Data for (Study ST004205)
(Analysis AN006993)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|
| (3-O-sulfo)GalCer(d18:1/16:0) | 1.0120 | NA | NA | 1.1189 | NA | 0.7199 | 1.0459 | NA | 1.1033 | NA |
| (3-O-sulfo)GalCer(d18:1/18:0) | 1.0714 | NA | NA | 1.0670 | NA | 0.8387 | 0.9462 | NA | 1.0768 | NA |
| (3-O-sulfo)GalCer(d18:1/18:0(2OH) | 1.0397 | NA | NA | 1.0389 | NA | 0.7760 | 1.0455 | NA | 1.1000 | NA |
| (3-O-sulfo)GalCer(d18:1/18:0(d3)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| (3-O-sulfo)GalCer(d18:1/24:0) | 1.8467 | 0.0016 | 0.0009 | 1.9951 | 0.0008 | 1.5195 | 1.8909 | 0.0010 | 1.7439 | 0.0010 |
| (3-O-sulfo)GalCer(d18:1/24:0(2OH)) | 0.9737 | NA | NA | 1.0875 | NA | 0.8504 | 1.1116 | NA | 0.9768 | NA |
| (3-O-sulfo)GalCer(d18:1/24:1) | 1.7331 | 0.0016 | 0.0015 | 1.9352 | 0.0018 | 1.8855 | 1.7499 | 0.0012 | 1.6906 | 0.0011 |
| (3-O-sulfo)GalCer(d18:1/24:1(2OH)) | 0.9739 | NA | NA | 1.0905 | NA | 0.9425 | 0.9843 | NA | 1.0088 | NA |
| Arachidonic acid | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Arachidonic acid-d8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Arachidonic acid-d8_MRM | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Arachidonic acid_MRM | 1.2869 | 2.0118 | 1.3624 | 0.9454 | 0.8719 | 0.9915 | 1.0347 | 1.0391 | 0.7105 | 0.5952 |
| BMP(14:0/14:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| BMP(16:0_18:1) | 1.2444 | 1.3112 | 0.6359 | 1.1943 | 0.7225 | 0.9770 | 1.8987 | 0.7970 | 0.9654 | 0.3959 |
| BMP(16:0_20:4) | 1.0387 | 1.5252 | 0.9204 | 0.9927 | 0.9664 | 0.9664 | 1.5383 | 1.5581 | 0.4996 | 0.3682 |
| BMP(16:0_22:6) | 1.6554 | 1.1824 | 0.7095 | 1.1233 | 0.6503 | 1.0051 | 1.8328 | 0.5518 | 0.9459 | 0.2956 |
| BMP(16:1/16:1) | 1.1581 | 1.5441 | 0.6863 | 1.0294 | 0.5147 | 0.9007 | 0.8364 | 0.4504 | 1.6085 | 1.6085 |
| BMP(18:0_18:1) | 1.4250 | 1.5358 | 0.6109 | 1.1053 | 0.6917 | 1.0905 | 1.6377 | 0.8025 | 1.0103 | 0.3948 |
| BMP(18:0_20:4) | 1.1418 | 1.6455 | 0.8172 | 1.0830 | 0.9403 | 1.0243 | 1.3433 | 1.6203 | 0.4701 | 0.3526 |
| BMP(18:0_22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| BMP(18:1/18:1) | 1.3978 | 1.3547 | 0.6868 | 1.2022 | 0.6844 | 0.9635 | 1.5626 | 0.6908 | 1.0575 | 0.5875 |
| BMP(20:4/20:4) | 0.7514 | 1.3473 | 1.0389 | 0.9198 | 1.1826 | 1.1215 | 1.0679 | 2.2097 | 0.2980 | 0.3331 |
| BMP(22:6/22:6) | 2.1500 | 1.2913 | 0.7252 | 1.3334 | 0.5561 | 0.8912 | 1.4934 | 0.4585 | 0.9726 | 0.2781 |
| Cholesterol sulfate | 0.4491 | 1.8713 | 1.6659 | 0.4648 | 1.5148 | 0.7960 | 0.4126 | 1.3039 | 0.4001 | 1.9414 |
| CL(14:0/14:0/14:0/14:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| CL(72:6/18:2) | 1.0477 | 1.7236 | 0.8894 | 0.8830 | 0.9512 | 0.9388 | 0.8787 | 1.0053 | 1.0683 | 1.1290 |
| CL(72:7/18:2) | 1.1252 | 1.6849 | 0.9872 | 0.8674 | 1.0000 | 1.0334 | 0.8625 | 0.9193 | 0.9126 | 1.1180 |
| CL(72:8/18:2) | 1.1780 | 2.1441 | 1.1908 | 0.8574 | 0.9834 | 0.9646 | 0.7772 | 0.7999 | 0.8574 | 1.1531 |
| CL(72:8-2(OOH)/18:2) | 1.6982 | 1.8983 | 0.7992 | 1.1309 | 0.4497 | 1.0740 | 0.8973 | 0.3935 | 1.4690 | 0.8133 |
| CL(74:9/18:2) | 1.2237 | 2.3016 | 1.0654 | 1.0359 | 1.1149 | 0.9771 | 0.8500 | 0.9261 | 0.7105 | 0.7874 |
| DHA | 1.1964 | 1.8571 | 1.3810 | 1.1250 | 1.0357 | 0.9464 | 1.0536 | 0.9286 | 0.6607 | 0.5536 |
| EPA | 1.4087 | 2.3010 | 1.5400 | 0.8244 | 0.9014 | 0.9784 | 0.9376 | 1.0463 | 0.5888 | 0.5843 |
| FAHFA(18:1/9-O-18:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GD1a/b(d36:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GD3(d34:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GD3(d36:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GM3(d18:1/18:0(d5)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GM3(d34:1) | 1.2960 | 1.7082 | 0.9299 | 0.9380 | 0.8089 | 1.2295 | 1.0779 | 0.8667 | 0.8425 | 0.8160 |
| GM3(d36:1) | 1.3857 | 1.6916 | 1.0180 | 1.1954 | 0.9137 | 1.1004 | 1.0914 | 0.8053 | 0.6865 | 0.6352 |
| GQ1b(d36:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(14:0/14:0)_14:0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(18:1/18:1)_16:0 | 2.0676 | 1.3378 | 0.7297 | 0.9426 | 0.3953 | 0.7905 | 2.0372 | 0.3345 | 1.3378 | 0.2128 |
| Hemi-BMP(18:1/18:1)_18:0 | 1.5149 | 1.0693 | 0.8317 | 0.9802 | 0.6238 | 0.8020 | 2.1386 | 0.6238 | 1.0693 | 0.3564 |
| Hemi-BMP(18:1/18:1)_18:1 | 1.9346 | 1.1776 | 0.7850 | 1.0093 | 0.5047 | 0.7991 | 1.8084 | 0.4626 | 1.2617 | 0.3364 |
| Hemi-BMP(20:4/20:4)_16:0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(20:4/20:4)_18:0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(20:4/20:4)_18:1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(20:4/20:4)_20:4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(22:6/22:6)_16:0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(22:6/22:6)_18:0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(22:6/22:6)_18:1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemi-BMP(22:6/22:6)_22:6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Linoleic acid | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Linolenic acid | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPE(16:0) | 1.4050 | 0.7106 | 0.7137 | 1.3843 | 0.5514 | 0.9390 | 1.2897 | 0.4914 | 1.8618 | 0.3645 |
| LPE(18:0) | 1.5537 | 0.6061 | 0.4516 | 1.1631 | 0.3745 | 0.8150 | 1.4120 | 0.3789 | 2.5743 | 0.2382 |
| LPE(18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPG(16:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPG(18:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPG(18:1) | 1.5407 | 1.6174 | 1.0875 | 0.5507 | 0.6274 | 1.0178 | 1.1294 | 1.0596 | 1.0666 | 0.7878 |
| LPG(20:4) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPG(22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPI(16:0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| LPI(18:0) | 2.2345 | 1.5893 | 1.1616 | 0.5759 | 0.4265 | 0.8748 | 1.3852 | 0.6160 | 1.1227 | 0.4957 |
| Oleic acid | 1.3211 | 1.5449 | 0.9189 | 0.8706 | 0.6688 | 0.9792 | 1.0789 | 0.8661 | 1.2518 | 0.8880 |
| PA(15:0/18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PA(16:0_18:1) | 2.1058 | 0.5341 | 0.2541 | 2.2276 | 0.1276 | 0.7687 | 1.2247 | 0.1345 | 1.8487 | 0.2382 |
| PA(18:0_18:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PA(18:0_20:4) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PA(18:0_22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PA(18:1/18:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Palmitic acid | 1.1307 | 1.2367 | 0.8742 | 0.9727 | 0.9660 | 1.0427 | 1.0335 | 1.0008 | 0.9269 | 0.9618 |
| Palmitoleic acid | 1.2129 | 1.6258 | 1.2387 | 0.9226 | 0.6516 | 1.0742 | 0.6742 | 0.6194 | 1.2613 | 1.2484 |
| PE(15:0/18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PE(O-16:0/20:4) | 1.3520 | 1.9051 | 1.1358 | 0.9829 | 0.8948 | 1.0420 | 0.8267 | 0.7033 | 1.0189 | 0.8513 |
| PE(O-16:0/22:6) | 1.4338 | 2.1342 | 1.1860 | 0.8157 | 0.6653 | 1.0900 | 0.6445 | 0.4068 | 1.3070 | 1.2139 |
| PE(O-18:0/20:4) | 1.8082 | 1.3444 | 0.7039 | 1.2823 | 0.5212 | 0.8958 | 1.2372 | 0.4903 | 1.4351 | 0.4659 |
| PE(O-18:0/22:6) | 1.8109 | 1.4319 | 0.7110 | 1.1554 | 0.4012 | 0.8999 | 0.8456 | 0.3222 | 1.9084 | 0.7653 |
| PE(P-16:0/20:4) | 1.3377 | 1.7907 | 1.1453 | 0.9888 | 0.9350 | 1.0496 | 0.8505 | 0.8516 | 0.8904 | 0.7897 |
| PE(P-16:0/20:5) | 1.7591 | 2.0384 | 1.0497 | 1.3183 | 0.8041 | 1.0864 | 0.8801 | 0.6121 | 0.7333 | 0.5097 |
| PE(P-16:0/22:4) | 1.6808 | 1.4479 | 0.7977 | 1.2118 | 0.5154 | 0.9788 | 1.0878 | 0.5022 | 1.3498 | 0.7131 |
| PE(P-16:0/22:6) | 1.7743 | 1.7086 | 0.9141 | 0.9114 | 0.4986 | 1.0040 | 0.7795 | 0.3674 | 1.5813 | 0.9707 |
| PE(P-18:0/18:1) | 2.0847 | 0.0811 | 0.0414 | 2.2426 | 0.0308 | 0.6738 | 1.7675 | 0.0346 | 2.0762 | 0.0386 |
| PE(P-18:0/18:1(d9)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PE(P-18:0/18:2) | 1.8790 | 0.6422 | 0.3483 | 1.6606 | 0.2101 | 0.7612 | 1.3965 | 0.2033 | 2.0646 | 0.4028 |
| PE(P-18:0/20:4) | 1.7841 | 1.2071 | 0.6742 | 1.2850 | 0.5513 | 0.9453 | 1.2840 | 0.5461 | 1.3141 | 0.4825 |
| PE(P-18:0/20:5) | 2.0605 | 1.5853 | 0.7076 | 1.3822 | 0.6118 | 0.9538 | 1.0940 | 0.5113 | 1.0743 | 0.3851 |
| PE(P-18:0/22:6) | 1.9157 | 0.9509 | 0.4688 | 1.4595 | 0.2769 | 0.8405 | 1.0143 | 0.2200 | 2.0554 | 0.6285 |
| PE(P-18:1/20:4) | 1.6155 | 1.3434 | 0.8579 | 1.1317 | 0.6293 | 1.0072 | 1.1095 | 0.5545 | 1.2376 | 0.7354 |
| PE(P-18:1/22:6) | 1.9213 | 1.2786 | 0.7390 | 0.9863 | 0.3472 | 0.9485 | 0.9205 | 0.2377 | 1.9021 | 0.8626 |
| PEth(16:0_18:1) | 1.7904 | 1.1597 | 0.8130 | 1.0073 | 0.4155 | 0.9475 | 0.9236 | 0.3079 | 1.7964 | 0.9117 |
| PEth(18:1/18:1) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PG(15:0/18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PG(16:0_18:1) | 1.5526 | 1.5337 | 1.0426 | 1.0816 | 0.8272 | 1.0340 | 0.9737 | 0.7487 | 0.9623 | 0.6544 |
| PG(16:0_20:4) | 1.5497 | 1.4305 | 0.7152 | 1.1325 | 0.7748 | 1.0132 | 1.5497 | 0.7152 | 0.8940 | 0.4768 |
| PG(16:0_22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PG(18:0_18:1) | 1.2308 | 1.0890 | 0.9090 | 0.8922 | 0.7092 | 1.0135 | 0.9792 | 0.7367 | 1.5099 | 0.9746 |
| PG(18:0_20:4) | 1.4438 | 1.0500 | 0.7000 | 1.4438 | 0.8167 | 0.9188 | 1.3562 | 0.5687 | 1.0500 | 0.5687 |
| PG(18:0_22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PG(18:1/18:1) | 1.3596 | 1.2513 | 0.9345 | 0.9686 | 0.7189 | 0.9836 | 0.9295 | 0.6708 | 1.5702 | 0.7851 |
| PI(15:0/18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PI(16:0_18:1) | 1.5919 | 0.5820 | 0.3928 | 1.3858 | 0.2661 | 0.8138 | 1.6737 | 0.3014 | 2.0098 | 0.5174 |
| PI(16:0_20:4) | 1.4263 | 1.5311 | 0.8339 | 1.2211 | 0.7264 | 0.9102 | 1.1906 | 0.7078 | 1.2775 | 0.5319 |
| PI(16:0_22:6) | 1.7030 | 0.7267 | 0.3913 | 1.8148 | 0.2835 | 0.7726 | 1.5193 | 0.2615 | 1.8707 | 0.2995 |
| PI(18:0_18:1) | 1.7213 | 0.5727 | 0.3744 | 1.1792 | 0.2065 | 0.7860 | 1.6823 | 0.2376 | 2.1617 | 0.6014 |
| PI(18:0_20:4) | 1.4586 | 1.6071 | 1.0007 | 1.1011 | 0.7723 | 0.9545 | 0.9579 | 0.7192 | 1.1051 | 0.7788 |
| PI(18:0_22:6) | 1.5293 | 1.2842 | 0.7091 | 1.2524 | 0.5026 | 0.9288 | 1.2560 | 0.4980 | 1.5088 | 0.6713 |
| PI(18:1/18:1) | 1.3168 | 1.0197 | 0.6914 | 0.8445 | 0.3853 | 0.9196 | 0.9124 | 0.3531 | 2.1425 | 1.3523 |
| PI(20:4/20:4) | 1.3023 | 1.8567 | 1.1862 | 0.9284 | 0.6834 | 0.9799 | 1.1218 | 1.1991 | 0.9155 | 0.5158 |
| PS(15:0/18:1(d7)) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PS(16:0_18:1) | 1.6053 | 1.7785 | 0.8932 | 0.9105 | 0.4466 | 0.8592 | 0.7413 | 0.4163 | 1.6017 | 1.3044 |
| PS(16:0_20:4) | 1.4832 | 1.9231 | 1.1627 | 1.1097 | 0.8300 | 1.0411 | 0.8278 | 0.6775 | 0.8709 | 0.8068 |
| PS(16:0_22:6) | 1.5102 | 1.8345 | 1.2393 | 0.8915 | 0.7870 | 1.0665 | 0.6716 | 0.5726 | 0.8535 | 1.2592 |
| PS(18:0_18:1) | 1.6210 | 1.3328 | 0.7027 | 1.4016 | 0.4719 | 0.8747 | 1.2680 | 0.4135 | 1.4495 | 0.6395 |
| PS(18:0_20:4) | 1.9910 | 1.9163 | 1.0787 | 0.9402 | 0.6132 | 0.8900 | 0.8264 | 0.4316 | 1.3270 | 0.6925 |
| PS(18:0_22:6) | 1.4454 | 1.9838 | 1.1261 | 0.9148 | 0.6872 | 0.9121 | 0.5631 | 0.4899 | 1.2557 | 1.3914 |
| PS(18:1/18:1) | 2.0137 | 0.6761 | 0.3104 | 1.5568 | 0.1528 | 0.7364 | 1.3045 | 0.1203 | 2.0554 | 0.6583 |
| PS(22:6/22:6) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Stearic acid | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Factors:
| F1 | Genotype:GPR34-KO | Treatment:Myelin | Sample source:iMicroglia |
| F2 | Genotype:GPR34 KO | Treatment:PBS | Sample source:iMicroglia |
| F3 | Genotype:GPR34-KO | Treatment:PBS | Sample source:iMicroglia |
| F4 | Genotype:GPR34/TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F5 | Genotype:GPR34/TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F6 | Genotype:NA | Treatment:NA | Sample source:iMicroglia |
| F7 | Genotype:TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F8 | Genotype:TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F9 | Genotype:WT | Treatment:Myelin | Sample source:iMicroglia |
| F10 | Genotype:WT | Treatment:PBS | Sample source:iMicroglia |
