Data for (Study ST003906)
(Analysis AN006411)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1_3-Bisphosphoglyceric acid | 1.0534 | 0.9537 | 0.9961 | 0.9839 |
| 2_3-Diphosphoglyceric acid | 1.0538 | 0.9531 | 0.9960 | 0.9840 |
| 2-dehydro-D-gluconate | 0.9469 | 1.2540 | 0.8912 | 1.0772 |
| 2-Hydroxy-2-methylbutanedioic acid | 1.2352 | 0.7031 | 1.4775 | 0.5010 |
| 3-phosphoglycerate | 1.0177 | 1.0981 | 0.9685 | 0.9626 |
| 3-phospho-serine | 1.0703 | 0.5460 | 1.0371 | 1.0742 |
| 4-aminobutyrate | 1.2054 | 0.9578 | 0.8723 | 0.9439 |
| 4-phosphopantothenate | 0.7232 | 1.2584 | 1.0514 | 1.1049 |
| 4-Pyridoxic acid | 0.8005 | 1.5495 | 0.9568 | 1.0670 |
| 5-aminopentanoic acid | 0.9935 | 0.9753 | 1.0122 | 1.0121 |
| 5-phosphoribosyl-1-pyrophosphate | 0.4717 | 0.8144 | 1.1947 | 1.3955 |
| 6-phospho-D-gluconate | 1.1252 | 1.0670 | 0.9884 | 0.8219 |
| acetyl-aspartate | 1.0304 | 2.1790 | 0.5053 | 0.8748 |
| acetyl-CoA | 0.8867 | 1.0117 | 1.0043 | 1.1091 |
| Acetyllysine | 0.9579 | 0.7697 | 1.2079 | 0.9447 |
| acetylphosphate | 1.0096 | 1.1493 | 0.8662 | 0.9748 |
| aconitate | 0.6821 | 1.2706 | 1.1307 | 1.0266 |
| adenine | 0.7054 | 1.3186 | 1.0882 | 1.0566 |
| adenosine 5^-phosphosulfate | 0.9256 | 1.1574 | 0.9554 | 1.0263 |
| ADP-D-glucose | 0.9400 | 1.2966 | 0.8736 | 0.9607 |
| a-ketoglutarate | 1.0938 | 0.7870 | 1.1241 | 0.9146 |
| alanine/sarcosine | 1.0346 | 0.9822 | 1.0150 | 0.9582 |
| Aminoadipic acid | 0.6626 | 0.9124 | 1.3014 | 1.0950 |
| arginine | 1.3795 | 0.7767 | 0.8486 | 0.8991 |
| asparagine | 1.0159 | 0.9198 | 1.0563 | 0.9742 |
| aspartate | 0.6525 | 1.3932 | 1.0599 | 1.0554 |
| carnitine | 0.8576 | NA | 1.0900 | 1.0524 |
| CDP | 0.6906 | 1.1544 | 1.0738 | 1.1493 |
| CDP-choline | 0.8512 | 1.6113 | 0.9857 | 0.9593 |
| CDP-ethanolamine | 1.0214 | NA | 1.0663 | 0.9123 |
| Citraconic acid | 0.7614 | 1.0898 | 1.3627 | 0.7973 |
| citrate/isocitrate | 0.4147 | NA | 1.6877 | 0.8976 |
| CMP | 0.9140 | 0.5068 | 0.8880 | 1.4447 |
| coenzyme A | 0.9883 | 0.7421 | 1.4348 | 0.7124 |
| creatine | 0.9550 | 1.2548 | 1.1431 | 0.6986 |
| CTP | 0.6751 | 1.2071 | 1.1342 | 1.0385 |
| cyclic-AMP | 0.6529 | NA | 1.2666 | 1.0804 |
| cytidine | 1.0808 | 0.8742 | 0.9645 | 1.0323 |
| DAL | 0.9880 | 0.9407 | 1.0206 | 1.0062 |
| dAMP | 0.9582 | 0.8018 | 0.6549 | 1.8776 |
| dATP | 1.2796 | 0.9318 | 0.9067 | 0.8388 |
| dCDP | 1.0852 | NA | 1.1608 | 0.7539 |
| dCMP | 0.9929 | 1.1079 | 0.9900 | 0.9901 |
| dCTP | 0.9421 | 1.1806 | 0.8950 | 1.0584 |
| D-erythrose-4-phosphate | 0.8317 | NA | 1.0271 | 1.1412 |
| dGDP/ADP | 0.9065 | 1.3324 | 0.9338 | 0.9932 |
| D-glucarate | 0.8821 | NA | 1.2604 | 0.8575 |
| D-gluconate | 1.0062 | 0.9647 | 0.9699 | 1.0454 |
| D-glucosamine-1/6-phosphate | 0.9239 | 1.1543 | 1.0177 | 0.9813 |
| dGMP/AMP | 0.6888 | 2.0278 | 0.9080 | 1.0683 |
| dGTP/ATP | 1.0584 | 1.1846 | 0.9857 | 0.8556 |
| dihydroorotate | 2.7844 | 0.0482 | 0.0449 | 1.1837 |
| dihydroxy-acetone-phosphate | 1.0530 | 0.9902 | 1.0136 | 0.9327 |
| DLH | 1.1151 | 0.8308 | 1.1512 | 0.8235 |
| DL-Pipecolic Acid | 1.1424 | 0.9356 | 0.9794 | 0.9109 |
| DLS | 1.4164 | 0.5345 | 0.9594 | 0.7517 |
| D-sedoheptulose-1/7-phosphate | 0.7756 | 2.6777 | 0.7981 | 1.0069 |
| dTDP | 0.5305 | 1.3243 | 1.1448 | 1.1721 |
| dTMP | 0.5439 | 0.9169 | 1.3806 | 1.1405 |
| dTTP | 0.5203 | 1.2425 | 1.2543 | 1.1102 |
| EV | 1.0027 | NA | 0.8675 | 1.1298 |
| FAD | 0.8971 | 1.2476 | 0.9688 | 1.0104 |
| FMN | 0.8206 | 0.9978 | 1.0642 | 1.1248 |
| folate | 1.1152 | 0.1052 | 1.1479 | 1.2212 |
| fructose-1-6-bisphosphate | 0.9877 | 0.8763 | 1.0633 | 1.0115 |
| fructose-6-phosphate | 0.7870 | 1.7678 | 0.9790 | 0.9217 |
| fumarate | 0.9532 | 1.1589 | 0.9623 | 0.9256 |
| GDP | 0.9971 | 1.2203 | 0.9762 | 0.9386 |
| glucono-lactone | 0.8304 | NA | 0.9497 | 1.2199 |
| glucose-1-phosphate | 0.7826 | 1.7771 | 0.9905 | 0.9100 |
| glutamate | 1.1879 | 0.9982 | 0.8826 | 0.9257 |
| glutamine | 0.9561 | 0.9885 | 1.0527 | 0.9979 |
| glutathione | 1.0236 | 0.0013 | 1.3071 | 1.0025 |
| glutathione disulfide | 0.9023 | 1.1887 | 0.9172 | 1.0912 |
| glycerate | 0.9603 | 0.4927 | 0.9385 | 1.3040 |
| GMP | 1.6284 | NA | 0.6120 | 0.7596 |
| GTP | 1.2994 | 1.0466 | 0.8968 | 0.7443 |
| Guanidoacetic acid | 1.0030 | 1.1641 | 1.0155 | 0.9269 |
| guanine | 1.1382 | 0.6193 | 0.8858 | 1.1815 |
| guanosine | 1.1717 | 0.8790 | 0.9897 | 0.9597 |
| Hexose | 1.0516 | 1.4398 | 1.0434 | 0.6565 |
| hexose-phosphate | 0.8705 | 2.5047 | 0.8856 | 0.8677 |
| histidine | 1.0530 | 0.9800 | 1.0572 | 0.8947 |
| homocysteic acid | 0.9050 | 1.2042 | 0.9353 | 1.0916 |
| HVDD | 1.3223 | 0.4441 | 1.2695 | 0.6862 |
| Hydroxyisocaproic acid | 1.1740 | 1.0029 | 0.8726 | 0.9258 |
| hydroxyproline/Aminolevulinate | 0.9870 | 0.9781 | 0.9959 | 1.0324 |
| hypoxanthine | 0.9199 | NA | 0.9826 | 1.0975 |
| IMP | 1.0198 | 1.2689 | 0.9266 | 0.9864 |
| inosine | 1.1414 | 0.8280 | 1.0110 | 0.9745 |
| isoleucine | 1.0121 | 1.0188 | 0.9582 | 1.0221 |
| Isopentyl-PP | 1.4459 | 0.7775 | 0.5467 | 1.3449 |
| Kynurenine | 0.7000 | 1.2276 | 0.7645 | 1.3080 |
| lactate | 1.0625 | NA | 0.7542 | 1.1833 |
| L-arginino-succinate | 0.9703 | 1.3040 | 0.9817 | 0.8560 |
| LD | 1.0966 | NA | 0.9591 | 0.9443 |
| leucine | 1.0575 | 0.9359 | 0.9415 | 1.0361 |
| lysine | 1.3829 | 0.8134 | 0.8344 | 0.8872 |
| malate | 0.9029 | 1.1982 | 1.0374 | 0.9582 |
| maleic acid | 0.9896 | 1.0366 | 1.0210 | 0.9651 |
| methionine | 1.0345 | 1.1053 | 0.9757 | 0.9214 |
| myo-inositol | 0.9771 | 1.1553 | 0.9939 | 0.9469 |
| N-acetyl-glutamate | 1.1726 | 1.2920 | 0.6603 | 0.9691 |
| N-acetyl-glutamine | 1.0021 | NA | 0.8399 | 1.1580 |
| N-Acetyl-L-alanine | 0.7760 | NA | 1.3088 | 0.9152 |
| N-acetyl-L-ornithine | 0.9684 | 1.0250 | 1.0939 | 0.9171 |
| NADH | 0.5789 | NA | 2.0817 | 0.3394 |
| NADP+ | 0.8041 | 1.1320 | 1.1684 | 0.9615 |
| NADPH | 0.9121 | 0.8878 | 1.4762 | 0.6678 |
| N-carbamoyl-L-aspartate | 2.5789 | 0.1134 | 0.0970 | 0.7537 |
| nicotinamide mononucleotide | 0.8402 | 1.0457 | 1.0512 | 1.0936 |
| nicotinate | 0.7041 | 0.5929 | 1.3163 | 1.1832 |
| Nicotinic acid mononucleotide | 0.9560 | 0.9485 | 0.9838 | 1.1257 |
| O-acetyl-L-serine | 1.1825 | 0.8968 | 0.9196 | 0.9625 |
| Octulose Bisphosphate | 0.9214 | 1.4314 | 0.9790 | 0.8839 |
| ornithine | 1.1489 | 1.4322 | 0.8850 | 0.8220 |
| orotate | 1.2388 | NA | 0.7753 | 0.9859 |
| oxaloacetate | 0.5378 | NA | 1.1614 | 1.3007 |
| pantothenate | 0.7629 | NA | 1.3461 | 0.8909 |
| PD | 1.1191 | 0.9841 | 0.9878 | 0.8957 |
| PE | 1.1312 | 1.0473 | 0.9739 | 0.8569 |
| PEE | 1.1157 | 1.2405 | 0.9732 | 0.8310 |
| PEEK | 1.0009 | 1.0080 | 1.1943 | 0.7857 |
| Phenol Red | 0.9715 | 1.0345 | 1.0074 | 1.0041 |
| phenylalanine | 1.0715 | 0.9631 | 0.9519 | 0.9946 |
| Phenylpropiolic acid | 1.1744 | NA | 1.2290 | 0.5966 |
| phosphoenolpyruvate | 0.9664 | 1.3053 | 0.8987 | 0.9806 |
| proline | 1.0003 | 1.1466 | 0.9466 | 0.9779 |
| PTT | 1.1941 | 0.8670 | 0.9688 | 0.9110 |
| PVNF | 0.7455 | NA | 1.3987 | 0.8558 |
| pyridoxine | 1.0227 | 0.8623 | 0.9528 | 1.1148 |
| Pyroglutamic acid | 0.8150 | NA | 0.7730 | 1.4120 |
| Pyrophosphate | 0.9566 | 1.1802 | 1.0349 | 0.8745 |
| riboflavin | 1.0109 | NA | 1.1458 | 0.8433 |
| ribose | 1.0360 | 1.1023 | 0.9741 | 0.9234 |
| Ribose-5-phosphate | 0.9214 | NA | 0.8365 | 1.2421 |
| ribulose-5-phosphate | 1.1476 | 0.5989 | 0.9362 | 1.1168 |
| SD | 1.1460 | 0.9048 | 1.0056 | 0.8866 |
| SDL | 1.3860 | 0.8344 | 0.8919 | 0.7773 |
| Sedoheptulose bisphosphate | 0.9854 | 1.2627 | 0.9904 | 0.8928 |
| serine | 1.0240 | 0.6573 | 1.0678 | 1.0252 |
| SID | 1.5566 | NA | 0.8335 | 0.6099 |
| S-methyl-5^-thioadenosine | 1.1619 | 0.8844 | 1.1340 | 0.7539 |
| sn-glycerol-3-phosphate | 1.0921 | 0.8087 | 0.8693 | 1.1868 |
| succinate/Methylmalonic acid | 0.7468 | 0.9632 | 1.1774 | 1.1689 |
| thiamine | 1.0199 | 0.8047 | 0.9987 | 1.1057 |
| Thiamine pyrophosphate | 0.7754 | 2.0964 | 0.8255 | 0.8509 |
| threonine/homoserine | 0.9998 | 0.9689 | 1.0488 | 0.9640 |
| tryptophan | 0.7396 | NA | 0.8337 | 1.4268 |
| tyrosine | 1.0944 | 0.7890 | 0.9805 | 1.0554 |
| UDP | 0.4242 | 1.7059 | 1.2353 | 1.0581 |
| UDP-D-glucose | 1.0287 | 1.1000 | 0.9003 | 1.0118 |
| UDP-D-glucuronate | 0.9641 | 1.1351 | 1.0962 | 0.8647 |
| UDP-N-acetyl-glucosamine | 0.9188 | 1.0089 | 1.0145 | 1.0658 |
| UMP | 0.6948 | 0.6570 | 1.0406 | 1.5692 |
| uridine | 0.9184 | 1.0964 | 0.9142 | 1.1173 |
| UTP | 0.3848 | 1.4922 | 1.2797 | 1.0946 |
| valine | 0.9686 | 1.0979 | 0.9746 | 1.0086 |
| VD | 1.1503 | 1.8205 | 0.8127 | 0.6880 |
| VDPVNF | 1.0047 | 1.1530 | 1.0655 | 0.8447 |
| xanthine | 0.8740 | 0.8408 | 1.0543 | 1.1815 |
| xanthosine | 1.2915 | NA | 1.0208 | 0.6877 |
| xanthosine-5-phosphate | 0.5300 | 1.6621 | 1.1301 | 1.0089 |
Factors:
| F1 | Genotype:WT | Treatment:10 nM Atovaquone |
| F2 | Genotype:WT | Treatment:140 nM Piperaquine |
| F3 | Genotype:WT | Treatment:None |
| F4 | Genotype:WT | Treatment:QC |
