Data for (Study ST003603)
(Analysis AN005919)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 |
|---|---|---|---|---|---|---|---|---|---|
| 1-4-beta-D-Xylan | 1.0680 | 1.5825 | 0.8335 | 0.2772 | 1.1361 | 2.1464 | 1.2157 | 0.6499 | 0.0906 |
| 2/3-Phospho-D-glycerate | 0.6424 | 1.1033 | 0.5746 | 0.2681 | 0.8328 | 1.9444 | 0.8055 | 2.3046 | 0.5243 |
| 2-Hydroxyglutarate/Citramalate | 1.0571 | 1.6498 | 0.8690 | 0.1550 | 1.3232 | 1.5803 | 1.5945 | 0.6614 | 0.1098 |
| 2-Oxoglutarate | 1.2651 | 1.2328 | 0.8332 | 0.1269 | 2.2635 | 0.7431 | 1.7621 | 0.3415 | 0.1476 |
| 2-Oxoglutarate 13C3 | NA | 1.2928 | NA | 0.8271 | NA | 0.8268 | NA | 0.7962 | 1.2571 |
| 2-Oxoglutarate 13C5 | NA | 1.0090 | NA | 0.5510 | NA | 1.0107 | NA | 1.3123 | 1.1169 |
| 3^,5^-Cyclic IMP | 1.0689 | 1.1291 | 0.9223 | 1.0208 | 0.6553 | 1.0126 | 0.9690 | 1.0396 | 1.1824 |
| 3-Phosphonooxypyruvate | 1.1043 | 0.9455 | 0.9779 | 0.5322 | 1.0565 | 1.0556 | 1.4081 | 1.1366 | 0.7833 |
| 5-6-Dihydrothymine | 1.1040 | 0.5458 | 0.8928 | 1.3305 | 1.0116 | 0.9187 | 0.9826 | 1.0227 | 1.1913 |
| 5-6-Dihydrouracil | 1.2770 | 0.8027 | 0.9164 | 1.0261 | 0.8746 | 0.9770 | 1.2261 | 0.9594 | 1.0162 |
| 6-Phospho-D-gluconate | NA | 0.7477 | 0.4240 | 1.1185 | 0.7882 | 0.9922 | 1.3214 | 1.4346 | 0.9633 |
| ADP | 0.6757 | 2.0229 | 0.6727 | 1.2293 | 0.1763 | 1.7858 | 0.6975 | 1.1205 | 0.6193 |
| ADP 13C1 | NA | 1.1354 | NA | 1.1068 | NA | 1.0212 | NA | 0.8915 | 0.8451 |
| ADP 13C2 | NA | 1.1953 | NA | 1.0272 | NA | 1.0002 | NA | 0.9155 | 0.8618 |
| ADP-D-ribose | 0.7807 | 0.8049 | 0.3525 | 0.7042 | 0.9858 | 1.5195 | 1.7789 | 1.2539 | 0.8196 |
| a-Linolenic acid (Octadecatrienoic acid) | 1.6503 | 1.3695 | 0.9562 | 0.6861 | 1.2117 | 0.5372 | 0.8794 | 0.6147 | 0.9710 |
| alpha-D-Glucosamine 1-phosphate | 1.2989 | 0.9008 | 1.1625 | 0.6000 | 1.3216 | 1.1830 | 1.0754 | 1.1719 | 0.2858 |
| alpha-D-Ribose 1-phosphate | 1.4968 | 1.0964 | 1.3393 | 0.3967 | 1.0106 | 1.0284 | 1.2339 | 0.9471 | 0.4508 |
| AMP | 0.8921 | 1.1264 | 0.8201 | 0.4933 | 0.5609 | 2.0096 | 0.9037 | 1.5785 | 0.6153 |
| AMP 13C10 | NA | 0.7764 | NA | NA | NA | NA | NA | 2.1357 | 0.0879 |
| AMP 13C2 | NA | 1.3737 | NA | 0.0516 | NA | 1.1216 | NA | 1.3679 | 0.4529 |
| AMP 13C4 | NA | 1.1841 | NA | NA | NA | NA | NA | 1.1161 | 0.0995 |
| AMP 13C5 | NA | 1.5584 | NA | NA | NA | NA | NA | 1.3154 | 0.1262 |
| AMP 13C6 | NA | 1.3719 | NA | 0.4276 | NA | 0.7368 | NA | 1.4637 | NA |
| AMP 13C7 | NA | 0.5858 | NA | 0.4852 | NA | NA | NA | 2.2492 | 0.6797 |
| AMP 13C8 | NA | 0.7938 | NA | NA | NA | NA | NA | 1.4040 | 0.4065 |
| AMP 13C9 | NA | 0.6924 | NA | NA | NA | NA | NA | 1.6222 | 0.0562 |
| Arachidonic acid (Eicosatetraenoic acid) | 2.3803 | 0.6020 | 1.0057 | 0.7185 | 1.2024 | 1.0140 | 1.1152 | 0.6386 | 0.3232 |
| Argininosuccinate | 0.8097 | 0.4577 | 0.6704 | 0.6165 | 0.3409 | 0.2927 | 0.4059 | 4.6525 | 0.5179 |
| Ascorbate | 1.0623 | 0.9511 | 0.8347 | 0.0689 | 1.8418 | 0.9374 | 1.7291 | 1.4444 | 0.1301 |
| Citrate | 1.4903 | 1.3836 | 1.4783 | 0.3464 | 0.6187 | 0.8853 | 1.2417 | 1.0496 | 0.5060 |
| Citrate 13C2 | NA | 1.0738 | NA | NA | NA | 0.3320 | NA | 1.1489 | NA |
| CMP-N-acetylneuraminate | 1.5522 | 0.7978 | 1.0735 | 0.3526 | 0.8405 | 1.1167 | 1.7747 | 1.0619 | 0.4300 |
| D-Arabitol | 1.8922 | 0.9919 | 1.2838 | 0.4657 | 0.5301 | 0.7723 | 1.7214 | 0.8418 | 0.5008 |
| Decanoic acid (capric acid) | 0.9171 | 0.8431 | 0.9445 | 1.1813 | 0.9167 | 1.4812 | 0.9225 | 0.9769 | 0.8166 |
| Dehydroascorbate | 1.6900 | 0.7259 | 1.4108 | 0.2178 | 0.9412 | 1.3580 | 1.3275 | 1.1372 | 0.1916 |
| D-Fructose 1-6-bisphosphate | 1.6986 | 0.9118 | 1.5621 | NA | 0.1679 | 0.4394 | 0.6446 | 1.0541 | 0.3393 |
| D-Glucono-1-5-lactone 6-phosphate | 1.1538 | 0.9911 | 1.2846 | 0.5095 | 0.6664 | 0.8574 | 1.4753 | 0.6347 | 1.1002 |
| D-Glucose | 1.4599 | 0.7377 | 0.8413 | 1.1388 | 0.4871 | 0.4841 | 0.6809 | 1.0845 | 2.0858 |
| D-Glyceraldehyde 3-phosphate/Glycerone phosphate | 1.9571 | 1.1406 | 2.0739 | 0.1314 | 0.4322 | 0.5209 | 1.9281 | 0.6860 | 0.1298 |
| Dihydrofolate | 1.0210 | 1.7527 | 0.8136 | 0.4382 | NA | 1.1818 | 1.2503 | 0.7367 | 0.4537 |
| Diphosphate | 1.1400 | 1.3239 | 0.7380 | 0.9163 | 0.6501 | 1.2113 | 0.9859 | 1.1438 | 0.8906 |
| Docosahexaenoic acid | 1.6631 | 1.2284 | 0.8440 | 0.7867 | 1.2277 | 0.8019 | 1.0484 | 0.8303 | 0.5696 |
| D-Ribose | 1.0753 | 0.3370 | 0.7820 | 1.6614 | 1.0293 | 0.5400 | 1.0791 | 1.1042 | 1.3917 |
| Eicosapentaenoic acid | 1.4884 | 0.5351 | 1.4581 | 0.5780 | 1.5052 | 1.6605 | 0.9994 | 0.4285 | 0.3468 |
| Ethanolamine phosphate | 1.7821 | 0.7049 | 1.4236 | 0.2279 | 0.9544 | 1.1410 | 1.4790 | 1.0705 | 0.2167 |
| Fumarate | 1.3476 | 0.7252 | 0.9102 | 0.1725 | 0.5999 | 0.7825 | 0.6851 | 3.4393 | 0.3377 |
| Glutathione | 1.5037 | 0.7587 | 1.1744 | 0.4254 | 1.1026 | 1.4533 | 0.9903 | 1.2213 | 0.3704 |
| Glycerol 3-phosphate | 1.0655 | 1.0271 | 1.5594 | 0.5096 | 0.7775 | 1.3329 | 0.9352 | 1.2460 | 0.5469 |
| GMP | 1.5369 | 0.7221 | 1.1481 | 0.2115 | 0.8791 | 1.3082 | 1.2471 | 1.7537 | 0.1933 |
| Heptanoic acid | 1.0075 | 1.2078 | 1.1143 | 0.9975 | 0.6478 | 1.0180 | 0.9071 | 1.2467 | 0.8532 |
| Hexadecanoic acid (palmitic acid) | 1.0331 | 1.1152 | 1.2668 | 0.8845 | 0.7937 | 1.0986 | 0.7157 | 0.8861 | 1.2063 |
| Hexadecenoic acid (Palmitoleic acid) | 1.1360 | 1.0726 | 1.4302 | 0.8043 | 0.7473 | 1.0396 | 0.9269 | 1.1684 | 0.6748 |
| Hexose phosphate 13C6 | NA | NA | NA | 1.9105 | NA | 0.3875 | NA | 0.9697 | 0.7627 |
| IDP | 1.0672 | 1.3574 | 0.7739 | 0.9481 | 0.5589 | 1.1586 | 1.0022 | 1.1495 | 0.9842 |
| IMP | 1.4985 | 0.7347 | 1.4523 | 0.1939 | 1.1983 | 1.7285 | 1.0888 | 0.9350 | 0.1700 |
| Inosine | 1.7525 | 0.6834 | 1.6946 | 0.2005 | 1.1389 | 1.2852 | 1.2785 | 0.8426 | 0.1239 |
| Itaconate | 1.6132 | 1.8173 | 1.0530 | 0.2089 | 0.5366 | 1.4288 | 1.5460 | 0.5741 | 0.2221 |
| Itaconate 13C1 | NA | 2.0639 | NA | 0.1807 | NA | 0.0913 | NA | 1.3376 | 0.1745 |
| Itaconate 13C2 | NA | 1.5494 | NA | NA | NA | NA | NA | 1.3365 | 0.1141 |
| Itaconate 13C3 | NA | 0.8374 | NA | 1.1066 | NA | 0.8597 | NA | 1.4255 | 0.7707 |
| Itaconate 13C4 | NA | 2.0187 | NA | 0.4373 | NA | 0.2485 | NA | 1.9561 | 0.3393 |
| Lactate | 0.7859 | 2.2831 | 0.6304 | 0.8110 | 0.4799 | 0.9881 | 1.2937 | 0.9302 | 0.7977 |
| Lactate 13C1 | NA | 1.8541 | NA | 0.8495 | NA | 0.4290 | NA | 0.5068 | 0.7233 |
| L-gamma-Glutamyl-L-hypoglycin | 0.3767 | NA | NA | 0.9355 | NA | NA | NA | NA | 1.2508 |
| Linoleic acid ((9Z,12Z)-Octadecadienoic acid) | 1.4663 | 0.9764 | 1.2996 | 0.8132 | 0.6173 | 0.8139 | 1.3454 | 0.8086 | 0.8593 |
| Malate | 1.4789 | 0.6692 | 0.8585 | 0.1298 | 0.6393 | 0.7818 | 0.7269 | 3.3635 | 0.3521 |
| Malate 13C1 | NA | 0.3828 | NA | 0.3220 | NA | NA | NA | 2.2405 | 0.4345 |
| Malate 13C2 | NA | 0.7424 | NA | 0.0819 | NA | 0.0364 | NA | 3.2952 | 0.2017 |
| Malate 13C3 | NA | 0.0860 | NA | 0.0481 | NA | 0.0285 | NA | 4.7657 | 0.0717 |
| Malate 13C4 | NA | 0.1977 | NA | 0.0079 | NA | NA | NA | 3.0730 | 0.0600 |
| Maltose | 0.4762 | 0.7099 | 0.7201 | 1.1004 | 0.9230 | 0.5143 | 0.6616 | 3.1458 | 0.7486 |
| Mannitol/Sorbitol | 1.7265 | 0.9803 | 1.0917 | 0.9279 | 0.7223 | 0.6578 | 1.3251 | 0.7669 | 0.8016 |
| N-Acetylneuraminate | 1.8888 | 0.6783 | 1.1681 | 0.2336 | 1.0693 | 0.8545 | 1.5796 | 1.1725 | 0.3553 |
| Nicotinate ribonucleotide | 1.0700 | 0.7580 | 1.2873 | 1.0754 | 1.1413 | 0.6380 | 0.9372 | 0.7296 | 1.3633 |
| N-Methylethanolamine phosphate | 1.6764 | 0.9340 | 0.9041 | 0.1529 | 0.3631 | 0.8865 | 1.9151 | 1.8723 | 0.2957 |
| Nonanoic acid (pelargonic acid) | 1.1198 | 1.0405 | 1.1249 | 1.2264 | 0.9562 | 1.0360 | 0.7541 | 0.9083 | 0.8337 |
| Octadecanoic acid (stearic acid) | 0.9531 | 0.8610 | 0.9625 | 1.1616 | 1.1229 | 1.1899 | 0.9870 | 0.9524 | 0.8095 |
| Octadecenoic acid (Oleic acid) | 1.5942 | 1.0787 | 1.0136 | 0.4526 | 0.6938 | 1.2865 | 0.9021 | 1.1170 | 0.8616 |
| Octanoic acid (caprylic acid) | 1.0953 | 0.9323 | 1.3787 | 1.3427 | 0.7716 | 1.1503 | 0.6884 | 0.9392 | 0.7017 |
| Oxaloacetate | 0.7675 | 1.5087 | 0.7867 | 0.9212 | 1.2706 | 0.8070 | 0.7424 | 1.2542 | 0.9417 |
| Phosphate | 1.1424 | 1.2288 | 0.8507 | 0.8045 | 0.7497 | 1.0911 | 1.0447 | 1.1673 | 0.9209 |
| Phosphocreatine | 0.8229 | 2.1325 | 1.0936 | 0.8287 | 0.4627 | 0.7131 | 0.9422 | 1.4767 | 0.5276 |
| Pyruvate | 0.9538 | 1.0396 | 1.4824 | 0.7410 | 1.0927 | 0.8036 | 0.9191 | 1.0286 | 0.9392 |
| Pyruvate 13C1 | NA | 0.3298 | NA | 0.4252 | NA | 1.0784 | NA | 1.6625 | 1.5303 |
| (S)(+)-Allantoin | 1.7062 | 1.1347 | 1.2783 | 0.4307 | 0.7145 | 0.8018 | 1.4535 | 0.8113 | 0.6690 |
| Sedoheptulose 1/7-phosphate | 1.4302 | 1.7638 | 1.5316 | 0.1358 | 0.8352 | 0.9827 | 1.2009 | 0.8980 | 0.2217 |
| Succinate 13C4 | NA | 1.1661 | NA | 0.9586 | NA | 1.1117 | NA | 0.8518 | 0.9118 |
| Taurine | 0.9736 | 1.0708 | 0.8538 | 0.4330 | 0.9752 | 1.8803 | 0.9901 | 1.4313 | 0.3920 |
| Tetradecanoic acid (myristic acid) | 1.7547 | 0.9292 | 1.0455 | 0.9632 | 0.8987 | 0.9830 | 0.7404 | 0.9723 | 0.7131 |
| Tetradecenoic acid (myristoleic acid) | 0.8493 | 0.8473 | 1.2316 | 0.9952 | 1.2440 | 1.1118 | 0.8308 | 0.9356 | 0.9543 |
| UDP-glucose | 0.8081 | 0.8635 | 0.8054 | 0.9876 | 0.8293 | 1.1634 | 0.6392 | 1.8521 | 1.0515 |
| UDP-N-acetyl-D-glucosamine | 1.3080 | 0.7941 | 1.4262 | 0.8584 | 0.9487 | 1.1145 | 0.8281 | 0.9465 | 0.7755 |
| UMP | 1.1377 | 0.7662 | 0.9006 | 0.2373 | 0.8908 | 1.2701 | 0.8471 | 2.6176 | 0.3326 |
| Urate | 1.3337 | 0.7334 | 0.4745 | 0.4726 | 1.1194 | 1.1935 | 1.4700 | 1.4287 | 0.7742 |
| Xanthine | 1.3871 | 0.6849 | 0.8789 | 0.4072 | 1.0564 | 1.4649 | 1.4507 | 1.3332 | 0.3368 |
Factors:
| F1 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:dead | Multiplicity of infection:25 | well vs insert source:NA |
| F2 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:dead | Multiplicity of infection:50 | well vs insert source:well |
| F3 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:live | Multiplicity of infection:25 | well vs insert source:NA |
| F4 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:NA | Multiplicity of infection:NA | well vs insert source:insert |
| F5 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:NA | Multiplicity of infection:NA | well vs insert source:NA |
| F6 | Timepoint (h):18 | LPS treatment (ng/ml):0 | E coli viability:NA | Multiplicity of infection:NA | well vs insert source:well |
| F7 | Timepoint (h):18 | LPS treatment (ng/ml):500 | E coli viability:NA | Multiplicity of infection:NA | well vs insert source:NA |
| F8 | Timepoint (h):6 | LPS treatment (ng/ml):0 | E coli viability:dead | Multiplicity of infection:50 | well vs insert source:well |
| F9 | Timepoint (h):6 | LPS treatment (ng/ml):0 | E coli viability:NA | Multiplicity of infection:NA | well vs insert source:insert |
