Data for (Study ST003604)

(Analysis AN005922)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4F5F6F7F8F9F10
2^,3^-Cyclic CMP 0.5320 0.5897 0.8197 0.3369 1.2507 1.4380 0.4480 0.7489 2.0875 1.3092
2-Aminomuconate 1.4850 1.4088 0.5318 0.2192 1.7357 1.0738 0.6021 0.5869 0.7803 0.8727
3-Methyldioxyindole 1.3104 0.7226 0.8226 0.5070 2.1021 1.7711 0.5992 0.4729 1.1790 0.7904
4-Acetamidobutanoate 1.4474 1.0449 0.8509 0.6787 1.0716 1.1688 0.8556 0.7719 1.0911 0.9741
5-6-Dihydrothymine 0.7685 0.5640 2.4387 0.5129 2.3916 1.2333 0.6525 0.5314 0.8567 0.4862
5-Aminopentanoate 1.3757 0.5979 1.1380 0.3082 2.3818 1.6380 0.6917 0.4595 1.1501 0.6613
5-Guanidino-2-oxopentanoate 0.0635 0.0761 4.9332 0.4407 0.5204 0.2400 2.0287 1.8980 0.4479 0.2754
5-Hydroxyindoleacetate 0.7305 1.1471 0.9992 0.2647 1.7060 0.8202 0.8722 0.7135 1.4705 1.1745
5-Hydroxyisourate 1.9504 1.1167 1.1068 0.0586 1.5563 1.4459 0.6834 0.4308 0.8386 0.6957
(5-L-Glutamyl)-L-glutamine 1.9567 0.7786 0.7427 0.2109 1.6968 1.1479 0.4651 0.3472 1.7567 1.1187
5-Oxoproline 1.2647 1.1671 1.1062 0.3753 0.7393 0.9663 1.2269 0.8716 0.9892 1.1263
5-Oxoproline 13C5 0.0935 0.0612 2.3957 0.4813 0.1277 0.1656 3.1269 2.5428 0.4679 1.4762
acetyl-carnitine (acyl-C2) 0.9316 1.0837 0.8259 0.0927 2.1550 1.4324 0.7623 0.5521 1.0557 1.0249
Acetylcholine 2.1894 1.3717 0.5156 0.1548 0.7882 0.5112 0.8866 0.6608 1.3942 1.1559
acyl-C18:2 (Linoleoyl-CoA) 3.0948 0.9875 0.0834 0.1835 0.1841 0.1415 0.6727 0.3163 1.8956 0.9533
acyl-C4-OH (Hydroxybutyrylcarnitine) 0.7009 1.3048 1.2043 0.1352 0.7582 0.5486 1.5832 0.7954 1.0213 1.6433
acyl-C5-OH (hydroxyisovalerylcarnitine) 1.9004 1.0196 0.9380 0.2139 1.4384 1.1791 0.6409 0.3887 1.3792 0.8821
Adenine 1.2466 1.0574 0.9682 0.3638 1.4877 0.9252 0.8090 0.7082 1.4007 0.9759
Adenosine 1.3268 1.6340 0.4340 0.1036 1.4951 1.0652 0.3366 0.2886 1.9180 0.7642
Alanine 13C3 0.0317 NA 1.1292 0.2436 0.2670 0.2560 2.2581 1.8711 0.7014 1.5158
Allantoate 0.3575 0.4360 3.7436 0.6223 1.7687 1.2712 0.8082 0.3992 0.4534 0.7040
AMP 2.0690 0.9747 0.7104 0.1249 1.8677 1.0685 0.6016 0.5807 1.2588 0.7690
Anthranilate 0.7033 0.8441 0.9339 0.2662 1.8364 1.6780 0.8955 0.3867 1.0147 1.5970
Arginine 13C6 NA NA 0.3024 0.2001 0.3243 0.2930 1.4885 0.8034 1.0424 2.0724
Argininosuccinate 0.9005 0.7859 1.3644 0.2223 1.2444 1.6617 0.9174 0.5073 0.9472 1.6630
Asparagine 13C5 0.0509 0.0727 1.7171 0.6546 0.1334 0.1652 2.8452 3.3984 0.3915 1.2665
butanoyl-l-carnitine (acyl-C4) 3.2466 0.9244 0.5514 0.3980 1.4902 0.8110 0.3882 0.6478 1.2239 0.5166
Cadaverine 0.0217 0.0191 3.3012 0.9402 0.8916 0.7795 1.3136 1.0289 0.3425 0.3827
Cadaverine 13C5 NA 0.0591 1.2541 0.5077 0.0672 0.0331 2.5429 2.2965 0.1652 0.1770
Carnosine 1.7454 0.7063 0.1226 NA 2.1168 1.4352 0.2125 0.1286 1.5396 0.8705
Citrulline 13C6 0.0241 0.0320 1.1749 0.2571 0.2300 0.2347 2.6440 1.8052 0.8678 1.3230
CMP 1.3929 1.3938 1.0222 0.0799 1.4330 1.3598 0.8124 0.4733 0.7483 0.8907
Creatine 0.7076 0.4487 3.4442 0.4213 2.0649 1.5628 0.4429 0.4730 0.6344 0.3514
Creatinine 0.9768 0.7940 1.4180 0.3730 1.8390 1.3404 0.8727 0.7718 1.0236 0.7968
Cys-Gly 1.7826 0.9068 0.8046 0.1393 1.7905 1.2523 0.5651 0.4655 1.4482 0.9384
Cystathionine 1.9433 0.7372 0.3308 0.0852 1.4082 0.9612 0.0884 0.0970 2.5373 1.3919
Cysteine 13C3 1.2417 0.8924 1.0199 0.1931 1.6550 1.8300 0.8849 0.4948 0.8928 1.0031
Cytidine 0.7162 1.2919 0.3762 0.0315 2.8633 3.4663 0.1685 0.0906 0.4177 0.2860
dAMP 0.4226 0.3874 0.8147 0.1002 1.4413 1.2919 0.9017 0.7398 2.4391 2.0738
Dimethylglycine 0.3273 0.3822 0.5125 0.1190 1.8955 1.2583 0.3175 0.2773 2.3461 3.1823
Dopamine 1.2203 0.6167 0.5545 0.3325 2.7914 1.4417 0.3710 0.2941 2.0257 0.5281
gamma-Glutamyl-gamma-aminobutyrate 2.3966 0.6208 0.0739 0.0128 2.1395 1.2592 0.1199 0.0611 2.0165 1.1851
gamma-Glutamyl-Se-methylselenocysteine 0.2618 0.4020 3.2330 0.7495 1.6189 1.9902 0.8670 0.3810 0.4039 0.6906
gamma-L-Glutamyl-D-alanine 1.9156 0.7399 0.4554 0.1295 1.9034 1.4142 0.2853 0.2366 2.0186 1.1616
gamma-L-Glutamylputrescine 1.9792 0.9616 0.0148 0.0136 1.4658 0.7577 0.0199 0.0377 2.1129 0.9383
Glutamate 13C5 0.0074 0.0098 2.5878 0.4649 0.1208 0.1650 3.1986 2.6661 0.4107 1.3592
Glutathione 1.5527 1.0134 1.0646 0.1769 1.5596 1.3621 0.7524 0.5965 1.1018 0.8066
Glutathione disulfide 0.5593 1.1832 1.6531 0.4718 1.3659 1.2822 1.3424 1.3609 0.2753 0.3226
GMP 1.0717 0.6956 1.3252 0.0742 2.7224 2.3714 0.5990 0.3299 0.7663 0.3485
g-Oxalo-crotonate 0.3763 0.8116 1.1089 0.0690 3.0708 2.4930 0.6746 0.2249 0.7336 0.6257
Guanidinoacetate 2.0932 1.1310 0.7715 0.0546 1.2258 0.9378 1.0180 0.2098 1.4851 0.9423
Guanine 1.2879 0.7109 0.4077 0.2779 2.9422 1.9955 0.7253 0.3024 1.2643 0.3750
Hexadecenoyl-carnitine (acyl-C16:1) 3.1135 0.8265 0.3263 0.3808 0.9620 0.4636 0.7248 0.6058 1.8870 0.8831
Histidine 13C6 1.4237 0.7028 1.0356 0.1444 0.8950 0.5504 1.8004 1.3225 1.4009 0.7987
Hypotaurine 1.4439 1.0571 1.1671 0.4486 1.2049 1.2937 0.9105 0.7900 0.8964 0.7309
Hypoxanthine 0.4622 0.7394 1.1627 0.0591 3.3904 2.8059 0.4268 0.1746 0.6216 0.4179
Hypoxanthine 13C5 0.0060 0.0062 1.0725 0.0551 3.3279 3.7563 0.7145 0.3304 0.7659 0.9592
Indole 1.3226 0.7070 0.5661 0.3405 2.5553 2.2481 0.4456 0.3192 1.1045 0.6840
Indole-3-acetaldehyde 1.1330 0.4487 3.2079 0.1270 1.7032 1.5315 0.6061 0.2676 1.0259 0.5003
Indole-3-acetate 1.5472 1.3642 0.5134 0.3097 1.7499 0.9651 0.6911 0.7226 0.8525 0.9202
Indolepyruvate 1.4455 0.5983 0.8127 0.0993 2.5108 1.5874 0.6391 0.3430 1.7440 0.6217
Inosine 0.5386 0.9360 0.7109 0.0304 3.5376 2.8058 0.2493 0.1441 0.7159 0.3953
kynurenine 1.1285 0.9519 0.8723 0.4743 0.9365 1.1462 0.3626 0.5144 2.7440 0.9542
L-Adrenaline 1.6732 1.1826 1.0358 0.1856 1.1950 1.0558 1.0652 0.6616 1.1608 0.6018
L-alanine 0.8969 0.8528 1.6522 0.3211 1.6572 1.4452 1.0626 0.5753 0.8922 0.7918
L-arginine 1.7927 0.9337 0.4478 0.1587 2.1379 1.2737 0.4374 0.5457 1.2303 1.1085
L-asparagine 1.3130 0.8404 0.8476 0.2136 1.8642 2.0870 0.7112 0.4110 0.8635 1.0081
L-aspartate 1.1574 1.0934 1.0273 0.7697 1.0786 0.5430 1.3845 1.2832 0.7178 0.8517
L-Citrulline 0.6447 0.4044 4.0017 0.2407 1.3930 1.5508 0.8189 0.4624 0.6010 0.4779
L-cysteine 1.1692 0.5672 0.5363 0.0614 2.6435 2.6573 0.3698 0.1889 1.2316 1.0074
Leucine/isoleucine 13C6 NA NA 0.8521 0.0507 0.6936 0.4400 1.2237 0.3920 2.1359 2.2121
L-glutamate 1.1455 1.1679 1.1903 0.4139 0.5944 0.7161 1.3881 0.9677 1.0632 1.1850
L-glutamine 1.6545 1.0379 0.9848 0.2364 1.5029 1.7260 0.6218 0.4636 0.8496 0.8845
L-histidine 1.1448 0.8930 1.0552 0.3062 1.7482 1.7703 0.9968 0.7672 0.8072 0.6182
L-Homocysteine 1.4590 0.6571 0.3271 NA 1.8961 0.8746 0.7359 0.1691 1.3719 1.0608
L-Homoserine 1.2068 0.8213 0.9412 0.2164 2.0802 2.0037 0.8554 0.5477 0.8578 0.6482
L-leucine 1.6969 0.5844 0.7698 0.1047 2.9272 1.7305 0.3878 0.1816 1.4441 0.5886
L-lysine 1.5074 0.7369 0.6694 0.0985 2.4241 2.1668 0.4495 0.2548 1.2121 0.7436
L-methionine 1.3636 0.6630 0.4454 0.0463 3.2426 2.4646 0.2662 0.1108 1.2978 0.4366
L-Methionine S-oxide 1.6349 0.6314 1.7253 0.1877 1.8340 1.1801 0.8167 0.4697 1.0243 0.8645
L-Palmitoylcarnitine (acyl-C16) 2.1807 1.1792 0.6119 0.3171 1.2473 0.8555 0.8013 0.6645 1.1543 0.8089
L-phenylalanine 1.5069 0.6281 0.4647 0.0713 3.1830 2.4190 0.2549 0.1259 1.1396 0.5788
L-proline 0.9292 0.8601 1.6600 0.2236 1.6661 1.6631 1.0559 0.4439 0.8027 0.8353
L-serine 1.2056 0.7601 0.8846 0.3993 2.0220 2.2459 0.7575 0.6949 0.6600 0.6100
L-threonine 1.2068 0.8213 0.9412 0.2164 2.0802 2.0037 0.8554 0.5477 0.8578 0.6482
L-tryptophan 1.4512 0.6463 0.7414 0.1145 2.6681 2.0056 0.5095 0.2895 1.2375 0.6900
L-tyrosine 1.6112 0.4862 0.7257 0.0972 3.2166 2.1773 0.3688 0.1888 1.1881 0.4541
L-valine 1.3757 0.5979 1.1380 0.3082 2.3818 1.6380 0.6917 0.4595 1.1501 0.6613
Lysine 13C6 NA NA 0.7407 0.0936 0.5619 0.6196 1.4792 0.6239 1.1460 1.9905
Methionine 13C5 0.1050 0.0696 0.7563 0.0584 1.3324 0.9555 1.5238 0.4403 1.6655 1.7097
N-Acetyl-L-citrulline 1.9831 1.0942 0.0301 0.0411 2.1029 1.3212 0.0444 0.0695 2.2491 0.9937
N-Acetylornithine 2.0692 0.8232 0.3242 0.0838 2.3154 1.1376 0.1337 0.0843 2.2229 0.9824
NAD+ 3.0101 1.4285 0.2136 0.1310 0.2379 0.1539 1.0214 0.6078 1.6373 1.1300
N-formyl kynurenine 2.1898 0.8180 0.1439 0.0405 1.5381 1.2225 0.1369 0.1220 2.5484 1.4219
Nicotinamide 0.9559 0.6842 1.0701 0.0520 2.5929 2.8221 0.4542 0.1513 1.0153 0.5179
O-dodecanoyl-carnitine (acyl-C12) 3.7847 0.8542 0.4628 0.3473 0.7893 0.6518 0.4478 0.4855 1.5805 0.7419
O-octadecenoyl-L-carnitine (acyl-C18:1) 2.9425 1.0210 0.3254 0.2844 1.1019 0.5071 0.8172 0.5116 1.6763 0.7918
Ornithine 0.3679 0.4143 3.6695 0.4505 1.8947 1.6623 0.7507 0.3524 0.4369 0.5862
O-tetradecanoyl-L-carnitine (acyl-C14) 3.2406 0.9998 0.3737 0.1580 1.2342 0.7358 0.5301 0.4531 1.6283 0.6466
Pantetheine 1.2213 0.9744 0.1656 NA 1.3672 0.5319 NA NA 1.4500 0.5467
Pantetheine 4--phosphate 1.6810 0.8608 0.2830 0.0510 1.6514 1.1015 0.3639 0.2610 1.9802 1.4310
Phosphocreatine 0.9455 0.5024 4.2774 0.3026 1.1855 1.1203 0.1789 0.2431 1.4073 0.3347
Phosphoserine 1.0039 1.4160 1.0289 0.8267 0.4441 0.5374 1.4697 1.0093 1.0669 0.8852
Picolinic acid 1.2227 0.8838 1.0273 0.1843 1.7143 1.7993 0.8887 0.4847 0.8964 1.0147
Proline 13C5 NA 0.0160 1.2191 0.1525 0.4182 0.5074 2.5675 1.2917 0.8937 2.1800
Putrescine 0.4653 0.3330 1.7121 0.2950 2.0760 1.3360 1.2284 1.0145 1.3028 0.9039
Putrescine 13C4 NA NA 1.5466 0.3913 0.9926 0.7226 1.8634 1.3928 0.4517 0.6389
Pyridoxal 1.0740 0.8860 0.9085 0.3338 1.4450 1.8816 0.8037 0.5310 1.0125 1.2378
S-Adenosyl-L-methionine 0.8491 0.5809 0.9820 0.2555 3.1819 1.8279 0.5560 0.5425 0.9513 0.6921
S-Adenosyl-L-methionine 13C15 0.6656 0.2182 2.3536 0.0356 2.7819 2.6973 0.4373 0.2057 0.5497 0.3546
Serine 13C3 NA NA 1.1684 0.2703 NA 0.3618 1.8748 1.7121 0.2857 0.8483
Serotonin 0.6305 0.3802 4.1189 0.2479 1.3827 1.6258 0.7508 0.5288 0.5584 0.3957
S-Glutathionyl-L-cysteine 0.6902 1.0241 3.5878 0.3960 1.1636 1.0183 0.7902 0.4752 0.3831 0.4473
Spermidine 1.3286 1.3864 0.5839 0.1061 1.3457 1.5652 0.4099 0.3217 1.2630 1.3032
Spermine 1.0511 2.6350 0.4477 0.1900 0.6496 0.4471 0.6224 0.3720 0.8790 1.0710
Tetradecenoyl Carnitine (acyl-C14:1) 4.5486 0.6421 0.1404 0.1519 1.1765 0.2683 0.4280 0.3638 1.9712 0.4523
Tryptophan 13C11 0.6880 0.6811 0.7705 0.8031 0.8429 0.7678 1.0598 0.7861 1.6099 2.3096
Xanthine 13C5 0.0840 0.0354 2.0876 0.0883 0.5255 1.0702 4.1100 0.8869 0.6231 1.2247
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Factors:

F1time (h):0 | Dead E coli treatment:no | inhibitor:none | | genotype:RagA GTP mutant
F2time (h):0 | Dead E coli treatment:no | inhibitor:none | | genotype:WT
F3time (h):18 | Dead E coli treatment:yes | inhibitor:150 nM concanamycin A | | genotype:WT
F4time (h):18 | Dead E coli treatment:yes | inhibitor:50 nM bafilomycin A1 | | genotype:WT
F5time (h):18 | Dead E coli treatment:yes | inhibitor:none | | genotype:RagA GTP mutant
F6time (h):18 | Dead E coli treatment:yes | inhibitor:none | | genotype:WT
F7time (h):6 | Dead E coli treatment:yes | inhibitor:150 nM concanamycin A | | genotype:WT
F8time (h):6 | Dead E coli treatment:yes | inhibitor:50 nM bafilomycin A1 | | genotype:WT
F9time (h):6 | Dead E coli treatment:yes | inhibitor:none | | genotype:RagA GTP mutant
F10time (h):6 | Dead E coli treatment:yes | inhibitor:none | | genotype:WT
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