Data for (Study ST003499)
(Analysis AN005743)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 2/3-phosphoglycerate | 1.4091 | 0.6632 | 0.9277 |
| 2-aminoadipic acid | 0.9807 | 0.8096 | 1.2097 |
| 2-hydroxyglutarate | 1.2862 | 0.9581 | 0.7557 |
| 2-ketoglutarate | 1.9227 | 0.6766 | 0.4007 |
| 4-guanidinobutanoate | 0.6546 | 1.4172 | 0.9282 |
| acetylcarnitine | 0.5037 | 1.1116 | 1.3847 |
| acetylcholine | 0.8048 | 0.8280 | 1.3672 |
| acetyl-CoA | 0.9658 | 1.2633 | 0.7709 |
| adenosine | 1.0268 | 0.6518 | 1.3215 |
| adenylosuccinate | 0.1669 | 0.2210 | 2.6121 |
| ADP | 1.1697 | 0.8175 | 1.0128 |
| ADP-ribose | 0.8863 | 0.8755 | 1.2382 |
| alanine | 0.8463 | 1.5558 | 0.5979 |
| aminobutyrate | 1.3946 | 0.5801 | 1.0254 |
| AMP | 1.2497 | 0.8073 | 0.9429 |
| arginine | 1.0665 | 1.0279 | 0.9056 |
| argininosuccinate | 1.0150 | 1.2976 | 0.6874 |
| asparagine | 1.2412 | 0.9099 | 0.8489 |
| aspartate | 1.1537 | 0.7516 | 1.0948 |
| aspartylglucosamine | 0.9024 | 0.9712 | 1.1264 |
| ATP | 1.3268 | 0.7387 | 0.9345 |
| beta-alanine | 0.6319 | 1.6405 | 0.7277 |
| beta-citrylglutamic acid | 0.6462 | 1.6493 | 0.7045 |
| betaine | 0.7006 | 0.5488 | 1.7506 |
| butyrylcarnitine | 0.3531 | 0.8022 | 1.8447 |
| cAMP | 1.0206 | 1.2833 | 0.6961 |
| carnitinamide | 1.4063 | 0.7041 | 0.8895 |
| carnitine | 0.4567 | 1.1628 | 1.3805 |
| carnosine | 1.3716 | 0.7931 | 0.8353 |
| CDP | 1.3381 | 0.6859 | 0.9761 |
| CDP-ethanolamine | 1.6415 | 0.3109 | 1.0476 |
| C-glycosyltryptophan | NA | NA | NA |
| choline | 1.2737 | 0.7267 | 0.9995 |
| cis-aconitate | 1.1433 | 0.8842 | 0.9725 |
| citicoline | 1.6389 | 0.6902 | 0.6709 |
| citrate | 1.4677 | 0.5205 | 1.0117 |
| citrulline | 1.0825 | 1.1661 | 0.7514 |
| CMP | 1.2399 | 0.7487 | 1.0115 |
| CMP-acetylneuraminic acid | 1.2477 | 0.8094 | 0.9429 |
| creatine | 0.7819 | 0.6932 | 1.5250 |
| creatinine | 1.2147 | 0.8857 | 0.8996 |
| CTP | 1.4582 | 0.6105 | 0.9313 |
| cyclic ADP-ribose | 0.9731 | 1.1048 | 0.9221 |
| Cys-Gly | 0.9457 | 0.9063 | 1.1480 |
| cystathionine | 1.5902 | 0.7792 | 0.6305 |
| cysteic acid | 1.0447 | 0.6684 | 1.2869 |
| cystine | 2.0853 | 0.5819 | 0.3327 |
| cytidine | 1.9288 | 0.5669 | 0.5044 |
| deoxycytidine | 0.7313 | 1.4879 | 0.7808 |
| deoxyribose 5-phosphate | 0.9866 | 0.8329 | 1.1805 |
| dihydroorotate | 0.7826 | 1.0758 | 1.1415 |
| dihydroxyacetone phosphate | 1.3618 | 0.8368 | 0.8014 |
| dimethylarginine | 0.9472 | 1.2314 | 0.8215 |
| dimethyllysine | 0.7865 | 1.4915 | 0.7221 |
| dTTP | 1.2124 | 0.9150 | 0.8726 |
| ethanolamine phosphate | 1.6554 | 0.1377 | 1.2069 |
| FAD | 1.2441 | 0.7620 | 0.9939 |
| fructose 1,6-bisphosphate | 1.2940 | 0.7299 | 0.9761 |
| fructose 6-Phosphate | 1.3899 | 0.9189 | 0.6912 |
| fumarate | 1.0247 | 1.3154 | 0.6598 |
| GDP | 1.2330 | 0.6893 | 1.0778 |
| GDP-glucose | 1.0373 | 1.1191 | 0.8436 |
| gluconate | 1.1584 | 1.2615 | 0.5801 |
| glucose 6-phosphate | 1.3910 | 1.0324 | 0.5766 |
| glucuronic acid | 1.1573 | 0.7686 | 1.0740 |
| glutamate | 1.4004 | 0.5763 | 1.0233 |
| glutamine | 1.2408 | 0.7852 | 0.9741 |
| glutamylcysteine | 1.1674 | 0.9565 | 0.8761 |
| glutamylproline | 0.9764 | 0.9970 | 1.0266 |
| glutathione | 0.9613 | 0.8959 | 1.1428 |
| glyceraldehyde 3-phosphate | 1.2103 | 0.9527 | 0.8370 |
| glycerol 3-phosphate | 1.8208 | 0.5870 | 0.5922 |
| glycerophosphoethanolamine | 1.9268 | 0.6565 | 0.4167 |
| glycerophosphoinositol | 0.8861 | 1.2035 | 0.9104 |
| glycerophosphorylcholine | 2.0101 | 0.6481 | 0.3417 |
| glycerophosphoserine | 1.1008 | 1.1191 | 0.7801 |
| glycerylphosphorylcholine | 2.0101 | 0.6481 | 0.3417 |
| glycine | 2.3181 | 0.2955 | 0.3864 |
| glycylglycine | 0.9126 | 0.8419 | 1.2455 |
| GMP | 1.1311 | 0.7183 | 1.1506 |
| GTP | 1.2873 | 0.6750 | 1.0378 |
| guanidineacetic acid | 0.4711 | 0.6067 | 1.9222 |
| guanine | 1.9489 | 0.1912 | 0.8598 |
| guanosine | 1.8914 | 0.2402 | 0.8684 |
| histidine | 1.1469 | 1.0561 | 0.7971 |
| homoarginine | 1.0613 | 1.0743 | 0.8644 |
| hydantoin-5-propionic acid | 1.1465 | 0.7956 | 1.0579 |
| hydroxyphenyllactate | 1.6851 | 0.5466 | 0.7683 |
| hydroxyproline | 1.2474 | 1.1233 | 0.6293 |
| hydroxytrimethyllysine | 1.2571 | 1.0883 | 0.6545 |
| hypotaurine | 0.8419 | 1.1134 | 1.0448 |
| hypoxanthine | 2.1026 | 0.3970 | 0.5004 |
| IMP | 1.6764 | 0.5282 | 0.7955 |
| indole | NA | NA | NA |
| inosine | 2.0128 | 0.4057 | 0.5815 |
| inositol | 0.9917 | 1.0911 | 0.9173 |
| isoleucine | 1.1566 | 1.0060 | 0.8374 |
| isovalerylcarnitine C5 | 0.7033 | 0.9654 | 1.3313 |
| ketoleucine+ketoisoleucine | NA | NA | NA |
| ketovaline | NA | NA | NA |
| kynurenine | 0.5854 | 0.9981 | 1.4165 |
| lactate | 0.9263 | 1.4575 | 0.6162 |
| leucine | 1.2506 | 0.8826 | 0.8668 |
| lysine | 1.2475 | 0.7565 | 0.9960 |
| malate | 1.0332 | 1.2986 | 0.6682 |
| methionine | 1.4001 | 0.6754 | 0.9245 |
| methionine sulfoxide | 1.1604 | 1.0255 | 0.8140 |
| N-acetylarginine | 1.0573 | 1.1669 | 0.7758 |
| N-acetylaspartate | 0.8277 | 0.9754 | 1.1968 |
| N-acetylaspartylglutamate | 0.4371 | 1.6054 | 0.9576 |
| N-acetylglutamate | 1.0285 | 0.9868 | 0.9847 |
| N-acetylhexosamine phosphate | 1.5073 | 0.6970 | 0.7957 |
| N-acetylhistidine | 1.1130 | 1.1859 | 0.7011 |
| N-acetylneuramic acid | 1.2624 | 0.8382 | 0.8994 |
| N-acetylornithine | 1.0879 | 1.0908 | 0.8213 |
| N-acetylserine | 0.8131 | 1.0445 | 1.1424 |
| NAD | 1.0046 | 1.0832 | 0.9122 |
| NADH | 0.6359 | 0.7620 | 1.6021 |
| NADP | 1.1276 | 0.7893 | 1.0831 |
| NADPH | 1.0306 | 0.8179 | 1.1515 |
| N-carbamoylaspartate | 0.5196 | 1.7196 | 0.7608 |
| N-carbamoylglutamate | 0.9777 | 0.8093 | 1.2130 |
| nicotinamide riboside | 1.0578 | 1.1802 | 0.7620 |
| ophthalmic acid | 1.6132 | 0.4150 | 0.9718 |
| ornithine | 1.1386 | 1.0024 | 0.8590 |
| orotate | 2.3362 | 0.3369 | 0.3269 |
| orotidine | 0.8660 | 1.0846 | 1.0494 |
| oxidized glutathione | 1.2326 | 0.7247 | 1.0427 |
| pantothenate | 1.6573 | 0.6063 | 0.7364 |
| phenylalanine | 1.2825 | 0.8076 | 0.9100 |
| phosphocholine | 1.1175 | 0.7360 | 1.1465 |
| phosphocreatine | 1.7359 | 0.6388 | 0.6253 |
| phosphoenolpyruvate | 1.2225 | 0.9226 | 0.8549 |
| phosphoethanolamine | 1.6718 | 0.1271 | 1.2011 |
| phosphorylcholine | 1.1174 | 0.7359 | 1.1467 |
| proline | 1.1027 | 0.9823 | 0.9150 |
| propionylcarnitine | 0.6879 | 1.1958 | 1.1163 |
| propionylcholine | 0.5724 | 1.2019 | 1.2257 |
| pyroglutamic acid | 1.0644 | 1.0833 | 0.8522 |
| pyruvate | 1.3109 | 1.3890 | 0.3002 |
| quinolinic acid | 1.4170 | 1.4635 | 0.1194 |
| S-(2-succinyl)cysteine | 1.2413 | 1.1815 | 0.5772 |
| S-(2-Succinyl)glutathione | 0.8887 | 1.3064 | 0.8049 |
| saccharopine | NA | NA | NA |
| S-adenosylhomocysteine | 0.8697 | 0.9473 | 1.1829 |
| S-adenosylmethionine | 1.2397 | 0.8388 | 0.9215 |
| SAICAR | NA | NA | 1.0000 |
| sarcosine | 1.0595 | 1.0526 | 0.8880 |
| sedoheptulose 7-phosphate | 1.1050 | 0.4927 | 1.4023 |
| serine | 1.8189 | 0.3053 | 0.8758 |
| S-lactoylglutathione | 0.7786 | 1.5264 | 0.6949 |
| succinate | 1.3348 | 1.0426 | 0.6226 |
| succinyladenosine | NA | 0.1333 | 1.8667 |
| succinylcarnitine | 0.5403 | 1.3746 | 1.0851 |
| succinylglutathione | 0.8887 | 1.3064 | 0.8049 |
| taurine | 0.8439 | 1.0652 | 1.0909 |
| thiamine | 0.5512 | 1.6103 | 0.8385 |
| threonine | 1.4663 | 0.6218 | 0.9119 |
| trimethyllysine | 0.8146 | 1.3249 | 0.8605 |
| tryptamine | NA | NA | NA |
| tryptophan | 1.3391 | 0.6760 | 0.9849 |
| tyrosine | 1.1684 | 0.9824 | 0.8492 |
| UDP | 1.3525 | 0.6946 | 0.9529 |
| UDP-GlcNac | 1.3564 | 0.9098 | 0.7339 |
| UDP-glucose | 1.5850 | 0.4850 | 0.9300 |
| UDP-hexose | 1.5852 | 0.4849 | 0.9299 |
| UMP | 1.2538 | 0.7422 | 1.0040 |
| uric acid | 1.0494 | 1.1463 | 0.8043 |
| uridine | 1.9609 | 0.4494 | 0.5896 |
| UTP | 1.4573 | 0.6689 | 0.8738 |
| valine | 1.2411 | 0.8659 | 0.8929 |
| valine-d8 | 0.9852 | 1.0216 | 0.9931 |
| xanthine | 1.1361 | 0.9880 | 0.8759 |
Factors:
| F1 | Phenotype:Control | Genotype:Wildtype |
| F2 | Phenotype:Mild | Genotype:R309H/c.1191+5G->C |
| F3 | Phenotype:Mild | Genotype:T450S/D332H |
