 | 1.5255 | 0.4950 | 0.7600 | 1.3967 | 1.1433 | 0.7862 | 1.1720 | 1.0449 | 1.1001 | 1.6391 | 0.9369 | 0.8165 | 1.3832 |
| 3^,5^-Cyclic AMP | 0.3306 | 0.0154 | 0.0705 | 0.1379 | 0.1255 | 0.6450 | 0.6188 | 0.1949 | 0.4316 | 0.1470 | 0.2282 | 0.1968 | 0.3025 | 0.3641 | 0.2711 | 0.3266 | 0.2271 | 1.4348 | 0.3318 | 0.6770 | 3.9394 | 5.5682 | 1.8722 | 3.1461 | 1.9278 | 1.8023 | 1.7861 | 0.4407 | 1.8170 | 0.6230 |
| 5-Hydroxyindoleacetate | 5.7695 | 0.0123 | 0.0454 | 0.0707 | 0.2151 | 1.6561 | 1.2249 | 0.0928 | 0.4506 | 0.4525 | 1.5308 | 0.3425 | 0.2567 | 1.7646 | 0.2253 | 5.4582 | 0.0134 | 0.0548 | 0.0243 | 0.1935 | 1.1463 | 3.8221 | 0.0615 | 0.2157 | 0.3756 | 0.8966 | 0.5511 | 0.0120 | 2.6914 | 0.0448 |
| 6-Hydroxykynurenic acid | 0.3579 | 0.2406 | 0.2145 | 0.7716 | 0.4917 | 2.1144 | 1.2424 | 0.9119 | 0.7838 | 0.5685 | 0.4090 | 1.6681 | 0.0849 | 0.9892 | 0.1992 | 0.4366 | 0.1406 | 0.6903 | 1.6355 | 0.7022 | 1.5109 | 2.2285 | 1.0706 | 2.3952 | 1.7707 | 1.7639 | 2.8706 | 0.0648 | 0.9302 | 0.3369 |
| 8-Methoxykynurenate | NA | 0.1925 | 0.2444 | 0.0919 | 0.1530 | 2.3591 | 1.3190 | 0.4835 | 0.6998 | 0.9238 | 1.7639 | 2.3403 | 0.0612 | 1.8169 | 0.0717 | NA | 0.2143 | 0.1764 | 0.1567 | 0.1620 | 2.2569 | 2.2600 | 0.5806 | 1.2743 | 0.6252 | 1.0442 | 2.1100 | 0.0674 | 1.6979 | 0.0767 |
| Acetylcholine | 7.3895 | 0.0849 | 0.1100 | 0.1797 | 0.1672 | 0.5616 | 0.3754 | 0.3259 | 0.4446 | 0.3004 | 0.4115 | 0.2825 | 0.6289 | 0.5806 | 0.5885 | 7.6969 | 0.1502 | 0.5388 | 0.1723 | 0.2433 | 0.8259 | 1.2203 | 0.5018 | 0.9465 | 0.6953 | 0.6688 | 1.2841 | 0.5737 | 1.2019 | 0.8490 |
| acyl-C10:1 (O-Decenoyl-L-carnitine) | 8.9935 | 0.5558 | 0.5280 | 0.2704 | 0.5085 | 0.5607 | 0.4333 | 0.4457 | 1.5063 | 0.3695 | 0.6325 | 0.4765 | 0.2373 | 0.4669 | 0.1121 | 7.0192 | 0.6242 | 0.6463 | 0.6010 | 0.4822 | 0.6325 | 0.5307 | 0.4912 | 0.6657 | 0.3309 | 0.7238 | 0.5717 | 0.1380 | 0.2879 | 0.1577 |
| acyl-C2 (acetyl-carnitine) | 5.7375 | 0.4064 | 0.1198 | 0.2625 | 0.2172 | 2.1389 | 1.3022 | 0.4995 | 0.8284 | 0.3824 | 0.4991 | 0.9172 | 0.3142 | 1.2027 | 0.2255 | 6.7456 | 0.1620 | 0.6907 | 0.2174 | 0.3949 | 1.9822 | 0.3797 | 0.5755 | 0.9500 | 0.5867 | 0.8975 | 0.5334 | 0.2119 | 0.2923 | 0.3264 |
| acyl-C3 (propionyl-carnitine) | 8.4439 | 0.1154 | 0.0546 | 0.1027 | 0.1034 | 2.0290 | 0.6266 | 0.2693 | 0.4920 | 0.2025 | 0.3839 | 0.4858 | 0.3829 | 0.7454 | 0.2388 | 7.7945 | 0.0563 | 0.1726 | 0.0636 | 0.1292 | 1.6805 | 1.3146 | 0.3744 | 0.4952 | 0.3555 | 0.5396 | 0.5724 | 0.2151 | 1.3162 | 0.2439 |
| acyl-C4 (butanoyl-l-carnitine) | 11.1352 | 0.1408 | 0.0948 | 0.1057 | 0.0870 | 0.5124 | 0.3018 | 0.1278 | 0.1871 | 0.1134 | 0.1403 | 0.0836 | 0.3227 | 0.2877 | 0.1677 | 12.0507 | 0.1002 | 0.1540 | 0.1037 | 0.1079 | 0.4922 | 0.8104 | 0.1843 | 0.2379 | 0.2324 | 0.2569 | 0.2304 | 0.1723 | 0.9097 | 0.1493 |
| acyl-C4-DC | 3.6407 | 0.1607 | 0.0790 | 0.1175 | 0.1906 | 0.9300 | 0.5409 | 0.7873 | 0.7284 | 0.3455 | 0.5244 | 0.6459 | 0.1809 | 0.9062 | 0.4126 | 4.3037 | 0.1832 | 0.6704 | 0.2141 | 0.3874 | 0.9021 | 2.1067 | 0.8316 | 1.8437 | 1.6743 | 1.3389 | 1.8655 | 0.2647 | 2.1465 | 0.7969 |
| acyl-C5 (isovalerylcarnitine) | 4.7026 | 0.5396 | 0.6507 | 0.3843 | 0.5294 | 1.2257 | 0.6306 | 0.8111 | 0.8413 | 0.4142 | 0.5816 | 0.5953 | 0.4134 | 0.4989 | 0.3777 | 5.0945 | 0.7244 | 0.6621 | 0.6048 | 0.7123 | 0.9646 | 2.5622 | 0.6279 | 0.5860 | 0.3722 | 0.9176 | 0.5978 | 0.3407 | 1.6884 | 0.3479 |
| acyl-C5-OH | 0.6334 | 0.0527 | 0.1009 | 0.2080 | 0.1713 | 1.9220 | 0.9239 | 0.7343 | 0.8107 | 0.5051 | 0.6405 | 1.0758 | 0.1399 | 1.6465 | 0.4338 | 0.6667 | 0.1326 | 0.5784 | 0.1327 | 0.3391 | 1.4418 | 3.8531 | 0.5658 | 1.4605 | 1.1740 | 1.0808 | 3.2309 | 0.1229 | 4.5207 | 0.7013 |
| acyl-C6 (hexanoyl-l-carnitine) | 11.2933 | 0.0883 | 0.0952 | 0.1158 | 0.1129 | 0.4209 | 0.2449 | 0.0917 | 0.1830 | 0.0990 | 0.2000 | 0.1118 | 0.4164 | 0.2781 | 0.2290 | 13.5687 | 0.0989 | 0.1289 | 0.0933 | 0.1078 | 0.4229 | 0.2531 | 0.1542 | 0.1991 | 0.1278 | 0.1789 | 0.1126 | 0.2473 | 0.1148 | 0.2113 |
| acyl-C8:1 (octenoyl-l-carnitine) | 3.4595 | 0.8439 | 1.0423 | 0.5626 | 0.8726 | 0.9970 | 0.7264 | 0.8345 | 1.2606 | 0.7227 | 1.1986 | 1.0811 | 0.4119 | 0.6558 | 0.4104 | 3.0441 | 1.0140 | 1.0388 | 0.9593 | 0.6896 | 0.9475 | 0.9555 | 0.9254 | 1.0472 | 0.7100 | 0.9995 | 1.1563 | 0.4274 | 0.7089 | 0.2966 |
| acyl-C8 (L-octanoylcarnitine | 13.1087 | 0.0385 | 0.0560 | 0.0278 | 0.1166 | 0.1897 | 0.1016 | 0.0788 | 0.0917 | 0.0657 | 0.1225 | 0.0995 | 0.1887 | 0.1722 | 0.0687 | 13.8648 | 0.0549 | 0.0721 | 0.0504 | 0.1288 | 0.2896 | 0.0974 | 0.0948 | 0.1330 | 0.1220 | 0.1965 | 0.0968 | 0.1121 | 0.0652 | 0.0947 |
| Adenine | 0.0711 | 0.3346 | 0.9245 | 1.7109 | 1.4451 | 0.9582 | 1.0488 | 0.1484 | 0.2618 | 0.1400 | 0.1755 | 0.2769 | 0.0799 | 0.1090 | 0.0672 | 0.0786 | 1.1931 | 4.2550 | 1.2484 | 2.6681 | 0.3272 | 5.2397 | 0.0731 | 0.2291 | 0.1715 | 0.1485 | 1.9817 | 0.0625 | 4.4714 | 0.0999 |
| Adenosine | 0.0499 | 0.3784 | 0.8514 | 1.8387 | 1.3514 | 0.9492 | 1.2211 | 0.0978 | 0.2130 | 0.1084 | 0.0914 | 0.2303 | 0.0619 | 0.0681 | 0.0517 | 0.0764 | 1.1005 | 4.1200 | 1.1807 | 2.8520 | 0.2878 | 5.3284 | 0.0225 | 0.1415 | 0.1410 | 0.0986 | 2.0696 | 0.0445 | 4.8701 | 0.1036 |
| Allantoate | 1.1652 | 0.8348 | 0.5016 | 0.4331 | 0.9754 | 0.6394 | 0.4127 | 0.7085 | 3.5552 | 0.3300 | 0.7136 | 0.5370 | 0.8959 | 1.0484 | 0.5071 | 1.4402 | 0.1701 | 1.7017 | 1.0198 | 2.6739 | 1.1130 | 1.1569 | 0.8944 | 0.9255 | 0.6185 | 2.9828 | 0.3662 | 0.6961 | 0.4116 | 0.6090 |
| AMP | 1.2866 | 0.3104 | 0.6520 | 0.7803 | 0.6734 | 0.4285 | 1.0005 | 0.2931 | 0.2665 | 0.4838 | 0.2417 | 0.4180 | 1.5406 | 0.3098 | 1.1309 | 1.9631 | 0.6399 | 1.1681 | 0.6643 | 0.8674 | 0.7869 | 3.0587 | 0.0460 | 0.5506 | 0.4471 | 0.2940 | 2.1572 | 1.3333 | 5.2193 | 0.9882 |
| Choline | 0.4644 | 0.2757 | 0.7176 | 1.0858 | 1.0810 | 2.4173 | 1.5950 | 0.5957 | 1.0377 | 0.6219 | 0.8118 | 1.2306 | 0.8987 | 1.2084 | 0.5856 | 0.4223 | 0.7593 | 1.7893 | 0.7892 | 1.0995 | 1.2199 | 1.7055 | 0.4918 | 0.9648 | 0.8731 | 0.8739 | 1.7333 | 0.6106 | 1.3778 | 0.6625 |
| Creatine | 2.6430 | 0.1440 | 0.2484 | 0.3274 | 0.3331 | 0.8350 | 0.7236 | 0.7610 | 0.8536 | 0.7282 | 0.9653 | 0.8950 | 0.3383 | 1.5073 | 0.3701 | 2.5429 | 0.2516 | 0.6575 | 0.2873 | 0.4317 | 1.7342 | 1.8075 | 0.6155 | 1.6172 | 1.3327 | 1.4292 | 2.1306 | 0.2011 | 2.7973 | 0.4906 |
| Creatinine | 0.5188 | 0.0506 | 0.0486 | 0.0499 | 0.0667 | 1.3565 | 0.3600 | 2.7420 | 2.3872 | 1.1451 | 2.5247 | 1.8189 | 0.0630 | 1.6564 | 0.0595 | 0.4525 | 0.0573 | 0.0953 | 0.0556 | 0.0798 | 2.2341 | 0.2613 | 2.5683 | 2.7276 | 2.1006 | 3.1486 | 0.9470 | 0.0352 | 0.3177 | 0.0711 |
| Cys-Gly | 1.0748 | 0.1140 | 0.3256 | 0.5963 | 0.4419 | 1.3157 | 1.3049 | 0.9542 | 1.2693 | 0.8935 | 1.0533 | 1.2385 | 0.2467 | 1.5829 | 0.1871 | 0.9800 | 0.2594 | 1.0953 | 0.3554 | 0.6706 | 1.7749 | 2.1623 | 0.5399 | 2.2172 | 1.5241 | 1.4340 | 1.7124 | 0.1283 | 2.2360 | 0.3114 |
| Cytosine | 1.1221 | 0.4509 | 0.6222 | 0.7775 | 0.6185 | 0.5697 | 0.7017 | 0.7253 | 0.4791 | 0.6874 | 0.7733 | 0.9429 | 1.1491 | 0.7505 | 0.8507 | 1.1894 | 0.6090 | 1.0277 | 0.6003 | 0.8823 | 0.5835 | 1.6146 | 0.3289 | 0.8966 | 0.8523 | 0.7048 | 3.5740 | 1.4850 | 3.6501 | 0.7808 |
| dAMP | 1.1521 | 0.1431 | 0.6850 | 1.2249 | 1.1339 | 2.2678 | 1.5401 | 0.8472 | 1.0214 | 0.6035 | 1.0447 | 1.1001 | 0.3124 | 1.0300 | 0.2150 | 1.1862 | 0.4949 | 2.1151 | 0.6012 | 1.4158 | 1.3745 | 2.7263 | 0.4093 | 1.2152 | 0.9455 | 0.9054 | 0.7765 | 0.1487 | 0.9203 | 0.4438 |
| dTMP | 0.7357 | 0.1785 | 0.3548 | 0.3211 | 0.4092 | 2.5584 | 0.7075 | 0.3521 | 1.1251 | 0.6148 | 2.0278 | 0.4250 | 0.7121 | 0.5858 | 0.4129 | 0.7373 | 0.7878 | 0.7566 | 0.1853 | 0.5652 | 0.8587 | 3.6765 | 3.6915 | 1.4797 | 1.2804 | 1.5341 | 0.8005 | 0.4404 | 0.9908 | 0.6944 |
| Ectoine | 0.3215 | 0.1810 | 0.2410 | 0.6514 | 0.4454 | 0.7544 | 1.1176 | 0.8261 | 1.2206 | 0.7418 | 0.9394 | 0.5010 | 0.2566 | 0.9459 | 0.2439 | 0.3510 | 0.3466 | 1.3127 | 0.3153 | 0.5944 | 1.3689 | 4.9138 | 0.9890 | 2.2705 | 1.5305 | 0.6392 | 1.2446 | 0.2751 | 4.1358 | 0.3250 |
| Ethanolamine phosphate | 0.9170 | 0.1227 | 0.1913 | 0.1922 | 0.2250 | 0.3305 | 0.3335 | 0.9939 | 1.1098 | 1.5249 | 1.6706 | 1.2455 | 1.4585 | 2.1069 | 1.4166 | 0.7955 | 0.1985 | 0.3611 | 0.2409 | 0.2414 | 0.6763 | 0.6990 | 0.5518 | 1.6637 | 1.4352 | 1.5919 | 2.0112 | 1.2921 | 2.9691 | 1.4335 |
| gamma-Glutamyl-gamma-aminobutyrate | 0.9990 | 0.0612 | 0.1208 | 0.2563 | 0.1642 | 1.6609 | 1.1338 | 0.9977 | 1.1869 | 0.6552 | 1.2477 | 1.0009 | 0.1261 | 1.4739 | 0.2332 | 1.0190 | 0.3357 | 0.5145 | 0.1627 | 0.4036 | 1.7855 | 2.4043 | 1.0289 | 1.8361 | 1.6950 | 1.6665 | 1.9591 | 0.0532 | 2.9446 | 0.2477 |
| gamma-L-Glutamyl-D-alanine | 4.7367 | 0.0658 | 0.1449 | 0.1553 | 0.1332 | 0.3578 | 0.2335 | 0.6061 | 0.7189 | 0.5193 | 0.6957 | 0.5322 | 0.4544 | 0.4909 | 0.5208 | 5.2323 | 0.0629 | 0.3698 | 0.2173 | 0.2933 | 0.9983 | 1.1177 | 1.0672 | 2.5903 | 2.4496 | 1.7581 | 0.9140 | 0.3641 | 1.3122 | 0.8871 |
| Glutathione | 1.2567 | 0.1290 | 0.3361 | 0.6139 | 0.4801 | 1.3068 | 1.2603 | 0.9385 | 1.2354 | 0.8602 | 1.0818 | 1.2503 | 0.2937 | 1.5545 | 0.2065 | 1.1674 | 0.2852 | 1.0671 | 0.3821 | 0.7058 | 1.7762 | 2.1750 | 0.5603 | 2.1159 | 1.4365 | 1.4228 | 1.6183 | 0.1442 | 2.0007 | 0.3385 |
| Glutathione disulfide | 2.4610 | 0.1020 | 0.2123 | 0.4047 | 0.3162 | 1.2568 | 0.2396 | 0.5388 | 0.9043 | 0.5763 | 0.7170 | 0.2894 | 2.6454 | 0.4224 | 1.9884 | 3.1204 | 0.1936 | 0.5785 | 0.2216 | 0.4747 | 0.5916 | 1.2319 | 2.1716 | 1.1630 | 1.0658 | 0.9003 | 0.2566 | 1.6729 | 0.5447 | 2.7384 |
| glycine | 1.5304 | 0.4825 | 0.5059 | 0.4582 | 0.5168 | 0.5085 | 0.4631 | 0.6074 | 0.8846 | 0.7552 | 1.1075 | 1.3341 | 0.7004 | 1.2283 | 0.7931 | 1.3955 | 0.4958 | 0.5948 | 0.4983 | 0.4907 | 1.5171 | 1.1135 | 0.8941 | 1.4818 | 1.1404 | 1.6095 | 2.6823 | 0.6381 | 2.5455 | 1.0265 |
| GMP | 0.7458 | 0.4035 | 0.9640 | 1.3132 | 1.1773 | 0.5885 | 1.3012 | 0.1809 | 0.2795 | 0.2793 | 0.2648 | 0.3270 | 0.8486 | 0.2304 | 0.5574 | 0.9658 | 0.7964 | 2.1376 | 0.7125 | 1.3532 | 0.7282 | 4.8091 | 0.0611 | 0.5263 | 0.4244 | 0.3236 | 1.7297 | 0.6527 | 4.7393 | 0.5787 |
| Guanidinoacetate | 0.4941 | 0.0842 | 0.2373 | 0.2164 | 0.2790 | 0.5513 | 0.6054 | 1.2101 | 1.3467 | 1.0062 | 1.9289 | 1.1973 | 0.2666 | 1.9924 | 0.4038 | 0.4499 | 0.1985 | 0.4905 | 0.2763 | 0.3166 | 0.6412 | 1.5654 | 1.2881 | 2.1412 | 1.4987 | 2.0240 | 2.3113 | 0.2307 | 4.0803 | 0.6675 |
| Homocarnosine | 0.2218 | 0.7809 | 0.5533 | 0.4655 | 0.5746 | 1.5750 | 0.9925 | 0.6501 | 1.4257 | 0.9882 | 1.8568 | 1.3466 | 1.3791 | 1.8981 | 0.3180 | 0.6333 | 0.3879 | 0.1388 | 0.5717 | 0.2690 | 1.1208 | 0.7007 | 1.1079 | 0.5984 | 0.4366 | 0.9221 | 1.2706 | 3.8690 | 0.9892 | 0.6479 |
| Hypotaurine | 3.1219 | 0.1122 | 0.2885 | 0.1740 | 0.2971 | 0.3211 | 0.2086 | 1.0871 | 1.1256 | 1.4592 | 1.9176 | 0.9468 | 0.4964 | 1.5172 | 0.2495 | 2.6634 | 0.3742 | 0.4649 | 0.3327 | 0.2513 | 1.2603 | 0.9816 | 0.8269 | 1.8766 | 1.4385 | 1.7468 | 1.7736 | 0.2538 | 2.1607 | 0.2720 |
| Hypoxanthine | 0.0329 | 0.9611 | 0.4235 | 0.6031 | 0.5803 | 1.4720 | 0.6605 | 0.7674 | 2.8448 | 0.7386 | 0.7931 | 0.5331 | 0.1640 | 0.3629 | 0.1445 | 0.0829 | 0.8715 | 2.0979 | 1.4960 | 2.7818 | 1.5177 | 2.2109 | 0.5668 | 0.8704 | 1.7777 | 2.1600 | 0.6557 | 0.2054 | 0.8778 | 0.7458 |
| IMP | 0.0212 | 0.2173 | 0.5383 | 0.7320 | 0.6467 | 2.8550 | 0.8099 | 0.4055 | 0.1154 | 0.3140 | 0.3549 | 0.5424 | 0.1421 | 0.2830 | 0.2434 | 0.0228 | 1.4337 | 4.0368 | 1.2519 | 2.2246 | 1.2781 | 4.0013 | 0.2321 | 0.9951 | 1.0170 | 0.8436 | 1.6024 | 0.2190 | 1.7752 | 0.5195 |
| Indole | 0.3906 | 0.0787 | 0.0913 | 0.0652 | 0.0776 | 0.6377 | 0.3573 | 2.6676 | 4.8601 | 2.1046 | 0.6654 | 0.4920 | 0.0752 | 0.4584 | 0.0731 | 0.2877 | 0.0797 | 0.0926 | 0.0886 | 0.0786 | 0.6908 | 0.6765 | 2.4894 | 4.9412 | 2.5833 | 3.4810 | 0.8213 | 0.0493 | 0.5020 | 0.0433 |
| Indole-3-acetaldehyde | 4.3761 | 0.2272 | 0.3063 | 0.5922 | 0.3082 | 0.5896 | 0.6067 | 0.8519 | 1.5673 | 0.5349 | 0.9594 | 0.3614 | 1.0689 | 0.8578 | 1.1295 | 4.0619 | 0.2122 | 0.5434 | 0.3703 | 0.8315 | 0.5111 | 1.3661 | 0.5768 | 0.8842 | 0.7618 | 0.9466 | 3.2367 | 0.1152 | 0.7784 | 0.2352 |
| Indolepyruvate | 2.8962 | 0.0955 | 0.2445 | 0.5557 | 0.4784 | 1.3242 | 0.9281 | 0.5221 | 1.4232 | 0.4133 | 0.7819 | 0.2875 | 0.5372 | 0.7753 | 0.6511 | 3.7914 | 0.3237 | 1.2333 | 0.2657 | 0.7609 | 1.2071 | 3.6826 | 0.5963 | 1.4704 | 0.8740 | 1.1212 | 0.5584 | 0.2334 | 1.2651 | 0.7023 |
| Indole-Pyruvate 13C11 | 0.1703 | NA | NA | NA | 0.0941 | NA | NA | NA | NA | NA | 0.0810 | NA | 0.1856 | 5.0531 | 0.1352 | 0.1457 | 0.1020 | 0.0795 | 0.0791 | 0.1062 | 2.6675 | 1.8084 | 0.1034 | 0.0676 | 0.1005 | 0.0863 | 2.5076 | 0.1230 | 4.8535 | 0.2214 |
| kynurenine | 5.8174 | 0.0269 | 0.0281 | 0.0729 | 0.2008 | 1.5731 | 1.2343 | 0.0925 | 0.3983 | 0.4743 | 1.4754 | 0.3171 | 0.2650 | 1.7722 | 0.2299 | 5.9078 | 0.0280 | 0.0510 | 0.0327 | 0.1759 | 1.1365 | 3.6075 | 0.0623 | 0.1820 | 0.3212 | 0.8833 | 0.5400 | 0.0228 | 2.6898 | 0.0571 |
| Kynurenine 13C10 | 0.0019 | NA | NA | NA | 0.2465 | NA | NA | NA | NA | NA | 1.7781 | NA | 0.0904 | 2.7862 | 0.1126 | 0.0021 | 0.0347 | 0.1185 | 0.1062 | 0.7538 | 0.4211 | 2.7061 | 0.1936 | 1.5505 | 1.5626 | 1.0642 | 3.1126 | 0.1433 | 3.8507 | 0.3644 |
| L-Adrenaline | 0.6115 | 0.1982 | 0.3228 | 0.6428 | 0.5780 | 2.0987 | 0.8383 | 0.7097 | 1.2486 | 0.6305 | 0.9010 | 0.9441 | 0.6413 | 1.0484 | 0.4976 | 0.5856 | 0.4125 | 1.3677 | 0.3815 | 0.6797 | 2.2641 | 3.0485 | 0.7209 | 1.6647 | 1.0666 | 1.1359 | 2.2461 | 0.3889 | 1.5240 | 0.6017 |
| L-alanine | 4.8972 | 0.2021 | 0.1940 | 0.1981 | 0.2720 | 0.3315 | 0.3372 | 0.5380 | 1.1300 | 0.5562 | 0.8236 | 0.4810 | 0.3931 | 0.7415 | 0.2759 | 4.2466 | 0.2781 | 0.5688 | 0.4411 | 0.5515 | 1.1274 | 1.2489 | 0.8723 | 1.5031 | 1.1377 | 1.7818 | 1.7326 | 0.2549 | 2.4823 | 0.4013 |
| L-arginine | 0.5664 | 0.1117 | 0.1890 | 0.1650 | 0.1949 | 0.5440 | 0.5507 | 0.6963 | 0.8978 | 0.5638 | 0.8098 | 0.7983 | 0.1728 | 1.3208 | 0.1711 | 0.6084 | 0.1862 | 0.2108 | 0.1579 | 0.1637 | 0.3805 | 0.4939 | 0.2950 | 0.6852 | 0.5740 | 10.1266 | 6.9891 | 0.1313 | 1.0370 | 0.2081 |
| L-asparagine | 0.9064 | 0.1123 | 0.2877 | 0.2543 | 0.3042 | 1.3641 | 0.8646 | 0.6631 | 1.3595 | 0.6685 | 1.0443 | 0.8812 | 0.3811 | 0.9330 | 0.3112 | 0.9195 | 0.4577 | 1.0267 | 0.4331 | 0.4456 | 1.6670 | 1.8171 | 0.8192 | 2.1056 | 1.4317 | 1.5186 | 4.1047 | 0.2779 | 2.0661 | 0.5742 |
| L-aspartate | 5.2113 | 0.1296 | 0.1884 | 0.1380 | 0.1972 | 0.1997 | 0.2762 | 0.7753 | 1.0657 | 0.9541 | 1.3932 | 0.7064 | 0.4759 | 1.8728 | 0.2399 | 4.2921 | 0.2084 | 0.2917 | 0.3045 | 0.2379 | 0.5489 | 0.6348 | 0.6555 | 1.2450 | 1.0199 | 1.5606 | 1.8437 | 0.3252 | 2.7373 | 0.2710 |
| L-cysteine | 0.1267 | 1.3308 | 1.2048 | 0.9130 | 1.3059 | 0.9468 | 1.2952 | 1.1549 | 1.3821 | 1.3855 | 1.3168 | 1.5101 | 0.0064 | 1.1441 | 0.0043 | 0.0955 | 1.4708 | 1.2148 | 1.5610 | 1.1085 | 1.2476 | 0.9424 | 1.4284 | 1.0415 | 1.0617 | 1.1894 | 1.4029 | 0.0084 | 1.1815 | 0.0182 |
| L-cystine | 0.7159 | 0.2908 | 0.7183 | 0.8055 | 0.8044 | 0.6337 | 0.4979 | 0.6065 | 0.7384 | 0.4280 | 0.5730 | 0.2248 | 4.5498 | 0.5121 | 1.7714 | 0.7814 | 0.5813 | 0.6805 | 0.6175 | 0.6552 | 0.5397 | 1.0332 | 0.5957 | 1.1034 | 1.2986 | 1.2783 | 0.7540 | 3.0842 | 0.6425 | 2.2257 |
| L-Formylkynurenine 13C11 | NA | NA | NA | NA | 0.0787 | NA | NA | NA | NA | NA | 1.1272 | NA | 0.0055 | 3.8934 | 0.0176 | NA | 0.0660 | 0.1302 | 0.0645 | 0.1553 | 0.4173 | 2.2287 | 0.1381 | 0.5239 | 0.5493 | 0.3728 | 3.2821 | 0.0371 | 4.4967 | 0.0978 |
| L-glutamate | 2.5268 | 0.1309 | 0.2281 | 0.2204 | 0.2646 | 0.2676 | 0.3506 | 1.1241 | 1.2775 | 1.4261 | 1.8437 | 0.5949 | 0.9262 | 1.5269 | 0.5483 | 2.1112 | 0.1944 | 0.3662 | 0.2513 | 0.2511 | 0.7390 | 0.9332 | 0.8692 | 1.7783 | 1.6090 | 1.9192 | 1.8353 | 0.6389 | 2.6717 | 0.5754 |
| L-glutamine | 2.4003 | 0.1078 | 0.1367 | 0.1410 | 0.1647 | 0.5476 | 0.4422 | 0.7671 | 1.0188 | 1.0546 | 1.4970 | 1.2676 | 0.5074 | 1.7627 | 0.4200 | 2.1598 | 0.1814 | 0.4335 | 0.2776 | 0.2610 | 1.3508 | 1.0687 | 0.7508 | 1.6313 | 1.2156 | 1.5264 | 2.6207 | 0.5204 | 3.0654 | 0.7011 |
| L-histidine | 2.3438 | 0.1777 | 0.2035 | 0.2200 | 0.2781 | 0.3239 | 0.5068 | 0.9067 | 1.7269 | 1.1611 | 1.1674 | 0.6853 | 0.4602 | 1.6926 | 0.4394 | 2.3397 | 0.3755 | 0.4507 | 0.4416 | 0.3933 | 1.0688 | 1.0261 | 1.1501 | 1.5808 | 1.1574 | 1.7753 | 1.6847 | 0.4216 | 3.3338 | 0.5072 |
| L-leucine/L-isoleucine | 2.6724 | 0.1383 | 0.2724 | 0.3613 | 0.4318 | 1.0190 | 0.9643 | 0.6781 | 1.4769 | 0.5737 | 1.1380 | 0.4669 | 0.4504 | 1.2131 | 0.4278 | 2.5210 | 0.3169 | 1.0297 | 0.3254 | 0.6678 | 1.1777 | 3.4444 | 0.7670 | 1.5421 | 0.8999 | 1.1702 | 1.0270 | 0.2287 | 2.1413 | 0.4566 |
| L-lysine | 2.1370 | 0.2939 | 0.3274 | 0.3280 | 0.4184 | 1.0235 | 0.9993 | 1.1997 | 2.2998 | 1.0557 | 1.4589 | 1.3241 | 0.4889 | 2.0097 | 0.4719 | 1.9985 | 0.3516 | 0.4853 | 0.4084 | 0.5621 | 0.7538 | 0.9700 | 0.8101 | 1.0048 | 0.9051 | 1.6179 | 2.2093 | 0.2092 | 1.6145 | 0.2631 |
| L-methionine | 3.2710 | 0.0792 | 0.1832 | 0.3115 | 0.2510 | 0.7655 | 1.0037 | 0.7150 | 1.2032 | 0.7182 | 1.0330 | 0.5398 | 0.4073 | 1.5559 | 0.3519 | 3.4935 | 0.1872 | 0.6712 | 0.2235 | 0.4549 | 1.1085 | 2.3124 | 0.8210 | 1.5097 | 1.0338 | 1.1051 | 1.0367 | 0.1718 | 3.0349 | 0.4463 |
| L-Methionine S-oxide | 2.3714 | 0.5207 | 0.5531 | 2.4794 | 0.6874 | 1.3315 | 1.6935 | 0.5936 | 0.5462 | 0.4274 | 0.3059 | 0.2669 | 1.5410 | 0.5510 | 1.6468 | 3.1497 | 0.3165 | 0.8761 | 0.5311 | 1.8067 | 0.7148 | 1.1224 | 0.3937 | 0.6880 | 0.6796 | 0.3552 | 0.2097 | 0.9685 | 0.6108 | 2.0613 |
| L-phenylalanine | 2.2950 | 0.1233 | 0.2315 | 0.4060 | 0.4127 | 0.9256 | 1.0225 | 0.7064 | 1.6016 | 0.5781 | 1.0445 | 0.4093 | 0.4205 | 1.1140 | 0.4194 | 2.3795 | 0.3205 | 1.0178 | 0.3053 | 0.6593 | 1.1195 | 3.4836 | 0.6784 | 1.5760 | 0.9829 | 1.3966 | 1.1549 | 0.2167 | 2.5498 | 0.4487 |
| L-proline | 1.9173 | 0.1596 | 0.2383 | 0.2184 | 0.2596 | 0.4975 | 0.5488 | 1.0721 | 1.4050 | 0.8207 | 1.2324 | 0.6150 | 0.5655 | 1.1960 | 0.4850 | 1.8563 | 0.2621 | 0.6936 | 0.4397 | 0.5380 | 1.3192 | 1.4679 | 0.8752 | 1.9955 | 1.5023 | 1.9057 | 2.0546 | 0.3924 | 2.7861 | 0.6802 |
| L-serine | 2.8408 | 0.3387 | 0.2189 | 0.1593 | 0.2992 | 0.3023 | 0.2806 | 0.6765 | 2.2408 | 0.7875 | 1.2177 | 1.0425 | 0.6280 | 1.1377 | 0.4533 | 2.5233 | 0.5239 | 0.5337 | 1.0331 | 0.6119 | 1.1497 | 0.5852 | 1.8737 | 1.3516 | 0.7590 | 2.2064 | 1.8342 | 0.3780 | 1.6267 | 0.3856 |
| L-threonine | 4.1470 | 0.1026 | 0.1583 | 0.1377 | 0.1834 | 0.4543 | 0.3563 | 0.6078 | 1.0627 | 0.6577 | 1.1296 | 0.9468 | 0.6838 | 1.2203 | 0.5379 | 3.4948 | 0.2117 | 0.4680 | 0.3162 | 0.3281 | 1.3457 | 1.0199 | 0.7869 | 1.5756 | 1.0649 | 1.6212 | 2.0845 | 0.3710 | 2.3831 | 0.5421 |
| L-tryptophan | 5.1289 | 0.1362 | 0.2261 | 0.4452 | 0.5091 | 0.3227 | 0.3337 | 0.6816 | 1.6492 | 0.5105 | 0.9621 | 0.2171 | 1.0991 | 0.6395 | 1.2119 | 4.7677 | 0.2380 | 0.6594 | 0.2482 | 0.6958 | 0.3245 | 1.1171 | 0.5693 | 0.9298 | 0.4857 | 1.1623 | 3.9044 | 0.0711 | 0.6431 | 0.1105 |
| L-tyrosine | 2.5822 | 0.1198 | 0.2422 | 0.3713 | 0.3864 | 0.8335 | 0.8255 | 0.6285 | 1.4736 | 0.6232 | 1.0716 | 0.4268 | 0.4780 | 1.0448 | 0.5071 | 2.7388 | 0.2845 | 0.8934 | 0.2959 | 0.6088 | 1.2165 | 2.8327 | 0.7375 | 1.7372 | 1.1564 | 1.3934 | 1.1186 | 0.2360 | 2.5941 | 0.5418 |
| L-valine | 2.5732 | 0.8975 | 0.3299 | 0.3415 | 0.3680 | 0.6405 | 0.6863 | 0.7590 | 1.1821 | 0.7791 | 0.9311 | 0.5594 | 0.7766 | 1.3560 | 0.6451 | 2.5277 | 0.3324 | 0.7233 | 0.4165 | 0.6117 | 0.9436 | 1.7749 | 0.8284 | 1.3189 | 1.1073 | 1.3083 | 1.2458 | 0.6471 | 2.5829 | 0.8059 |
| NAD+ | 1.2590 | 0.1374 | 0.3195 | 0.3508 | 0.2887 | 0.8852 | 0.7023 | 1.2636 | 1.8506 | 1.0972 | 1.1835 | 0.9435 | 0.8193 | 1.5305 | 0.8321 | 1.4716 | 0.1769 | 0.5097 | 0.1938 | 0.3083 | 1.1095 | 1.1597 | 1.0249 | 2.2873 | 1.6711 | 1.6328 | 1.2528 | 0.6443 | 2.1793 | 0.9150 |
| N-formyl kynurenine | 8.5648 | 0.0819 | 0.1156 | 0.0934 | 0.2764 | 1.8342 | 0.6770 | 0.1672 | 0.5696 | 0.3233 | 0.7456 | 0.4458 | 0.4913 | 1.2338 | 0.3802 | 8.9812 | 0.0583 | 0.2038 | 0.1449 | 0.4346 | 1.0971 | 0.5186 | 0.1276 | 0.2859 | 0.2773 | 0.5119 | 0.1925 | 0.0339 | 0.2581 | 0.0789 |
| N-Glycoloyl-neuraminate | 0.0084 | NA | NA | NA | NA | 1.7336 | 1.3096 | 0.1477 | 0.3769 | 0.8919 | 1.5960 | 1.4281 | NA | 1.7763 | NA | NA | NA | NA | 0.0124 | NA | 1.6789 | 1.7633 | 0.2166 | 0.3951 | 0.2807 | 0.3024 | 1.3490 | NA | 1.7428 | NA |
| Nicotinamide | 0.6398 | 0.6402 | 0.3639 | 0.6802 | 0.5107 | 0.9489 | 0.6480 | 0.8859 | 1.8877 | 0.7897 | 0.8245 | 0.8140 | 0.5897 | 0.8690 | 0.4325 | 0.7362 | 0.9156 | 2.8594 | 1.1502 | 1.9693 | 0.9128 | 1.5841 | 0.7569 | 1.3980 | 1.2468 | 1.0396 | 1.1739 | 0.6377 | 1.4833 | 0.6113 |
| N-Methylethanolamine phosphate | 3.2789 | 1.9539 | 0.7818 | 0.5808 | 0.6876 | 0.7187 | 0.5422 | 0.5830 | 0.6294 | 0.5869 | 0.6083 | 0.5165 | 1.2179 | 0.6567 | 0.7678 | 2.9189 | 0.4751 | 1.0633 | 1.0845 | 1.3252 | 1.1996 | 0.7114 | 0.3186 | 0.6691 | 0.9692 | 0.8453 | 1.0820 | 1.0003 | 1.2573 | 0.9699 |
| Ornithine | 0.3654 | 0.7496 | 0.3077 | 0.2789 | 0.5410 | 0.3049 | 0.4833 | 0.6139 | 4.8932 | 0.9350 | 1.2015 | 1.0026 | 0.3526 | 1.0445 | 0.1309 | 0.3987 | 0.4550 | 1.0519 | 1.3518 | 1.9895 | 0.9093 | 0.6503 | 2.7721 | 0.7628 | 0.4748 | 3.9294 | 1.1103 | 0.2116 | 0.5639 | 0.1636 |
| Pantetheine | 0.8953 | 0.3022 | 0.1938 | 0.4784 | 0.5114 | 1.2654 | 0.8736 | 0.5931 | 3.1566 | 0.5656 | 0.9824 | 0.7075 | 0.5209 | 0.6702 | 0.5065 | 0.9272 | 1.4679 | 1.1361 | 0.5157 | 1.4468 | 1.4719 | 2.7383 | 0.7104 | 1.4901 | 0.7679 | 1.5089 | 1.6520 | 0.2145 | 2.1637 | 0.4643 |
| Pantothenol | 0.6342 | 0.1433 | 0.3164 | 0.6336 | 0.5650 | 2.0216 | 0.8896 | 0.7315 | 1.1990 | 0.6169 | 0.9588 | 0.9809 | 0.6713 | 0.9443 | 0.5670 | 0.6950 | 0.3846 | 1.3740 | 0.3560 | 0.7083 | 2.2010 | 2.9445 | 0.6772 | 1.6322 | 1.1617 | 1.1335 | 2.0909 | 0.4257 | 1.5946 | 0.7474 |
| Picolinic acid | 1.0951 | 0.2830 | 0.3390 | 0.2985 | 0.4219 | 1.2027 | 0.7500 | 1.2607 | 2.6570 | 0.8735 | 1.5343 | 0.9108 | 0.4604 | 1.3961 | 0.3485 | 0.7824 | 0.4763 | 0.8484 | 0.3759 | 0.4396 | 1.1026 | 0.9286 | 1.2410 | 1.7195 | 1.5844 | 1.7369 | 3.4896 | 0.2378 | 0.8743 | 0.3310 |
| Putrescine | 0.0605 | 0.2008 | 0.3750 | 0.6661 | 0.4918 | 5.3047 | 1.7346 | 0.2634 | 0.8733 | 0.2473 | 0.3909 | 2.4298 | 0.4440 | 1.1745 | 0.3169 | 0.0596 | 0.3550 | 1.4889 | 0.3643 | 0.7442 | 1.8387 | 3.7928 | 0.4428 | 0.9218 | 0.7027 | 1.5208 | 1.0929 | 0.1231 | 1.1047 | 0.4742 |
| Pyridoxal | 0.7488 | 0.1585 | 0.1796 | 0.4110 | 0.2292 | 1.4882 | 1.3714 | 1.0683 | 1.6385 | 1.2525 | 0.8490 | 0.4722 | 0.7241 | 1.4734 | 0.5356 | 1.0349 | 0.2049 | 0.4882 | 0.1985 | 0.4287 | 1.2671 | 2.9012 | 1.0499 | 2.0890 | 1.8862 | 1.1225 | 1.3501 | 0.4274 | 2.1388 | 0.8124 |
| S-Adenosyl-L-homocysteine | 1.1292 | 0.2110 | 0.5788 | 1.1919 | 0.7937 | 1.3990 | 1.0062 | 0.5817 | 0.7776 | 0.5225 | 0.5510 | 0.4957 | 0.9132 | 0.7014 | 0.8030 | 1.6604 | 0.4723 | 1.6751 | 0.6603 | 1.4036 | 0.9164 | 2.6762 | 0.7671 | 1.3233 | 1.0916 | 0.9945 | 1.1750 | 0.6060 | 1.7378 | 1.1068 |
| Spermidine | 0.2496 | 0.8615 | 0.3974 | 1.4036 | 0.5280 | 4.8485 | 0.8499 | 0.1115 | 2.1501 | 0.3319 | 0.2306 | 0.7888 | 0.7047 | 0.5350 | 0.2245 | 0.1930 | 0.2926 | 1.8443 | 0.1130 | 0.5885 | 0.4265 | 5.4733 | 0.3315 | 0.4205 | 0.1755 | 0.5915 | 3.3543 | 0.1319 | 0.3124 | 0.5716 |
| Spermine | 0.7809 | 2.2494 | 1.4518 | 0.8514 | 0.6719 | 1.7896 | 0.9184 | 0.2806 | 3.9694 | 0.9775 | 0.7922 | 0.3597 | 1.9976 | 0.4395 | 0.6882 | 0.3841 | 0.5044 | 2.1427 | 0.1716 | 0.7222 | 0.4922 | 1.2840 | 0.3695 | 0.9152 | 0.4201 | 1.1917 | 2.1424 | 0.1537 | 0.2515 | 0.4264 |
| Tryptophan 13C11 | 0.0039 | NA | NA | NA | 0.1873 | NA | NA | NA | NA | NA | 0.6964 | NA | 0.0915 | 2.9866 | 0.1504 | 0.0037 | 0.2029 | 0.6875 | 0.1799 | 0.2689 | 0.9032 | 0.4504 | 0.5268 | 1.0424 | 0.7213 | 0.4722 | 5.8174 | 0.7662 | 3.1562 | 1.6848 |
| Uracil | 0.1985 | 0.4989 | 0.6675 | 0.9348 | 0.9637 | 0.8284 | 0.5643 | 0.3313 | 0.6801 | 0.1895 | 0.3817 | 0.4164 | 0.2287 | 0.2418 | 0.2076 | 0.2085 | 1.8821 | 2.8609 | 1.1081 | 2.4972 | 0.6055 | 1.9780 | 0.2430 | 0.4204 | 0.2895 | 0.5214 | 7.3974 | 0.1846 | 2.2196 | 0.2508 |
Factors:
| F1 | Growth condition:Attached | time (h):0 | treatment:none |
| F2 | Growth condition:Attached | time (h):24 | treatment:10µM 68c091 |
| F3 | Growth condition:Attached | time (h):24 | treatment:10µM AT0174 |
| F4 | Growth condition:Attached | time (h):24 | treatment:1µM AT0174 |
| F5 | Growth condition:Attached | time (h):24 | treatment:DMSO |
| F6 | Growth condition:Attached | time (h):24 | treatment:NFkB cocktail 10 ng/ml IL1b + 10 ng/ml TNFa |
| F7 | Growth condition:Attached | time (h):24 | treatment:Vehicle |
| F8 | Growth condition:Attached | time (h):48 | treatment:10µM 68c091 |
| F9 | Growth condition:Attached | time (h):48 | treatment:10µM AT0174 |
| F10 | Growth condition:Attached | time (h):48 | treatment:1µM AT0174 |
| F11 | Growth condition:Attached | time (h):48 | treatment:DMSO |
| F12 | Growth condition:Attached | time (h):48 | treatment:NFkB cocktail 10 ng/ml IL1b + 10 ng/ml TNFa |
| F13 | Growth condition:Attached | time (h):48 | treatment:none |
| F14 | Growth condition:Attached | time (h):48 | treatment:Vehicle |
| F15 | Growth condition:Attached | time (h):72 | treatment:none |
| F16 | Growth condition:Suspension | time (h):0 | treatment:none |
| F17 | Growth condition:Suspension | time (h):24 | treatment:10µM 68c091 |
| F18 | Growth condition:Suspension | time (h):24 | treatment:10µM AT0174 |
| F19 | Growth condition:Suspension | time (h):24 | treatment:1µM AT0174 |
| F20 | Growth condition:Suspension | time (h):24 | treatment:DMSO |
| F21 | Growth condition:Suspension | time (h):24 | treatment:NFkB cocktail 10 ng/ml IL1b + 10 ng/ml TNFa |
| F22 | Growth condition:Suspension | time (h):24 | treatment:Vehicle |
| F23 | Growth condition:Suspension | time (h):48 | treatment:10µM 68c091 |
| F24 | Growth condition:Suspension | time (h):48 | treatment:10µM AT0174 |
| F25 | Growth condition:Suspension | time (h):48 | treatment:1µM AT0174 |
| F26 | Growth condition:Suspension | time (h):48 | treatment:DMSO |
| F27 | Growth condition:Suspension | time (h):48 | treatment:NFkB cocktail 10 ng/ml IL1b + 10 ng/ml TNFa |
| F28 | Growth condition:Suspension | time (h):48 | treatment:none |
| F29 | Growth condition:Suspension | time (h):48 | treatment:Vehicle |
| F30 | Growth condition:Suspension | time (h):72 | treatment:none |