Data for K13 mutations driving artemisinin resistance rewrite Plasmodium falciparum’s programmed intra-erythrocytic development and transform mitochondrial physiology (Study ST001279)
(Analysis AN002120)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 2,3-Diphosphoglyceric acid | 1.0652 | 0.7004 | 1.0450 | 2.0256 |
| 2-dehydro-D-gluconate | 1.1848 | 0.8549 | 1.0078 | 0.8103 |
| 2-Hydroxy-2-methylbutanedioic acid | 1.0359 | 0.5669 | 1.1085 | 1.9817 |
| 2-oxo-4-methylthiobutanoate | 0.9539 | 0.6545 | 0.9761 | 2.0251 |
| 3-phosphoglycerate | 1.1573 | 0.7126 | 1.1302 | NA |
| 4-hydroxyphenyllactate | 0.9549 | 0.7287 | 0.9883 | 2.2015 |
| 4-phosphopantothenate | 0.8348 | 0.8361 | 1.0163 | 2.8763 |
| 4-Pyridoxic acid | 1.0036 | 0.6734 | 1.0207 | 3.2425 |
| 6-phospho-D-gluconate | 1.1137 | 0.7389 | 1.0882 | 1.1327 |
| acetyl-aspartate | 1.0581 | 0.6531 | 0.9949 | 2.0368 |
| Acetylcarnitine | 1.0473 | 0.7642 | 1.0281 | 1.8866 |
| acetyl-CoA | 0.9974 | 0.6098 | 1.0077 | 3.3057 |
| Acetyllysine | 0.7899 | 0.4698 | 1.7409 | 0.4641 |
| acetylphosphate | 1.0160 | 0.4918 | 1.0405 | 3.6538 |
| aconitate | 1.0272 | 0.5537 | 1.1254 | 1.9964 |
| ADP-D-glucose | 1.1289 | 0.6384 | 1.1267 | 1.5392 |
| a-ketoglutarate | 0.9449 | 0.7727 | 0.9094 | 2.4012 |
| arginine | 0.9044 | 1.0671 | 0.9900 | 1.1806 |
| asparagine | 0.9855 | 1.0326 | 0.9687 | 1.0657 |
| aspartate | 1.0459 | 0.8938 | 0.9391 | 1.2968 |
| biotin | 0.8874 | 0.8551 | 1.0959 | 2.2283 |
| CDP | 0.7797 | 1.3672 | 0.8532 | NA |
| Citraconic acid | 0.8990 | 0.6106 | 0.9235 | 3.1119 |
| citrate/isocitrate | 0.8837 | 0.8516 | 0.9764 | 3.2284 |
| cyclic-AMP | 0.9368 | 0.7524 | 1.0170 | 2.1751 |
| dGDP | 1.0074 | 0.6971 | 0.9959 | 2.7941 |
| dGTP | 1.0029 | 0.7237 | 1.0252 | 2.4613 |
| dihydroorotate | 1.1573 | 0.8483 | 1.2151 | 0.3215 |
| DLH | 0.5721 | 0.4602 | 1.7370 | 1.4275 |
| DL-Pipecolic Acid | 1.0194 | 0.9052 | 1.0954 | 0.7654 |
| DLS | 0.4603 | 0.3884 | 1.6052 | 2.9397 |
| D-sedoheptulose-1/7-phosphate | 0.9980 | 1.0190 | 1.1496 | 0.3835 |
| FAD | 0.9996 | 0.8561 | 1.0821 | 1.3842 |
| folate | 0.8623 | 0.9033 | 1.0019 | 1.8916 |
| fructose-1,6-bisphosphate | 1.1106 | 0.6047 | 1.1613 | 1.6537 |
| fumarate | 1.1485 | 0.6830 | 1.1684 | NA |
| GDP | 0.9830 | 0.8810 | 1.1360 | NA |
| glucosamine | 0.8894 | 0.4350 | 0.9636 | 4.8537 |
| glutamine | 0.9612 | 1.0701 | 0.9675 | 1.0326 |
| glutathione disulfide | 1.0610 | 0.6707 | 1.0793 | 1.6241 |
| glycodeoxycholic acid | 0.9132 | 0.8492 | 0.9698 | 2.7246 |
| Guanidoacetic acid | 0.9918 | 0.8038 | 1.0328 | 2.2622 |
| guanine | 0.9355 | 1.0211 | 0.8369 | 1.8348 |
| histidine | 0.9805 | 0.9855 | 1.0332 | 0.9973 |
| hydroxyproline | 0.9977 | 0.9299 | 0.9981 | 1.2695 |
| hypoxanthine | 0.9693 | 0.7886 | 0.9703 | 2.6312 |
| IDP | 0.9453 | 1.0043 | 0.9656 | 1.7252 |
| IMP | 1.0427 | 0.5703 | 1.0317 | 3.5913 |
| indole | 0.9258 | 0.8712 | 1.1115 | 1.6493 |
| Inositol | 1.0146 | 0.9177 | 0.9918 | 1.2703 |
| Kynurenic acid | 1.0559 | 0.7298 | 1.0331 | 1.6167 |
| lactate | 0.8819 | 1.2452 | 0.8892 | NA |
| LD | 0.8764 | 0.7785 | 1.1290 | 1.7759 |
| leucine/isoleucine | 0.9683 | 0.8485 | 0.9315 | 1.7954 |
| malate | 1.0876 | 0.5941 | 1.0607 | 2.7838 |
| methionine | 0.9607 | 0.8796 | 1.1047 | 1.1718 |
| N-acetyl-glutamate | 1.0857 | 0.7220 | 1.0418 | 2.0014 |
| N-acetyl-glutamine | 1.2347 | 0.9004 | 0.8608 | 0.9350 |
| N-acetyl-L-ornithine | 0.6973 | 0.5160 | 1.6981 | 1.1607 |
| NAD+ | 0.9267 | 0.9821 | 1.0912 | NA |
| NADP+ | 1.0542 | 0.7093 | 1.1063 | 1.8158 |
| N-carbamoyl-L-aspartate | 0.8717 | 0.7463 | 0.9784 | 2.5130 |
| Octoluse Bisphosphate | 1.0355 | 0.8879 | 1.0766 | NA |
| ornithine | 0.9897 | 0.9599 | 0.9265 | 1.3308 |
| orotate | 1.0187 | 1.0658 | 0.9155 | NA |
| pantothenate | 0.9294 | 0.7952 | 1.0441 | 2.6591 |
| PD | 0.7660 | 0.7037 | 1.3820 | 1.4744 |
| PE | 0.5981 | 0.8419 | 1.2219 | 2.2574 |
| PEE | 0.7215 | 0.4772 | 1.6110 | 1.5519 |
| phenylalanine | 1.0363 | 0.8867 | 1.1365 | 0.3816 |
| Phenyllactic acid | 0.9776 | 0.7169 | 1.0927 | 2.2067 |
| phenylpyruvate | 1.0424 | 0.6957 | 1.0365 | 1.7801 |
| phosphoenolpyruvate | 1.1242 | 0.5785 | 1.0827 | 2.4021 |
| proline | 0.9888 | 0.8952 | 1.0409 | 1.2581 |
| PVNF | 0.5814 | 0.3044 | 1.8037 | 1.1561 |
| pyridoxine | 1.0252 | 0.8565 | 0.9557 | 1.6505 |
| Pyroglutamic acid | 0.9808 | 0.9448 | 1.1053 | 0.6826 |
| Pyrophosphate | 0.9837 | 0.8297 | 1.0284 | 2.0106 |
| pyruvate | 0.9825 | 0.9663 | 1.0129 | 1.2915 |
| riboflavin | 0.8807 | 0.9050 | 1.2143 | NA |
| SD | 0.6413 | 0.6181 | 1.4935 | 1.8352 |
| Sedoheptoluse bisphosphate | 1.0667 | 0.5672 | 1.1502 | 2.4026 |
| serine | 1.0299 | 0.9501 | 0.9976 | 1.0696 |
| taurine | 1.1030 | 0.9761 | 1.0135 | 0.4406 |
| threonine | 1.0310 | 0.9268 | 1.0220 | 1.0516 |
| tryptophan | 0.9546 | 0.8189 | 1.2865 | 0.6874 |
| tyrosine | 0.9316 | 0.7612 | 1.1556 | 1.5109 |
| UDP | 0.7623 | 1.5750 | 0.7875 | 0.5148 |
| UDP-D-glucose | 0.9780 | 0.8941 | 1.0062 | 1.4447 |
| UDP-D-glucuronate | 1.0214 | 0.4511 | 1.1096 | 4.0024 |
| UDP-N-acetyl-glucosamine | 0.9673 | 0.8939 | 0.9918 | 1.5458 |
| uridine | 0.8807 | 1.1950 | 1.0247 | 0.5986 |
| valine | 0.9806 | 0.8744 | 1.0817 | 1.2031 |
| xanthine | 0.7356 | 1.0870 | 1.0683 | 1.3401 |
| xanthosine-5-phosphate | 0.9884 | 0.9181 | 1.0678 | 1.1269 |
| xylose/ribose | 1.0034 | 0.6920 | 1.0265 | 1.9891 |
Factors:
| F1 | Treatment:350nM DHA |
| F2 | Treatment:70nM DHA |
| F3 | Treatment:DMSO |
| F4 | Treatment:None |
