Data for Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability (Study ST001119)
(Analysis AN001831)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 2-hydroxybutyric acid | 0.6782 | 0.6611 | 1.6312 | 0.7901 | 0.5597 | 2.2624 |
| 2-hydroxyglutaric acid | 1.4045 | 1.9945 | 0.5858 | 0.7239 | 0.5394 | 1.5131 |
| 3-hydroxyisobutyric acid | 0.7595 | 0.8365 | 0.8143 | 1.2916 | 1.3285 | 0.6993 |
| 3-Methyl-2-oxovaleric acid | 1.9872 | 2.0123 | 0.3127 | 0.9170 | 0.6346 | 0.7356 |
| 3-methyl pyruvic acid | 0.7977 | 0.8428 | 0.6080 | 1.0743 | 1.6056 | 0.4664 |
| 3-Phosphoglyceric acid | 1.6187 | 1.9477 | 1.5598 | 0.0740 | 0.0764 | 0.9836 |
| 5^-Methylthioadenosine | 1.1157 | 2.5802 | 0.9890 | 0.1191 | 0.2706 | 0.3970 |
| Allantoin | 0.7999 | 1.9558 | 0.7457 | 0.5926 | 1.0971 | 0.4275 |
| AMP | 2.6346 | 0.6486 | 1.0926 | 0.3522 | 0.7885 | 0.1841 |
| Argininosuccinic acid | 1.0552 | 1.1339 | 1.1417 | 0.4063 | 0.3708 | 1.7643 |
| Aspartic acid | 0.9801 | 1.4919 | 1.8094 | 0.0602 | 0.2342 | 1.3599 |
| beta-hydroxybutyric acid | 0.4037 | 0.4692 | 0.8652 | 1.6510 | 1.6436 | 0.2950 |
| Cis-Aconitic acid | 0.7675 | 1.0594 | 0.5938 | 1.1148 | 1.2783 | 1.2508 |
| Citric acid | 0.8753 | 1.1070 | 0.8035 | 0.9821 | 1.0472 | 1.3872 |
| CTP | NA | 0.0104 | 1.0275 | NA | NA | 1.1484 |
| Cysteic acid | 0.3387 | 0.1788 | 3.1612 | NA | NA | 3.3229 |
| Dihydroxyacetone phosphate | 0.8279 | 1.3084 | 1.5768 | 0.0388 | 0.3268 | 2.6203 |
| dTMP | 0.1343 | 0.1338 | 1.2737 | NA | NA | 1.7831 |
| Fumaric acid | 0.1965 | 0.3564 | 1.4725 | NA | 0.1850 | 2.1553 |
| Glucose | 0.8225 | 0.5275 | 0.5883 | 2.3374 | 1.2420 | 0.9058 |
| glucose-1-phosphate/fructose-6 -hosphate | 0.8610 | 1.5558 | 1.9096 | 0.0308 | 0.1042 | 1.5788 |
| Glucose-6-phosphate | 0.8301 | 1.4520 | 1.8783 | 0.0184 | 0.1047 | 1.7381 |
| Glutamic acid | 1.3584 | 2.0373 | 1.4294 | 0.0665 | 0.1231 | 1.4270 |
| Glyceric acid | 0.8470 | 1.5152 | 1.5699 | 0.4338 | 0.5096 | 1.0634 |
| GMP | 1.7315 | 0.8208 | 2.2575 | 0.2131 | 0.1936 | 0.0202 |
| Itaconic acid | 1.3824 | 1.7670 | 0.5061 | 1.7358 | 0.5918 | 0.8237 |
| Ketoisovaleric acid | 1.3997 | 1.4689 | 0.7529 | 0.6718 | 0.8945 | 0.8884 |
| Lactic acid | 1.3891 | 1.6775 | 0.6423 | 0.6931 | 0.8570 | 0.9072 |
| Malic acid | 1.2294 | 1.8159 | 1.2117 | 0.6412 | 0.3503 | 1.1778 |
| N-6-trimethyllysine | 1.2123 | 1.7105 | 0.6678 | 1.0337 | 0.7355 | 1.0814 |
| Orotic acid | 1.6781 | 1.7910 | 0.5567 | 0.4451 | 0.7951 | 0.5455 |
| Oxoglutaric acid | 0.8905 | 1.6542 | 0.3503 | 2.3675 | 0.7921 | 0.7934 |
| P-Aminobenzoic acid | NA | 0.0218 | 1.0711 | NA | 2.0975 | 1.6480 |
| Phosphoethanolamine | 1.6416 | 2.5101 | 1.2792 | 0.0651 | 0.0878 | 0.5777 |
| Pyruvic acid | 0.5515 | 1.1114 | 0.4461 | 1.2212 | 1.5999 | 0.6203 |
| Ribose-5-phosphate | 1.1185 | 2.7423 | 1.2589 | 0.0714 | 0.1488 | 0.7797 |
| Sorbitol | 1.7867 | 2.1020 | 0.9586 | 1.1345 | 0.1919 | 0.4009 |
| Succinic acid | 0.7832 | 1.2197 | 0.6929 | 0.1876 | 1.5625 | 0.7174 |
| Thiamine | 0.9893 | 1.9453 | 1.1115 | 0.1898 | 0.3921 | 1.9751 |
| Thymidine | 0.0847 | 0.0884 | 0.4311 | 0.0521 | 1.8292 | 4.0331 |
| UDP-glucose | 2.1331 | 2.2318 | 0.6940 | 0.0638 | 0.1278 | 0.2609 |
| UDP-N-acetylglucosamine | 2.2139 | 1.9628 | 1.1568 | 0.0444 | 0.0926 | 0.5620 |
| Uracil | 0.9445 | 1.8518 | 1.7459 | 0.0733 | 0.1636 | 1.4197 |
| Vitamin C | 0.3567 | 0.1045 | 2.2378 | NA | 0.5504 | 2.3646 |
| Xanthine | 1.4016 | 2.0775 | 1.2519 | 0.0005 | 0.4065 | 0.8332 |
Factors:
| F1 | Sample Type:Keap1_mutant_lung_subcutaneous |
| F2 | Sample Type:lung_subcutaneous |
| F3 | Sample Type:pancreatic ductal adenocarcinoma |
| F4 | Sample Type:pancreatic ductal adenocarcinoma plasma |
| F5 | Sample Type:pancreatic ductal adenocarcinoma plasma cardiac puncture |
| F6 | Sample Type:pancreatic ductal adenocarcinoma subcutaneous |
