Data for (Study ST003724)
(Analysis AN006644)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1H-Imidazole-4-propionic acid | 1.5328 | 0.4818 | 0.9635 | 0.5146 |
| 1-Methyl-4-imidazoleacetic acid | 1.3333 | 0.8261 | NA | 0.5217 |
| 1-Methyladenosine | 0.9453 | 1.0553 | 0.6515 | 1.1279 |
| 1-Methylhistamine | 0.7253 | 0.8772 | 0.8033 | 1.4450 |
| 1-Methylnicotinamide | 0.7271 | 1.1882 | 0.5583 | 1.3835 |
| 2-Aminobutyric acid | 1.1634 | 0.9051 | 1.1250 | 0.8642 |
| 2-Aminooctanoic acid | NA | NA | NA | 1.0000 |
| 2^-Deoxycytidine | 0.9062 | 1.0270 | 0.7723 | 1.2302 |
| 2-Methylthiazolidine-4-carboxylic acid | 0.7405 | NA | 0.8544 | 1.4051 |
| 3-Amino-2-piperidone | 0.6607 | 1.1607 | 0.9464 | 1.1250 |
| 3-Aminopropionitrile | 1.1511 | 1.0889 | NA | 0.8193 |
| 3-Hydroxyisovalerylcarnitine | 0.6229 | 0.9854 | 0.8725 | 1.4184 |
| 3-Methylhistidine" | 1.2620 | 1.0494 | 0.8801 | 0.8369 |
| 4-Acetamido-2-aminobutyric acid | 1.2857 | NA | NA | 0.7143 |
| 4-Guanidinobutyric acid | 1.4412 | 0.9589 | 0.8419 | 0.5365 |
| 4-Oxopyrrolidine-2-carboxylic acid | 1.2359 | 1.2841 | 0.7300 | 0.7432 |
| "5-Amino-3,4-dihydro-2H-pyrrole-2-carboxylic acid" | 1.5764 | 1.0000 | 1.0069 | 0.5333 |
| 5^-Deoxy-5^-methylthioadenosine | 1.2615 | 0.8201 | 0.9752 | 0.9905 |
| 5-Hydroxylysine | 1.1163 | 1.1109 | 0.8608 | 0.8843 |
| 6-Aminohexanoic acid | NA | NA | 1.3533 | 0.5289 |
| Acetylcholine | NA | 1.0000 | NA | NA |
| Adenine | 1.1729 | 1.0831 | 0.8109 | 0.9299 |
| Adenosine | 1.3661 | 0.9214 | 0.5201 | 1.1696 |
| ADMA | 1.1718 | 0.9233 | 0.9111 | 1.0103 |
| Ala | 1.1352 | 0.8499 | 1.1603 | 0.9137 |
| Ala-Ala | NA | NA | 0.9796 | 1.0068 |
| Anserine_divalent | 0.9089 | 1.0194 | 0.9490 | 1.0943 |
| Arg | 1.3051 | 1.2508 | 0.6662 | 0.7722 |
| Argininosuccinic acid | 1.1273 | 1.2509 | 0.7091 | 0.8800 |
| Asn | 0.8568 | 0.9529 | 0.8847 | 1.2539 |
| Asp | 0.8894 | 0.9379 | 0.9071 | 1.2249 |
| Betaine | 0.9966 | 1.0759 | 0.8924 | 1.0129 |
| Butyrylcarnitine | 1.5569 | 0.7200 | 1.2672 | 0.6207 |
| Carboxymethyllysine | 1.3866 | 1.5328 | 0.5118 | 0.5486 |
| Carnitine | 1.1285 | 1.0598 | 0.9743 | 0.8579 |
| Carnosine | 0.5904 | 0.6557 | 1.3498 | 1.3921 |
| CDP-ethanolamine | 0.8098 | 1.2690 | 0.7597 | 1.0753 |
| Choline | 0.8159 | 1.0290 | 0.7696 | 1.3026 |
| Citrulline | 1.2319 | 0.9409 | 1.1389 | 0.7624 |
| Creatine | 1.0368 | 0.9706 | 1.0147 | 0.9882 |
| Creatinine | 1.1131 | 0.9494 | 1.1607 | 0.8316 |
| Cystathionine | 1.0909 | 1.1818 | NA | 0.7273 |
| Cysteine glutathione disulfide | NA | 1.2762 | 0.6695 | 1.0181 |
| Cytidine | 0.9416 | 1.0957 | 0.7337 | 1.1641 |
| Cytosine | 0.9919 | NA | 1.0081 | NA |
| Diethanolamine | 1.8856 | 0.8021 | 0.8443 | 0.9287 |
| Dimethylaminoethanol | 0.7665 | 1.2335 | NA | NA |
| Ectoine | 1.1012 | 1.1716 | 0.6018 | 1.0030 |
| Ethanolamine | 0.9684 | 1.0139 | 0.9256 | 1.0709 |
| GABA | 1.3270 | 0.9327 | 0.9984 | 0.7583 |
| Gln | 1.1337 | 1.0419 | 0.9360 | 0.9023 |
| Glu | 1.2057 | 1.3298 | 0.6976 | 0.7476 |
| Gluconolactone | NA | 1.0263 | 0.9825 | 1.0000 |
| Glucosamine | NA | 0.6197 | 1.4245 | 0.9117 |
| Glu-Glu | 0.7353 | 0.8767 | 0.8880 | 1.2941 |
| Glutathione (GSH) | 1.1507 | 1.0588 | 0.8914 | 0.9076 |
| Glutathione (GSSG)_divalent | 1.0366 | 1.0366 | 0.9811 | 0.9492 |
| Gly | 1.1643 | 0.8024 | 1.1997 | 0.9063 |
| Gly-Asp | 0.7554 | 0.9552 | 0.7554 | 1.4361 |
| Glycerol | 1.0862 | 0.8408 | 0.8182 | 1.2357 |
| Glycerophosphocholine | 0.8097 | 1.4251 | 0.5237 | 1.1081 |
| Glycerophosphorylethanolamine | 0.8817 | 1.2916 | 0.6641 | 1.0718 |
| Gly-Gly | 0.8536 | 0.9808 | 0.8037 | 1.2641 |
| Guanidoacetic acid | 0.9339 | 1.1440 | 0.7646 | 1.0973 |
| Guanosine | 0.8365 | 1.0330 | 0.6251 | 1.3227 |
| H-Asp(Gly-OH)-OH | NA | 1.0000 | NA | NA |
| H-Asp(Lys-OH)-OH" | 0.8442 | 0.9905 | 0.9095 | 1.2066 |
| His | 1.2238 | 0.9941 | 0.9226 | 0.8887 |
| Histamine | 0.9669 | 0.9521 | 0.9174 | 1.1405 |
| Homocarnosine | 0.8660 | 1.0325 | 0.9170 | 1.1411 |
| Homocitrulline | 1.1485 | 0.9856 | 1.1381 | 0.7852 |
| Homoserine | 1.1634 | 0.6648 | 1.0057 | 0.6648 |
| Hydroxyproline | 1.6598 | 0.5404 | 1.6137 | 0.4408 |
| Hypotaurine | 1.0097 | 1.0495 | 1.1767 | 0.8014 |
| Hypoxanthine | 0.7542 | 1.1356 | 0.6737 | 1.3220 |
| Ile | 1.0431 | 1.0771 | 0.9097 | 0.9606 |
| Imidazolelactic acid | 1.1884 | 0.7008 | 1.2493 | 0.5485 |
| Inosine | 0.8166 | 1.0723 | 0.7153 | 1.3021 |
| Isovalerylcarnitine-1 | NA | 0.7862 | 1.0861 | 1.0766 |
| Isovalerylcarnitine-2 | 0.9783 | 0.8478 | 2.4203 | 0.5710 |
| Kynurenine | NA | NA | 1.0638 | 0.9787 |
| Lauroylcarnitine | 1.2772 | 0.9419 | 0.9300 | 0.8355 |
| Leu | 0.9982 | 1.0585 | 0.8873 | 1.0331 |
| Lys | 1.3732 | 1.2375 | 0.6783 | 0.7213 |
| Malonylcarnitine | 1.1867 | 1.0823 | 0.9707 | 0.7918 |
| Met | 1.0041 | 0.9564 | 0.9840 | 1.0531 |
| Methionine sulfoxide | 1.0763 | 0.9935 | 0.9545 | 0.9818 |
| N1-Methyl-4-pyridone-5-carboxamide | 1.2719 | 0.7815 | 1.1363 | 0.8649 |
| N5-Ethylglutamine | 1.1473 | 0.9243 | 1.1635 | 0.8270 |
| N6-Formyllysine | 1.1753 | 0.7878 | 1.1365 | 0.8007 |
| N6-Methyllysine | 1.3664 | 1.1877 | 0.8672 | 0.6254 |
| "N6,N6,N6-Trimethyllysine" | 1.0603 | 1.3907 | 0.6288 | 0.8581 |
| N-Acetylcarnosine | 0.5826 | 0.8261 | 1.0604 | 1.3760 |
| N-Acetyllysine | 0.7232 | 1.1313 | 0.8889 | 1.0279 |
| N-Acetylserine | 0.6995 | 0.7279 | 0.7080 | 1.6463 |
| Nicotinamide" | 0.7503 | 0.9363 | 1.1333 | 1.1568 |
| NMN | 1.0988 | 1.1660 | 0.9249 | 0.8221 |
| "N,N-Dimethylglycine" | 1.1230 | 0.9369 | 1.1350 | 0.8567 |
| N-α-Acetylarginine | NA | 0.9842 | NA | 1.0237 |
| Nα-Succinylarginine | 0.7013 | 0.9965 | 1.3010 | 1.1522 |
| Nω-Methylarginine | 1.2164 | 1.0155 | NA | 0.8402 |
| O-Acetylcarnitine | 1.1696 | 0.9786 | 1.0625 | 0.8357 |
| O-Acetylhomoserine" | 1.0395 | 1.1781 | 0.7103 | 1.0221 |
| Octanoylcarnitine | 1.4404 | 0.8211 | 0.7793 | 0.9602 |
| Ophthalmic acid | 0.8277 | 0.6099 | 1.1545 | 1.1109 |
| Ornithine | 1.2527 | 0.9072 | 0.9973 | 0.8928 |
| Phe | 0.9474 | 0.9880 | 0.9474 | 1.0962 |
| Phosphorylcholine | 0.8665 | 0.7602 | 1.2857 | 1.1180 |
| Pipecolic acid | 1.3477 | 0.9137 | 1.1421 | 0.6944 |
| Pro | 0.9120 | 1.1065 | 0.8820 | 1.0584 |
| Propionylcarnitine | 0.9173 | 1.0629 | 0.9913 | 1.0102 |
| Putrescine | 0.5204 | 1.4262 | 0.5582 | 1.3109 |
| Pyridoxamine 5^-phosphate | 1.2284 | 1.0086 | 0.9860 | 0.8198 |
| S-(2-Carboxyethyl)cysteine | 1.0256 | 0.7033 | 1.3089 | 0.7814 |
| Saccharopine | 0.6929 | 0.8373 | 1.0177 | 1.1520 |
| S-Adenosylhomocysteine | 1.2279 | 0.9962 | 0.9685 | 0.8467 |
| S-Adenosylmethionine | 1.2040 | 0.8083 | 1.0332 | 1.0019 |
| Sarcosine | 1.1461 | 0.7663 | 1.4775 | 0.6685 |
| SDMA | 1.5509 | 1.1512 | 0.6636 | 0.5965 |
| Ser | 1.0237 | 0.9096 | 1.0019 | 1.0699 |
| Ser-Glu | 0.7504 | 1.1017 | 0.7197 | 1.3425 |
| Serotonin | 0.7264 | 1.0786 | 0.8750 | 1.1623 |
| S-Lactoylglutathione | 1.2819 | 1.1652 | 0.8708 | 0.7126 |
| Spermidine | 0.6993 | 1.1068 | 0.9882 | 1.1432 |
| Spermine | 1.0893 | 0.8969 | 1.2510 | 0.8810 |
| Stachydrine | 1.1185 | 0.9676 | 1.0665 | 0.8844 |
| Succinylcarnitine | 1.3262 | 1.0252 | 1.2070 | 0.5483 |
| Taurine | 1.0371 | 1.0172 | 1.0010 | 0.9523 |
| Taurocyamine | 1.2629 | 1.2458 | 0.8828 | 0.6376 |
| Thiaproline | 0.7704 | 0.8175 | 0.8036 | 1.5233 |
| Thr | 1.0478 | 0.9027 | 1.0746 | 0.9994 |
| Triethanolamine | NA | NA | 1.0000 | NA |
| Trigonelline | 1.0648 | 1.0401 | 1.0311 | 0.8832 |
| Trimethylamine | 0.6140 | 1.0351 | 1.4386 | 0.4737 |
| Trimethylamine N-oxide | 0.9841 | 1.0879 | 1.0236 | 0.9059 |
| Trp | 0.9302 | 0.9922 | 0.9218 | 1.1263 |
| Tyr | 0.9673 | 0.9075 | 1.0097 | 1.1109 |
| Tyramine | 1.0000 | NA | NA | NA |
| Tyr-Glu | NA | 0.5333 | NA | 1.4667 |
| Urea | 1.1915 | 0.9138 | 1.1225 | 0.8350 |
| Uridine | NA | NA | NA | 1.0000 |
| Urocanic acid | 1.0173 | 1.2171 | 0.8157 | 0.9165 |
| Val | 1.0259 | 1.0271 | 1.0133 | 0.9415 |
| Xanthine | 0.7663 | 1.1071 | 0.6743 | 1.2285 |
| β-Ala | 0.4016 | 0.4802 | 1.2875 | 1.7685 |
| β-Ala-Lys | 1.1521 | 1.0570 | 1.0328 | 0.8434 |
| γ-Butyrobetaine | 1.1827 | 1.3615 | 0.6538 | 0.7692 |
| γ-Glu-Asp | 0.6912 | 1.0057 | 0.6611 | 1.2321 |
| γ-Glu-Cys | 0.8323 | 0.8812 | 0.8160 | 1.4002 |
| γ-Glu-Gln | 1.0234 | 1.0185 | 0.8961 | 1.0459 |
| γ-Glu-Gly | 0.7246 | 1.0649 | 1.0923 | 1.0264 |
| γ-Glu-Leu" | 1.0551 | 1.1723 | 0.8477 | 0.9499 |
| γ-Glu-Lys_divalent | 0.9540 | 0.6120 | 0.8640 | 1.2960 |
| γ-Glu-Ser | NA | NA | NA | 1.0000 |
Factors:
| F1 | Group:TKO-Control | Sample source:Gastrocnemius muscle | Genotype:FoxO1,3,4-/- | Treatment:Control | Time:- |
| F2 | Group:TKO-IM11 | Sample source:Gastrocnemius muscle | Genotype:FoxO1,3,4-/- | Treatment:Immobilization | Time:11 days |
| F3 | Group:WT-Control | Sample source:Gastrocnemius muscle | Genotype:FoxO1,3,4flox/flox | Treatment:Control | Time:- |
| F4 | Group:WT-IM11 | Sample source:Gastrocnemius muscle | Genotype:FoxO1,3,4flox/flox | Treatment:Immobilization | Time:11 days |
