Data for Different dose exposure of OPC-163493 on HepG2 cells (part-I) (Study ST001135)
(Analysis AN001861)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 2,3-Diphosphoglyceric acid | 1.6216 | 1.1441 | 0.1735 | 0.6475 |
| 2-hydroxyglutaric acid | 1.1107 | 0.9847 | 0.9160 | 0.9885 |
| 2-Phosphoglyceric acid | 1.0260 | 0.8607 | 1.0393 | 1.0740 |
| 3^,5^ cyclic AMP | 0.9909 | 0.9909 | 0.9519 | 1.0663 |
| 3^,5^ cyclic GMP | 1.0809 | 0.7986 | 1.1391 | 0.9813 |
| 3-hydroxy-3-methylglutaryl-CoA | 0.6416 | 0.7574 | 1.5630 | 1.0380 |
| 3-Phosphoglyceric acid | 1.0790 | 0.9100 | 0.9181 | 1.0929 |
| 6-Phosphogluconic acid | 1.1808 | 0.9950 | 0.8262 | 0.9980 |
| Acetyl-CoA | 0.9059 | 0.9892 | NA | 1.1157 |
| Adenylsuccinic acid | 1.1740 | 1.0189 | 0.9015 | 0.9057 |
| ADP | 0.7289 | 0.8062 | 1.4950 | 0.9699 |
| ADP-ribose | 1.1878 | 0.9551 | 0.7551 | 1.1020 |
| AMP | 0.7313 | 0.6940 | 1.6287 | 0.9459 |
| ATP | 1.0024 | 0.9830 | 0.9703 | 1.0443 |
| Cis-Aconitic acid | 0.8065 | 1.0079 | 0.6366 | 1.4523 |
| Citric acid | 0.9032 | 0.9760 | 0.9476 | 1.1732 |
| Coenzyme A | 0.8954 | 0.5328 | 1.6467 | 0.9251 |
| Dihydroxyacetone phosphate | 1.3753 | 1.2353 | 0.4514 | 0.9379 |
| Folic acid | 1.0286 | 1.0876 | 0.9209 | 0.9629 |
| Fructose-1,6-biphosphate | 1.3703 | 1.1468 | 0.5947 | 0.8882 |
| Fructose-1-phosphate | 1.0321 | 0.9851 | 0.8943 | 1.0885 |
| Fructose-6-phosphate | 1.0236 | 0.9407 | 0.9778 | 1.0579 |
| Fumaric acid | 1.4870 | 1.4099 | 0.0441 | 1.0590 |
| Galactose-1-phosphate | 1.1788 | 0.8483 | 0.8483 | 1.1245 |
| GDP | 0.8196 | 0.8449 | 1.3291 | 1.0063 |
| Glucose-1-phosphate | 1.4758 | 0.6401 | 0.9344 | 0.9497 |
| Glucose-6-phosphate | 0.9667 | 0.9730 | 1.0239 | 1.0364 |
| Glyceraldehyde-3-phosphate | 1.4931 | 1.1523 | 0.2390 | 0.7351 |
| Glycerol 3-phosphate | 0.9310 | 0.9498 | 1.1255 | 0.9938 |
| GMP | 0.6959 | 0.7520 | 1.6434 | 0.9088 |
| GTP | 1.0695 | 0.9909 | 0.8763 | 1.0632 |
| IMP | 0.8788 | 0.8351 | 1.3837 | 0.9024 |
| Ketoisovaleric acid | 0.9003 | 0.9389 | 1.0429 | 1.1179 |
| Lactic acid | 0.8829 | 0.8831 | 1.1765 | 1.0575 |
| Malic acid | 1.3751 | 1.1528 | 0.4653 | 1.0068 |
| Malonyl-CoA | 1.1687 | 0.9253 | 0.8382 | 1.0305 |
| Mevalonic acid | 1.2455 | 0.7373 | NA | 0.8858 |
| N-acetylglutamic acid | 0.8304 | 0.9520 | 1.1724 | 1.0451 |
| NAD+ | 0.9693 | 0.9659 | 1.0212 | 1.0436 |
| NADH | 1.4733 | 1.1309 | 0.5960 | 0.7998 |
| NADP+ | 0.9712 | 0.9749 | 1.0312 | 1.0227 |
| NADPH | 1.1697 | 1.0360 | 0.7364 | 1.0580 |
| N-carbamoylaspartic acid | 1.5276 | 1.2105 | 0.3561 | 0.9058 |
| Oxoglutaric acid | 0.6898 | 0.5780 | 1.5663 | 1.1660 |
| Phosphocreatine | 1.2308 | 1.1062 | 0.6203 | 1.0427 |
| Phosphoenolpyruvic acid | 1.0628 | 0.8775 | 0.9477 | 1.1120 |
| Phosphoribosyl pyrophosphate | 1.0887 | 1.1823 | 0.4584 | 1.2706 |
| Pyruvic acid | 0.9638 | 1.2043 | 0.8563 | 0.9756 |
| Ribose-1-phosphate | 1.1044 | 0.9616 | 0.9638 | 0.9703 |
| Ribose-5-phosphate | 1.3831 | 1.1232 | 0.5323 | 0.9614 |
| Ribulose-5-phosphate | 1.2151 | 1.0602 | 0.7690 | 0.9557 |
| Sedoheptulose 7-phosphate | 0.9085 | 0.8954 | 1.1106 | 1.0854 |
| Succinic acid | 0.8460 | 0.8602 | 1.3320 | 0.9619 |
| UDP-glucose | 1.1288 | 1.0115 | 0.8304 | 1.0292 |
| XMP | 1.1121 | 1.0135 | 0.8879 | 0.9865 |
| Xylulose-5-phosphate | 1.4236 | 1.1300 | 0.6104 | 0.8359 |
Factors:
| F1 | Treatment:- |
| F2 | Treatment:1 |
| F3 | Treatment:10 |
| F4 | Treatment:3 |
