Data for Metabolomic and Transcriptomic Signatures of Prenatal Excessive Methionine in Mice (Study ST001413)
(Analysis AN002363)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1_15N2-L-Arginine iSTD | 0.9603 | NA | 1.0397 | NA |
| 15N2-L-Arginine iSTD | NA | 0.9863 | NA | 1.0137 |
| 1_CUDA iSTD | 1.0001 | NA | 0.9999 | NA |
| 1_D3-1-Methylnicotinamide iSTD | 1.0072 | NA | 0.9928 | NA |
| 1_D3-AC(2:0) iSTD | 0.9725 | NA | 1.0275 | NA |
| 1_D3-Creatine iSTD | 0.9748 | NA | 1.0252 | NA |
| 1_D3-Creatinine iSTD | 0.9901 | NA | 1.0099 | NA |
| 1_D3-DL-Alanine iSTD | 0.9179 | NA | 1.0821 | NA |
| 1_D3-DL-Aspartic acid iSTD | 0.9852 | NA | 1.0148 | NA |
| 1_D3-DL-Glutamic acid iSTD | 0.9661 | NA | 1.0339 | NA |
| 1_D3-Histamine, N-methyl- iSTD | 0.9888 | NA | 1.0112 | NA |
| 1_D3-L-Carnitine iSTD | 0.9865 | NA | 1.0135 | NA |
| 1_D5-L-Glutamine iSTD | 0.9627 | NA | 1.0373 | NA |
| 1_D9-Betaine iSTD | 0.9715 | NA | 1.0285 | NA |
| 1_D9-Butyrobetaine iSTD | 0.9962 | NA | 1.0038 | NA |
| 1_D9-Caffeine iSTD | 0.9820 | NA | 1.0180 | NA |
| 1_D9-Choline iSTD | 0.9974 | NA | 1.0026 | NA |
| 1_D9-Crotonobetaine iSTD | 0.9792 | NA | 1.0208 | NA |
| 1_D9-TMAO iSTD | 1.0004 | NA | 0.9996 | NA |
| 1-Methyladenosine A | NA | 0.9563 | NA | 1.0437 |
| 1-Methyladenosine B | 1.1071 | NA | 0.8929 | NA |
| 1-Methylguanosine | NA | 0.9289 | NA | 1.0711 |
| 1-Methylhistamine | NA | 0.6878 | NA | 1.3122 |
| 1-Methylnicotinamide | NA | 0.9659 | NA | 1.0341 |
| 1_Val-Tyr-Val iSTD | 0.9880 | NA | 1.0120 | NA |
| 2^-Deoxycytidine | NA | 0.9231 | NA | 1.0769 |
| 2^-Fucosyllactose | NA | 0.6122 | NA | 1.3878 |
| 2-Methylbutyryl-L-carnitine | NA | 1.0831 | NA | 0.9169 |
| 2-Propanamidoacetic acid | NA | 1.0196 | NA | 0.9804 |
| (2R)-3-Hydroxyisovaleroylcarnitine | 0.6648 | 0.9097 | 0.6796 | 1.5819 |
| 3.alpha.-Galactobiose | NA | 1.9892 | NA | 0.0108 |
| 3-Aminoisobutyric acid | NA | 0.8741 | NA | 1.1259 |
| 3-Hydroxybutyrylcarnitine | 0.8337 | 1.1632 | 0.7206 | 1.1711 |
| 3-Methoxytyramine | 0.9100 | NA | 1.0900 | NA |
| 3-Methylcrotonylglycine | 0.9561 | NA | 1.0439 | NA |
| 4-Acetamidobutyric acid | NA | 1.0046 | NA | 0.9954 |
| 4-Aminomethylcyclohexanecarboxylic acid | 1.1219 | NA | 0.8781 | NA |
| 4-Guanidinobutyric acid | 0.4273 | 1.5658 | 0.4392 | 1.2843 |
| 5-Cholesten-3-beta-7-alpha-diol | NA | 1.1468 | NA | 0.8532 |
| 5^-Methylthioadenosine | NA | 2.0440 | NA | 0.0865 |
| 5^-S-Methyl-5^-thioadenosine | NA | 0.9790 | NA | 1.0210 |
| 7-Methylguanine | NA | 0.8822 | NA | 1.1178 |
| Acetylcarnitine | 2.0159 | 0.2635 | 1.9442 | 0.2665 |
| Acetylcholine cation | 1.1860 | NA | 0.8140 | NA |
| Adenine | 1.3961 | 0.6234 | 1.3703 | 0.8018 |
| Adenosine | 2.2518 | 0.0522 | 2.2576 | 0.0657 |
| Adenosine-3-monophosphate | NA | 0.9836 | NA | 1.0164 |
| Adenosine 5^-monophosphate | NA | 1.0086 | NA | 0.9914 |
| Adenosine monophosphate | 1.3838 | NA | 0.6162 | NA |
| Aspartic acid | NA | 0.8942 | NA | 1.1058 |
| Benzyldimethylstearylammonium cation | NA | 1.4363 | NA | 0.5637 |
| Benzyldimethyltetradecylammonium cation | NA | 1.9425 | NA | 0.0575 |
| Betaine | NA | 0.7771 | NA | 1.2229 |
| Betaine aldehyde cation | 1.1335 | 0.6472 | 1.2886 | 1.0362 |
| .beta.-Nicotinamide adenine dinucleotide | NA | 0.9717 | NA | 1.0283 |
| Biliverdin | NA | 0.8427 | NA | 1.1573 |
| Carnitine | 0.6089 | 1.2695 | 0.6150 | 1.3126 |
| Carnosine | NA | 0.9238 | NA | 1.0762 |
| Choline cation | 0.7039 | 1.1315 | 0.7099 | 1.3083 |
| Citrulline | NA | 0.7980 | NA | 1.2020 |
| Creatine | 0.0701 | 1.5953 | 0.0618 | 1.8058 |
| Creatinine | NA | 1.1756 | NA | 0.8244 |
| CUDA iSTD | NA | 0.9762 | NA | 1.0238 |
| Cystathionine | NA | 0.8548 | NA | 1.1452 |
| Cytidine | NA | 0.8964 | NA | 1.1036 |
| Cytidine 5^-diphosphocholine | NA | 0.7758 | NA | 1.2242 |
| Cytidine 5^-monophosphate | NA | 0.9074 | NA | 1.0926 |
| D3-1-Methylnicotinamide iSTD | NA | 0.9788 | NA | 1.0212 |
| D3-AC(2:0) iSTD | NA | 1.0104 | NA | 0.9896 |
| D3-Creatine iSTD | NA | 1.0243 | NA | 0.9757 |
| D3-Creatinine iSTD | NA | 0.9447 | NA | 1.0553 |
| D3-DL-Alanine iSTD | NA | 0.9954 | NA | 1.0046 |
| D3-DL-Aspartic acid iSTD | NA | 1.0302 | NA | 0.9698 |
| D3-DL-Glutamic acid iSTD | NA | 0.9846 | NA | 1.0154 |
| D3-Histamine, N-methyl- iSTD | NA | 1.0577 | NA | 0.9423 |
| D3-L-Carnitine iSTD | NA | 0.9923 | NA | 1.0077 |
| D5-L-Glutamine iSTD | NA | 0.9805 | NA | 1.0195 |
| D9-Betaine iSTD | NA | 1.0372 | NA | 0.9628 |
| D9-Butyrobetaine iSTD | NA | 0.9924 | NA | 1.0076 |
| D9-Choline Istd | NA | 0.9758 | NA | 1.0242 |
| D9-Crotonobetaine iSTD | NA | 0.9989 | NA | 1.0011 |
| D9-TMAO iSTD | NA | 0.9809 | NA | 1.0191 |
| DL-Norepinephrine | 0.6480 | NA | 1.3520 | NA |
| Dopamine | 1.1636 | NA | 0.8364 | NA |
| (-)-Epinephrine | 0.4685 | NA | 1.5315 | NA |
| Ergothioneine | 0.7142 | 0.8614 | 0.6167 | 1.6404 |
| Erythromycin | 0.1613 | NA | 1.8387 | NA |
| Erythromycin A enol ether | 0.2158 | NA | 1.7842 | NA |
| Ethylenediaminetetraacetic acid | NA | 0.8425 | NA | 1.1575 |
| gamma-Aminobutyric Acid (GABA) | 1.0074 | NA | 0.9926 | NA |
| gamma.-Glutamyl-L-glutamic acid | NA | 0.7974 | NA | 1.2026 |
| Glutamic acid | NA | 0.9474 | NA | 1.0526 |
| Glutamine | NA | 0.9099 | NA | 1.0901 |
| Glutathione (reduced) | 1.1677 | NA | 0.8323 | NA |
| Guanine | 0.7304 | 1.1699 | 0.4668 | 1.4321 |
| Guanosine | 0.9883 | 0.8723 | 1.1540 | 1.0209 |
| Guanosine 5^-tetraphosphate | NA | 0.8627 | NA | 1.1373 |
| H-gamma-glutamyl-glutamine | NA | 0.6967 | NA | 1.3033 |
| Histamine | 0.5525 | NA | 1.4475 | NA |
| Homocysteine | 0.7826 | NA | 1.2174 | NA |
| Hypoxanthine | 1.6793 | 0.8033 | 1.8916 | 0.0186 |
| Indole-3-lactic acid | NA | 1.0484 | NA | 0.9516 |
| Inosine | 0.9707 | 0.9656 | 1.0471 | 1.0211 |
| Isoleucine | NA | 0.7756 | NA | 1.2244 |
| Isovaleryl-L-carnitine | 0.9108 | NA | 1.0892 | NA |
| Kynurenine | NA | 1.7150 | NA | 0.2850 |
| L-Arachidonoylcarnitine | 1.0472 | NA | 0.9528 | NA |
| Malonyl-carnitine | NA | 0.1181 | NA | 1.8819 |
| Maltotetraose | NA | 0.9614 | NA | 1.0386 |
| Melibiose | NA | 0.8777 | NA | 1.1223 |
| Methacholine cation | NA | 0.8842 | NA | 1.1158 |
| Methionine | NA | 0.7599 | NA | 1.2401 |
| Methioninesulfoxide | NA | 1.0569 | NA | 0.9431 |
| Methylglycinate | NA | 1.1224 | NA | 0.8776 |
| Myristoyl-L-carnitine | 1.0945 | NA | 0.9055 | NA |
| N-(15Z-Tetracosenoyl)-1-.beta.-galactosylsphing-4-enine | 0.9791 | NA | 1.0209 | NA |
| N8-Acetylspermidine | NA | 0.9154 | NA | 1.0846 |
| N-Acetylalanine | NA | 0.9744 | NA | 1.0256 |
| N-Acetylaspartylglutamic acid | NA | 0.8626 | NA | 1.1374 |
| N-Acetyl-Asp-Glu | NA | 0.8819 | NA | 1.1181 |
| N-Acetyl-D-lactosamine | 1.1143 | NA | 0.8857 | NA |
| N-Acetylhistidine | 1.1594 | NA | 0.8406 | NA |
| N-Acetyl-L-aspartic acid | 1.0979 | NA | 0.9021 | NA |
| N-alpha-methylhistamine | 0.4377 | NA | 1.5623 | NA |
| N-Demethylerythromycin | 0.2504 | NA | 1.7496 | NA |
| Nicotinamide | 1.0808 | 0.9165 | 1.0920 | 0.9539 |
| N,N,N trimethyllysine | NA | 0.7750 | NA | 1.2250 |
| Norleucine | NA | 0.8142 | NA | 1.1858 |
| Nudifloramide | NA | 0.9929 | NA | 1.0071 |
| Oleoyl-L-carnitine | 1.0650 | NA | 0.9350 | NA |
| Palmitamide | NA | 1.9872 | NA | 0.0128 |
| Palmitoylcarnitine | 2.3474 | 0.1020 | 2.1250 | 0.0437 |
| Pantothenic acid | 0.5142 | 1.1320 | 0.7549 | 1.4161 |
| Phenylacetylglutamine | NA | 1.8555 | NA | 0.1445 |
| Phenylacetyl-L-glutamine | NA | 1.8747 | NA | 0.1253 |
| Phenylalanine | NA | 0.8017 | NA | 1.1983 |
| Pro-Gln | NA | 0.6689 | NA | 1.3311 |
| Proline | NA | 0.8225 | NA | 1.1775 |
| Propionylcarnitine | 0.8998 | 0.9600 | 1.1908 | 0.9721 |
| Pyrrole-2-carboxylic acid | NA | 0.9278 | NA | 1.0722 |
| S-(5^-Adenosyl)-L-homocysteine | 1.2544 | 0.1561 | 2.9671 | 0.1778 |
| S-Adenosyl-L-methionine | 2.0685 | 0.2759 | 1.7242 | 0.3796 |
| SDMA | NA | 0.8671 | NA | 1.1329 |
| Serine | NA | 0.8080 | NA | 1.1920 |
| Serotonin | 1.2337 | NA | 0.7663 | NA |
| Stachydrine | NA | 1.2628 | NA | 0.7372 |
| Stearoyl-L-carnitine | 0.9980 | NA | 1.0020 | NA |
| Succinic acid | NA | 0.8672 | NA | 1.1328 |
| Sucrose | NA | 1.5779 | NA | 0.4221 |
| Taurine | 0.6583 | 1.1720 | 0.6050 | 1.3805 |
| Thionin | NA | 0.9742 | NA | 1.0258 |
| Threonine | NA | 0.8410 | NA | 1.1590 |
| TMAO | 0.7035 | NA | 1.2965 | NA |
| Tributylamine | 0.9699 | NA | 1.0301 | NA |
| Trigonelline | NA | 1.3315 | NA | 0.6685 |
| Tryptophan | NA | 1.0442 | NA | 0.9558 |
| Turanose | NA | 1.9051 | NA | 0.0949 |
| Tyrosine | NA | 1.2695 | NA | 0.7305 |
| Urea | 1.0737 | NA | 0.9263 | NA |
| Uridine | NA | 0.8966 | NA | 1.1034 |
| Uridine-5-diphosphoacetylglucosamine | NA | 0.8723 | NA | 1.1277 |
| Uridine 5^-monophosphate | NA | 0.8960 | NA | 1.1040 |
| Urocanic acid | NA | 0.9154 | NA | 1.0846 |
| Valine | 0.7816 | NA | 1.2184 | NA |
| Val-Tyr-Val iSTD | NA | 0.9929 | NA | 1.0071 |
Factors:
| F1 | Condition:Control | Age:13 weeks |
| F2 | Condition:Control | Age:24 hour |
| F3 | Condition:Methionine | Age:13 weeks |
| F4 | Condition:Methionine | Age:24 hour |
