Data for (Study ST003604)

(Analysis AN005921)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10
1-4-beta-D-Xylan 1.8931 1.3074 0.4810 0.5123 0.5091 0.6592 0.8703 0.5710 1.7984 1.0909
2/3-Phospho-D-glycerate 0.8434 0.9156 3.5363 0.2301 1.2296 0.7329 0.8763 0.2788 0.8338 0.6075
2-Hydroxyglutarate/Citramalate 2.1675 1.0849 0.9316 0.2494 0.9597 1.2467 0.8168 0.3175 1.2876 0.8534
2-Oxoglutaramate 0.6561 0.9233 1.7567 0.4647 1.0379 1.1616 1.3182 0.9743 0.9176 0.8663
2-Oxoglutarate 3.1581 1.4091 0.2766 0.1755 0.5120 0.5479 1.2155 0.2512 1.1562 0.8887
2-Oxoglutarate 13C5 0.8775 0.9500 0.8363 0.8530 0.9231 0.9523 1.6936 0.7288 0.9736 1.2618
3-Phosphonooxypyruvate 1.1055 1.0706 1.2359 0.5135 1.1885 1.0347 1.0041 0.8655 1.0331 0.8781
3-Sulfino-L-alanine 0.8740 0.7848 1.8319 0.5574 0.9317 1.1295 0.9078 0.9607 1.3124 0.9250
4-Pyridoxate 1.0613 0.8023 1.9137 0.1252 1.6456 1.5185 0.7760 0.2278 0.9273 0.9811
5-L-Glutamyl-taurine 0.1646 0.5350 4.1067 1.2837 0.1117 0.1367 1.6481 1.5593 0.1949 0.1131
Adenine 13C5 NA 0.0303 0.5197 0.1478 0.8665 1.2810 0.6320 0.7079 1.8894 1.9851
Adenosine 13C5 0.4059 0.2609 0.3500 NA 0.2622 0.5430 0.1935 0.2118 0.3552 4.3366
ADP 2.4638 1.2485 0.2533 0.2585 1.3636 0.6879 0.6255 0.4993 1.3558 0.9952
ADP 13C10 0.0678 NA NA 0.0501 0.6005 0.8712 0.2074 0.7092 1.6212 2.2628
ADP-D-ribose 1.2217 0.6681 0.6894 0.3196 2.1355 2.1671 0.3105 0.6753 1.2985 0.6760
a-Linolenic acid (Octadecatrienoic acid) 0.5745 0.5326 1.2249 0.2063 3.1310 2.2346 0.6801 0.3236 0.9122 0.6476
alpha-D-Glucosamine 1-phosphate 1.2405 1.1677 1.2742 0.2760 1.0262 0.9781 1.0245 0.8804 1.2597 0.7051
alpha-D-Ribose 1-phosphate 0.6094 0.8241 1.1461 0.0832 2.5296 2.7341 0.4843 0.2596 1.0297 0.4757
AMP 13C10 NA 0.0034 0.1079 0.0219 1.4095 1.5633 0.5012 0.9722 1.1466 2.0375
Arachidonic acid (Eicosatetraenoic acid) 0.5887 0.9633 0.5976 0.1985 2.7005 2.5559 0.6976 0.2854 0.7291 0.7200
Ascorbate 2.4283 1.9134 0.2868 0.0347 0.3180 1.1508 0.5689 0.0377 0.8914 1.4567
beta-L-Arabinose 1-phosphate 0.6094 0.8241 1.1461 0.0832 2.5296 2.7341 0.4843 0.2596 1.0297 0.4757
Citrate 1.0624 0.4582 0.7112 0.1004 6.8329 0.9362 0.1000 0.0726 0.1718 0.0961
Citrate 13C1 NA 0.5773 3.3314 0.4506 0.5715 1.7659 0.8025 0.7493 0.8399 0.4137
Citrate 13C2 0.8864 0.4114 2.5805 0.3605 3.6031 0.6275 0.3572 0.2450 0.6232 0.4397
Citrate 13C3 0.2290 0.6391 4.3169 0.4678 1.5995 0.5563 0.4431 0.3168 0.3791 0.5091
Citrate 13C4 0.3444 0.2214 2.5541 0.3338 4.0131 0.6743 0.3402 0.5635 0.2890 0.3244
CMP-N-acetylneuraminate 1.5732 1.1923 0.5118 0.0623 1.3077 1.8206 0.3517 0.1599 1.0482 1.3112
D-Arabitol 0.0463 0.0382 2.2319 0.4525 0.1839 0.1982 3.0587 2.8174 0.5722 1.3626
Dehydroascorbate 0.9407 0.5148 0.5764 0.5343 3.4615 0.8586 0.9484 0.8709 0.5367 0.8098
D-Erythrose 4-phosphate 0.4355 0.3934 1.0069 0.1259 0.8435 3.8229 0.6110 0.4435 0.2674 0.1754
D-Glucono-1-5-lactone 6-phosphate 0.3467 0.4407 1.3676 0.3589 1.5679 5.3850 0.2611 0.1490 0.3020 0.3804
D-Glucose 0.9840 0.6377 1.4668 0.6557 1.6907 1.4435 0.7068 0.7118 0.8382 1.2271
D-Glyceraldehyde 3-phosphate/Glycerone phosphate 0.4064 0.4295 1.3277 0.4064 2.4344 3.8128 0.5008 0.4021 0.4057 0.4447
Dihomo-gamma-linolenic acid ((8Z-11Z-14Z)-Icosatrienoic acid) 0.7334 0.9323 0.6875 0.1964 2.5470 2.3143 0.7306 0.2748 0.8208 0.8307
Diphosphate 0.8134 0.9598 0.9999 0.6477 1.4208 1.0510 1.0216 0.7765 1.3450 1.0045
Docosahexaenoic acid 0.9710 1.1893 0.7442 0.2034 1.9376 1.6013 0.9787 0.3761 0.9548 0.8542
Docosapentaenoic acid ((7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid) 0.8540 1.3455 0.4944 0.2216 1.9032 1.7600 0.8973 0.3880 0.9032 0.8871
Dodecanoic acid (lauric acid) 1.0000 0.9169 1.0796 0.9335 1.2032 1.3756 0.8822 0.9040 0.9083 0.8798
D-Ribose 0.8020 0.7647 0.9964 0.7390 1.4404 1.1853 0.8496 0.7530 0.8595 1.8453
Eicosapentaenoic acid 0.7919 1.2937 0.6126 0.2935 1.8378 1.5420 1.2744 0.4753 0.6290 0.9560
Ethanolamine phosphate 1.3016 1.0091 1.2908 0.2637 1.3068 1.4458 0.7715 0.6598 1.0388 0.9029
Fructose bisphosphate 13C6 0.8287 1.0228 1.1456 0.9681 0.8964 1.2906 1.1036 0.4987 1.0514 1.1714
Fumarate 1.4157 0.6806 0.9725 0.4707 0.3958 0.5957 1.1881 0.5041 0.7503 3.3460
Fumarate 13C4 0.0259 0.1722 2.2777 0.3027 0.1428 0.1826 1.8961 1.1376 0.2444 1.6542
gamma-L-Glutamyl-L-cysteine 1.5669 0.9608 0.7700 0.1384 1.7923 1.0044 0.9902 0.3440 1.3551 1.1171
Glutathione 13C10 0.5484 0.2869 4.0457 0.2504 2.2191 1.8453 0.2287 0.2032 0.3056 0.2092
Glycerol 3-phosphate 0.3927 0.9354 2.1165 0.6705 0.9246 1.0140 1.2968 1.2611 0.6873 0.7655
Heptanoic acid 1.0434 0.9716 1.0682 1.0948 1.0270 1.0577 1.0014 0.8878 0.8968 0.9798
Hexadecanoic acid (palmitic acid) 1.0760 1.0009 1.0873 0.9101 1.0108 1.0741 0.9659 0.9635 0.9740 0.9366
Hexadecenoic acid (Palmitoleic acid) 0.7412 0.6059 1.8763 0.4826 2.1292 1.6365 0.8224 0.5301 0.9158 0.6541
Hexanoic acid (caproate) 0.8985 0.9713 0.9365 0.9269 0.9809 1.0499 1.2057 1.1350 0.9236 1.0004
IMP 0.3692 0.8102 2.0175 0.1301 1.4448 2.4676 1.3237 0.2509 0.4930 0.8830
Itaconate 13C3 1.2221 1.0757 1.0803 0.6389 1.1015 0.6031 1.2834 1.2358 0.8237 0.8598
Itaconate 13C4 1.0289 0.9459 1.0586 0.5806 1.0608 0.7123 1.3061 1.2540 0.9709 1.1359
Itaconate 13C5 0.8607 0.7837 0.8191 0.8858 0.9687 1.0779 1.1137 1.0483 1.2136 1.4448
Lactate 0.4630 0.9085 2.7905 0.2404 1.0089 1.2393 1.4286 0.3340 0.5742 1.1042
L-Arabinose 0.8020 0.7647 0.9964 0.7390 1.4404 1.1853 0.8496 0.7530 0.8595 1.8453
L-Cysteate 0.8039 1.1050 0.8929 0.9833 0.9838 0.8826 1.0254 1.0847 1.0751 1.0583
Linoleic acid ((9Z,12Z)-Octadecadienoic acid) 1.0378 0.7533 1.3882 0.2917 1.9758 1.8451 0.8649 0.4080 0.9578 0.7241
L-Selenomethionine 1.5808 1.1713 0.8502 1.7964 1.0781 0.4089 0.3290 0.6620 1.0587 0.8934
Malate 0.7762 0.9961 1.3886 0.6205 0.4938 0.8238 1.6197 0.5742 0.9321 1.7788
Malate 13C4 NA NA 2.1762 0.4050 0.0376 0.1359 2.2768 0.8221 0.3384 1.8080
Maltose 0.2181 0.2052 7.8243 0.2495 0.4643 0.4596 0.3885 0.4031 0.2230 0.3593
Mannitol 2.8813 0.0887 0.2077 0.1355 0.3935 0.3264 0.1222 0.4723 0.3053 5.9785
N-Acetylneuraminate 1.3684 1.2079 0.1918 0.0250 1.1239 2.1864 0.4227 0.3387 0.9640 1.9633
N-Glycoloyl-neuraminate 1.4910 0.8650 0.1816 0.1297 0.9679 1.8125 0.3577 0.8480 1.2774 1.7818
N-Methylethanolamine phosphate 1.5756 0.6281 2.2499 0.1735 1.6953 1.7308 0.5037 0.5933 0.6807 0.5410
Nonanoic acid (pelargonic acid) 0.9819 0.9572 1.0666 0.9599 1.0835 1.1174 0.9786 0.9543 0.9565 0.9868
Octadecanoic acid (stearic acid) 1.0819 0.9381 1.1791 0.8764 0.9369 1.0479 0.9114 1.0203 1.0665 1.0035
Octadecenoic acid (Oleic acid) 1.0158 0.6805 1.5289 0.3436 2.0854 1.7443 0.7554 0.4954 1.0400 0.6301
Octanoic acid (caprylic acid) 1.0802 0.9550 1.0577 1.0311 1.0475 0.9968 1.0438 0.8866 0.9050 1.0411
Pantothenol 0.3802 0.4077 4.0708 0.1122 0.9675 0.5116 2.3212 0.6954 0.6344 0.4911
Phosphate 0.8865 0.9701 1.0577 0.6794 1.3222 1.1479 0.9910 0.7262 1.2110 1.0379
Phosphoglycerate 13C3 1.0889 0.5107 1.1378 0.1410 2.5829 1.6038 0.2313 0.0977 1.2470 0.6993
Pyruvate 1.0235 0.7917 1.7934 0.6827 0.6975 0.8675 2.1202 0.9492 0.5357 0.7469
Ribose phosphate 13C5 0.0697 0.0603 0.3597 0.0681 1.6711 2.1039 1.3858 0.5063 1.2677 1.1045
(S)(+)-Allantoin 1.1151 0.7520 1.0951 0.3183 2.1695 1.5125 0.6866 0.5559 1.1214 0.7512
Sedoheptulose 1-phosphate 0.2281 0.4001 2.8863 0.3368 2.0076 3.3501 0.5103 0.1603 0.2679 0.4522
Sedoheptulose 1-phosphate 13C7 0.9223 0.8656 0.7602 0.2653 2.0566 1.7832 0.7834 0.6787 1.1043 0.9149
sn-glycero-3-Phosphoethanolamine 1.0225 0.4244 2.4334 0.1779 2.8172 2.3856 0.2693 0.1920 0.5351 0.3182
Sphingosine 1-phosphate 1.1181 0.7000 1.9370 0.2278 1.6392 1.4927 0.8300 0.4679 0.9008 0.7935
Succinate 1.3325 0.7408 0.9126 0.1379 2.5121 1.7706 0.6438 0.3396 1.3361 0.5332
Succinate 13C4 0.9352 0.7975 1.2716 0.9416 1.5640 1.1984 0.8957 0.8616 0.6658 0.9384
Taurine 1.4506 1.1544 1.2553 0.5824 0.9951 1.0827 0.9323 0.9017 0.8034 0.6878
Tetradecanoic acid (myristic acid) 0.9962 0.9531 1.2050 0.8817 1.1712 1.0521 1.0152 0.8566 0.9579 0.9582
Tetradecenoic acid (myristoleic acid) 1.0449 0.8883 1.3582 0.6537 1.6359 1.3079 0.8954 0.6467 0.8817 0.7990
Thymine 1.0138 1.0034 1.0511 0.8801 0.9881 1.0252 1.0225 0.9352 1.0952 0.9821
trans-4-Hydroxy-L-proline 1.1319 0.8050 1.4867 0.3036 1.5653 1.4029 0.9430 0.6445 1.0850 0.8271
UDP-glucose 1.4473 0.7487 1.6366 0.1333 0.9598 1.8571 0.6145 0.2985 1.2108 1.3446
UDP-N-acetyl-D-glucosamine 1.5604 0.8710 1.2045 0.1044 1.3549 1.9584 0.6460 0.3215 1.2068 0.9011
UMP 1.2542 0.6391 1.2522 0.0644 1.4543 2.3408 0.7985 0.4575 1.3304 0.7694
Uracil 0.6869 0.7464 1.8298 0.5663 0.8800 2.8103 0.7555 0.6595 0.7163 0.6026
Xanthine 0.8117 0.8625 1.5478 0.1083 1.6005 1.6577 1.5093 0.4345 0.9524 0.6527
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Factors:

F1time (h):0 | Dead E coli treatment:no | inhibitor:none | | genotype:RagA GTP mutant
F2time (h):0 | Dead E coli treatment:no | inhibitor:none | | genotype:WT
F3time (h):18 | Dead E coli treatment:yes | inhibitor:150 nM concanamycin A | | genotype:WT
F4time (h):18 | Dead E coli treatment:yes | inhibitor:50 nM bafilomycin A1 | | genotype:WT
F5time (h):18 | Dead E coli treatment:yes | inhibitor:none | | genotype:RagA GTP mutant
F6time (h):18 | Dead E coli treatment:yes | inhibitor:none | | genotype:WT
F7time (h):6 | Dead E coli treatment:yes | inhibitor:150 nM concanamycin A | | genotype:WT
F8time (h):6 | Dead E coli treatment:yes | inhibitor:50 nM bafilomycin A1 | | genotype:WT
F9time (h):6 | Dead E coli treatment:yes | inhibitor:none | | genotype:RagA GTP mutant
F10time (h):6 | Dead E coli treatment:yes | inhibitor:none | | genotype:WT
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