Data for Validation of the application of targeted metabolomic appraoch in the diagnosis of CFS (Study ST000617)

(Analysis AN000947)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2
1,25-Dihydroxyvitamin D3 0.7532 1.2743
1-Methyladenosine 0.9914 1.0095
1-Methylhistidine 1.0378 0.9580
1-Methylnicotinamide 1.5383 0.4019
1-Pyrroline-5-carboxylic acid 1.1581 0.8243
24,25-Dihydrolanosterol 0.9647 1.0392
24,25-Epoxycholesterol 0.7075 1.3250
2-Arachidonylglycerol 1.0629 0.9301
2-Octenoylcarnitine 0.8388 1.1792
3, 5-Tetradecadiencarnitine 1.0291 0.9677
3-Aminoisobutyric acid 1.0345 0.9617
3-Hydroxy-cis-5-tetradecenoylcarnitine 0.9656 1.0382
3-Hydroxydodecanoylcarnitine 0.8926 1.1194
3-Hydroxyhexadecanoylcarnitine 0.9045 1.1061
3-Hydroxyhexadecenoylcarnitine 0.9562 1.0487
3-Hydroxyisovaleryl Carnitine 0.9821 1.0199
3-Hydroxylinoleylcarnitine 1.0869 0.9034
3-Hydroxyoleoylcarnitine 1.0128 0.9858
5,6-trans-25-Hydroxyvitamin D3 0.9150 1.0945
5-Methylthioadenosine 1.0845 0.9061
7-Dehydrocholesterol 1.0669 0.9256
7-ketocholesterol 0.9025 1.1083
7-methylguanine 1.0014 0.9984
9-Decenoylcarnitine 0.9337 1.0736
9-Hexadecenoylcarnitine 1.0027 0.9970
Adenine 0.9854 1.0162
Adenosine 0.7442 1.2842
Adenosine monophosphate 0.8081 1.2132
Adenosine triphosphate 1.3814 0.5762
Adipoylcarnitine 0.9907 1.0104
Alanine 1.0391 0.9565
Alpha-Tocopherol 1.0275 0.9694
Arachidonyl carnitine 0.8831 1.1299
Aspartylglycosamine 0.9842 1.0176
beta-Alanine 1.0434 0.9518
Betaine 1.1298 0.8558
BMP(16:0/16:0) 0.8985 1.1128
BMP(18:1/16:0) 0.9246 1.0838
BMP(18:1/16:1) 1.1856 0.7938
BMP(18:1/18:1) 1.0214 0.9763
BMP(18:1/18:2) 1.0821 0.9088
Butyrylcarnitine 0.9584 1.0462
Carnosine 0.9780 1.0245
Ceramide(d18:1/12:0) 1.1718 0.8092
Ceramide(d18:1/16:0) 0.7917 1.2314
Ceramide(d18:1/16:0 OH) 0.8915 1.1205
Ceramide(d18:1/16:1) 0.8660 1.1489
Ceramide(d18:1/16:1 OH) 0.8060 1.2155
Ceramide(d18:1/16:2) 0.8652 1.1498
Ceramide(d18:1/18:0) 0.7539 1.2734
Ceramide(d18:1/18:0 OH) 0.8965 1.1150
Ceramide(d18:1/18:1) 0.9303 1.0775
Ceramide(d18:1/18:1 OH) 0.9329 1.0745
Ceramide(d18:1/18:2) 0.9616 1.0427
Ceramide(d18:1/20:0) 0.8844 1.1284
Ceramide(d18:1/20:0 OH) 1.0412 0.9542
Ceramide(d18:1/20:1) 0.9007 1.1103
Ceramide(d18:1/20:1 OH) 0.9553 1.0497
Ceramide(d18:1/20:2) 0.8802 1.1331
Ceramide(d18:1/22:0) 0.9480 1.0578
Ceramide(d18:1/22:0 OH) 0.9224 1.0862
Ceramide(d18:1/22:1) 0.8154 1.2051
Ceramide(d18:1/22:2) 0.8733 1.1408
Ceramide(d18:1/22:2 OH) 0.8593 1.1563
Ceramide(d18:1/23:0) or Ceramide(d18:1/22:1 OH) 1.0046 0.9948
Ceramide(d18:1/24:0) 0.9712 1.0320
Ceramide(d18:1/24:0 OH) 0.8258 1.1936
Ceramide(d18:1/24:1) 0.8287 1.1903
Ceramide(d18:1/24:2) 0.7002 1.3331
Ceramide(d18:1/24:2 OH) 0.8974 1.1140
Ceramide(d18:1/25:0) 0.8573 1.1586
Ceramide(d18:1/26:0) 0.9913 1.0096
Ceramide(d18:1/26:0 OH) 0.9672 1.0365
Ceramide(d18:1/26:1) 1.0080 0.9912
Ceramide(d18:1/26:2) 0.7874 1.2362
Cholestenone 1.0056 0.9937
Cholesterol 1.0612 0.9320
Choline 0.9850 1.0167
Cortisol 1.0467 0.9481
Creatine 1.0190 0.9789
Creatinine 0.9793 1.0230
Cysteamine 1.0076 0.9915
Cytidine 1.0487 0.9458
Cytosine 0.9678 1.0358
Decanoylcarnitine 0.9309 1.0768
Desmosterol 1.0795 0.9117
DHC(18:1/16:0) 0.7885 1.2350
DHC(18:1/20:0) 1.0759 0.9157
DHC(18:1/22:0) 1.0165 0.9816
DHC(18:1/24:1) 0.8808 1.1324
Dimethylglycine 1.0832 0.9075
Dimethyl-L-arginine 1.0008 0.9991
DL-2-Aminooctanoic acid 1.8075 0.1028
Dodecanoylcarnitine 0.9426 1.0637
Dodecenoylcarnitine 0.9013 1.1096
Dopamine 0.9264 1.0818
Ethanolamine 0.9049 1.1056
FAD 0.9053 1.1052
Gamma-Aminobutyric acid 0.9985 1.0017
GC(18:1/16:0) 0.7011 1.3321
Glycerophosphocholine 0.9364 1.0707
Glycine 1.0248 0.9725
Glycylproline 1.0132 0.9854
Hexanoylcarnitine 1.0179 0.9801
Histamine 0.9797 1.0226
Homoarginine 1.0538 0.9402
Homocysteine 1.0073 0.9919
Hydroxyproline 1.1791 0.8010
Hypotaurine 1.0112 0.9876
Imidazoleacetic acid 0.9752 1.0275
Isovalerylcarnitine 1.0265 0.9706
L-Acetylcarnitine 0.9901 1.0110
L-Asparagine 1.0468 0.9480
Lathosterol 0.7203 1.3107
L-Carnitine 0.9878 1.0135
L-Glutamic acid 1.0564 0.9373
L-Glutamine 0.9930 1.0078
L-Glutarylcarnitine 0.9848 1.0169
L-Histidine 1.0125 0.9861
L-Homoserine 1.0893 0.9008
Linoleylcarnitine 0.9878 1.0135
L-isoleucine 1.0085 0.9906
L-Kynurenine 1.0148 0.9835
L-leucine 1.0093 0.9897
L-Lysine 1.0003 0.9997
L-Methionine 1.1000 0.8889
L-Palmitoylcarnitine 0.8818 1.1314
L-Phenylalanine 0.9817 1.0203
L-Proline 1.0076 0.9916
L-Serine 1.0983 0.8908
L-Tryptophan 0.9760 1.0267
L-Tyrosine 1.0143 0.9841
L-Valine 1.0192 0.9787
LysoPC(16:0) 0.9158 1.0936
LysoPC(18:0) 0.9512 1.0543
LysoPC(24:1) 1.1826 0.7971
Malonylcarnitine 0.9925 1.0083
Methionine sulfoxide 1.1535 0.8295
Methylcysteine 1.2215 0.7539
Myristoylcarnitine 0.9316 1.0760
N-Acetylornithine 1.0359 0.9601
N-alpha-Acetylarginine 0.9962 1.0042
Niacinamide 1.7323 0.1863
Nicotinamide N-oxide 1.6937 0.2292
N-oleoylethanolamine 1.0406 0.9549
O-acetylserine 0.9942 1.0064
Octadecanoylcarnitine 0.9685 1.0350
Octanoylcarnitine 0.9778 1.0247
Oleoylcarnitine 1.0015 0.9984
Ornithine 1.0489 0.9457
Palmitoylethanolamide 0.9685 1.0350
PC(16:0/16:0) 0.8746 1.1393
PC(16:0/18:1) 1.0132 0.9853
PC(16:0/18:2) 1.0098 0.9891
PC(16:0/20:4) 0.9159 1.0934
PC(16:0/22:6) 1.0389 0.9567
PC(18:0/18:2) 1.0144 0.9840
PC(18:1/22:6) 0.9138 1.0958
PC(20:4/P-16:0) 0.9802 1.0220
PC(20:5/P-16:0) 1.1822 0.7975
PC(22:6/P-18:0) 1.1464 0.8373
PC(24:0/P-18:0) 1.0072 0.9920
PC(30:0) 0.8466 1.1704
PC(32:1) 0.8901 1.1222
PC(32:2) 0.9188 1.0902
PC(36:0) 1.0608 0.9324
PC(36:1) 1.0211 0.9765
PC(38:5) 1.0808 0.9103
PC(40:6) 1.0847 0.9058
Phosphorylcholine 0.9604 1.0440
Pimelylcarnitine 0.8513 1.1653
Pipecolic acid 1.0400 0.9556
Propionylcarnitine 0.9589 1.0456
PS(34:1) 0.8658 1.1491
PS(34:2) 1.0673 0.9252
Purine 0.9742 1.0287
Riboflavin 1.4324 0.5196
Saccharopine 1.0049 0.9946
Sarcosine 1.1171 0.8699
Serotonin 0.9314 1.0763
Spermine 1.0053 0.9941
Suberylcarnitine 0.9751 1.0277
Testosterone 1.1425 0.8417
THC 18:1/16:0 0.8655 1.1495
THC 18:1/22:0 0.8338 1.1847
THC 18:1/24:0 0.7882 1.2353
Thiamine 1.7267 0.1926
Tiglylcarnitine 0.8687 1.1458
Trimethylamine-N-oxide 1.2026 0.7748
Urea 0.9920 1.0089
Ureidopropionic acid 1.0469 0.9479
Vitamin D3 1.0100 0.9889
Vitamin K2 1.0287 0.9681
Zymosterol 1.0097 0.9892
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Factors:

F1Treatment:CFS
F2Treatment:Control
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