Data for (Study ST004164)
(Analysis AN006912)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetyl-CoA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Adenine | 1.1022 | 1.3652 | 1.3239 | 1.1804 | 1.2763 | 0.5979 | 0.5559 | 0.5148 | 0.7126 | 0.8180 | 0.8917 | 0.9888 | 0.8276 | 0.7243 | 0.8681 | 1.1432 | 1.7038 | 1.5164 | 1.0848 | 1.5316 | 0.9657 | 0.6814 | 0.8781 | 0.5697 | 0.9048 | 1.3168 | 1.2485 | 1.0478 | 0.9776 |
| Adenosine | 0.9515 | 1.1645 | 1.5902 | 0.8111 | 0.8676 | 0.5379 | 0.5760 | 0.4726 | 0.4054 | 1.5252 | 0.7592 | 1.5972 | 0.9172 | 0.7996 | 1.0152 | 1.8770 | 1.9414 | 1.6303 | 0.7511 | 0.8862 | 0.8765 | 0.7150 | 0.8037 | 0.5277 | 0.5257 | 1.9545 | 1.0096 | 0.8277 | 1.0707 |
| Adenosine diphosphate ribose | 1.4580 | 1.0414 | 1.3032 | 0.9006 | 1.0612 | 1.4056 | 1.0693 | 1.0100 | 0.9797 | 0.9890 | 1.0751 | 1.2543 | 0.9995 | 0.9006 | 1.0274 | 0.9099 | 1.3009 | 1.0658 | 1.1217 | 1.7186 | 0.8963 | 0.6691 | 0.9634 | 0.6970 | 1.0577 | 1.0577 | 0.9355 | 0.9704 | 0.7972 |
| ADP | 1.3203 | 1.1922 | 1.4177 | 1.2629 | 1.0410 | 1.0369 | 1.2294 | 1.2036 | 0.9983 | 0.5503 | 0.6459 | 0.6963 | 1.2108 | 1.0322 | 1.7397 | 1.4041 | 1.8039 | 1.5744 | 1.2017 | 0.6340 | 0.7962 | 0.5895 | 0.4961 | 0.4639 | 0.9451 | 1.3810 | 1.0283 | 0.8506 | 0.9127 |
| AMP | 1.1501 | 0.8772 | 1.0556 | 0.9618 | 1.0052 | 0.8824 | 0.9414 | 1.1520 | 1.3684 | 0.7532 | 0.7485 | 0.8742 | 1.2790 | 1.2951 | 1.5007 | 1.1838 | 1.5518 | 1.1280 | 1.0837 | 0.8026 | 0.8564 | 0.8337 | 0.7203 | 0.6478 | 0.9153 | 0.9864 | 0.7545 | 0.6651 | 1.1479 |
| ATP | 1.1655 | 1.1842 | 1.2006 | 1.1192 | 1.0224 | 0.8976 | 0.8267 | 0.8786 | 0.8949 | 0.9824 | 1.0439 | 1.0690 | 1.0917 | 0.9579 | 1.0442 | 1.1833 | 1.1711 | 1.1110 | 1.0219 | 1.0932 | 0.9464 | 0.5969 | 0.8467 | 0.7109 | 0.9458 | 1.0932 | 1.0671 | 0.9353 | 1.0367 |
| CDP | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| CMP | 2.1117 | 1.2664 | 1.3327 | 1.0323 | 1.2073 | 1.3559 | 1.1897 | 1.4382 | 1.5413 | 0.9013 | 0.9061 | 1.0483 | 1.2057 | 0.8725 | 1.3599 | 0.9540 | 1.2424 | 1.0411 | 1.4829 | 1.0611 | 0.6673 | 0.6040 | 0.7918 | 0.7047 | 1.2504 | 1.3479 | 0.7087 | 0.9979 | 0.7288 |
| CTP | 1.3975 | 1.4154 | 1.6001 | 1.4631 | 1.1828 | 1.3459 | 1.0234 | 1.1253 | 0.9659 | 1.2187 | 1.3825 | 1.4964 | 0.7927 | 0.6383 | 0.7165 | 0.8300 | 0.9082 | 0.8733 | 1.3157 | 1.5145 | 0.7055 | 0.7995 | 1.1008 | 0.8032 | 1.1611 | 1.4783 | 1.4177 | 1.1998 | 0.6492 |
| Cytidine | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Cytosine | 0.9412 | 1.5163 | 1.6489 | 1.4817 | 1.2788 | 0.6679 | 0.6982 | 0.6965 | 0.4929 | 1.0148 | 1.1070 | 1.4510 | 0.8320 | 0.5411 | 0.7528 | 1.1844 | 2.2134 | 2.2125 | 0.7013 | 1.2002 | 0.8751 | 0.4603 | 0.3668 | 0.5179 | 0.6956 | 1.2217 | 1.2673 | 1.0441 | 0.9447 |
| Fenclonine (IS) | 1.0475 | 0.7801 | 0.8765 | 0.8382 | 0.7933 | 1.0630 | 1.0804 | 1.0155 | 0.9781 | 0.7468 | 0.7593 | 0.8165 | 1.0909 | 1.0485 | 1.0443 | 0.8512 | 0.7574 | 0.8751 | 0.9927 | 0.7524 | 1.0789 | 1.2381 | 1.1444 | 0.9913 | 1.2683 | 0.9930 | 1.0357 | 0.9700 | 1.0998 |
| GABA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GDP | 1.1245 | 1.0784 | 1.1801 | 1.0897 | 1.1048 | 1.0501 | 0.9648 | 1.0305 | 1.0009 | 0.8281 | 0.8692 | 1.0058 | 1.0197 | 0.9367 | 1.1370 | 1.0428 | 1.2814 | 1.2313 | 1.1038 | 0.7488 | 0.9150 | 0.9217 | 0.7752 | 0.7601 | 0.9738 | 1.2796 | 1.1095 | 1.0341 | 0.9854 |
| GMP | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GSH | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GSNO | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GSSG | 1.4300 | 1.2355 | 1.3451 | 1.1962 | 1.0031 | 1.0587 | 0.9687 | 1.1584 | 1.1915 | 0.9541 | 1.0007 | 1.1336 | 1.0753 | 0.9422 | 1.0885 | 0.9722 | 0.9944 | 0.9614 | 1.1630 | 1.2659 | 0.9174 | 0.6311 | 0.8374 | 0.7419 | 1.1015 | 1.1921 | 1.0990 | 0.9649 | 0.8120 |
| GTP | 1.3290 | 1.2345 | 1.3053 | 1.1559 | 0.9626 | 1.0285 | 0.8404 | 0.9609 | 0.9397 | 1.0210 | 1.1312 | 1.1219 | 1.0893 | 0.8926 | 0.9698 | 1.0579 | 1.0654 | 1.0024 | 1.1652 | 1.2643 | 0.9004 | 0.6730 | 1.0242 | 0.7380 | 1.1050 | 1.1490 | 1.0814 | 1.0228 | 0.8943 |
| Guanine | 0.6053 | 1.5426 | 1.3832 | 1.4541 | 1.5770 | 0.4719 | 0.4726 | 0.5003 | 0.4973 | 1.3545 | 1.3068 | 1.7434 | 0.6112 | 0.4894 | 0.6322 | 1.2805 | 3.1752 | 2.7626 | 0.6303 | 0.5434 | 0.7871 | 0.5107 | 0.4321 | 0.2856 | 0.5225 | 1.7432 | 1.4879 | 1.1588 | 0.8860 |
| Guanosine | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| NAD+ | 0.9743 | 1.0136 | 1.3380 | 0.8320 | 0.9280 | 0.9585 | 1.0081 | 1.4918 | 0.9113 | 1.8090 | 1.8629 | 2.0042 | 1.1760 | 0.8305 | 1.0424 | 1.0343 | 1.8256 | 1.2682 | 0.7353 | 1.1853 | 0.6598 | 0.4856 | 0.7249 | 0.4187 | 0.9042 | 1.5965 | 1.2021 | 0.9193 | 0.8168 |
| NADH | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| NADP+ | 0.8546 | 0.9018 | 0.9892 | 0.6826 | 0.8243 | 0.7329 | 0.8096 | 1.2369 | 0.5988 | 1.2691 | 1.4262 | 1.4212 | 0.9766 | 0.8195 | 1.0586 | 1.0968 | 1.7420 | 1.2770 | 0.6446 | 1.2372 | 0.9757 | 0.9426 | 0.8727 | 0.7036 | 1.0528 | 1.1565 | 1.1183 | 1.0670 | 0.9429 |
| NADPH | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide riboside | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinic acid riboside | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Succinyl-CoA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Total protein | 0.9616 | 1.2797 | 0.9387 | 0.8251 | 0.6886 | 1.2568 | 0.8930 | 0.9616 | 0.9838 | 1.0974 | 1.1431 | 0.9387 | 0.8251 | 1.0974 | 0.9838 | 0.8022 | 1.4390 | 0.9159 | 1.0974 | 0.9838 | 0.9970 | 1.0524 | 0.9616 | 0.9616 | 0.8930 | 0.9616 | 1.0524 | 1.6206 | 0.9008 |
Factors:
| F1 | Sample source:mouse primary astrocytes | Genotype:Ent10 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F2 | Sample source:mouse primary astrocytes | Genotype:Ent11 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F3 | Sample source:mouse primary astrocytes | Genotype:Ent12 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F4 | Sample source:mouse primary astrocytes | Genotype:Ent13 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F5 | Sample source:mouse primary astrocytes | Genotype:Ent14 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F6 | Sample source:mouse primary astrocytes | Genotype:Ent15 knockout | treatment:TNFš¯¯°/IL-1š¯¯°/Forodesine |
| F7 | Sample source:mouse primary astrocytes | Genotype:Ent16 knockout | treatment:TNFš¯¯°/IL-2š¯¯°/Forodesine |
| F8 | Sample source:mouse primary astrocytes | Genotype:Ent17 knockout | treatment:TNFš¯¯°/IL-3š¯¯°/Forodesine |
| F9 | Sample source:mouse primary astrocytes | Genotype:Ent18 knockout | treatment:TNFš¯¯°/IL-4š¯¯°/Forodesine |
| F10 | Sample source:mouse primary astrocytes | Genotype:Ent19 knockout | treatment:TNFš¯¯°/IL-5š¯¯°/Forodesine |
| F11 | Sample source:mouse primary astrocytes | Genotype:Ent20 knockout | treatment:TNFš¯¯°/IL-6š¯¯°/Forodesine |
| F12 | Sample source:mouse primary astrocytes | Genotype:Ent21 knockout | treatment:TNFš¯¯°/IL-7š¯¯°/Forodesine |
| F13 | Sample source:mouse primary astrocytes | Genotype:Ent2 knockout | treatment:Vehicle |
| F14 | Sample source:mouse primary astrocytes | Genotype:Ent3 knockout | treatment:Vehicle |
| F15 | Sample source:mouse primary astrocytes | Genotype:Ent4 knockout | treatment:Vehicle |
| F16 | Sample source:mouse primary astrocytes | Genotype:Ent5 knockout | treatment:Vehicle |
| F17 | Sample source:mouse primary astrocytes | Genotype:Ent6 knockout | treatment:Vehicle |
| F18 | Sample source:mouse primary astrocytes | Genotype:Ent7 knockout | treatment:Vehicle |
| F19 | Sample source:mouse primary astrocytes | Genotype:Ent8 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F20 | Sample source:mouse primary astrocytes | Genotype:Ent9 knockout | treatment:TNFš¯¯°/IL-1š¯¯° |
| F21 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-1š¯¯° |
| F22 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-1š¯¯°/Forodesine |
| F23 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-2š¯¯°/Forodesine |
| F24 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-3š¯¯°/Forodesine |
| F25 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-4š¯¯°/Forodesine |
| F26 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-5š¯¯°/Forodesine |
| F27 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-6š¯¯°/Forodesine |
| F28 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:TNFš¯¯°/IL-7š¯¯°/Forodesine |
| F29 | Sample source:mouse primary astrocytes | Genotype:Wild-type | treatment:Vehicle |
