Data for Metabolme analysis of OPC-163493 on the Liver of ZDF rats (part-II) (Study ST001136)
(Analysis AN001862)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 2,3-Diphosphoglyceric acid | 0.7785 | 1.0770 | 1.1446 |
| 2-hydroxyglutaric acid | 1.4277 | 0.8584 | 0.7139 |
| 2-Phosphoglyceric acid | 0.4796 | 1.0897 | 1.4306 |
| 3^,5^ cyclic AMP | 1.0927 | 0.9781 | 0.9292 |
| 3-hydroxy-3-methylglutaryl-CoA | 0.8790 | 0.9492 | 1.1718 |
| 3-Phosphoglyceric acid | 0.5632 | 1.0676 | 1.3692 |
| 6-Phosphogluconic acid | 0.7859 | 1.0637 | 1.1504 |
| Acetyl-CoA | 0.8104 | 1.0337 | 1.1559 |
| Adenylsuccinic acid | 1.1560 | 0.9723 | 0.8716 |
| ADP | 0.8633 | 1.0571 | 1.0796 |
| ADP-ribose | 1.1223 | 0.8815 | 0.9962 |
| AMP | 1.0290 | 1.0357 | 0.9353 |
| ATP | 0.6301 | 1.0349 | 1.3349 |
| Cis-Aconitic acid | 1.1538 | 0.9231 | 0.9231 |
| Citric acid | 1.1353 | 0.9819 | 0.8828 |
| Coenzyme A | 0.8924 | 1.0356 | 1.0720 |
| Dihydroxyacetone phosphate | 0.6809 | 1.1099 | 1.2091 |
| Fructose-1,6-biphosphate | 0.8484 | 1.0228 | 1.1288 |
| Fructose-1-phosphate | 0.8686 | 1.1418 | 0.9896 |
| Fructose-6-phosphate | 1.0035 | 0.9510 | 1.0456 |
| Fumaric acid | 0.9993 | 0.9883 | 1.0124 |
| Galactose-1-phosphate | 1.1338 | 0.9327 | 0.9335 |
| GDP | 0.9575 | 1.0023 | 1.0402 |
| Glucose-1-phosphate | 0.9971 | 0.8876 | 1.1153 |
| Glucose-6-phosphate | 1.0052 | 0.9662 | 1.0286 |
| Glyceraldehyde-3-phosphate | 1.0141 | 0.9271 | 1.0550 |
| Glycerol 3-phosphate | 1.0144 | 0.9847 | 1.0010 |
| GMP | 1.0478 | 1.0071 | 0.9451 |
| GTP | 0.6953 | 1.0061 | 1.2985 |
| IMP | 0.9208 | 1.0285 | 1.0507 |
| Lactic acid | 1.0856 | 0.9812 | 0.9332 |
| Malic acid | 0.9693 | 0.9962 | 1.0345 |
| N-acetylglutamic acid | 0.7958 | 0.9726 | 1.2316 |
| NAD+ | 0.8751 | 1.0309 | 1.0940 |
| NADH | 0.9679 | 1.0298 | 1.0023 |
| NADP+ | 0.8677 | 1.0075 | 1.1249 |
| NADPH | 1.2605 | 1.0339 | 0.7056 |
| N-carbamoylaspartic acid | 0.8770 | 0.9749 | 1.1481 |
| Phosphocreatine | 0.8792 | 0.9914 | 1.1295 |
| Phosphoenolpyruvic acid | 0.4760 | 1.0554 | 1.4687 |
| Phosphoribosyl pyrophosphate | 0.8514 | 1.1097 | 1.0914 |
| Pyruvic acid | 1.2498 | 0.9876 | 0.7627 |
| Ribose-1-phosphate | 1.0669 | 0.9657 | 0.9675 |
| Ribose-5-phosphate | 0.9941 | 1.1570 | 0.8489 |
| Ribulose-5-phosphate | 0.9234 | 1.0686 | 1.0080 |
| Sedoheptulose 7-phosphate | 1.0260 | 1.0415 | 0.9325 |
| Succinic acid | 1.1920 | 0.9257 | 0.8823 |
| UDP-glucose | 0.9466 | 1.0518 | 1.0016 |
| Uric acid | 1.4229 | 0.7437 | 0.8334 |
| Xanthine | 1.0534 | 1.0015 | 0.9451 |
| XMP | 0.9469 | 1.0082 | 1.0449 |
| Xylulose-5-phosphate | 0.8561 | 1.0419 | 1.1020 |
Factors:
| F1 | Genotype:11-week-old ZDF rat | Treatment:- | Duration (weeks):- |
| F2 | Genotype:17-week-old ZDF rat | Treatment:6 | Duration (weeks):6 |
| F3 | Genotype:17-week-old ZDF rat | Treatment:- | Duration (weeks):6 |
