Data for db/db WT ozone and air exposed mice (Study ST000815)
(Analysis AN001290)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1,2-dipalmitoylglycerol | 1.1823 | 0.9675 | 0.8862 | 0.9600 |
| 1,3-dipalmitoylglycerol | 1.1421 | 0.9440 | 0.9066 | 1.0003 |
| 1,5-anhydroglucitol (1,5-AG) | 0.4345 | 0.4976 | 1.7614 | 1.2358 |
| 1-oleoylglycerol (1-monoolein) | 1.2517 | 1.2315 | 0.6274 | 0.9184 |
| 1-stearoylglycerol (1-monostearin) | 1.1994 | 1.0018 | 0.9144 | 0.8846 |
| 2-aminoadipate | 0.8116 | 0.6151 | 1.5081 | 1.0652 |
| 2-aminobutyrate | 0.5283 | 0.9227 | 0.7250 | 1.8240 |
| 2-hydroxybutyrate (AHB) | 1.0381 | 1.2574 | 0.7293 | 0.9752 |
| 2-hydroxyglutarate | 1.3155 | 0.9604 | 0.9088 | 0.8153 |
| 2-oleoylglycerol (2-monoolein) | 1.1389 | 1.0769 | 0.7417 | 1.0886 |
| 2-palmitoylglycerol (2-monopalmitin) | 1.2312 | 0.9939 | 0.8545 | 0.9204 |
| 3-hydroxybutyrate (BHBA) | 1.1731 | 1.4055 | 0.5508 | 0.8705 |
| 3-hydroxyisobutyrate | 1.1715 | 1.1711 | 0.9457 | 0.7117 |
| 3-phosphoglycerate | 1.1715 | 1.1003 | 0.8982 | 0.8301 |
| 5-hydroxyindoleacetate | 0.8551 | 0.8923 | 1.4592 | 0.7933 |
| 6-phosphogluconate | 1.3622 | 1.2078 | 0.7377 | 0.5899 |
| 7-alpha-hydroxycholesterol | 1.3731 | 1.0435 | 0.8216 | 0.7672 |
| 7-beta-hydroxycholesterol | 1.4133 | 1.0365 | 0.8432 | 0.7115 |
| 7-ketocholesterol | 1.5050 | 0.8827 | 0.7118 | 0.7517 |
| adenine | 1.0749 | 1.1631 | 0.8807 | 0.8813 |
| alanine | 0.9564 | 1.2621 | 0.8416 | 0.9399 |
| allantoin | 1.1360 | 1.0572 | 1.1271 | 0.6797 |
| alpha-hydroxyisovalerate | 1.0262 | 1.1724 | 0.9157 | 0.7798 |
| alpha-tocopherol | 0.7883 | 0.8374 | 1.2226 | 1.1315 |
| arabitol | 1.2110 | 0.9287 | 1.1112 | 0.7754 |
| ascorbate (Vitamin C) | 1.0817 | 1.1114 | 0.9341 | 0.8728 |
| asparagine | 0.8399 | 1.2228 | 0.8453 | 1.0920 |
| aspartate | 0.8529 | 0.9492 | 1.1812 | 1.0167 |
| benzoate | 0.7491 | 1.2318 | 0.7453 | 1.2738 |
| beta-alanine | 0.9163 | 1.0129 | 1.1326 | 0.9382 |
| beta-sitosterol | 1.1287 | 1.0479 | 0.9208 | 0.9046 |
| campesterol | 1.1101 | 1.0301 | 0.8993 | 0.9643 |
| chiro-inositol | 0.9626 | 0.8871 | 1.2729 | 0.7811 |
| cholesterol | 1.0596 | 0.9646 | 0.9846 | 0.9868 |
| cis-vaccenate (18:1n7) | 1.3846 | 1.3019 | 0.6375 | 0.6760 |
| citrate | 1.1591 | 1.1738 | 0.8104 | 0.8566 |
| cysteine | 1.1019 | 0.9729 | 1.2255 | 0.6997 |
| dehydroascorbate | 1.1845 | 1.0068 | 1.1148 | 0.6502 |
| dihydrocholesterol | 1.4013 | 1.2382 | 0.6891 | 0.7012 |
| erythritol | 1.3891 | 1.1537 | 0.8735 | 0.5461 |
| erythronate | 1.4413 | 1.1341 | 0.8387 | 0.5858 |
| ethanolamine | 1.1107 | 0.9349 | 1.0595 | 0.8949 |
| fructose | 1.5646 | 1.0787 | 0.7567 | 0.6001 |
| fructose-6-phosphate | 1.2484 | 1.0307 | 0.9626 | 0.7583 |
| fumarate | 1.0360 | 1.2862 | 0.8496 | 0.8282 |
| gamma-aminobutyrate (GABA) | 1.3329 | 1.2545 | 0.7539 | 0.6588 |
| gamma-glutamylglycine | 0.9343 | 0.9448 | 1.1754 | 0.9456 |
| glucarate (saccharate) | 0.5922 | 0.5031 | 1.6341 | 1.2705 |
| glucose | 1.4794 | 1.4630 | 0.5646 | 0.4930 |
| glucose-6-phosphate (G6P) | 1.1632 | 1.0603 | 0.9715 | 0.8050 |
| glutamate | 0.8883 | 0.9486 | 1.1325 | 1.0306 |
| glycerate | 1.2596 | 1.1047 | 0.8734 | 0.7102 |
| glycerol | 1.2228 | 1.2149 | 0.7631 | 0.7992 |
| glycerol 2-phosphate | 1.1837 | 1.0309 | 1.0247 | 0.7608 |
| glycerol 3-phosphate (G3P) | 1.3259 | 1.0390 | 0.9255 | 0.7096 |
| glycine | 1.1138 | 1.1268 | 0.9286 | 0.8308 |
| glycylglycine | 1.0479 | 1.2072 | 0.7685 | 0.9730 |
| gulono-1,4-lactone | 1.3686 | 1.3751 | 0.5313 | 0.7251 |
| homoserine | 0.9172 | 1.0851 | 1.0420 | 0.9557 |
| hypotaurine | 0.7286 | 1.8532 | 0.7151 | 0.7032 |
| inositol 1-phosphate (I1P) | 1.1458 | 1.1948 | 0.9014 | 0.7581 |
| Isobar: ribulose 5-phosphate, xylulose 5-phosphate | 0.9128 | 0.9952 | 1.1183 | 0.9737 |
| lactate | 1.1201 | 1.2857 | 0.7826 | 0.8116 |
| lathosterol | 0.8317 | 1.1651 | 1.0959 | 0.9910 |
| lysine | 0.8713 | 1.0417 | 0.9178 | 1.1693 |
| malate | 0.9671 | 1.1566 | 0.9071 | 0.9692 |
| maltose | 1.2239 | 1.3565 | 0.7379 | 0.6818 |
| maltotriose | 1.3654 | 1.3020 | 0.7567 | 0.6136 |
| mannitol | 1.4118 | 1.2782 | 0.5697 | 0.5802 |
| mannose | 1.2338 | 1.0952 | 0.8546 | 0.8164 |
| mannose-1-phosphate | 1.1099 | 1.2231 | 0.7811 | 0.8858 |
| mannose-6-phosphate | 1.1338 | 1.0978 | 0.9565 | 0.8119 |
| methylphosphate | 1.0588 | 1.1083 | 0.8949 | 0.9380 |
| myo-inositol | 1.1579 | 0.8197 | 1.2330 | 0.7894 |
| N-acetylaspartate (NAA) | 1.1582 | 0.8250 | 1.1923 | 0.8413 |
| N-acetylglucosamine | 0.9569 | 1.2085 | 0.8483 | 0.9863 |
| N-acetylglycine | 1.0237 | 1.0854 | 0.8487 | 1.0422 |
| N-acetylneuraminate | 1.0699 | 0.9259 | 1.0866 | 0.9175 |
| N-glycolylneuraminate | 0.9783 | 0.9435 | 0.8753 | 1.2029 |
| oleate (18:1n9) | 1.2860 | 1.3418 | 0.6175 | 0.7547 |
| ornithine | 0.9201 | 1.4451 | 0.7393 | 0.8954 |
| orotate | 0.7156 | 1.3073 | 0.6621 | 1.1821 |
| palmitate, methyl ester | 1.2444 | 1.0773 | 0.8624 | 0.7987 |
| palmitoyl sphingomyelin | 1.1008 | 1.0794 | 0.9256 | 0.9042 |
| pentadecanoate (15:0) | 1.1924 | 0.9926 | 0.8131 | 1.0019 |
| phosphate | 1.0131 | 1.0198 | 0.9874 | 0.9796 |
| phosphoenolpyruvate (PEP) | 1.2234 | 1.1036 | 0.8507 | 0.8223 |
| phosphoethanolamine | 1.0845 | 1.1145 | 0.9378 | 0.8633 |
| putrescine | 0.6528 | 1.3593 | 0.5044 | 1.4836 |
| pyrophosphate (PPi) | 0.9767 | 0.6652 | 1.2928 | 1.0653 |
| ribose | 1.0716 | 1.1405 | 0.9933 | 0.7946 |
| ribose 5-phosphate | 0.7576 | 1.0441 | 1.1719 | 1.0264 |
| ribulose | 1.0262 | 1.0545 | 1.1259 | 0.7665 |
| sarcosine (N-Methylglycine) | 1.2176 | 1.0114 | 0.9114 | 0.8595 |
| scyllo-inositol | 0.8454 | 0.7277 | 1.4859 | 0.9410 |
| sedoheptulose-7-phosphate | 1.0414 | 0.9835 | 0.9751 | 1.0000 |
| serine | 0.9444 | 1.2271 | 0.8594 | 0.9691 |
| S-methylcysteine | 0.9124 | 1.2047 | 0.8852 | 0.9974 |
| sorbitol | 1.5231 | 1.1960 | 0.6609 | 0.6199 |
| squalene | 1.2919 | 0.9401 | 0.7495 | 1.0185 |
| stearoyl sphingomyelin | 0.9495 | 0.8921 | 1.0873 | 1.0576 |
| threonate | 1.1533 | 1.0454 | 1.2963 | 0.5051 |
| trans-4-hydroxyproline | 0.9117 | 0.9950 | 1.0650 | 1.0283 |
| UDP-galactose | 0.9727 | 1.0713 | 1.1144 | 0.8559 |
| uracil | 0.9476 | 1.1060 | 0.9053 | 1.0412 |
| urea | 1.0931 | 1.0071 | 1.1660 | 0.7338 |
| xanthine | 0.9878 | 1.1340 | 0.9453 | 0.9329 |
| xylitol | 1.2368 | 1.3036 | 0.8140 | 0.6456 |
| xylonate | 1.3636 | 0.8875 | 1.0077 | 0.7412 |
Factors:
| F1 | Genotype:db/db | exposure:air |
| F2 | Genotype:db/db | exposure:ozone |
| F3 | Genotype:WT | exposure:air |
| F4 | Genotype:WT | exposure:ozone |
