Data for (Study ST003891)
(Analysis AN006392)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| 1-Methylhistidine_C12 PARENT | 1.0970 | 1.2444 | 0.6933 | 0.6403 | 0.9104 | 1.1418 | 0.7159 | 1.3772 |
| 1-Methylhistidine_C13-label-1 | 1.2142 | 1.3897 | 0.9315 | 0.4691 | 0.8282 | 1.2826 | 0.7535 | 0.9554 |
| 2-Hydroxypyridine_C12 PARENT | 1.1033 | 1.0632 | 0.9406 | 1.1158 | 0.7820 | 1.1552 | 0.9699 | 0.8976 |
| 2-Hydroxypyridine_C13-label-1 | 1.2570 | 0.9708 | 1.1212 | 0.8713 | 0.9904 | 1.0081 | 0.9208 | 0.9019 |
| 4-Pyridoxic acid_C12 PARENT | 0.7909 | 0.9338 | 0.6776 | 0.6895 | 0.8224 | 0.6009 | 0.9593 | 2.3823 |
| 4-Pyridoxic acid_C13-label-5 | 1.5399 | 0.8234 | 0.5897 | 0.3439 | 0.6750 | 2.1240 | 1.5440 | 0.9543 |
| Acetyl-arginine_C12 PARENT | 0.7108 | 0.6711 | 2.0206 | 0.7234 | 0.9533 | 0.4416 | 0.5813 | 1.8954 |
| Acetyl-arginine_C13-label-1 | NA | 0.6255 | 0.8040 | 0.0481 | 0.8566 | NA | NA | 3.0578 |
| Acetyl proline_C12 PARENT | 1.0483 | 0.6684 | 0.9365 | 0.6065 | 0.7431 | 1.2267 | 0.9929 | 1.6365 |
| Acetyl-tryptophan_C12 PARENT | 0.9481 | 1.0732 | 1.1224 | 0.8347 | 1.0905 | 1.0907 | 0.5797 | 1.1431 |
| Acetyl-tryptophan_C13-label-1 | 0.9396 | 1.4588 | 0.9769 | 0.8511 | 1.1276 | 0.8033 | 0.5710 | 1.0003 |
| Acetyl-tryptophan_C13-label-2 | NA | 1.0000 | NA | NA | NA | NA | NA | NA |
| Adenosine_C12 PARENT | 1.6319 | 1.0349 | 0.4690 | 1.1601 | 1.5477 | 0.8480 | 1.0898 | 0.3955 |
| Adenosine_C13-label-1 | 1.0051 | 1.5069 | 0.4667 | 1.0127 | 1.0532 | 0.8337 | 1.0518 | 0.4228 |
| Adenosine_C13-label-10 | NA | 0.6691 | 0.8903 | 1.1493 | 0.8487 | NA | 1.2269 | 1.3462 |
| Adenosine_C13-label-2 | 0.9650 | 0.9669 | NA | 1.0022 | NA | 1.2183 | 0.9138 | NA |
| Adenosine_C13-label-4 | NA | 1.0000 | NA | NA | NA | NA | NA | NA |
| Alanine_C12 PARENT | 1.1253 | 1.2357 | 0.7837 | 0.9709 | 0.8180 | 1.3102 | 0.7190 | 0.9492 |
| Alanine_C13-label-1 | 0.8215 | 1.1053 | 1.1190 | 0.7469 | 0.6384 | 1.4140 | 1.1142 | 0.8917 |
| Alanine_C13-label-2 | 0.7360 | 1.2181 | 1.3068 | 0.7018 | 0.4437 | 1.2477 | 1.4764 | 0.7854 |
| Alanine_C13-label-3 | 0.9483 | 1.4179 | 0.9661 | 0.8281 | 0.6203 | 1.0542 | 1.0955 | 1.0067 |
| Arginine_C12 PARENT | 1.4054 | 0.9623 | 0.8402 | 1.3334 | 0.7897 | 1.0529 | 0.7716 | 0.9927 |
| Arginine_C13-label-1 | 1.2912 | 1.1639 | 0.6562 | 1.1586 | 1.2668 | 0.8625 | 0.7032 | 0.9543 |
| Asparagine_C12 PARENT | 0.8468 | 1.1984 | 0.8824 | 0.9829 | 0.8990 | 1.0412 | 0.7661 | 1.2784 |
| Aspartate_C12 PARENT | 0.7127 | 1.1039 | 0.7242 | 1.2743 | 1.0126 | 0.9099 | 0.7774 | 1.4230 |
| Carnitine_C12 PARENT | 0.7751 | 0.1689 | 0.6880 | 1.7244 | 1.7329 | 0.5554 | 1.1081 | 1.4242 |
| Carnitine_C13-label-1 | 1.3467 | 1.2315 | 1.4092 | 1.1998 | 0.9637 | 0.7580 | 0.7023 | 0.5954 |
| Carnitine_C13-label-2 | 1.1852 | 1.0213 | 1.1968 | 0.9418 | 0.7852 | 1.2198 | 0.6490 | 0.9837 |
| Choline_C12 PARENT | 1.0674 | 1.3157 | 0.9147 | 1.0213 | 0.7874 | 1.0594 | 0.7606 | 1.0441 |
| Choline_C13-label-1 | 0.8942 | 1.5917 | 1.0213 | 1.2585 | 0.7317 | 0.8647 | 0.6665 | 0.9897 |
| Choline_C13-label-2 | 1.1877 | 1.3142 | 1.0490 | 1.0890 | 0.9429 | 1.0347 | 0.4933 | 0.8980 |
| Citrulline_C12 PARENT | 0.9842 | 0.9781 | 0.6819 | 0.7822 | 1.0353 | 1.1580 | 0.7003 | 1.5024 |
| Citrulline_C13-label-1 | 1.3770 | 0.9708 | 0.6084 | 1.0381 | 1.3662 | 0.8339 | 0.6299 | 1.2092 |
| Citrulline_C13-label-2 | 1.0980 | 1.0557 | 0.3623 | 0.8791 | 0.6389 | 1.2428 | 0.6966 | 1.6649 |
| Citrulline_C13-label-3 | 0.9133 | 1.0625 | 0.9089 | 1.0107 | NA | 1.0096 | 0.9940 | 1.0045 |
| Creatine_C12 PARENT | 1.0331 | 1.5786 | 1.6550 | 1.0673 | 0.3993 | 0.9643 | 0.3417 | 0.9940 |
| Creatine_C13-label-1 | 1.0022 | 1.5697 | 0.7417 | 1.0102 | 1.3106 | 0.8141 | 0.3087 | 1.1372 |
| Creatine_C13-label-2 | 1.2341 | 1.2644 | 0.8307 | 1.1252 | 1.2214 | 0.8586 | 0.6306 | 0.8809 |
| Creatine phosphate_C12 PARENT | 0.7577 | 0.8706 | 0.8913 | 1.4238 | 1.3820 | 0.9228 | 0.7683 | 1.0583 |
| Creatine phosphate_C13-label-1 | 1.0424 | 0.7818 | 0.8280 | 1.2767 | 1.4400 | 0.7671 | 0.9308 | 1.1157 |
| Creatinine_C12 PARENT | 1.3466 | 0.7042 | 0.9889 | 0.4218 | 1.0251 | 0.9672 | 1.2647 | 1.2563 |
| Creatinine_C13-label-1 | 0.9873 | 0.9427 | 0.6871 | 0.8601 | 0.6422 | 0.8793 | 0.6962 | 2.1906 |
| Creatinine_C13-label-2 | 1.0375 | 0.8489 | 0.6017 | 0.6709 | 0.6253 | 1.0133 | 0.6199 | 2.3324 |
| Cytosine_C12 PARENT | 1.0472 | 1.1582 | 1.1870 | 0.5023 | 1.0266 | 1.1169 | 0.8554 | 0.9671 |
| Cytosine_C13-label-1 | 1.2237 | 0.8798 | 1.1911 | 0.9525 | 0.9322 | 1.0471 | 0.7347 | 1.0719 |
| Deoxycytidine_C12 PARENT | 1.2203 | 1.2367 | 0.9419 | 0.9913 | 0.9182 | 1.1170 | 0.8238 | 0.7611 |
| Deoxycytidine_C13-label-1 | 1.0704 | 1.1088 | 1.0174 | 0.3485 | 1.6036 | 0.9864 | 0.9236 | 0.8264 |
| Deoxycytidine_C13-label-5 | NA | 1.4499 | NA | NA | 0.5029 | NA | NA | 1.1416 |
| Dimethyl-arginine_C12 PARENT | 0.7782 | 1.4058 | 0.5176 | 0.7299 | 0.7714 | 0.7590 | 0.8591 | 1.9838 |
| Dimethyl-arginine_C13-label-1 | 1.1809 | 1.2192 | 0.9557 | 0.8860 | 0.8966 | 1.0557 | 0.7044 | 1.0641 |
| Glutamate_C12 PARENT | 0.6979 | 0.9966 | 1.1883 | 1.1013 | 1.0834 | 0.9453 | 0.6157 | 1.2937 |
| Glutamate_C13-label-1 | 0.7369 | 1.2493 | 1.0154 | 1.1262 | 0.9751 | 0.8035 | 1.0037 | 1.0816 |
| Glutamate_C13-label-2 | 0.9606 | 0.8917 | 1.0179 | 0.8970 | 1.1667 | 1.2671 | 0.9377 | 0.7760 |
| Glutamate_C13-label-3 | 1.2700 | 1.1300 | 0.8829 | 1.0939 | 1.1023 | 1.2024 | 1.0087 | 0.3942 |
| Glutamine_C12 PARENT | 0.7477 | 1.3667 | 1.2247 | 0.4299 | 0.6828 | 0.8786 | 1.2458 | 1.2734 |
| Glutamine_C13-label-1 | 1.1085 | 0.7516 | 0.9685 | 1.1381 | 0.8638 | 1.1513 | 0.9061 | 1.1430 |
| Glutamine_C13-label-2 | 0.8318 | 1.4032 | 0.9175 | 1.0262 | 0.7347 | 1.0770 | 1.0934 | 0.8662 |
| Glutamine_C13-label-3 | 1.0649 | 1.3123 | 0.8314 | 0.9473 | 0.6379 | 1.2474 | 1.1707 | 0.7564 |
| Glutamine_C13-label-4 | 1.6302 | 0.8255 | 0.6470 | 1.3966 | 1.1834 | 0.6305 | 0.8928 | 1.0744 |
| Glutathione_C12 PARENT | 0.2539 | 0.7625 | 2.3144 | 0.8855 | 0.3185 | 0.6117 | 1.4272 | 1.4848 |
| Glutathione_C13-label-2 | 0.9401 | NA | 1.2297 | NA | NA | 0.9586 | 0.7956 | NA |
| Glycerol 3-phosphate_C12 PARENT | 0.7251 | 1.4968 | 0.9140 | 0.7303 | 0.9286 | 0.9228 | 0.8360 | 1.2661 |
| Glycerol 3-phosphate_C13-label-1 | 0.5275 | 1.3509 | 1.1460 | 1.0500 | 0.8801 | 0.6757 | 0.9663 | 1.3620 |
| Glycerol 3-phosphate_C13-label-3 | 0.7414 | 1.6005 | 0.6445 | 1.3181 | 1.4710 | 0.7444 | 0.4073 | 0.6105 |
| Glycine_C12 PARENT | 1.0711 | 1.0636 | 1.1505 | 1.4182 | 0.8542 | 0.9192 | 0.9598 | 0.7305 |
| Glycine_C13-label-1 | 1.0620 | 1.3159 | 1.0658 | 1.0746 | 0.5983 | 0.6974 | 1.5070 | 0.7282 |
| Histamine_C12 PARENT | 1.1928 | 1.1581 | 0.9231 | 0.6963 | 0.8736 | 0.9146 | 0.9193 | 1.2802 |
| Histamine_C13-label-1 | 0.9482 | 1.0429 | 0.8024 | 0.5360 | 1.2126 | 0.8236 | 0.6715 | 1.7654 |
| Histidine_C12 PARENT | 0.7774 | 1.0141 | 1.0047 | 1.1248 | 0.7295 | 1.1160 | 0.8284 | 1.3368 |
| Histidine_C13-label-1 | 0.7560 | 0.7610 | 0.7984 | 0.8592 | 1.2464 | 1.2517 | 1.0163 | 1.1386 |
| Hypotaurine_C12 PARENT | 0.4776 | 0.8111 | 0.9401 | 1.2603 | 1.0096 | 0.8399 | 0.8606 | 1.7574 |
| Isoleucine_C12 PARENT | 1.4586 | 1.7700 | 0.5802 | 0.9318 | 0.7181 | 0.9161 | 0.8110 | 0.9541 |
| Isoleucine_C13-label-1 | 1.0064 | 1.3773 | 0.8499 | 1.0098 | 0.9605 | 0.9358 | 0.8349 | 0.9941 |
| Leucine_C12 PARENT | 1.1146 | 1.0549 | 0.8268 | 0.4670 | 1.4281 | 1.0870 | 0.8212 | 1.0183 |
| Leucine_C13-label-1 | 0.9389 | 1.2166 | 0.8693 | 0.7392 | 1.4112 | 1.0405 | 0.6336 | 0.9819 |
| Methionine_C12 PARENT | 1.3722 | 0.8562 | 0.5668 | 1.2079 | 0.8605 | 1.2397 | 0.5898 | 1.3179 |
| Methionine_C13-label-1 | 1.2026 | 1.1589 | 0.7555 | 1.1550 | 0.9165 | 1.0179 | 0.8828 | 0.9588 |
| Methionine_C13-label-2 | 0.6459 | 1.0772 | 1.1474 | NA | 1.1740 | NA | NA | 1.1550 |
| N-Acetylglycine_C12 PARENT | 1.0954 | 0.9302 | 1.1768 | 0.6572 | 0.6603 | 0.9644 | 1.2357 | 1.2733 |
| Nicotinamide_C12 PARENT | 1.1047 | 1.4737 | 0.4410 | 0.8930 | 1.0830 | 1.1598 | 0.6163 | 1.0703 |
| Nicotinamide_C13-label-1 | 1.0818 | 1.4225 | 0.5174 | 1.0406 | 0.9643 | 1.2463 | 0.5399 | 1.0523 |
| Nicotinamide_C13-label-2 | 1.0435 | 1.4817 | 0.7210 | 0.8971 | 0.9605 | 1.4878 | 0.8671 | 0.8221 |
| Ornithine_C12 PARENT | 0.7742 | 1.0645 | 0.8314 | 0.7481 | 0.9525 | 0.9141 | 0.6179 | 1.8945 |
| Ornithine_C13-label-1 | 0.7546 | 0.7080 | 0.6993 | 0.9636 | 1.1835 | 0.8996 | 0.7246 | 1.9183 |
| Phenylalanine_C12 PARENT | 1.2889 | 1.0532 | 1.0195 | 0.8763 | 0.9428 | 1.2738 | 0.4563 | 1.0224 |
| Phenylalanine_C13-label-1 | 1.1819 | 0.7720 | 1.0499 | 0.9837 | 1.2484 | 1.0078 | 0.6118 | 1.1423 |
| Phenylalanine_C13-label-2 | 0.8677 | 1.1361 | 0.9921 | 0.8688 | 1.4371 | 0.9979 | 0.7105 | 0.9348 |
| Pipecolate_C12 PARENT | 1.0090 | 1.0237 | 0.7420 | 0.8247 | 0.8166 | 1.0813 | 0.9960 | 1.4101 |
| Pipecolate_C13-label-1 | 1.2194 | 1.0887 | 0.8752 | 0.9192 | 0.7472 | 0.9163 | 1.0277 | 1.2440 |
| Pipecolate_C13-label-2 | NA | 0.6964 | NA | 1.1833 | NA | NA | NA | 1.4238 |
| Proline_C12 PARENT | 1.2827 | 0.9263 | 1.3220 | 1.0890 | 0.5772 | 1.0391 | 0.9635 | 0.9416 |
| Proline_C13-label-1 | 0.9227 | 0.8924 | 1.2038 | 0.7447 | 0.6343 | 1.2233 | 1.1782 | 1.1283 |
| Proline_C13-label-2 | 0.6736 | 1.0839 | 1.2884 | 0.7243 | 0.3971 | 1.4836 | 1.4792 | 0.6129 |
| Proline_C13-label-3 | 0.6015 | 0.7052 | 1.1421 | 0.2361 | 0.3817 | 1.7964 | 1.3467 | 0.5320 |
| Pyridoxal_C12 PARENT | 0.8854 | 1.4985 | 1.0018 | 0.9915 | 0.7391 | 0.9126 | 0.9843 | 0.9622 |
| Pyridoxal_C13-label-1 | 0.8349 | 1.5470 | 1.0747 | 1.1849 | 0.6286 | 0.8459 | 1.0437 | 0.8849 |
| Serine_C12 PARENT | 1.1673 | 1.1256 | 0.8721 | 0.9421 | 0.9059 | 1.1307 | 0.7314 | 1.0807 |
| Serine_C13-label-1 | 0.8793 | 1.3859 | 0.9415 | 0.8465 | 0.7633 | 1.1015 | 0.8931 | 1.0726 |
| Taurine_C12 PARENT | 0.9384 | 1.3145 | 0.7179 | 0.7887 | 1.0981 | 0.9790 | 0.9452 | 1.0951 |
| Taurine_C13-label-1 | 0.9120 | 0.8740 | 0.6674 | 1.0876 | 1.2485 | 0.9687 | 0.8329 | 1.3420 |
| Thiamine_C12 PARENT | 1.0124 | 0.9497 | 0.8202 | 1.4687 | 0.8586 | 0.6765 | 0.9116 | 1.4477 |
| Thiamine_C13-label-1 | 0.9860 | 0.9223 | 0.6527 | 0.8205 | 0.9721 | 1.0144 | 0.9454 | 1.5719 |
| Threonine_C12 PARENT | 1.1437 | 1.1260 | 0.7255 | 0.9753 | 1.2848 | 0.9336 | 0.8172 | 0.9721 |
| Threonine_C13-label-1 | 1.0581 | 0.9925 | 0.7433 | 0.7225 | 1.2130 | 1.1321 | 0.8532 | 1.1460 |
| trans-4-Hydroxy-L-proline_C12 PARENT | 1.3303 | 1.0652 | 0.8455 | 0.9947 | 0.8224 | 1.0335 | 0.7919 | 1.1528 |
| trans-4-Hydroxy-L-proline_C13-label-1 | 1.4087 | 0.8634 | 0.6458 | 1.0697 | 1.2047 | 0.8687 | 0.9402 | 1.1536 |
| Trimethylglycine (Betaine)_C12 PARENT | 1.2340 | 1.0296 | 0.9042 | 0.9048 | 0.8769 | 0.9951 | 0.8528 | 1.2083 |
| Trimethylglycine (Betaine)_C13-label-1 | 1.1207 | 1.3574 | 0.3799 | 0.8877 | 0.9620 | 1.0409 | 1.1303 | 1.0475 |
| Trimethylglycine (Betaine)_C13-label-2 | 1.0880 | 1.0629 | 0.8191 | 1.0209 | 0.8525 | 1.1650 | 0.8487 | 1.1030 |
| Tryptophan_C12 PARENT | 1.2113 | 1.1834 | 0.8608 | 1.1300 | 0.9452 | 0.9133 | 0.7587 | 1.0529 |
| Tryptophan_C13-label-1 | 1.3522 | 0.9850 | 0.9561 | 1.0259 | 1.3014 | 0.8104 | 0.7826 | 0.8842 |
| Tryptophan_C13-label-2 | 0.9580 | 1.4687 | 0.9217 | 0.9750 | 1.0408 | 0.7777 | 0.7538 | 1.0706 |
| Tyrosine_C12 PARENT | 0.9803 | 1.3405 | 0.8618 | 0.9562 | 1.0743 | 0.9322 | 1.0027 | 0.8242 |
| Tyrosine_C13-label-1 | 1.1415 | 1.1833 | 0.7250 | 0.7234 | 1.2535 | 0.7940 | 0.9720 | 1.1549 |
| Uridine_C12 PARENT | 0.8821 | 0.7477 | 0.7558 | 0.8562 | 0.8149 | 0.6894 | 0.7975 | 2.3623 |
| Xylose_C12 PARENT | 1.2026 | 1.1589 | 0.7555 | 1.1550 | 0.9165 | 1.0179 | 0.8828 | 0.9588 |
Factors:
| F1 | Diet:Control | | Genotype:KP |
| F2 | Diet:Control | | Genotype:PGKP |
| F3 | Diet:Control | | Genotype:PolG |
| F4 | Diet:Control | | Genotype:wt |
| F5 | Diet:Ser/Gly free | | Genotype:KP |
| F6 | Diet:Ser/Gly free | | Genotype:PGKP |
| F7 | Diet:Ser/Gly free | | Genotype:PolG |
| F8 | Diet:Ser/Gly free | | Genotype:wt |
