Data for (Study ST003551)

(Analysis AN005837)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8
10-HYDROXYDECANOATE 1.0313 0.9817 0.9578 0.9718 1.2652 1.1478 0.8383 0.9241
1-METHYLNICOTINAMIDE_NF 1.0843 1.2430 0.8424 0.6841 1.2845 1.5252 1.1034 0.8007
2,3-DIHYDROXYBENZOATE 1.5143 1.0690 0.5648 1.0054 1.4873 1.2736 0.5580 0.8336
2,3-DIPHOSPHO-D-GLYCERIC ACID 1.0665 0.4764 0.8890 1.3265 1.3481 0.5903 0.7494 1.1322
2-HYDROXYGLUTARIC ACID 1.0548 0.7967 1.0701 1.1252 0.9889 0.8007 0.9940 1.0106
2-OXOADIPIC ACID 0.6128 0.7121 0.7022 2.1100 0.6545 1.1890 0.7796 0.6145
2-PHOSPHOGLYCERATE 1.0130 0.6831 1.2761 1.0982 0.9655 0.6981 1.2348 0.9205
3-HYDROXYMETHYLGLUTARATE 1.0535 1.0704 1.1469 1.1092 0.8783 0.9026 0.8958 0.8925
3-METHYL-2-OXOBUTYRATE 0.9925 0.7593 0.8686 1.0347 1.2877 0.9259 0.7595 1.1905
3-PHOSPHOGLYCERATE 1.0127 0.6831 1.2759 1.0984 0.9653 0.6978 1.2345 0.9210
3-SULFINOALANINE 0.8702 1.2863 0.6361 0.4587 1.4295 1.7907 1.1958 0.9976
4-GUANIDINOBUTANOATE 1.6147 1.9275 0.4895 0.4625 1.6242 2.0303 0.5869 0.4860
4-HYDROXY-L-PROLINE 1.0666 1.0000 1.0856 1.0055 1.0275 0.9754 1.0232 0.8911
4-IMIDAZOLEACETATE 0.6800 0.5025 0.8123 1.6328 0.6690 0.5183 0.7219 1.4466
4-PYRIDOXATE 0.8468 0.8970 1.1785 0.9673 0.8798 0.9572 1.3843 0.9312
5-METHYLCYTIDINE 1.1263 0.9285 1.0482 1.0239 1.0915 0.8969 0.9262 0.9593
6-PHOSPHOGLUCONATE 1.0428 0.7494 1.1372 1.2545 0.8254 0.6389 1.3167 0.8674
ADENOSINE 2^,3^-CYCLIC PHOSPHATE 1.0161 0.7970 1.0437 1.1575 0.9787 0.8368 0.9887 1.0048
ADENOSINE DIPHOSPHATE RIBOSE_NF 1.1254 0.3940 1.1984 1.7196 0.0516 0.0877 1.9400 0.8488
ADP / dGDP 1.1352 1.0168 0.9526 1.0951 1.1082 0.9631 0.8670 0.8913
AICAR 0.7525 0.6613 1.2230 1.3806 0.5994 0.5260 1.0873 1.1575
ALANINE / SARCOSINE 0.9365 0.7451 1.0964 1.1272 0.9301 0.7720 1.0538 1.0897
ALPHA-HYDROXYISOBUTYRATE 1.0450 0.9515 0.9395 1.0602 1.0582 0.9830 0.9872 0.9677
ALPHA-KETOGLUTARIC ACID 0.9025 0.8015 1.1215 1.1377 1.0173 0.8367 0.9450 1.0298
AMINOADIPATE 0.3379 0.1449 0.7442 3.4856 0.1162 0.0391 0.3714 0.6802
AMP / dGMP 1.0828 1.0765 1.0569 1.0128 0.9755 0.8762 1.1049 0.8913
ARGININE 0.4408 0.2612 0.7994 1.8586 0.4528 0.2918 0.7218 1.6909
ARGININOSUCCINIC ACID 0.7854 0.6009 1.1857 1.2836 0.7617 0.5761 1.1034 1.1789
ASPARAGINE 0.9043 1.1504 0.9573 0.9553 0.9922 1.2189 0.8977 0.9915
ASPARTATE 1.0115 0.9486 0.9798 1.1011 0.9930 0.9457 0.9106 1.0077
ATP / dGTP 1.0078 0.8390 0.9975 1.1116 1.0837 0.9004 0.9552 0.9971
BETA-ALANINE 0.7724 0.5651 1.0194 1.2942 0.7736 0.5865 1.0891 1.2995
BETA-GLYCEROPHOSPHATE 0.9547 2.2397 0.7405 0.5285 1.0002 2.2123 0.8563 0.5128
BETA-HYDROXY(ISO)BUTYRATE 0.9464 0.7393 1.0037 1.1508 0.9448 0.7677 1.0310 1.1321
BETAINE 0.8522 0.9613 0.8988 1.1625 0.9640 1.0221 1.0219 0.9944
BUTYRYL-L-CARNITINE 0.8354 0.7933 1.0676 1.2423 0.7802 0.7480 1.0107 1.1289
CARNOSINE 0.7670 0.8109 1.0572 1.0714 0.8145 0.8575 1.2252 1.1529
CDP-ETHANOLAMINE 0.5685 0.8073 0.9239 0.9428 0.8642 1.0485 1.5323 1.1975
CIS-ACONITIC ACID 1.0514 1.0007 1.0362 1.0052 1.0643 0.9684 0.9673 0.9447
CITICOLINE 0.8740 0.9598 0.8991 0.9009 1.0626 1.2011 1.2320 1.0016
CITRATE / ISOCITRATE 1.0714 1.0276 0.9641 0.9762 1.1124 1.0476 0.9814 0.9276
COENZYME A 1.0676 0.7329 0.8940 1.2653 0.9888 0.7254 0.9534 1.0714
CREATINE 0.7327 0.6316 1.0415 1.2140 0.8367 0.7487 1.0548 1.2561
CREATININE 0.5945 0.3037 1.4099 1.3732 0.4422 0.3306 1.1317 1.4522
CYCLIC AMP 1.0329 0.8154 1.0531 1.1654 0.9717 0.8239 0.9756 0.9894
CYS-GLY 0.9734 0.9345 1.0302 1.0739 1.0605 0.9303 0.9067 1.0033
CYSTATHIONINE 1.0903 1.0107 0.9562 0.9353 1.1194 1.0653 0.9536 0.9742
CYSTEATE 0.9659 1.2263 0.9240 0.7622 1.1246 1.4930 1.0329 0.8672
CYTIDINE 0.8136 0.7157 1.1837 1.0724 0.9073 0.8370 1.2396 1.0486
CYTIDINE DIPHOSPHATE 0.9853 0.7779 0.9260 1.1512 1.1185 0.8450 0.8778 1.0960
CYTIDINE MONOPHOSPHATE 0.8269 0.9268 1.0742 1.1364 0.8564 0.9355 1.0416 1.0205
CYTIDINE TRIPHOSPHATE 0.9917 0.6798 1.0178 1.2126 1.0513 0.7306 0.9305 1.0836
CYTOSINE_iso1 0.8637 0.6410 1.0325 1.1888 0.9221 0.7227 1.0598 1.1848
DEOXYADENOSINE 0.9841 0.6551 1.0820 1.2014 1.0155 0.7286 0.8585 1.1231
DEOXYADENOSINE TRIPHOSPHATE 1.0009 0.7314 0.9697 1.1514 1.0655 0.7798 0.9419 1.1091
DEOXYCARNITINE 0.6737 0.6586 1.0827 1.3409 0.6437 0.6326 1.1066 1.2463
DEOXYCYTIDINE 0.8682 0.6522 1.0828 1.1658 0.9077 0.7199 1.0959 1.1570
DEOXYCYTIDINE DIPHOSPHATE 0.9058 0.7004 0.9739 1.1307 1.2877 0.7460 0.8392 1.1472
DEOXYCYTIDINE MONOPHOSPHATE 0.8736 0.6231 1.0745 1.2864 0.7616 0.6839 1.0537 1.1660
DEOXYCYTIDINE TRIPHOSPHATE 1.0193 0.7916 0.9849 1.0791 1.1381 0.8144 0.9272 1.0857
DEOXYGUANOSINE 0.8087 0.9361 0.9809 0.8426 1.0639 1.2379 1.2001 1.0467
DEOXYURIDINE MONOPHOSPHATE 0.8180 0.6908 1.0072 1.0095 0.9658 0.7836 0.8291 1.4420
D-GLUCOSE 1.0172 1.1891 0.9874 0.9795 0.9935 1.1609 0.9045 0.8962
DIETHANOLAMINE 1.0339 0.9876 0.9658 1.0424 1.0717 1.0310 0.9169 0.9599
DIHYDROBIOPTERIN 1.0212 0.8216 1.0336 1.1611 0.8109 0.6931 1.0999 1.0932
DIHYDROOROTATE 0.7694 0.3299 1.3371 1.4593 0.4266 0.3392 1.4057 1.1806
DIHYDROXYACETONE PHOSPHATE 1.0255 1.4647 0.5839 0.8148 1.4177 1.1600 0.4376 1.2098
D-RIBOSE 5-PHOSPHATE 1.0367 0.8332 0.8425 1.1304 1.1737 0.9052 0.7613 1.1196
DTDP-D-GLUCOSE 0.9539 0.7853 0.9969 1.1859 0.9942 0.8006 0.8852 1.1066
ETHYL 3-UREIDOPROPIONATE 0.9775 0.7568 1.0979 1.0937 1.0103 0.9480 0.9573 1.0160
FRUCTOSE 6-PHOSPHATE 1.0556 1.0136 0.9356 1.0876 1.0327 0.9862 0.8324 0.9951
FRUCTOSE BISPHOSPHATE 1.1612 0.7774 0.8835 1.0891 1.2680 0.9477 0.8474 0.9876
FUMARATE 1.0051 0.7202 1.0184 1.1915 0.9883 0.7209 0.9669 1.0955
GALACTITOL 0.9049 1.0564 1.0447 1.0092 1.1499 1.0355 0.9232 0.9261
GAMMA-AMINOBUTYRATE 0.6484 0.5753 0.9719 1.4663 0.6364 0.5715 0.9665 1.3534
GDP-MANNOSE 0.9995 0.9489 1.0026 1.1015 0.9730 0.9242 1.0169 0.9655
GLUCOSAMINE 6-PHOSPHATE 1.0022 0.9099 1.0369 1.0531 1.0431 0.8791 0.9800 1.0152
GLUCOSE 6-PHOSPHATE 0.9654 1.0371 0.9783 1.0605 0.9630 1.0182 0.9385 0.9929
GLUCURONATE 1.0195 0.9458 0.9624 1.0121 1.0690 1.0063 1.0212 0.9820
GLUTAMATE 1.1002 1.0651 0.9950 0.9773 1.0778 1.0478 0.9319 0.9147
GLUTAMINE 1.0608 1.0523 1.0110 0.9988 1.0193 1.0260 0.9528 0.9383
GLUTATHIONE OXIDIZED 0.9562 0.8506 1.0309 1.1346 0.9266 0.9646 1.1654 0.9131
GLUTATHIONE REDUCED 1.0371 0.9918 0.9730 1.0488 1.0895 0.9605 0.8770 0.9912
GLYCERALDEHYDE 3-PHOSPHATE 0.9513 0.6966 0.9923 1.1438 1.0632 0.6666 0.9224 1.2112
GLYCEROL 3-PHOSPHATE 0.9040 1.0352 1.0931 0.9800 0.9411 1.0562 1.1069 0.9362
GLYCEROPHOSPHOCHOLINE 1.0800 2.3499 0.7592 0.4857 1.0140 2.1520 0.8688 0.4425
GLYCINE 1.1333 1.0886 0.9622 0.9729 1.0784 1.0769 0.9089 0.9092
GLYCOCHENODEOXYCHOLATE 1.0614 1.0421 1.0204 1.0559 0.9509 1.0211 0.8797 0.9528
GUANIDINOACETATE 0.3556 0.1836 0.7538 2.0160 0.3693 0.1787 0.7635 1.7227
GUANOSINE 0.8338 0.8824 0.9947 0.8013 1.0716 1.2384 1.3170 1.0306
GUANOSINE DIPHOSPHATE 1.0285 1.0019 0.9474 1.0967 1.0692 1.0004 0.9117 0.9325
GUANOSINE MONOPHOSPHATE 0.7095 0.7484 1.1949 1.3838 0.6748 0.6905 1.3739 0.8877
GUANOSINE TRIPHOSPHATE 1.0078 0.8604 0.9454 1.0878 1.1609 0.9833 0.8773 1.0038
HYPOTAURINE 0.8027 0.7512 1.0800 1.1827 0.7827 0.7255 1.1439 1.1609
HYPOXANTHINE 0.8329 0.7527 0.8360 0.7018 0.9291 1.0009 0.7651 1.7672
INDOLE-3-LACTIC ACID 0.9379 0.9246 1.1230 1.1137 0.8102 0.8501 1.1910 0.9474
INOSINE 0.8521 0.7755 0.8232 0.6882 0.8957 0.9899 0.6984 1.8239
INOSINE MONOPHOSPHATE 1.2120 0.8069 1.0864 1.0581 1.0254 0.8878 0.9779 0.9293
ISOLEUCINE 1.0064 1.0003 1.0159 1.0260 0.9831 0.9775 0.9601 0.9997
ISOPENTENYL PYROPHOSPHATE 1.0093 0.9264 0.9211 1.1037 1.1868 0.9809 0.8314 0.9815
KYNURENINE 1.2510 1.3368 0.6213 0.8171 1.3876 1.3248 0.6281 0.9712
LACTATE 0.9280 0.6972 0.9908 1.1265 1.0150 0.7643 1.0564 1.1492
L-CARNITINE 0.7482 0.8074 1.0951 1.2540 0.6985 0.7602 1.1127 1.1192
LEUCINE 0.9936 0.9793 0.9961 1.0453 0.9707 0.9588 0.9637 1.0243
LYSINE 0.3899 0.2092 0.6181 2.0345 0.3924 0.2347 0.5879 1.8131
MALATE 0.9827 0.7340 1.0620 1.1707 0.9626 0.7252 0.9957 1.0879
MALEATE 0.8839 0.8790 0.6880 0.8688 1.5919 1.6523 0.8049 0.9332
METHIONINE 1.0910 1.0598 1.0311 1.0319 1.0252 1.0091 0.9066 0.9016
METHYL GALACTOSIDE_NF 0.8083 0.8023 1.0743 1.0458 0.8278 0.9232 1.2941 1.0769
METHYLTHIOADENOSINE 0.9943 0.8591 1.0233 1.1758 1.0797 0.9143 0.8406 0.9647
N6-(DELTA2-ISOPENTENYL)-ADENINE 0.8030 0.5946 1.1233 1.1119 1.0137 0.8567 1.1113 1.1162
N-ACETYLALANINE 1.2358 1.3670 0.9159 1.0489 0.9807 0.8804 0.8232 0.8636
N-ACETYLASPARTATE 1.0656 1.0158 1.0941 0.9857 1.0487 0.9903 0.9825 0.9001
N-ACETYLCYSTEINE 0.9393 1.1400 1.0009 0.8651 1.0750 1.1745 1.0368 0.9514
N-ACETYLGLUCOSAMINE / MANNOSAMINE / GALACTOSAMINE 0.9721 0.9088 1.0324 1.0890 1.0017 0.9096 0.9767 1.0050
N-ACETYLGLUTAMATE 1.0909 1.1060 1.1173 0.8646 1.0861 1.0814 1.0745 0.8378
N-ACETYLMETHIONINE 0.9413 0.9864 1.0993 1.0827 0.9112 0.9282 0.9937 0.9707
N-ACETYLNEURAMINATE 0.8032 2.2509 0.7112 0.6832 0.8378 2.0876 0.7145 0.6624
N-ACETYLPHENYLALANINE 0.9644 1.1901 0.8637 0.8339 1.2582 1.3502 0.9389 0.9061
N-ACETYLPUTRESCINE 0.7791 0.2526 1.2474 1.5246 0.7068 0.2383 0.9951 1.3245
N-ACETYLSERINE 0.9941 1.0072 1.0887 1.0142 0.9837 0.9980 1.0216 0.9244
NAD 0.9876 0.9121 0.9938 1.0912 1.0244 0.9184 0.9229 1.0303
NADH 0.9326 0.9826 1.7976 1.3751 0.4349 0.3246 1.1198 0.6959
NADP 1.0501 1.0012 0.8815 1.0779 1.1644 1.0253 0.6911 1.0350
N-EPSILON-ACETYLLYSINE 1.2158 1.4007 1.0756 0.6627 1.2541 1.4737 0.9923 0.6186
N-FORMYL-L-METHIONINE 0.9632 1.0643 1.0601 1.0803 0.8855 0.9495 1.0130 0.9419
NICOTINAMIDE 0.9151 0.8371 1.1413 1.1589 0.8787 0.8783 0.9477 1.0185
N,N-DIMETHYLARGININE 1.0342 1.8230 0.8083 0.6398 1.1222 1.9764 0.7774 0.6214
N,N,N-TRIMETHYLLYSINE 1.1558 1.7597 0.9158 0.4957 1.3056 1.9892 0.9239 0.4933
NORADRENALINE 0.9654 0.8741 1.0476 1.1393 0.9351 0.8439 0.9816 1.0289
O-ACETYLCARNITINE 0.8689 0.9045 1.2753 1.0473 0.8117 0.8513 1.2748 0.9136
O-PHOSPHOETHANOLAMINE 0.2109 0.3534 1.3311 1.0029 0.4210 0.8346 2.1568 1.2880
ORNITHINE 0.8213 0.8496 0.8626 1.3126 0.8366 0.8664 0.7365 1.2238
OROTATE 0.7485 0.4011 1.1178 1.4066 0.7598 0.5377 0.9683 1.3072
OXALATE 0.8246 0.8035 0.8528 0.7779 1.5747 1.6525 1.0503 0.8674
OXALOACETATE 1.0988 1.0533 0.9730 0.9928 1.1389 1.0022 0.9301 0.9135
PANTOTHENATE 0.9226 0.9850 1.0897 1.1521 0.8323 0.8675 1.0103 0.9793
PHENYLALANINE 1.0211 0.9481 1.0190 1.0820 0.9856 0.9362 0.9347 0.9924
PHOSPHOCREATINE 0.7057 0.5788 1.0318 1.4325 0.6283 0.5096 1.0514 1.3094
PHOSPHOENOLPYRUVATE 1.0958 0.7901 1.1516 1.1346 0.9579 0.7045 1.0634 0.9585
PHOSPHORIBOSYL PYROPHOSPHATE_NF 1.3529 0.9039 0.9105 1.0108 1.5081 1.0226 0.6729 0.8187
PHOSPHORYLCHOLINE 1.0420 1.0078 0.9975 1.0310 0.9948 0.9879 0.9735 0.9676
PHOSPHOSERINE 1.0622 0.8508 0.9898 1.1983 1.0615 0.8638 0.8051 0.9867
PIPECOLATE 0.6978 0.6978 0.6978 0.6469 0.5096 0.6058 0.7242 2.4371
PIPERIDINE 6-CARBOXYLATE (P6C / P2C) 0.0098 0.0071 0.0124 0.0305 0.5292 0.1662 0.4565 4.5435
P-OCTOPAMINE 0.8013 0.8137 1.2249 1.1265 0.8225 0.8072 1.1551 1.0237
PROLINE 0.9945 0.9468 0.9882 1.0963 0.9434 0.9205 0.9527 1.0327
PROPIONYL-L-CARNITINE 0.6408 0.6518 1.0574 1.4212 0.5895 0.6063 1.0111 1.2908
PTERIN 0.9518 0.9977 0.9809 0.8772 1.0477 1.2875 1.3243 0.8310
PYRIDOXINE 0.9651 0.8746 1.0471 1.1394 0.9364 0.8434 0.9822 1.0283
PYROGLUTAMATE 1.0109 0.8845 1.1017 1.0803 0.9545 0.8689 0.9550 1.0150
RIBOFLAVIN 0.8473 0.7170 1.7607 1.2732 0.4820 0.4094 1.5605 0.7115
RIBOSE 1,5-BISPHOSPHATE 1.1659 1.0522 0.9890 0.9252 1.1404 1.1128 0.9583 0.8674
SACCHAROPINE 0.1738 0.1373 0.2661 0.7062 0.7848 0.6255 1.2755 2.7846
S-ADENOSYLHOMOCYSTEINE 0.8263 0.5334 1.2138 1.4267 1.0251 0.6349 1.0887 0.8766
S-ADENOSYLMETHIONINE 0.9903 0.8170 0.9781 1.0642 1.0187 0.8761 0.9890 1.1048
SERINE 1.1031 1.2064 0.9406 0.9453 1.0688 1.2047 0.8814 0.8620
SUCCINATE 0.9356 0.7277 1.0214 1.1267 0.9482 0.7171 1.0854 1.1520
TARTRATE / MESO-TARTRATE 0.6908 0.8194 0.6420 0.5822 2.0587 2.1936 0.8929 0.8288
TAURINE 0.8025 0.7251 1.0499 1.2129 0.7913 0.7204 1.0877 1.1903
THREITOL 0.8320 0.9612 1.0916 1.0325 0.8194 0.9266 1.2487 1.0125
THREONINE 1.1076 1.1132 1.0257 0.9493 1.1056 1.0609 0.9082 0.8858
THYMIDINE MONOPHOSPHATE 0.7966 0.5256 0.9933 1.1625 0.8971 0.6511 1.1109 1.3513
THYMIDINE_NF 0.8742 0.7952 1.0650 1.0275 0.9215 0.9149 1.2906 1.0309
TRYPTOPHAN 0.9373 0.9294 1.0842 1.0800 0.9572 0.9113 0.9794 1.0066
TYROSINE 0.9960 0.9455 1.0261 1.0645 0.9961 0.9446 0.9536 1.0002
UDP-GLUCOSE / GALACTOSE 1.0133 0.7644 0.9744 1.1915 0.9971 0.7566 0.9197 1.1001
UDP-GLUCURONIC ACID 1.0268 0.8793 0.9824 1.0737 1.0725 0.8954 0.9618 1.0201
UDP-N-ACETYLGALACTOSAMINE / GLUCOSAMINE 1.0305 0.7966 1.0520 1.1462 0.9907 0.8073 0.9567 1.0282
URIDINE 0.8612 0.8832 0.9602 0.8998 1.0859 1.2329 1.0849 1.0526
URIDINE 5^-DIPHOSPHATE 1.0058 0.8516 0.9456 1.1140 1.1423 0.8741 0.8827 1.0441
URIDINE MONOPHOSPHATE 0.9104 0.5868 1.7148 1.1476 0.5228 0.4439 1.4508 0.9185
URIDINE TRIPHOSPHATE 0.9870 0.7031 1.0317 1.1852 1.0539 0.7459 0.9974 1.0500
UROCANATE 0.7665 0.8226 1.1812 1.0528 0.7825 0.8042 1.0586 1.2092
VALERYL-L-CARNITINE 0.7751 0.8889 1.0105 1.3303 0.6738 0.7576 0.9382 1.1460
VALINE 1.0262 1.0160 1.0193 1.0179 1.0036 1.0087 0.9601 0.9620
XANTHINE 0.2253 0.2099 1.5841 1.2425 0.2158 0.2521 2.2355 1.2988
XANTHOSINE-MONOPHOSPHATE 1.0261 0.7625 1.0340 1.1239 1.1880 0.7759 0.7675 1.0934
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Genotype:CRISPR/Cas9 Control (sgTomato) | Treatment:N-methyl-arginine (10 mM)
F2Genotype:CRISPR/Cas9 Control (sgTomato) | Treatment:N-methyl-arginine (20 mM)
F3Genotype:CRISPR/Cas9 Control (sgTomato) | Treatment:N-methyl-arginine (5 mM)
F4Genotype:CRISPR/Cas9 Control (sgTomato) | Treatment:PBS
F5Genotype:CRISPR/Cas9 KO (sgALDH7A1) | Treatment:N-methyl-arginine (10 mM)
F6Genotype:CRISPR/Cas9 KO (sgALDH7A1) | Treatment:N-methyl-arginine (20 mM)
F7Genotype:CRISPR/Cas9 KO (sgALDH7A1) | Treatment:N-methyl-arginine (5 mM)
F8Genotype:CRISPR/Cas9 KO (sgALDH7A1) | Treatment:PBS
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