Data for MuRF1-Related Metabolomic Changes in Stretched and Unloaded HL-1 Cells (Study ST000925)

(Analysis AN001518)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1,2-Propanediol 1.0148 1.0489 1.0169 1.0163 1.0251 0.9495 0.9678 1.0002 0.9981 1.0114 1.0179 0.9522
1,3-Dihydroxyacetone 0.9824 0.9828 0.9680 0.9999 0.9514 0.9819 1.0009 1.0266 1.0185 1.0197 1.0186 1.0253
1-Dodecanol 1.0179 1.0072 1.0001 1.0412 0.9644 0.9926 NA 0.9573 NA NA 0.9551 NA
2-Amino-2-Methyl-1,3-Propanediol 1.0019 0.9985 0.9979 0.9940 NA 0.9845 1.0083 NA 0.9990 1.0114 0.9951 1.0107
2-Ethylhexanoic Acid NA 1.0029 1.0021 1.0878 1.0411 0.9855 0.8988 NA NA NA 0.9618 0.9530
2-Hydroxy-3-Methylvaleric Acid 0.9840 0.9775 0.9888 0.9701 0.9898 1.0544 0.9826 1.0431 0.9748 0.9950 1.0106 NA
2-Hydroxybutyric Acid 0.9662 NA NA NA 1.0880 0.9759 1.0160 0.9780 NA NA NA NA
2-Hydroxyglutaric Acid 0.9955 0.9995 0.9750 0.9954 0.9845 1.0152 0.9802 1.0114 1.0118 0.9936 0.9922 1.0329
2-Isopropylmalic Acid 1.0152 1.0085 0.9886 1.0112 1.0216 0.9849 NA NA NA NA 0.9667 0.9544
2-Ketoleucine/Ketoisoleucine 1.0048 1.0243 1.0072 1.0219 0.9999 1.0078 0.9578 0.9816 0.9998 0.9947 1.0065 0.9937
2-Ketovaline 1.0079 1.0262 1.0065 1.0228 1.0060 1.0198 0.9526 0.9769 0.9910 0.9930 1.0085 0.9887
2-Phenylacetamide NA NA 0.8873 0.9646 NA 0.9523 1.0012 1.0237 1.0262 1.0203 1.0190 0.9866
2-Phenylacetic Acid NA 0.9549 0.9149 0.9322 0.9270 0.9260 1.0013 1.0381 1.0307 1.0403 0.9878 1.0238
3-Indolelactic Acid 0.9934 1.0083 0.9728 1.0320 0.9638 1.0154 0.9829 1.0054 0.9883 0.9939 1.0419 0.8829
3- Or 4-Methylcatechol 1.0593 1.0128 0.9811 1.0345 1.0113 1.0175 NA NA NA 0.9044 1.0066 0.9726
3-Phenyllactic Acid 0.9591 NA NA 1.0529 NA 1.0107 0.9576 1.0194 0.9846 1.0078 1.0026 0.9976
4-Hydroxy-3-Methoxybenzoic Acid 1.0144 1.0449 1.0195 1.0031 1.0303 0.9767 0.9909 0.9516 0.9835 0.9982 0.9847 0.9904
4-Hydroxybenzaldehyde 0.9600 NA NA NA NA 0.9985 0.9781 0.9774 NA 1.0065 1.0679 NA
4-Hydroxymandelic Acid NA NA NA NA NA NA 0.9786 1.0239 0.9962 1.0052 1.0310 0.9702
4-Hydroxyphenylacetic Acid 0.8812 0.9008 0.8678 0.9158 0.8900 0.8946 1.0294 1.0707 1.0590 1.0819 1.0632 1.0508
4-Hydroxypyridine 0.9830 0.9966 0.9770 0.9842 1.0132 0.9805 1.0127 1.0188 1.0214 1.0000 1.0243 1.0213
4-Methyl-5-Thiazoleethanol 0.9326 1.0210 0.9750 0.9910 0.9789 0.9269 1.0166 1.0406 1.0271 1.0523 1.0214 NA
5,6-Dihydrouracil 0.9688 1.0397 1.0200 1.0259 1.0345 0.9519 0.9444 0.9764 0.9794 1.0096 1.0193 NA
5-Aminovaleric Acid NA 1.0248 1.0120 0.9667 1.0074 1.0120 1.0169 1.0022 0.9781 0.9982 1.0071 0.9765
5-Hydroxylysine 1.0050 1.0097 1.0022 0.9651 0.9743 1.0619 1.0142 0.9838 0.9740 0.9676 1.0453 NA
5-(Hydroxymethyl)Furfural 1.0138 1.0302 1.0152 1.0207 1.0199 1.0129 0.9446 0.9675 0.9835 0.9907 0.9972 0.9935
Adenine 0.9349 1.0188 0.9968 1.0072 1.0063 0.9270 NA NA NA NA NA NA
Alanine 0.9922 0.9984 0.9904 0.9947 0.9812 1.0171 1.0051 1.0021 1.0060 1.0068 1.0104 0.9956
Aldopentoses 0.9837 1.0105 0.9796 1.0086 0.9832 1.0151 0.9736 1.0150 1.0011 1.0050 1.0214 1.0032
Alpha Ketoglutaric Acid 0.9729 1.0398 1.0163 1.0466 1.0093 1.0520 0.9729 0.9509 0.9581 0.9648 0.9806 1.0108
Aminomalonic Acid 1.0402 1.0365 1.0242 1.0294 1.0218 1.0217 0.9619 0.9470 0.9502 0.9803 0.9924 0.9945
Arachidic Acid 0.9930 1.0221 1.0136 1.0017 0.9995 0.9969 0.9924 0.9788 1.0008 1.0055 1.0048 0.9891
Asparagine 0.9713 1.0009 0.9727 1.0140 0.9914 0.9815 1.0037 1.0042 1.0115 1.0151 1.0164 NA
Aspartic Acid 1.0253 1.0092 0.9910 0.9937 1.0058 1.0103 0.9771 0.9542 0.9686 0.9470 0.9872 1.0711
Benzene-1,2,4-Triol NA 1.0712 NA 0.9746 NA NA NA 0.9713 1.0207 1.0177 1.0099 NA
Benzoic Acid 1.0045 1.0089 0.9999 1.0061 1.0048 0.9981 0.9915 0.9936 0.9975 0.9943 0.9992 1.0017
Beta-Alanine 0.9939 1.0090 1.0080 1.0305 0.9859 0.9845 0.9698 1.0089 1.0060 1.0098 1.0100 0.9898
Cholesterol 0.9887 0.9747 0.9891 1.0190 1.0348 1.0340 0.9926 0.9703 0.9597 1.0116 1.0232 1.0023
Citramalic Acid NA NA NA NA NA NA 1.0003 1.0318 0.9870 0.9811 1.0318 0.9809
Citric Acid/Isocitric Acid 0.9961 1.0138 0.9791 0.9973 0.9960 1.0302 0.9870 1.0095 0.9664 0.9708 1.0093 1.0106
Citrulline 1.0080 1.0733 1.0607 1.0222 1.0446 0.9447 0.9086 1.0090 0.9782 1.0300 1.0256 0.8742
Decanoic Acid 1.0216 1.0186 0.9970 1.0260 1.0041 1.0187 0.9465 0.9581 0.9851 1.0104 0.9999 1.0146
Diethylene Glycol 0.9678 1.0731 1.0252 0.9916 1.0450 0.9062 0.9792 1.0133 0.9901 1.0034 1.0205 1.0171
Docosanoic Acid 1.0027 1.0003 0.9480 1.0411 0.9906 0.9918 1.0053 0.9999 1.0480 0.9680 1.0019 0.9920
Erythronic Acid 0.9960 1.0166 1.0590 0.9990 0.9945 0.9987 0.9618 0.9957 0.9954 1.0113 1.0103 0.9617
Ethanolamine 1.0018 1.0184 1.0009 1.0162 1.0210 0.9883 0.9830 0.9822 0.9968 0.9907 0.9929 NA
Fructose Or Similar Ketohexose 1.0054 1.0187 1.0211 1.0183 1.0048 1.0002 0.9856 0.9958 0.9888 1.0005 1.0040 0.9569
Fumaric Acid 1.0042 1.0292 0.9994 0.9917 0.9877 1.0446 0.9734 0.9830 0.9854 0.9907 1.0029 1.0034
Gamma-Hydroxybutyric Acid/Ethylmalonic Acid 1.0459 1.0232 1.0449 0.9918 0.9643 0.9667 0.9910 1.0305 1.0069 1.0418 1.0046 0.9437
Gluconic Acid Lactone 0.9986 1.0016 1.0014 0.9962 1.0052 0.9997 0.9989 1.0006 0.9986 0.9977 1.0023 0.9992
Gluconic Acid Or Similar Sugar Acid 0.9847 1.0770 1.0224 1.0173 1.0136 0.9894 0.9640 0.9767 0.9828 0.9868 1.0047 0.9935
Glucose And Other Aldohexoses 0.9970 1.0045 0.9984 1.0024 0.9997 0.9989 0.9980 1.0018 1.0039 1.0001 1.0029 0.9925
Glutamic Acid 0.9906 1.0170 1.0010 1.0092 0.9835 0.9958 0.9757 1.0092 1.0065 1.0221 1.0242 0.9651
Glutamine 1.0348 1.0204 1.0220 0.9737 1.0269 0.9886 0.9677 0.9728 0.9930 1.0073 1.0120 0.9852
Glyceric Acid 1.0042 1.0145 0.9948 1.0020 0.9918 1.0124 0.9877 0.9867 0.9893 0.9979 1.0005 1.0182
Glycerol 1.0001 1.0020 0.9861 1.0071 0.9897 0.9949 0.9971 0.9962 1.0027 1.0046 1.0062 1.0133
Glycerol 1-Phosphate 1.0577 1.0232 0.9585 1.0015 1.0763 0.9687 0.9707 0.9855 1.0226 1.0175 1.0324 0.9322
Glycine 1.0040 1.0105 0.9951 0.9987 0.9880 1.0032 0.9866 0.9971 1.0006 1.0037 1.0076 1.0050
Glycolic Acid 1.0033 1.0126 0.9885 1.0063 1.0032 0.9731 0.9815 1.0093 0.9781 1.0153 1.0219 0.9999
Guanine 0.9484 1.0226 0.9663 1.0348 1.0145 1.0108 0.9696 0.9684 0.9532 0.9641 0.9712 1.0425
Heptadecanoic Acid/Octadecanol 1.0081 1.0025 1.0074 1.0024 1.0098 0.9975 0.9789 0.9973 1.0024 0.9908 1.0024 1.0004
Histidine 1.0430 1.0108 1.0215 1.0126 1.0244 0.9727 0.9961 0.9719 0.9712 0.9851 0.9879 NA
Homocysteine NA NA NA NA NA NA 0.9541 1.0522 1.0144 0.9940 1.0795 0.8443
Hydroquinone 0.9613 0.9987 0.9946 1.0158 0.9772 0.9924 0.9850 1.0210 1.0048 1.0289 1.0315 0.9887
Hydroxyprolines 1.0034 1.0105 1.0064 0.9942 1.0042 1.0008 0.9817 0.9971 1.0009 1.0065 1.0002 0.9801
Isoleucine 0.9940 1.0190 1.0094 1.0100 1.0050 0.9942 0.9714 0.9940 1.0042 1.0056 1.0080 0.9852
Isomaltose Or Similar Disaccharide 1.0101 1.0242 1.0041 1.0026 1.0001 1.0029 0.9607 0.9855 1.0009 1.0009 1.0074 1.0005
Lactic Acid 1.0026 0.9943 1.0004 1.0096 0.9982 1.0000 1.0079 0.9992 1.0008 0.9971 0.9853 1.0046
Lactose Or Similar Disaccharide 1.0180 0.9925 0.9975 0.9857 0.9922 1.0503 0.9622 0.9803 1.0276 0.9602 0.9873 1.0410
Lauric Acid NA NA NA 1.0373 1.0449 0.9681 0.9545 1.0237 1.0042 1.0235 1.0110 0.9500
Leucine 0.9975 1.0209 1.0078 1.0093 1.0020 0.9958 0.9702 0.9921 1.0038 1.0041 1.0073 0.9889
Lysine 1.0032 1.0014 1.0171 1.0055 0.9930 0.9958 0.9840 1.0017 0.9987 1.0069 1.0072 0.9855
Maleamic Acid 1.3726 NA 0.9833 NA NA NA NA 1.0017 NA 0.8781 NA 1.0083
Malic Acid 0.9933 1.0106 0.9861 0.9967 0.9938 1.0236 0.9826 0.9969 1.0043 1.0040 1.0154 0.9916
Maltose Or Similar Disaccharide 1.0090 1.0123 1.0034 1.0030 0.9970 1.0085 0.9765 0.9978 0.9984 0.9945 1.0145 0.9857
Methionine 1.0289 1.0363 1.0231 1.0249 1.0169 1.0273 0.9562 0.9553 0.9712 0.9795 0.9925 0.9880
Methionine Sulfoxide NA 0.9234 NA NA 0.8766 NA 0.9782 1.0180 1.0236 1.0304 1.0066 0.9893
Myoinositol 1.0035 1.0132 1.0038 1.0055 1.0002 0.9980 0.9810 0.9922 0.9976 1.0034 1.0013 1.0004
N1-Methyltryptamine 0.9999 1.0146 0.9981 1.0003 1.0111 0.9866 0.9690 0.9922 0.9895 1.0235 1.0117 0.9997
N-Acetylleucine NA NA NA NA NA NA 0.9746 1.0491 0.9905 1.0118 1.0071 0.9977
Nicotinamide 1.0064 1.0149 1.0025 1.0104 1.0040 1.0054 0.9887 0.9766 1.0028 1.0050 1.0099 0.9669
N-Methylglutamic Acid 1.0755 1.0674 1.0621 1.0634 1.0513 1.0248 0.9398 0.8943 0.9229 0.9595 0.9685 0.9301
Nonanoic Acid 1.0100 0.9861 0.9630 1.0031 1.0281 1.0041 0.9720 1.0360 1.0256 0.9930 1.0326 0.9515
O-Methylphosphate NA NA NA NA NA NA 0.9608 NA 1.0392 NA NA NA
Ornithine 0.9995 1.0214 0.9990 1.0079 0.9926 1.0010 0.9728 0.9958 1.0039 1.0047 1.0073 0.9942
Pantothenic Acid 1.0032 1.0183 1.0011 1.0059 0.9987 1.0018 0.9751 0.9908 0.9985 1.0030 1.0053 0.9983
Pentitols 0.9837 1.0441 1.0255 1.0180 1.0201 0.9960 0.9575 0.9961 0.9948 1.0011 1.0012 0.9620
Pentonic Acids 0.9999 1.0294 1.0055 1.0111 1.0171 0.9900 0.9630 1.0002 1.0024 1.0038 1.0156 0.9775
Phenylalanine 1.0060 1.0285 1.0135 1.0126 1.0064 0.9922 0.9665 0.9889 0.9954 1.0068 1.0074 0.9759
Phenyl-Beta-Glucopyranoside 1.0040 0.9948 0.9916 1.0357 0.9753 0.9906 0.9645 1.0113 0.9984 1.0324 1.0237 0.9776
Phenylpyruvate 0.9881 0.9686 0.9984 1.0458 1.0091 1.0089 0.8947 0.9655 NA NA 1.0490 NA
Phosphoric Acid 1.0195 0.9691 1.0337 0.9716 0.9603 0.9757 1.0223 1.0228 1.0160 1.0233 0.9990 0.9868
Proline 1.0218 1.0230 0.9755 1.0092 1.0011 1.0044 0.9759 0.9807 0.9860 0.9956 0.9985 1.0299
Pseudouridine 1.0315 1.0032 1.0012 1.0230 1.0648 1.0450 0.9882 0.9181 0.9840 0.9760 0.9789 NA
Putrescine 1.0017 1.0284 0.9931 1.0065 0.9926 1.0145 0.9573 1.0063 0.9905 1.0018 1.0179 0.9894
Pyridine-2,6-Dicarboxylic Acid 1.0062 1.0280 1.0168 1.0181 0.9964 1.0291 0.9793 0.9863 0.9842 0.9940 0.9787 0.9702
Pyridoxine 0.8454 1.0445 1.0436 0.9672 1.0384 NA NA 0.9569 0.9831 0.9972 1.0500 NA
Pyruvic Acid 1.0170 1.0295 0.9719 0.9935 1.0144 1.0483 0.9615 0.9903 0.9873 0.9938 0.9953 0.9973
Serine 1.0072 1.0114 0.9967 0.9982 0.9861 1.0093 0.9848 0.9919 0.9997 1.0024 1.0070 1.0052
Spermidine NA 1.0108 NA NA NA 0.9835 NA 1.0280 NA 1.0189 0.9904 NA
Stearic Acid 0.9983 1.0071 1.0001 1.0057 1.0116 0.9964 0.9872 0.9996 0.9985 0.9969 1.0026 0.9962
Succinic Acid 0.9881 1.0063 0.9857 0.9932 0.9874 1.0046 0.9889 1.0085 1.0056 1.0111 1.0135 1.0070
Sucrose And Similar Disaccharides 0.9764 0.9926 0.9589 1.0395 1.0707 0.9569 0.9268 0.9987 0.9790 1.0285 1.0790 0.9917
Tartaric Acid 0.9784 1.0277 1.0177 NA 1.0197 1.0057 0.9840 NA 0.9370 1.0117 1.0310 0.9204
Tetradecanedioic Acid NA NA NA 0.9635 1.0203 NA 0.9355 0.9908 0.9657 NA 1.1403 NA
Threitol/Erythritol 1.0019 1.0216 1.0086 1.0045 1.0059 1.0119 0.9684 0.9923 0.9946 0.9984 0.9987 0.9931
Threonic Acid 0.9958 1.0426 1.0243 1.0249 1.0348 0.9940 0.9529 0.9935 0.9922 1.0134 0.9984 0.9772
Threonine 0.9973 1.0161 1.0069 1.0071 0.9950 0.9963 0.9768 0.9996 1.0024 1.0055 1.0099 0.9871
Threose/Erythrose 1.0115 1.0398 1.0267 1.0409 1.0377 1.0281 0.9318 0.9457 0.9345 0.9679 1.0075 0.9839
Trisaccharide 0.9982 1.0188 0.9733 0.9977 0.9941 1.0294 0.9821 1.0104 0.9920 1.0022 1.0287 0.9763
Tryptophan 1.0162 1.0288 1.0203 0.9890 1.0232 0.9959 0.9585 0.9719 0.9941 1.0098 1.0086 0.9875
Tyrosine 1.0053 1.0149 1.0133 1.0054 1.0044 0.9913 0.9751 0.9987 0.9966 1.0090 1.0082 0.9778
Uracil 1.0247 1.0156 0.9728 0.9939 1.0061 1.0379 0.9675 0.9558 0.9567 0.9468 0.9906 1.0953
Urea 1.0118 1.0218 1.0112 0.9931 0.9991 1.0083 0.9706 0.9857 0.9931 1.0043 1.0033 0.9976
Uric Acid 1.1240 0.9129 NA 1.0028 0.9635 1.0889 NA NA 0.9061 NA NA NA
Valine 1.0093 1.0086 1.0029 0.9853 1.0055 0.9953 1.0040 0.9868 0.9939 0.9955 0.9967 1.0161
Willardiine 0.9741 1.0181 1.0006 1.0881 0.9680 0.9978 0.9038 0.9734 1.0010 1.0365 0.9796 0.9590
Xanthine 1.1171 1.0205 NA 0.9713 NA NA NA NA NA NA NA 0.9782
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Factors:

F1Sample type:Ad.shRNA MuRF1 | Stretch Cycle:6 hours stretch
F2Sample type:Ad.shRNA MuRF1 | Stretch Cycle:6 hours stretch, 12 hours unloading
F3Sample type:Ad.shRNA MuRF1 | Stretch Cycle:6 hours stretch, 1 hour unloading
F4Sample type:Ad.shRNA MuRF1 | Stretch Cycle:6 hours stretch, 3 hours unloading
F5Sample type:Ad.shRNA MuRF1 | Stretch Cycle:6 hours stretch, 6 hours unloading
F6Sample type:Ad.shRNA MuRF1 | Stretch Cycle:Non-stretched
F7Sample type:Ad.shRNA Scramble | Stretch Cycle:6 hours stretch
F8Sample type:Ad.shRNA Scramble | Stretch Cycle:6 hours stretch, 12 hours unloading
F9Sample type:Ad.shRNA Scramble | Stretch Cycle:6 hours stretch, 1 hour unloading
F10Sample type:Ad.shRNA Scramble | Stretch Cycle:6 hours stretch, 3 hours unloading
F11Sample type:Ad.shRNA Scramble | Stretch Cycle:6 hours stretch, 6 hours unloading
F12Sample type:Ad.shRNA Scramble | Stretch Cycle:Non-stretched
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