Data for (Study ST003737)
(Analysis AN006132)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1,3-15N2-Uric acid | 1.0065 | 1.0303 | 0.9805 | 0.9827 |
| 13C10,15N5-Adenosine | 1.0280 | 1.0409 | 0.9333 | 0.9978 |
| 13C3-Thiamine | 0.9732 | 1.0490 | 0.9406 | 1.0373 |
| 13C5-Hypoxanthine | 1.0217 | 1.0485 | 0.9416 | 0.9882 |
| 13C5-Xanthosine | 0.9673 | 1.1829 | 0.8491 | 1.0007 |
| 15N4-Inosine | 1.0085 | 1.0378 | 0.9526 | 1.0011 |
| 1-Methylhistidine | 1.0273 | 0.8997 | 1.1663 | 0.9068 |
| 1-Methylnicotinamide | 0.9052 | 1.0426 | 1.1389 | 0.9133 |
| 1-Methylxanthine | NA | NA | NA | NA |
| 1-Methylxanthosine | NA | NA | NA | NA |
| 2-Aminobenzoic acid | NA | NA | NA | NA |
| 3-Hydroxybutyric acid | NA | NA | NA | NA |
| 3-Hydroxykynurenine | NA | NA | NA | NA |
| 3-Hydroxy-N6,N6,N6-Trimethyllysine | 0.7906 | 0.9827 | 0.9712 | 1.2555 |
| 3-Hydroxytyrosol | 0.9719 | 0.9570 | 1.1620 | 0.9091 |
| 3-Methoxytyrosine | NA | NA | NA | NA |
| 3-Methylxanthine | NA | NA | NA | NA |
| 3-Methylxanthosine | NA | NA | NA | NA |
| 4-Hydroxyproline | NA | NA | NA | NA |
| 4-Trimethylammoniobutanal | 1.0872 | 1.0076 | 1.0138 | 0.8914 |
| 5-Glutamylalanine | NA | NA | NA | NA |
| 5-Hydroxyindoleacetic acid | NA | NA | NA | NA |
| 5-Hydroxytryptophan | 1.1020 | 1.2064 | 0.8505 | 0.8411 |
| 5^-Methylthioadenosine | 0.9424 | 0.9177 | 1.0908 | 1.0491 |
| 6-Aminouracil | NA | NA | NA | NA |
| 6C13-Phenylalanine | 1.0081 | 1.0241 | 0.9436 | 1.0242 |
| 6C13-Tyrosine | 0.9746 | 0.9907 | 0.9603 | 1.0743 |
| 7-alpha-Hydroxy-3-oxo-4-cholestenoate | NA | NA | NA | NA |
| 7-Methylguanine | NA | NA | NA | NA |
| 7-Methylguanosine | NA | NA | NA | NA |
| 7-Methylxanthine | NA | NA | NA | NA |
| 7-Methylxanthosine | NA | NA | NA | NA |
| 8-Hydroxy-deoxyguanosine | NA | NA | NA | NA |
| 8-Hydroxyguanosine | 1.1807 | 1.0439 | 0.9321 | 0.8433 |
| 8-Oxo-deoxyguanosine-13C,15N2 | NA | NA | NA | NA |
| 9-Hexadecenoylcarnitine | 0.9194 | 0.8620 | 0.8721 | 1.3465 |
| Acetylcarnitine | 0.8263 | 0.8486 | 1.2342 | 1.0909 |
| Acetylcarnitine-d3 | 1.0124 | 1.0299 | 0.9573 | 1.0004 |
| Adenine | NA | NA | NA | NA |
| Adenosine | 0.8250 | 1.0835 | 0.9584 | 1.1332 |
| Adenosine diphosphate ribose | NA | NA | NA | NA |
| Adenosylcobalamin | NA | NA | NA | NA |
| AICA-riboside | NA | NA | NA | NA |
| Alanine | 1.0129 | 0.9592 | 1.0358 | 0.9921 |
| Alanine-d4 | 1.0250 | 1.0158 | 0.9378 | 1.0214 |
| alpha-Tocopherol | 0.7927 | 0.8661 | 1.1361 | 1.2051 |
| Arabitol | 1.0117 | 1.1404 | 0.9190 | 0.9289 |
| Arginine | 1.0698 | 1.0158 | 0.9855 | 0.9288 |
| Arginine-d4C13 | 0.9832 | 1.0032 | 0.9853 | 1.0282 |
| Ascorbate | NA | NA | NA | NA |
| Asparagine | 1.0255 | 1.0093 | 0.9782 | 0.9871 |
| Aspartic acid | 0.9698 | 1.0449 | 0.9254 | 1.0599 |
| Aspartic acid-d3 | 1.0198 | 1.0084 | 0.9468 | 1.0250 |
| Asymmetric dimethylarginine | 0.9056 | 0.8738 | 1.0812 | 1.1394 |
| Betaine | NA | NA | NA | NA |
| Betaine-d11 | 1.0465 | 1.0456 | 0.9250 | 0.9830 |
| Bilirubin | NA | NA | NA | NA |
| Butyrobetaine | 0.8217 | 0.9321 | 1.0612 | 1.1850 |
| Butyrylcarnitine | 1.0513 | 0.7799 | 1.2475 | 0.9213 |
| Butyrylcarnitine-d3 | 1.0317 | 1.0229 | 0.9347 | 1.0107 |
| Cadaverine | NA | NA | NA | NA |
| cADPRibose | NA | NA | NA | NA |
| Caffeine | NA | NA | NA | NA |
| Capsaicin | NA | NA | NA | NA |
| Carnitine | 0.9176 | 0.9317 | 1.0632 | 1.0875 |
| Carnitine-d9 | 1.0225 | 1.0273 | 0.9484 | 1.0018 |
| Choline | 0.9880 | 0.9549 | 1.0554 | 1.0017 |
| Citrulline | NA | NA | NA | NA |
| Citrulline-d2 | 0.9875 | 1.0438 | 0.9235 | 1.0452 |
| Cotinine | NA | NA | NA | NA |
| Creatine | 0.9146 | 0.8856 | 1.0934 | 1.1065 |
| Creatinine | NA | NA | NA | NA |
| Creatinine-d3 | NA | NA | NA | NA |
| Curcumin | NA | NA | NA | NA |
| Cyanocobalamin | NA | NA | NA | NA |
| Cystathionine | NA | NA | NA | NA |
| Cysteine | NA | NA | NA | NA |
| Cysteinylglycine | 0.9830 | 1.0297 | 0.9810 | 1.0063 |
| Cystine | NA | NA | NA | NA |
| Cytosine | NA | NA | NA | NA |
| Decanoylcarnitine | NA | NA | NA | NA |
| Demethoxycurcumin | NA | NA | NA | NA |
| Deoxyadenosine | NA | NA | NA | NA |
| Deoxyguanosine | NA | NA | NA | NA |
| Deoxyinosine | NA | NA | NA | NA |
| Dimethylethanolamine | 1.0399 | 1.0026 | 0.8850 | 1.0725 |
| Dimethylglycine | 0.9220 | 0.8985 | 1.1923 | 0.9873 |
| DNL201 | NA | NA | NA | NA |
| Dodecanoylcarnitine | 0.7138 | 0.9961 | 0.9468 | 1.3433 |
| Dopa | NA | NA | NA | NA |
| Dopamine | 1.0941 | 1.1332 | 0.8697 | 0.9030 |
| Dopamine 3-o-sulfate | NA | NA | NA | NA |
| Dopamine 4-o-sulfate | NA | NA | NA | NA |
| Epinephrine | 1.0576 | 0.9959 | 0.9665 | 0.9801 |
| Ergothioneine | NA | NA | NA | NA |
| Ethanolamine | 0.8254 | 0.7785 | 1.1575 | 1.2386 |
| Formylanthranilic acid | NA | NA | NA | NA |
| gamma-Aminobutyric acid | 0.8151 | 0.5991 | 1.4930 | 1.0929 |
| Gamma-Glutamylcysteine | NA | NA | NA | NA |
| Glucosamine | NA | NA | NA | NA |
| Glucose | NA | NA | NA | NA |
| Glutamic acid | 0.9390 | 0.9507 | 1.0548 | 1.0555 |
| Glutamic acid-d3 | 1.0638 | 1.0195 | 0.8626 | 1.0542 |
| Glutamine | 1.0487 | 0.9882 | 1.0260 | 0.9372 |
| Glutathione | 0.9272 | 0.8339 | 1.3197 | 0.9192 |
| Glutathione disulfide | NA | NA | NA | NA |
| Glutathione-(glycine-13C2,15N) | NA | NA | NA | NA |
| Glycerophosphocholine | 1.0270 | 0.7693 | 1.3152 | 0.8886 |
| Glycine | 1.0827 | 0.9222 | 1.0900 | 0.9051 |
| Guanine | 1.0042 | 1.0825 | 0.9768 | 0.9365 |
| Guanosine | NA | NA | NA | NA |
| Hexanoylcarnitine | 1.1381 | 0.8869 | 1.0487 | 0.9263 |
| Histamine | NA | NA | NA | NA |
| Histidine | 1.0330 | 0.9866 | 1.0170 | 0.9634 |
| Homocysteine | 1.0082 | 1.0188 | 0.9384 | 1.0345 |
| Homoserine | 1.0534 | 0.9750 | 1.0104 | 0.9611 |
| Hydroxybutyrylcarnitine | 0.9104 | 0.8960 | 1.1910 | 1.0026 |
| Hydroxyhexanoylcarnitine | NA | NA | NA | NA |
| Hydroxyisovaleroyl carnitine | 0.9163 | 0.8288 | 1.2855 | 0.9694 |
| Hydroxypropionylcarnitine | NA | NA | NA | NA |
| Hypoxanthine | 0.8899 | 0.8978 | 1.2620 | 0.9503 |
| Imidazoleacetic acid | 0.8920 | 0.8735 | 0.9213 | 1.3132 |
| Indole | NA | NA | NA | NA |
| Inosine | 0.8971 | 1.0720 | 1.0728 | 0.9581 |
| Isovalerylcarnitine | 1.0267 | 0.9152 | 1.1400 | 0.9180 |
| Isovalerylcarnitine-d9 | 1.0251 | 1.0353 | 0.9426 | 0.9969 |
| Kynurenic acid | NA | NA | NA | NA |
| Kynurenine | NA | NA | NA | NA |
| Leucine | 1.0498 | 1.0158 | 0.9601 | 0.9742 |
| Leucine-d3 | 1.0070 | 1.0153 | 0.9578 | 1.0199 |
| Linoleyl carnitine | 0.9038 | 0.6965 | 1.1527 | 1.2470 |
| LPC(18:1(d7)) | 0.9991 | 1.0002 | 0.9655 | 1.0352 |
| Lysine | 1.0531 | 1.0076 | 0.9947 | 0.9445 |
| Mannitol | NA | NA | NA | NA |
| Mannose | 1.2219 | 1.0667 | 0.8710 | 0.8404 |
| Melatonin | 1.1153 | 0.6492 | 1.4122 | 0.8234 |
| Methionine | 1.0196 | 0.9264 | 1.0697 | 0.9843 |
| Methionine-d3 | 1.0025 | 1.0057 | 0.9628 | 1.0290 |
| Methionine S-oxide | 1.1139 | 1.0885 | 0.8435 | 0.9541 |
| Methylcobalamin | NA | NA | NA | NA |
| Myristoylcarnitine | NA | NA | NA | NA |
| Myristoylcarnitine-d9 | 0.9734 | 1.0080 | 1.0330 | 0.9856 |
| N15C13-Glycine | 1.0314 | 1.0333 | 0.9199 | 1.0153 |
| N1-Acetylspermidine | 0.9732 | 0.6868 | 1.5523 | 0.7877 |
| N1-Acetylspermidine-d6 | NA | NA | NA | NA |
| N1-Acetylspermine | NA | NA | NA | NA |
| N1-N12-Diacetylspermine | NA | NA | NA | NA |
| N1-N8-Diacetylspermidine | NA | NA | NA | NA |
| N1-N8-Diacetylspermidine-d6 | NA | NA | NA | NA |
| N6,N6,N6-Trimethyllysine | 0.8989 | 0.9655 | 0.9838 | 1.1517 |
| N-Acetylalanine | NA | NA | NA | NA |
| N-Acetylaspartic acid | 1.0211 | 0.9655 | 1.0027 | 1.0107 |
| N-Acetylcysteine | NA | NA | NA | NA |
| N-Acetylglutamic acid | NA | NA | NA | NA |
| N-Acetylneuraminic acid | 1.2804 | 1.0876 | 0.9313 | 0.7007 |
| N-Acetylputrescine | 1.1085 | 0.7844 | 1.4005 | 0.7067 |
| N-Acetylserine | 0.8814 | 0.8476 | 1.2368 | 1.0342 |
| NAD | 0.8662 | 0.8282 | 1.1405 | 1.1651 |
| N-Alpha-acetyllysine | NA | NA | NA | NA |
| Niacinamide | 1.0234 | 0.8938 | 1.1955 | 0.8873 |
| Niacinamide-d4 | 0.9932 | 1.0155 | 0.9744 | 1.0169 |
| Nicotinamide mononucleotide | NA | NA | NA | NA |
| Nicotinamide riboside | NA | NA | NA | NA |
| Nicotinic acid | NA | NA | NA | NA |
| Nitrotyrosine | NA | NA | NA | NA |
| N,N^-Bis(gamma-glutamyl)cystine | NA | NA | NA | NA |
| Nonanoylcarnitine | NA | NA | NA | NA |
| Norepinephrine | NA | NA | NA | NA |
| Octanoylcarnitine | 0.9555 | 1.1649 | 0.9471 | 0.9324 |
| Octanoylcarnitine-d3 | 1.0325 | 1.0546 | 0.9303 | 0.9826 |
| Ornithine | 1.0159 | 0.7518 | 1.2548 | 0.9776 |
| Ornithine-d2 | 1.0007 | 0.9744 | 1.0063 | 1.0185 |
| Palmitoylcarnitine | 0.8264 | 0.8614 | 1.0291 | 1.2831 |
| Palmitoylcarnitine-d3 | 0.9867 | 0.9958 | 0.9898 | 1.0278 |
| Paraxanthine | NA | NA | NA | NA |
| Phenylalanine | 1.0510 | 1.0153 | 0.9815 | 0.9522 |
| Piperanine | NA | NA | NA | NA |
| Piperine | NA | NA | NA | NA |
| Pipernonaline | NA | NA | NA | NA |
| Piperyline | NA | NA | NA | NA |
| Proline | 1.0925 | 0.9279 | 1.0198 | 0.9598 |
| Propionylcarnitine | 0.8336 | 0.9180 | 1.1692 | 1.0793 |
| Propionylcartinine-d3 | 1.0233 | 1.0287 | 0.9456 | 1.0024 |
| Putrescine | NA | NA | NA | NA |
| Pyridoxamine | 1.0976 | 1.1353 | 0.8524 | 0.9148 |
| Pyroglutamic acid | 1.0986 | 1.0050 | 1.0111 | 0.8853 |
| S-Adenosylhomocysteine | 0.8403 | 0.8338 | 1.3413 | 0.9846 |
| S-Adenosylmethionine | 0.8410 | 0.8034 | 1.3155 | 1.0401 |
| Sarcosine | 1.0128 | 0.9527 | 1.0540 | 0.9805 |
| Serine | 1.0687 | 1.0580 | 0.9231 | 0.9503 |
| Serotonin | NA | NA | NA | NA |
| Spermidine | NA | NA | NA | NA |
| Spermine | NA | NA | NA | NA |
| Stearoylcarnitine | NA | NA | NA | NA |
| Sucrose | 1.0683 | 1.0969 | 0.9425 | 0.8922 |
| Taurine | 0.9451 | 0.9371 | 0.9698 | 1.1480 |
| Tetrahydrocurcumin | NA | NA | NA | NA |
| Theobromine | NA | NA | NA | NA |
| Theophylline | NA | NA | NA | NA |
| Thiamine | 1.0252 | 0.9983 | 1.0615 | 0.9150 |
| Threonine | 1.0805 | 0.9704 | 1.0012 | 0.9479 |
| Trigonelline | NA | NA | NA | NA |
| Trimethylamine-d9 N-oxide | 1.0252 | 1.0358 | 0.9401 | 0.9989 |
| Trimethylamine-N-oxide | 1.0363 | 1.0173 | 0.9413 | 1.0051 |
| Tryptophan | 1.1177 | 0.9887 | 0.9274 | 0.9661 |
| Tyrosine | 1.0160 | 0.9503 | 1.0364 | 0.9973 |
| Uracil | NA | NA | NA | NA |
| Ureidopropionic acid | NA | NA | NA | NA |
| Uric acid | NA | NA | NA | NA |
| Uridine | NA | NA | NA | NA |
| Valerobetaine | NA | NA | NA | NA |
| Valerobetaine-d9 | 1.0238 | 1.0450 | 0.9339 | 0.9974 |
| Valine | 0.9332 | 0.8657 | 1.0198 | 1.1813 |
| Valine-d8 | 0.9451 | 0.9371 | 0.9698 | 1.1480 |
| Xanthine | 1.0657 | 1.0215 | 0.9566 | 0.9562 |
| Xanthosine | 1.0558 | 1.1265 | 0.9190 | 0.8988 |
Factors:
| F1 | genotype:PILRAKO | treatment:LPS |
| F2 | genotype:PILRAKO | treatment:Vehicle |
| F3 | genotype:WT | treatment:LPS |
| F4 | genotype:WT | treatment:Vehicle |
