Data for (Study ST004417)
(Analysis AN007389)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 |
|---|---|---|---|---|---|---|---|---|---|
| 2.oxobutyric acid | 0.8882 | 1.2666 | 0.8088 | 0.8978 | 1.1450 | 1.0480 | 0.7534 | 0.9684 | 1.2238 |
| 3.phosphoglycerate | 0.4495 | 0.5534 | 0.6500 | 0.7267 | 2.4508 | 2.6132 | 0.3066 | 0.5712 | 0.5179 |
| acetylcarnitine | 1.3494 | 2.1394 | 1.9257 | NA | NA | NA | 0.4128 | 0.1022 | 0.0704 |
| Acetyl.CoA | 0.6315 | 0.9677 | 1.4008 | NA | NA | NA | NA | NA | NA |
| adenine | 0.6879 | 0.9987 | 1.4691 | NA | NA | NA | 0.6499 | 1.0196 | 1.0708 |
| AICAR | 0.3617 | 0.3552 | 0.0199 | 0.4744 | 0.5245 | 0.0400 | 2.5165 | 1.7725 | 2.6087 |
| alanine | 0.0667 | 0.0856 | 0.0872 | 0.1327 | 0.2678 | 0.4028 | 1.8093 | 2.8977 | 3.2503 |
| arginine | NA | NA | NA | 0.9591 | 0.9504 | 0.8516 | 0.9613 | 1.0446 | 1.2329 |
| argininosuccinate | 2.3666 | 3.0962 | 2.8976 | 0.1433 | 0.1481 | 0.1303 | 0.0593 | 0.0773 | 0.0813 |
| ascorbate | 0.8648 | 0.9922 | 0.9359 | 1.0675 | 1.0630 | 0.9200 | 0.7829 | 1.2079 | 1.1658 |
| asparagine | 0.0304 | 0.1840 | 0.1740 | 1.7902 | 2.3878 | 2.4798 | 0.2182 | 0.8278 | 0.9077 |
| aspartate | 0.0438 | 0.0600 | 0.0458 | 0.2628 | 4.8493 | 3.5570 | 0.0659 | 0.0564 | 0.0591 |
| asymmetric.dimethylarginine | NA | NA | NA | 1.0155 | 0.9247 | 1.0598 | NA | NA | NA |
| ATP | 0.4376 | 0.8812 | 1.0608 | 0.6069 | 1.3871 | 1.4345 | 0.8335 | 1.0363 | 1.3222 |
| Butyrylcarnitine | 1.2665 | 2.0792 | 2.2888 | 0.2145 | 1.2358 | 1.2226 | 0.2718 | 0.2087 | 0.2121 |
| C5.Carnitines | 1.1560 | 3.2140 | 2.3768 | 0.0059 | 0.5464 | 0.5215 | 0.0565 | 0.6619 | 0.4610 |
| carnitine | 0.9952 | 1.7983 | 1.5850 | 0.4373 | 0.7245 | 0.7372 | 0.7354 | 1.0822 | 0.9049 |
| CDP | NA | NA | NA | 0.6725 | 1.4257 | 1.4276 | 1.2356 | 0.5304 | 0.7081 |
| CDP.choline | NA | NA | NA | NA | NA | NA | 1.6809 | 0.5394 | 0.7797 |
| cis.aconitate | NA | NA | NA | 0.4325 | 1.2015 | 1.3661 | NA | NA | NA |
| citrate | 0.7577 | 1.5903 | 1.4479 | 0.4447 | 1.8788 | 1.7138 | 0.1291 | 0.4462 | 0.5914 |
| CMP | 0.9948 | 0.4768 | 0.3509 | 1.1670 | 1.9063 | 1.9818 | 1.4833 | 0.3666 | 0.2725 |
| creatine | 0.1086 | 0.0858 | 0.0999 | 2.9415 | 2.1389 | 3.3167 | 0.0879 | 0.1312 | 0.0896 |
| CTP | 0.5557 | 0.9730 | 1.1590 | 0.2858 | 1.6495 | 1.6653 | 0.9116 | 0.7947 | 1.0054 |
| cystathionine | 1.4404 | 1.8703 | 2.0791 | 0.0648 | 0.2653 | 0.2801 | NA | NA | NA |
| Cysteine-Ellmans | NA | NA | NA | NA | NA | NA | 0.7283 | 1.4913 | 0.7804 |
| dihydroorotate | 3.9428 | 1.2438 | 0.9940 | 1.3833 | 0.0143 | 0.0104 | 0.8066 | 0.5927 | 0.0122 |
| dihydroxyacetone phosphate | 1.4413 | 0.9391 | 0.9145 | 0.8547 | 0.9370 | 0.9133 | NA | NA | NA |
| F6P.G1P | NA | NA | NA | 2.3855 | 0.7699 | 0.8602 | 1.1598 | 0.4610 | 0.3636 |
| FAD | NA | NA | NA | 0.9107 | 0.8178 | 1.2715 | NA | NA | NA |
| formyl methionine | NA | NA | NA | 0.4546 | 1.3948 | 1.1505 | NA | NA | NA |
| Fructose.1.6.bisphosphate | 2.1568 | 1.0673 | 0.8217 | 2.1218 | 0.7592 | 0.8420 | 0.5450 | 0.3701 | 0.3161 |
| fumarate | 0.6498 | 1.0192 | 1.0901 | 0.8264 | 2.0132 | 2.2261 | 0.3298 | 0.4029 | 0.4425 |
| GDP | NA | NA | NA | 1.5138 | 1.1251 | 1.1376 | 0.8534 | 0.6036 | 0.7664 |
| Glucose.6.phosphate | 1.0953 | 1.0217 | 0.8407 | 1.7191 | 0.6308 | 0.6924 | NA | NA | NA |
| glutamate | 0.9474 | 1.0353 | 1.0069 | 1.2739 | 1.1647 | 1.0560 | 0.7135 | 0.8290 | 0.9733 |
| glutamine | NA | NA | NA | 0.8453 | 1.0562 | 0.9230 | 0.8066 | 1.1519 | 1.2170 |
| Glycerol.3.Phosphate | 2.0822 | 0.8548 | 1.0586 | 3.3228 | 0.1752 | 0.1902 | 0.9470 | 0.1579 | 0.2114 |
| Glycerophosphocholine | 0.7789 | 0.7281 | 1.1196 | 0.8430 | 1.1012 | 1.4341 | 0.8149 | 0.9617 | 1.2185 |
| glycine | 0.6664 | 0.2980 | 1.4249 | 1.0664 | 1.2328 | 2.2415 | 0.6415 | 0.6749 | 0.7534 |
| GMP | 0.8586 | 0.7728 | 0.4156 | 3.2736 | 0.5904 | 1.0975 | 1.1740 | 0.4045 | 0.4131 |
| GSH Ellmans | 1.3265 | 1.5475 | 1.6145 | 0.7825 | 0.7681 | 0.9175 | 0.5828 | 0.7764 | 0.6842 |
| GSSG | 1.4926 | 1.5577 | 1.4804 | 0.7217 | 0.7355 | 0.9529 | 0.6027 | 0.7751 | 0.6812 |
| GTP | 0.6208 | 0.7686 | 0.8783 | 1.0935 | 1.3183 | 1.4672 | 0.8021 | 0.9174 | 1.1339 |
| guanidinoacetate | NA | NA | NA | 1.9792 | 0.9646 | 1.0516 | 0.0032 | 0.0071 | 0.0034 |
| guanine | NA | NA | NA | NA | NA | NA | 0.8571 | 0.9204 | 1.2225 |
| hypotaurine | 1.1856 | 1.2411 | 0.8686 | 1.0586 | 0.8851 | 0.7610 | NA | NA | NA |
| IMP | 2.4698 | 0.1125 | 0.1132 | 5.7746 | 0.1506 | 0.1520 | 0.1954 | 0.0232 | 0.0087 |
| isoleucine | 1.1068 | 0.9867 | 0.9979 | 0.8649 | 0.9935 | 0.8143 | 0.9263 | 1.0830 | 1.2267 |
| leucine | 0.1905 | 0.1591 | 0.1341 | 1.1771 | 1.4493 | 1.4577 | 1.2942 | 1.5809 | 1.5571 |
| lysine | 2.3569 | 2.0184 | 2.0803 | 0.4677 | 0.3250 | 0.2556 | 0.4434 | 0.4910 | 0.5616 |
| methionine | NA | NA | NA | 0.8493 | 0.9617 | 0.9137 | 0.9423 | 1.1413 | 1.1917 |
| methylthioadenosine | 0.3711 | 0.4392 | 0.4753 | 0.7827 | 2.8116 | 2.9784 | 0.3746 | 0.4007 | 0.3666 |
| N.acetylglutamate | 1.6863 | 1.1063 | 1.1121 | 0.6514 | 0.7065 | 0.7374 | NA | NA | NA |
| NAD | 0.9498 | 1.1562 | 1.4692 | 0.7014 | 1.2133 | 1.0498 | 0.7177 | 0.8926 | 0.8501 |
| NADH | 0.9584 | 0.5434 | 0.6795 | 2.0055 | 0.8084 | 1.0047 | NA | NA | NA |
| NADP | 0.6693 | 0.9425 | 1.1729 | 0.6468 | 1.5713 | 1.5795 | 0.8207 | 0.6659 | 0.9310 |
| NADPH | 0.5472 | 0.9073 | 1.0024 | 0.8295 | 1.6423 | 1.5192 | 0.7102 | 0.8252 | 1.0167 |
| niacinamide | 0.9713 | 1.0456 | 0.8153 | 0.9272 | 1.4716 | 1.2718 | 0.9261 | 0.8041 | 0.7670 |
| ornithine | NA | NA | NA | 1.0011 | 0.9076 | 0.7421 | 1.0287 | 1.0321 | 1.2884 |
| phosphocholine | 0.0264 | 0.0353 | 0.0220 | 1.2352 | 3.9025 | 3.6413 | 0.0307 | 0.0463 | 0.0603 |
| phosphocreatine | 1.1893 | 1.6615 | 2.1928 | 0.0012 | 0.0010 | 0.0014 | 0.7809 | 1.5245 | 1.6474 |
| phosphoenolpyruvate | NA | NA | NA | 0.1834 | 2.3470 | 2.3346 | 0.1905 | 0.4858 | 0.4586 |
| proline | 1.1581 | 1.2762 | 1.1772 | 0.9860 | 1.2302 | 1.1051 | 0.4845 | 0.8054 | 0.7774 |
| PRPP | 2.0977 | 0.7078 | 1.0814 | 1.3828 | 1.1405 | 1.2536 | 0.3724 | 0.4288 | 0.5351 |
| Pyridoxine | 0.9927 | 1.0945 | 1.1005 | 0.8667 | 1.4396 | 1.4549 | 0.5598 | 0.6892 | 0.8021 |
| Ribose.1.phosphate | 3.4176 | 0.5115 | 0.4840 | 1.7614 | 0.4899 | 0.5248 | 0.6471 | 0.7177 | 0.4460 |
| saccharopine | NA | NA | NA | 3.0395 | 0.4222 | 0.3192 | 0.0541 | 1.2207 | 0.9443 |
| S.Adenosyl.L.methionine | 0.8771 | 1.0528 | 1.0710 | 0.8333 | 1.6194 | 1.3522 | 0.6705 | 0.7506 | 0.7731 |
| sarcosine | 0.3880 | 0.4911 | 0.5005 | 0.7659 | 1.5398 | 2.3148 | NA | NA | NA |
| Sedoheptulose.7.phosphate | 3.1728 | 0.9108 | 1.1460 | 1.2977 | 0.1963 | 0.2248 | 1.1924 | 0.4939 | 0.3653 |
| serine | 0.7177 | 0.9193 | 0.7111 | 0.9013 | 0.8583 | 0.7498 | 0.9704 | 1.5406 | 1.6316 |
| sorbitol | NA | NA | NA | NA | NA | NA | 0.7642 | 1.3701 | 0.8657 |
| succinate | NA | NA | NA | 1.4407 | 1.0894 | 0.8228 | 0.6407 | 0.8449 | 1.1615 |
| tryptophan | 1.1093 | 0.9908 | 0.9664 | 0.8534 | 1.0168 | 0.9241 | 0.9073 | 1.1064 | 1.1255 |
| tyrosine | 1.0754 | 0.9611 | 0.8772 | 0.9230 | 0.7424 | 0.6932 | 1.0509 | 1.3526 | 1.3242 |
| UDP | NA | NA | NA | 0.7850 | 1.5079 | 1.4780 | 1.2652 | 0.4076 | 0.5563 |
| UDP.GlcNAc | 0.3887 | 1.0601 | 1.2193 | 0.2098 | 1.7885 | 1.5968 | 0.7902 | 0.9135 | 1.0330 |
| UMP | NA | NA | NA | NA | NA | NA | 1.9596 | 0.5237 | 0.5168 |
| Ureidosuccinic acid | NA | NA | NA | 2.5246 | 0.0217 | 0.0377 | 1.4160 | NA | NA |
| UTP | 0.5757 | 0.9670 | 1.1143 | 0.2826 | 1.7933 | 1.7924 | 0.9040 | 0.6774 | 0.8934 |
Factors:
| F1 | Sample source:MOLT16 leukemia cells | treatment:BCS |
| F2 | Sample source:MOLT16 leukemia cells | treatment:BCS and CuCl2 |
| F3 | Sample source:MOLT16 leukemia cells | treatment:Vehicle |
| F4 | Sample source:NALM6 leukemia cells | treatment:BCS |
| F5 | Sample source:NALM6 leukemia cells | treatment:BCS and CuCl2 |
| F6 | Sample source:NALM6 leukemia cells | treatment:Vehicle |
| F7 | Sample source:REH leukemia cells | treatment:BCS |
| F8 | Sample source:REH leukemia cells | treatment:BCS and CuCl2 |
| F9 | Sample source:REH leukemia cells | treatment:Vehicle |
