Data for Microbial depletion and ozone exposure - Lung tissue (part I) (Study ST001143)
(Analysis AN001883)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 10-heptadecenoate (17:1n7) | 0.7137 | 1.1564 | 0.7935 | 1.2811 |
| 10-nonadecenoate (19:1n9) | 0.7206 | 1.2350 | 0.6815 | 1.2985 |
| 10-undecenoate (11:1n1) | 1.0107 | 1.0175 | 0.6800 | 1.1242 |
| 1-(1-enyl-oleoyl)-GPE (P-18:1)* | 0.8687 | 1.0611 | 1.0465 | 0.9996 |
| 1-(1-enyl-palmitoyl)-GPE (P-16:0)* | 0.9490 | 0.9237 | 1.2140 | 0.9164 |
| 1-(1-enyl-stearoyl)-GPE (P-18:0)* | 0.9234 | 0.7998 | 1.5003 | 0.7920 |
| 12,13-DiHOME | 0.7639 | 0.9276 | 1.2079 | 1.0801 |
| 1,2,3-benzenetriol sulfate (2) | 0.3438 | 0.7548 | 1.5712 | 1.2535 |
| 12-HEPE | 0.9753 | 0.8905 | 1.1187 | 1.0261 |
| 12-HETE | 1.0625 | 0.9551 | 0.9982 | 0.9977 |
| 13-HODE + 9-HODE | 0.8693 | 0.9368 | 1.0825 | 1.1030 |
| 1,5-anhydroglucitol (1,5-AG) | 1.2134 | 0.9945 | 0.9713 | 0.8482 |
| 16-hydroxypalmitate | 0.9822 | 0.9393 | 1.1741 | 0.9098 |
| 17-HDoHe | 1.1580 | 0.9223 | 1.0622 | 0.8870 |
| 17-methylstearate | 0.7087 | 1.2129 | 0.7797 | 1.2357 |
| 1-arachidonoyl-GPC (20:4)* | 0.9698 | 1.1729 | 0.7761 | 1.0559 |
| 1-arachidonoyl-GPE (20:4)* | 0.8536 | 1.0747 | 0.9359 | 1.1082 |
| 1-arachidonoyl-GPI (20:4)* | 1.1727 | 0.8858 | 1.2781 | 0.6993 |
| 1-arachidonylglycerol (20:4) | 0.6320 | 1.6178 | 0.4495 | 1.1775 |
| 1-dihomo-linolenylglycerol (alpha, gamma) | 0.6981 | 1.2597 | 0.7411 | 1.2310 |
| 1-dihomo-linoleoylglycerol (20:2) | 0.6198 | 1.7117 | 0.5591 | 1.1508 |
| 1-docosahexaenoylglycerol (22:6) | 0.7245 | 1.4855 | 0.5331 | 1.1618 |
| 1-linoleoylglycerol (18:2) | 0.5206 | 1.4328 | 0.5193 | 1.4132 |
| 1-linoleoylglycerophosphoserine* | 0.9686 | 1.0213 | 0.9931 | 1.0105 |
| 1-linoleoyl-GPE (18:2)* | 0.8481 | 1.0199 | 1.0593 | 1.0512 |
| 1-margaroylglycerol (17:0) | 0.7999 | 1.2478 | 0.6693 | 1.2270 |
| 1-myristoylglycerol (14:0) | 0.8655 | 1.2731 | 0.7496 | 1.0609 |
| 1-oleoylglycerol (18:1) | 0.5520 | 1.3619 | 0.5713 | 1.4135 |
| 1-oleoyl-GPE (18:1) | 0.8465 | 1.0414 | 1.0384 | 1.0493 |
| 1-oleoyl-GPG (18:1)* | 0.6134 | 1.2414 | 0.6421 | 1.4246 |
| 1-oleoyl-GPS (18:1) | 0.8507 | 1.1921 | 0.7436 | 1.1710 |
| 1-palmitoleoylglycerol (16:1)* | 0.5945 | 1.4301 | 0.6543 | 1.2704 |
| 1-palmitoylglycerol (16:0) | 0.6900 | 1.2276 | 0.7185 | 1.2968 |
| 1-palmitoyl-GPE (16:0) | 0.8699 | 0.9808 | 1.1056 | 1.0298 |
| 1-palmitoyl-GPG (16:0)* | 0.9206 | 1.0846 | 0.8235 | 1.1509 |
| 1-palmitoyl-GPI (16:0)* | 1.0388 | 0.8534 | 1.2014 | 0.9297 |
| 1-palmitoyl-GPS (16:0)* | 1.0358 | 1.0224 | 0.8148 | 1.1287 |
| 1-pentadecanoylglycerol (15:0) | 0.6646 | 1.1489 | 0.7287 | 1.2795 |
| 1-stearoyl-GPG (18:0) | 0.8248 | 1.1795 | 0.7229 | 1.2285 |
| 1-stearoyl-GPI (18:0) | 1.0870 | 0.9073 | 1.0913 | 0.9369 |
| 1-stearoyl-GPS (18:0)* | 0.9983 | 1.0275 | 0.9291 | 1.0415 |
| 2,3-diphosphoglycerate | 0.8845 | 1.1275 | 1.0211 | 0.9365 |
| 2-aminophenol sulfate | 0.7731 | 0.8847 | 1.4767 | 0.5802 |
| 2-arachidonoylglycerol (20:4) | 0.8015 | 1.4456 | 0.6273 | 1.0451 |
| 2^-deoxycytidine | 1.0379 | 1.0427 | 0.8724 | 1.0463 |
| 2^-deoxyinosine | 1.0137 | NA | 0.9932 | NA |
| 2-docosahexaenoylglcyerol* | 0.7767 | 1.4697 | 0.6181 | 1.0488 |
| 2-hydroxy-3-methylvalerate | 2.1364 | 0.8444 | 0.4972 | 0.6835 |
| 2-hydroxydecanoate | 0.9405 | 1.0138 | 1.1163 | 0.9203 |
| 2-hydroxyhippurate (salicylurate) | 0.9422 | 1.0043 | 0.9420 | 1.3615 |
| 2-hydroxyoctanoate | 0.9766 | 1.1308 | 0.9129 | 0.9547 |
| 2-hydroxypalmitate | 1.0441 | 0.9464 | 1.1594 | 0.8622 |
| 2-hydroxystearate | 1.0728 | 0.9875 | 1.1659 | 0.7844 |
| 2-linoleoylglycerol (18:2) | 0.6057 | 1.4812 | 0.6030 | 1.2007 |
| 2-myristoylglycerol (14:0) | 0.7846 | 1.2399 | 0.8186 | 1.1000 |
| 2-oleoylglycerol (18:1) | 0.6789 | 1.2595 | 0.7114 | 1.2776 |
| 2-oxindole-3-acetate | 1.2020 | 0.9334 | 1.3240 | 0.3995 |
| 2-palmitoleoylglycerol (16:1)* | 0.4268 | 1.5851 | 0.4653 | 1.3780 |
| 2-palmitoylglycerol (16:0) | 0.7051 | 1.2079 | 0.7735 | 1.2507 |
| 2-stearoyl-GPE (18:0)* | 0.6851 | 0.9139 | 1.3766 | 0.9958 |
| 3-[3-(sulfooxy)phenyl]propanoic acid | NA | NA | 1.6681 | 0.2364 |
| 3-(4-hydroxyphenyl)lactate | 1.0082 | 1.0394 | 0.9592 | 0.9893 |
| 3-hydroxydecanoate | 0.9283 | 1.0091 | 0.7686 | 1.2839 |
| 3-hydroxylaurate | 0.8755 | 0.9886 | 0.7647 | 1.3571 |
| 3-hydroxyoctanoate | 0.9434 | 0.9608 | 0.9758 | 1.1178 |
| 3-indoxyl sulfate | 0.6940 | 0.7231 | 1.5005 | 1.0788 |
| 3-methylhistidine | 1.1857 | 0.9905 | 0.4580 | 1.2662 |
| 3-phenylpropionate (hydrocinnamate) | 0.8289 | 0.8526 | 0.9232 | 1.3923 |
| 3-phosphoglycerate | 0.9470 | 1.0449 | 1.0080 | 0.9879 |
| 4-allylphenol sulfate | 0.5238 | 0.5883 | NA | 1.7798 |
| 4-ethylphenylsulfate | NA | NA | 0.7111 | 1.2528 |
| 4-hydroxy-nonenal-glutathione | 1.8237 | 0.6432 | 1.0273 | 0.6533 |
| 4-hydroxyphenylpyruvate | 0.9467 | 0.9453 | 1.2143 | 0.8938 |
| 4-methyl-2-oxopentanoate | 0.7736 | 1.1029 | 0.9353 | 1.1470 |
| 4-vinylphenol sulfate | 1.3022 | 0.6978 | NA | NA |
| 5-dodecenoate (12:1n7) | 0.8540 | 1.0988 | 0.8177 | 1.1989 |
| 5-HETE | 0.9716 | 1.0371 | 0.9830 | 1.0002 |
| 5-KETE | 0.8691 | 1.0559 | 0.9995 | 1.0521 |
| 5-oxoproline | 0.8378 | 1.1200 | 0.9468 | 1.0601 |
| 6-keto prostaglandin F1alpha | 1.0416 | 0.9280 | 1.0182 | 1.0265 |
| 6-phosphogluconate | 1.0743 | 0.8600 | 1.2617 | 0.8307 |
| 7-ketodeoxycholate | NA | 0.2381 | 1.3335 | 0.2138 |
| 8-hydroxyoctanoate | 0.9809 | 1.0053 | 1.1249 | 0.8858 |
| 9,10-DiHOME | 0.7210 | 0.8905 | 1.2818 | 1.0855 |
| adenosine 2^-monophosphate (2^-AMP) | 1.0745 | 0.9573 | 1.1306 | 0.8522 |
| adenosine 3^,5^-cyclic monophosphate (cAMP) | 1.0051 | 0.8781 | 1.2733 | 0.8594 |
| adenosine 3^,5^-diphosphate | 1.1537 | 0.8283 | 1.2554 | 0.8032 |
| adenosine 3^-monophosphate (3^-AMP) | 1.5554 | 0.4966 | 1.7823 | 0.2981 |
| adenosine 5^-diphosphate (ADP) | 0.9524 | 0.9433 | 1.2969 | 0.7768 |
| adrenate (22:4n6) | 0.9408 | 1.1679 | 0.7825 | 1.0803 |
| alpha-hydroxycaproate | 0.9891 | 1.0030 | 1.1059 | 0.9002 |
| alpha-hydroxyisocaproate | 1.1969 | 0.9414 | 0.9421 | 0.9442 |
| anserine | 0.9734 | 0.7484 | 1.6526 | 0.6538 |
| arachidate (20:0) | 0.8639 | 1.1496 | 0.8935 | 1.0573 |
| arachidonate (20:4n6) | 0.9789 | 1.1053 | 0.8642 | 1.0358 |
| argininosuccinate | 0.9695 | 0.8435 | 1.1415 | 1.0573 |
| azelate (nonanedioate) | 0.8862 | 1.0501 | 1.0984 | 0.9448 |
| benzoate | 0.8823 | 1.0535 | 0.7178 | 1.3249 |
| butyrylglycine | 0.3029 | 0.8529 | 1.3066 | 1.0266 |
| caprate (10:0) | 0.9932 | 1.0459 | 0.9083 | 1.0460 |
| caproate (6:0) | 0.7652 | 1.4337 | 0.5427 | 1.1748 |
| caprylate (8:0) | 0.8762 | 1.2626 | 0.7898 | 1.0231 |
| carnosine | 0.7934 | 0.9004 | 1.2463 | 1.0464 |
| catechol sulfate | NA | 0.3724 | 1.8030 | 0.5108 |
| cholate | 0.7552 | 0.8875 | 1.2917 | 0.9431 |
| cinnamoylglycine | 0.5632 | 0.9458 | 1.3396 | 1.1036 |
| creatine | 1.0937 | 0.9089 | 1.1055 | 0.9150 |
| creatinine | 1.1829 | 1.0510 | 0.9350 | 0.8476 |
| cysteine s-sulfate | 1.0141 | 1.0586 | 0.9544 | 0.9674 |
| cytidine diphosphate | 1.0800 | 0.5930 | 1.0417 | NA |
| daidzein | 1.4436 | 1.4242 | 0.7078 | 0.4269 |
| dihomo-linoleate (20:2n6) | 0.7730 | 1.1547 | 0.8187 | 1.2060 |
| dihomo-linolenate (20:3n3 or n6) | 0.8684 | 1.0520 | 0.9526 | 1.1040 |
| dihydrobiopterin | 0.9991 | 1.1616 | 0.8071 | 1.0119 |
| docosadienoate (22:2n6) | 0.8165 | 1.1462 | 0.8426 | 1.1534 |
| docosahexaenoate (DHA; 22:6n3) | 0.8968 | 1.1687 | 0.7355 | 1.1651 |
| docosapentaenoate (n3 DPA; 22:5n3) | 0.8084 | 1.1037 | 0.8511 | 1.1999 |
| docosatrienoate (22:3n3) | 0.8391 | 1.1509 | 0.8118 | 1.1591 |
| dopamine sulfate (2) | 1.4443 | 0.8453 | 1.1222 | 0.8053 |
| eicosapentaenoate (EPA; 20:5n3) | 0.8367 | 1.1071 | 0.8836 | 1.1388 |
| eicosenoate (20:1) | 0.7427 | 1.1721 | 0.7691 | 1.2625 |
| equol sulfate | NA | NA | 1.2896 | 0.7104 |
| ergothioneine | 1.1945 | 0.7976 | 1.3546 | 0.7029 |
| erucate (22:1n9) | 0.8090 | 1.2344 | 0.7424 | 1.1610 |
| ferulic acid 4-sulfate | 1.2742 | 1.3417 | 0.8101 | 0.4397 |
| flavin adenine dinucleotide (FAD) | 1.0283 | 0.9371 | 1.1552 | 0.8909 |
| flavin mononucleotide (FMN) | 0.9510 | 1.2112 | 0.7971 | 1.0082 |
| glycerol | 0.9021 | 0.9743 | 0.9805 | 1.1341 |
| glycerol 3-phosphate | 1.0789 | 0.9912 | 0.9717 | 0.9692 |
| guanosine | 1.0763 | 0.6906 | 1.6466 | 0.6348 |
| guanosine 3^-monophosphate (3^-GMP) | 1.6614 | 0.4525 | 1.7797 | 0.2575 |
| heptanoate (7:0) | 0.7626 | 1.2594 | 0.6601 | 1.2558 |
| hexanoylglycine | 0.6477 | 1.0212 | 0.6798 | 1.6045 |
| hippurate | 0.9379 | 1.0535 | 1.0163 | 0.9779 |
| histidine | 1.0983 | 0.9945 | 0.9856 | 0.9346 |
| hypoxanthine | 1.1824 | 0.1406 | 2.6784 | 0.1288 |
| indole-3-carboxylic acid | 0.9908 | 0.9546 | 1.1411 | 0.9181 |
| indolelactate | 1.4000 | 1.2684 | 0.4550 | 0.8249 |
| inosine | 1.0855 | 0.6598 | 1.7485 | 0.5594 |
| isobutyrylglycine | 0.8296 | 0.8246 | 1.4269 | 0.9459 |
| isovalerylglycine | 0.8528 | 0.8731 | 1.3608 | 0.9107 |
| kynurenate | 1.2275 | 1.0462 | 0.8170 | 0.9320 |
| lactate | 0.9723 | 0.9679 | 1.0804 | 0.9799 |
| laurate (12:0) | 0.9558 | 1.0003 | 0.9534 | 1.0850 |
| linoleamide (18:2n6) | 1.0189 | 0.9629 | 0.9105 | 1.1147 |
| linoleate (18:2n6) | 0.7501 | 1.0525 | 0.8857 | 1.2738 |
| linolenate [alpha or gamma; (18:3n3 or 6)] | 0.6500 | 1.0238 | 0.9246 | 1.3548 |
| malate | 0.9749 | 0.9548 | 1.0514 | 1.0215 |
| margarate (17:0) | 0.7902 | 1.1530 | 0.8199 | 1.1916 |
| methionine sulfoxide | 0.9967 | 0.8147 | 1.4535 | 0.7579 |
| myristate (14:0) | 0.8429 | 1.0763 | 0.8888 | 1.1628 |
| myristoleate (14:1n5) | 0.9209 | 1.0506 | 0.8961 | 1.1161 |
| N2-methylguanosine | 1.0748 | 0.4245 | 1.5939 | 0.3769 |
| N6-carbamoylthreonyladenosine | 1.1103 | 0.9582 | 1.1294 | 0.8212 |
| N-acetylglycine | 0.9781 | 0.9390 | 0.9523 | 1.1531 |
| N-acetylisoleucine | 1.1067 | 0.9193 | 1.1218 | 0.8578 |
| N-acetylleucine | 1.0094 | 0.9030 | 1.2248 | 0.8760 |
| N-acetylmethionine | 1.0390 | 1.0391 | 0.9615 | 0.9604 |
| N-acetylmethionine sulfoxide | 0.9830 | 0.7251 | 1.4338 | 0.8903 |
| N-acetylphenylalanine | 1.0490 | 1.0159 | 0.9539 | 0.9852 |
| N-acetyltaurine | 1.1471 | 0.8679 | 1.2643 | 0.7556 |
| N-acetylthreonine | 1.1124 | 0.9628 | 1.0490 | 0.8945 |
| N-acetyltyrosine | 1.0218 | 1.0586 | 1.0337 | 0.8471 |
| N-acetylvaline | 1.1576 | 0.9471 | 1.0319 | 0.8898 |
| N-formylmethionine | 0.9603 | 0.9662 | 1.1010 | 0.9718 |
| N-formylphenylalanine | 1.0631 | 0.9222 | 1.1816 | 0.8507 |
| nicotinamide adenine dinucleotide (NAD+) | 1.0391 | 0.9191 | 1.1579 | 0.9039 |
| nicotinate | 0.3579 | 0.3985 | 3.2897 | 0.4038 |
| N-oleoyltaurine | 0.6965 | 1.2084 | 0.5614 | 1.4698 |
| nonadecanoate (19:0) | 0.8377 | 1.0734 | 0.9817 | 1.0778 |
| N-palmitoyltaurine | 1.1258 | 0.8200 | 1.2713 | 0.8211 |
| N-stearoyltaurine | 1.0066 | 0.9451 | 1.1961 | 0.8599 |
| oleamide | 1.0465 | 0.8820 | 1.0162 | 1.0758 |
| oleic ethanolamide | 0.8464 | 1.2807 | 0.8528 | 0.9658 |
| O-sulfo-L-tyrosine | 1.0953 | 0.8962 | 1.0963 | 0.9370 |
| oxalate (ethanedioate) | 1.0029 | 0.9576 | 1.1483 | 0.8968 |
| palmitate (16:0) | 0.8809 | 1.0492 | 0.9582 | 1.0907 |
| palmitoleate (16:1n7) | 0.7867 | 1.1267 | 0.8389 | 1.2052 |
| palmitoyl ethanolamide | 0.9604 | 1.1438 | 1.0335 | 0.8394 |
| p-cresol-glucuronide* | NA | 0.5983 | 0.2282 | 1.5907 |
| pelargonate (9:0) | 0.8496 | 1.0974 | 0.9314 | 1.0906 |
| pentadecanoate (15:0) | 0.8632 | 1.0561 | 0.9678 | 1.0887 |
| phenol sulfate | 1.7757 | 0.5925 | 1.0007 | 0.7790 |
| phenylalanylglycine | 1.1369 | 0.9690 | 1.0792 | 0.8360 |
| phenylpyruvate | 0.9219 | 0.9681 | 1.0914 | 1.0128 |
| phosphate | 0.9760 | 1.0091 | 1.0051 | 1.0056 |
| phosphoenolpyruvate (PEP) | 0.9457 | 1.0618 | 1.0071 | 0.9709 |
| prostaglandin E2 | 1.4454 | 0.7509 | 0.9719 | 0.9186 |
| prostaglandin F2alpha | 1.2376 | 0.8587 | 1.0701 | 0.8810 |
| pyridoxate | 0.5427 | 1.1644 | 0.9795 | 1.2357 |
| S-(3-hydroxypropyl)mercapturic acid (HPMA) | 1.0721 | 0.8966 | 1.0871 | 0.9589 |
| S-adenosylhomocysteine (SAH) | 0.9616 | 0.9993 | 1.0880 | 0.9464 |
| S-adenosylmethionine (SAM) | 1.0529 | 1.1274 | 0.9283 | 0.8820 |
| sedoheptulose-7-phosphate | 0.9615 | 0.9994 | 1.0346 | 0.9998 |
| stearate (18:0) | 0.9174 | 1.0736 | 0.9412 | 1.0483 |
| stearidonate (18:4n3) | 0.8356 | 1.0228 | 1.0151 | 1.1030 |
| sucrose | 0.7970 | 1.0248 | 0.4896 | 1.6815 |
| sulfate* | 0.8796 | 0.9090 | 1.1995 | 1.0082 |
| tartronate (hydroxymalonate) | 0.9049 | 1.0187 | 1.1793 | 0.8829 |
| taurine | 1.1502 | 0.9455 | 1.0893 | 0.8406 |
| tauro-beta-muricholate | 0.0924 | 3.3939 | 0.0809 | 0.0201 |
| taurochenodeoxycholate | 0.1215 | 1.7993 | 0.1231 | 0.0371 |
| taurocholate | 0.1144 | 3.2464 | 0.2006 | 0.0471 |
| taurodeoxycholate | NA | 1.7179 | 0.0755 | 0.0265 |
| tauroursodeoxycholate | 0.0436 | 1.8464 | 0.0636 | 0.0174 |
| thiamin diphosphate | 1.0512 | 1.0005 | 1.0843 | 0.8703 |
| thiamin monophosphate | 1.0068 | 1.1170 | 0.5535 | 1.3089 |
| thymine | 1.3092 | 0.9736 | 0.8183 | 0.9409 |
| uracil | 0.9941 | 0.9740 | 1.0263 | 1.0081 |
| urate | 1.0098 | 1.0195 | 1.0042 | 0.9653 |
| uridine | 1.1702 | 0.8236 | 1.2395 | 0.8100 |
| uridine 2^-monophosphate (2^-UMP)* | 1.7854 | 0.3761 | 1.8359 | 0.1788 |
| uridine 3^-monophosphate (3^-UMP) | 1.4906 | 0.6172 | 1.5030 | 0.4985 |
Factors:
| F1 | Treament:Antibiotics | Exposure:Air |
| F2 | Treament:Antibiotics | Exposure:Ozone |
| F3 | Treament:Water | Exposure:Air |
| F4 | Treament:Water | Exposure:Ozone |
