Data for (Study ST003501)
(Analysis AN005746)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 1-O-Palmitoyl-Cer(d18:1/18:0) | NA | NA | NA | NA | NA | NA |
| 24-Hydroxycholesterol | NA | NA | NA | NA | NA | NA |
| 24-Hydroxycholesterol(d7) | NA | NA | NA | NA | NA | NA |
| 3-O-SulfoLacCer(d18:1/18:0) | NA | NA | NA | NA | NA | NA |
| 4-beta-Hydroxycholesterol | NA | NA | NA | NA | NA | NA |
| 7-keto-Cholesterol | NA | NA | NA | NA | NA | NA |
| CE(16:1) | NA | NA | NA | NA | NA | NA |
| CE(18:1) | 0.9367 | 1.0442 | 1.0016 | 0.9632 | 1.0003 | 1.0254 |
| CE(18:1(d7)) | 0.9688 | 1.0161 | 0.9921 | 0.9708 | 1.0015 | 1.0242 |
| CE(18:2) | NA | NA | NA | NA | NA | NA |
| CE(20:4) | NA | NA | NA | NA | NA | NA |
| CE(20:5) | NA | NA | NA | NA | NA | NA |
| CE(22:6) | NA | NA | NA | NA | NA | NA |
| CE HETE | NA | NA | NA | NA | NA | NA |
| CE HODE | NA | NA | NA | NA | NA | NA |
| CE HpODE | NA | NA | NA | NA | NA | NA |
| CE oxoHETE | NA | NA | NA | NA | NA | NA |
| CE oxoODE | NA | NA | NA | NA | NA | NA |
| Cer(d18:0/16:0) | NA | NA | NA | NA | NA | NA |
| Cer(d18:0/18:0) | NA | NA | NA | NA | NA | NA |
| Cer(d18:0/24:0) | NA | NA | NA | NA | NA | NA |
| Cer(d18:0/24:1) | NA | NA | NA | NA | NA | NA |
| Cer(d18:1/16:0) | 1.0548 | 0.9623 | 1.0225 | 1.0393 | 0.9676 | 0.9929 |
| Cer(d18:1/16:0(d7)) | 0.9956 | 1.0008 | 1.0006 | 1.0003 | 0.9998 | 1.0018 |
| Cer(d18:1/18:0) | 1.0327 | 1.0755 | 1.0289 | 1.0302 | 0.9355 | 0.9732 |
| Cer(d18:1/24:0) | 1.0327 | 0.9488 | 1.0231 | 1.0446 | 0.9374 | 1.0409 |
| Cer(d18:1/24:1) | 1.0512 | 0.9535 | 1.0256 | 1.0432 | 0.9461 | 1.0180 |
| Cholesterol | 0.9965 | 0.9902 | 0.9865 | 1.0146 | 1.0083 | 1.0007 |
| Cholesterol(d7) | 0.9967 | 1.0005 | 1.0006 | 0.9989 | 1.0011 | 1.0007 |
| Cholesteryl hexoside | NA | NA | NA | NA | NA | NA |
| Coenzyme Q10 | 1.0083 | 0.8765 | 1.0145 | 1.0586 | 0.8528 | 1.0800 |
| DG(15:0/18:1(d7)) | 0.9901 | 1.0026 | 0.9964 | 1.0029 | 1.0004 | 1.0046 |
| DG(16:0_18:1) | 1.0347 | 0.9385 | 1.0055 | 1.0214 | 0.9835 | 1.0195 |
| DG(16:0_20:4) | 1.0799 | 0.9353 | 1.0321 | 1.0243 | 0.9580 | 1.0046 |
| DG(18:0_18:1) | 1.0125 | 0.9416 | 0.9936 | 1.0477 | 0.9825 | 1.0269 |
| DG(18:0_20:4) | 0.9964 | 0.9662 | 1.0148 | 1.0071 | 0.9891 | 1.0207 |
| DG(18:0_22:6) | 1.0377 | 0.9305 | 1.0871 | 1.0295 | 1.0137 | 0.9422 |
| DG(18:1/18:1) | 1.0124 | 0.9576 | 0.9851 | 1.0106 | 1.0004 | 1.0208 |
| DG(18:1_20:4) | 1.0836 | 0.9472 | 1.0357 | 1.0170 | 0.9453 | 1.0094 |
| GB3(d18:1/16:0) | NA | NA | NA | NA | NA | NA |
| GB3(d18:1/18:0) | NA | NA | NA | NA | NA | NA |
| GB3(d18:1/18:0(d3)) | 0.9956 | 1.0034 | 1.0014 | 1.0007 | 0.9984 | 1.0010 |
| GB3(d18:1/24:0) | NA | NA | NA | NA | NA | NA |
| GB3(d18:1/24:1) | NA | NA | NA | NA | NA | NA |
| GlcCer(d18:1/16:0(d3)) | 0.9966 | 0.9988 | 0.9996 | 1.0010 | 0.9999 | 1.0026 |
| GlcCer(d18:1(d5)/18:0) | 0.9956 | 1.0021 | 0.9998 | 0.9994 | 1.0000 | 1.0017 |
| Glucosylsphingosine(d5) | 0.9992 | 1.0035 | 1.0016 | 0.9950 | 0.9984 | 1.0013 |
| HexCer(d18:1/12:0) | NA | NA | NA | NA | NA | NA |
| HexCer(d18:1/16:0) | 1.0394 | 0.9768 | 1.0175 | 0.9995 | 1.0024 | 0.9786 |
| HexCer(d18:1/18:0) | 1.0005 | 0.9997 | 1.0014 | 1.0930 | 0.9846 | 0.9746 |
| HexCer(d18:1/22:0) | 1.0014 | 0.9542 | 1.0037 | 1.0783 | 0.9768 | 1.0129 |
| HexCer(d18:1/24:0) | 0.9842 | 0.9540 | 0.9818 | 1.1266 | 0.9871 | 1.0043 |
| HexCer(d18:1/24:1) | 0.9679 | 0.9832 | 0.9661 | 1.1400 | 1.0230 | 0.9643 |
| Hexosylsphingosine | NA | NA | NA | NA | NA | NA |
| LacCer(d18:1/16:0) | 0.9181 | 0.9711 | 0.9803 | 1.0202 | 1.0492 | 1.0138 |
| LacCer(d18:1/17:0) | 0.9965 | 1.0012 | 0.9998 | 1.0011 | 1.0006 | 1.0004 |
| LacCer(d18:1/18:0) | 1.0598 | 1.0482 | 1.0626 | 1.0345 | 0.9307 | 0.9398 |
| LacCer(d18:1/24:0) | NA | NA | NA | NA | NA | NA |
| LacCer(d18:1/24:1) | NA | NA | NA | NA | NA | NA |
| Lactosylsphingosine | NA | NA | NA | NA | NA | NA |
| LPC(16:0) | 1.0028 | 0.9910 | 0.9977 | 1.0060 | 0.9975 | 1.0048 |
| LPC(16:1) | 1.0222 | 0.9809 | 1.0051 | 1.0051 | 0.9913 | 1.0018 |
| LPC(18:0) | 1.0006 | 1.0028 | 0.9923 | 1.0057 | 0.9986 | 1.0014 |
| LPC(18:1) | 1.0028 | 0.9999 | 0.9967 | 1.0024 | 0.9981 | 1.0013 |
| LPC(18:1(d7)) | 0.9972 | 1.0022 | 1.0007 | 0.9988 | 1.0013 | 0.9992 |
| LPC(20:4) | 1.0229 | 0.9942 | 1.0070 | 1.0048 | 0.9771 | 1.0070 |
| LPC(22:6) | 1.0388 | 1.0004 | 1.0114 | 1.0060 | 0.9668 | 1.0018 |
| LPC(24:0) | NA | NA | NA | NA | NA | NA |
| LPC(24:1) | NA | NA | NA | NA | NA | NA |
| LPC(26:0) | 0.9948 | 0.9880 | 1.0132 | 0.9827 | 1.0077 | 1.0020 |
| LPC(26:1) | NA | NA | NA | NA | NA | NA |
| lyso-GB3 | NA | NA | NA | NA | NA | NA |
| lyso-GB3-d7 | 0.9936 | 1.0003 | 1.0031 | 0.9992 | 0.9988 | 1.0033 |
| lyso-GB4 | NA | NA | NA | NA | NA | NA |
| MG(16:0) | NA | NA | NA | NA | NA | NA |
| MG(16:1) | NA | NA | NA | NA | NA | NA |
| MG(18:0) | NA | NA | NA | NA | NA | NA |
| MG(18:1) | 1.0858 | 0.9827 | 0.9885 | 0.9995 | 0.9738 | 0.9880 |
| MG(18:1(d7)) | 1.0026 | 1.0022 | 1.0017 | 1.0129 | 0.9961 | 0.9947 |
| MG(20:4) | NA | NA | NA | NA | NA | NA |
| N-Oleoylethanolamine | NA | NA | NA | NA | NA | NA |
| N-Palmitoyl-O-phosphocholineserine | NA | NA | NA | NA | NA | NA |
| Palmitoylethanolamine | NA | NA | NA | NA | NA | NA |
| PC(15:0/18:1(d7)) | 0.9986 | 1.0008 | 1.0000 | 0.9997 | 1.0004 | 1.0001 |
| PC(16:0/5:0(CHO)) | 0.9937 | 0.9440 | 1.0020 | 1.0075 | 0.9330 | 1.0982 |
| PC(16:0/9:0(CHO)) | 0.9555 | 1.0003 | 1.0056 | 1.0125 | 0.9613 | 1.0553 |
| PC(16:0/9:0(COOH)) | 0.9854 | 0.9913 | 1.0261 | 1.0122 | 0.9854 | 1.0077 |
| PC(18:0/20:4(OH[S])) | NA | NA | NA | NA | NA | NA |
| PC(18:0/20:4(OOH[S])) | NA | NA | NA | NA | NA | NA |
| PC(34:1) | 1.0289 | 0.9788 | 1.0166 | 1.0133 | 0.9728 | 1.0076 |
| PC(36:1) | 0.9874 | 0.9923 | 0.9940 | 1.0275 | 0.9963 | 1.0070 |
| PC(36:2) | 1.0431 | 0.9708 | 1.0157 | 1.0167 | 0.9751 | 1.0008 |
| PC(36:4) | 1.0325 | 0.9714 | 1.0229 | 1.0120 | 0.9603 | 1.0192 |
| PC(38:4) | 1.0154 | 0.9681 | 1.0249 | 1.0080 | 0.9593 | 1.0325 |
| PC(38:6) | 1.0343 | 0.9832 | 1.0218 | 1.0131 | 0.9588 | 1.0131 |
| PC(40:5) | 1.0139 | 0.9705 | 1.0220 | 1.0109 | 0.9662 | 1.0255 |
| PC(40:6) | 1.0036 | 0.9941 | 1.0180 | 1.0073 | 0.9636 | 1.0244 |
| PC(O-16:0/0:0) | 1.0061 | 1.0019 | 1.0012 | 1.0046 | 0.9963 | 0.9965 |
| PC(O-16:0/2:0) | NA | NA | NA | NA | NA | NA |
| PC(O-18:0/2:0) | 1.0064 | 0.9936 | 0.9770 | 1.0254 | 1.0008 | 1.0014 |
| PE(15:0/18:1(d7)) | 0.9957 | 1.0022 | 1.0004 | 1.0000 | 1.0004 | 1.0005 |
| PE(18:0/20:4(OH[S])) | NA | NA | NA | NA | NA | NA |
| PE(18:0/20:4(OOH[S])) | NA | NA | NA | NA | NA | NA |
| PE(34:1) | 1.0614 | 0.9788 | 1.0256 | 1.0388 | 0.9745 | 0.9713 |
| PE(36:1) | 0.9868 | 0.9788 | 0.9897 | 1.0547 | 1.0069 | 0.9953 |
| PE(36:2) | 1.0390 | 0.9856 | 0.9967 | 1.0452 | 1.0153 | 0.9531 |
| PE(36:4) | 1.0736 | 0.9590 | 1.0408 | 1.0243 | 0.9448 | 1.0029 |
| PE(38:4) | 1.0166 | 0.9756 | 1.0204 | 1.0124 | 0.9723 | 1.0151 |
| PE(38:5) | 1.0480 | 0.9574 | 1.0205 | 1.0205 | 0.9707 | 1.0057 |
| PE(38:6) | 1.0538 | 0.9844 | 1.0256 | 1.0223 | 0.9642 | 0.9898 |
| PE(40:4) | 1.0029 | 0.9924 | 1.0069 | 1.0228 | 0.9982 | 0.9908 |
| PE(40:5) | NA | NA | NA | NA | NA | NA |
| PE(40:6) | 1.0027 | 0.9877 | 1.0169 | 1.0109 | 0.9697 | 1.0214 |
| PE(40:7) | 1.0543 | 0.9729 | 1.0291 | 1.0239 | 0.9626 | 0.9950 |
| Sitosteryl hexoside | 0.9868 | 1.0095 | 1.0160 | 1.0960 | 0.9911 | 0.9588 |
| SM(d18:1/16:0) | 1.0031 | 0.9997 | 0.9923 | 1.0084 | 1.0094 | 0.9898 |
| SM(d18:1/18:0) | 0.9963 | 0.9863 | 1.0051 | 1.0277 | 0.9827 | 1.0124 |
| SM(d18:1/24:0) | 0.9965 | 0.9685 | 1.0030 | 1.0288 | 0.9726 | 1.0333 |
| SM(d18:1/24:1) | 1.0008 | 0.9750 | 1.0025 | 1.0186 | 0.9912 | 1.0133 |
| SM(d18:1(d9)/18:1) | 0.9979 | 1.0002 | 1.0005 | 0.9989 | 1.0002 | 1.0010 |
| Sphinganine | NA | NA | NA | NA | NA | NA |
| Sphinganine 1-phosphate | NA | NA | NA | NA | NA | NA |
| Sphingosine | NA | NA | NA | NA | NA | NA |
| Sphingosine 1-phosphate | NA | NA | NA | NA | NA | NA |
| Sphingosine 1-phosphate-d7 | NA | NA | NA | NA | NA | NA |
| Sphingosine 1-phosphocholine | NA | NA | NA | NA | NA | NA |
| Sphingosine(d17:1) | 0.9987 | 1.0007 | 1.0022 | 1.0017 | 0.9951 | 1.0033 |
| TG(15:0/18:1(d7)/15:0) | 0.9637 | 1.0191 | 0.9906 | 0.9776 | 1.0015 | 1.0233 |
| TG(18:0_36:2) | 1.0001 | 0.9835 | 1.0261 | 0.9980 | 0.9899 | 1.0055 |
| TG(18:1_34:2) | 0.9912 | 0.9933 | 0.9901 | 1.0054 | 0.9979 | 1.0143 |
| TG(18:1_34:3) | NA | NA | NA | NA | NA | NA |
| TG(20:4_32:1) | NA | NA | NA | NA | NA | NA |
| TG(20:4_34:2) | NA | NA | NA | NA | NA | NA |
| TG(20:4_34:3) | NA | NA | NA | NA | NA | NA |
| TG(20:4_36:0) | NA | NA | NA | NA | NA | NA |
| TG(20:4_36:2) | NA | NA | NA | NA | NA | NA |
| TG(20:4_36:3) | NA | NA | NA | NA | NA | NA |
| TG(22:6_36:2) | NA | NA | NA | NA | NA | NA |
| TG(22:6_38:1) | NA | NA | NA | NA | NA | NA |
| TG(22:6_38:2) | NA | NA | NA | NA | NA | NA |
Factors:
| F1 | genotype:APP | condition:high | group:high_disease | Sample source:microglia |
| F2 | genotype:APP | condition:low | group:low_disease | Sample source:microglia |
| F3 | genotype:APP | condition:mid | group:mid_disease | Sample source:microglia |
| F4 | genotype:NA | condition:NA | group:NA | Sample source:microglia |
| F5 | genotype:WT | condition:low | group:low_healthy | Sample source:microglia |
| F6 | genotype:WT | condition:mid | group:mid_healthy | Sample source:microglia |
