Data for A Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans (Study ST001515)
(Analysis AN002514)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-methylurate | 1.0999 | 1.0111 | 0.8688 | 0.6979 | 0.8563 | 1.3110 | 0.9855 | 0.5772 | 0.5775 | 0.6540 | 0.6342 | 2.1675 | 1.1776 | 0.9456 | 0.7723 | 0.8769 | 0.8556 | 1.9809 |
1-stearoyl-2-arachidonoyl-GPS (18:0/20:4) | 1.0515 | 1.1272 | 0.9779 | 1.3038 | 0.8664 | 1.0789 | 1.1133 | 1.0282 | 1.1087 | 1.1688 | 0.7386 | 0.9979 | 1.0217 | 0.7543 | 1.0562 | 0.8180 | 0.7544 | 0.9225 |
1-stearoyl-2-oleoyl-GPG (18:0/18:1) | 1.1618 | 0.9309 | 1.0746 | 0.8267 | 1.0857 | 1.1421 | 0.8760 | 0.9357 | 1.0732 | 0.7951 | 1.0034 | 0.8972 | 1.0941 | 0.8514 | 0.9876 | 1.0250 | 1.1431 | 1.1293 |
2,2^-Methylenebis(6-tert-butyl-p-cresol) | 0.7185 | 0.9371 | 0.8712 | 0.8692 | 0.8022 | 1.0330 | 0.9563 | 0.9790 | 0.8181 | 0.8834 | 1.0472 | 1.2848 | 0.8292 | 1.4803 | 0.9938 | 1.1403 | 1.0600 | 1.4111 |
2,3-dihydroxyisovalerate | 0.9354 | 1.4172 | 0.6096 | 0.4209 | 0.3477 | 1.0622 | 1.0463 | 1.4534 | 0.6329 | 0.5213 | 0.4766 | 1.2905 | 1.1425 | 2.9592 | 1.1327 | 0.6878 | 1.0038 | 1.3248 |
2,4-dihydroxybutyrate | 1.1099 | 0.8998 | 0.7721 | 0.9256 | 0.8062 | 1.0313 | 1.0433 | 0.9817 | 0.8432 | 0.9553 | 0.8303 | 1.0503 | 1.0459 | 1.2739 | 1.2149 | 0.9756 | 1.2306 | 1.1177 |
2-aminoadipate | 1.1940 | 0.6756 | 0.5943 | 0.8859 | 0.6120 | 1.0227 | 1.1088 | 0.9052 | 0.8785 | 1.0965 | 0.9279 | 1.1894 | 1.1932 | 1.2575 | 1.0708 | 0.9164 | 1.2007 | 1.3264 |
2^-deoxyuridine | 0.6937 | 0.6878 | 0.9294 | 1.1566 | 0.8931 | 0.8848 | 0.7597 | 0.9355 | 1.0691 | 1.3819 | 0.8864 | 1.0312 | 1.0347 | 1.1838 | 0.9481 | 1.5311 | 1.0770 | 0.9675 |
2-hydroxybutyrate/2-hydroxyisobutyrate | 0.8039 | 1.2497 | 1.2386 | 1.0081 | 1.2682 | 0.7206 | 0.8297 | 1.0705 | 1.2952 | 1.0655 | 1.1388 | 0.7984 | 0.9028 | 0.8012 | 0.8476 | 1.2171 | 0.8767 | 0.8298 |
2-hydroxyglutarate | 1.0051 | 1.0733 | 0.7332 | 1.0312 | 1.2031 | 0.8542 | 1.2204 | 1.3786 | 1.4495 | 1.0219 | 1.4860 | 0.6626 | 0.8066 | 0.8017 | 0.8555 | 0.4849 | 0.8735 | 0.8343 |
2-hydroxyheptanoate* | 0.8805 | 0.8532 | 0.6908 | 0.7052 | 0.9450 | 1.0811 | 0.9516 | 0.9622 | 0.7495 | 0.8484 | 0.9075 | 1.3177 | 0.9785 | 1.2842 | 1.0173 | 1.4936 | 1.1692 | 1.2795 |
2-hydroxyhippurate (salicylurate) | 1.6054 | 1.3799 | 1.1342 | 0.4764 | 0.8122 | 1.0781 | 0.9206 | 1.0173 | 0.7221 | 0.2523 | 0.5425 | 0.7952 | 2.3720 | 1.5358 | 1.0343 | 0.6931 | 0.9219 | 1.0432 |
2-keto-3-deoxy-gluconate | 0.9852 | 0.8386 | 0.7207 | 0.8181 | 0.8250 | 0.9786 | 1.3527 | 0.8939 | 0.8612 | 1.1247 | 0.7925 | 0.9923 | 1.0915 | 1.1354 | 0.9564 | 1.5264 | 1.0727 | 1.0507 |
2-ketocaprylate | 0.9971 | 1.2905 | 0.7750 | 0.7360 | 0.8467 | 1.1571 | 0.8008 | 1.0941 | 0.6667 | 0.6740 | 0.7744 | 0.9282 | 1.0930 | 1.8321 | 1.0842 | 1.0193 | 1.0982 | 1.4347 |
2R,3R-dihydroxybutyrate | 1.5997 | 0.3864 | 0.2921 | 1.3466 | 0.3308 | 1.3839 | 1.4379 | 0.4321 | 0.3476 | 1.0351 | 0.4461 | 1.2296 | 1.3909 | 1.3700 | 1.5384 | 0.9936 | 1.3422 | 1.2719 |
2S,3R-dihydroxybutyrate | 1.0473 | 0.9885 | 1.0345 | 0.9856 | 1.2611 | 0.8133 | 0.9700 | 0.8876 | 0.9964 | 0.9887 | 1.0488 | 0.8271 | 1.0334 | 1.0793 | 0.9999 | 1.1829 | 0.9958 | 0.9381 |
3,4-dihydroxybutyrate | 0.9591 | 0.9049 | 0.9830 | 0.8170 | 0.9120 | 0.9623 | 0.9824 | 0.9037 | 0.9776 | 0.9103 | 0.9878 | 0.9881 | 1.0072 | 1.2732 | 1.1246 | 1.0541 | 1.2490 | 1.1293 |
3,5-dichloro-2,6-dihydroxybenzoic acid | 1.0016 | 0.9924 | 0.9302 | 0.9978 | 0.9655 | 0.9588 | 1.1224 | 1.0978 | 1.1304 | 1.1287 | 1.1635 | 1.1235 | 0.8828 | 0.8362 | 0.9229 | 0.8907 | 0.8700 | 0.8501 |
3-hydroxy-3-methylglutarate | 1.0384 | 1.0274 | 1.0175 | 0.9795 | 0.8866 | 0.9111 | 1.0945 | 1.0226 | 1.0170 | 1.0858 | 0.9238 | 0.9991 | 1.0152 | 0.9444 | 0.9516 | 1.0366 | 1.0191 | 0.9990 |
3-hydroxybutyrate (BHBA) | 0.3250 | 2.8956 | 1.9315 | 0.0756 | 2.3579 | 0.2161 | 0.5557 | 1.6754 | 1.9263 | 0.2489 | 1.9617 | 0.3773 | 0.4934 | 0.2718 | 0.2121 | 1.5061 | 0.4104 | 0.4080 |
3-hydroxyhippurate | 1.0535 | 1.0442 | 0.7960 | 0.4624 | 0.7040 | 1.8766 | 0.6411 | 1.0337 | 0.6491 | 0.4540 | 0.5513 | 1.5477 | 1.0614 | 1.4392 | 1.1922 | 0.6856 | 1.5915 | 1.4343 |
3-hydroxyisobutyrate | 1.0420 | 1.2848 | 1.5207 | 0.5400 | 1.6513 | 0.8821 | 0.9146 | 0.9689 | 1.0605 | 0.5457 | 1.6232 | 0.7548 | 0.8462 | 0.9422 | 0.8960 | 0.8147 | 0.9080 | 0.8652 |
3-hydroxysebacate | 0.7078 | 1.8771 | 1.1465 | 0.2881 | 1.0782 | 0.5684 | 0.9579 | 1.3572 | 1.7231 | 0.4036 | 1.6764 | 0.8558 | 0.7610 | 0.6700 | 0.4272 | 1.9192 | 0.7266 | 0.7181 |
3-methylglutaconate | 0.9029 | 0.9747 | 0.9276 | 0.8203 | 0.9546 | 0.8686 | 1.0013 | 1.0160 | 1.0350 | 0.9004 | 0.9590 | 0.9551 | 1.1738 | 1.0630 | 1.1370 | 1.1276 | 1.1566 | 1.0954 |
4-hydroxy-2-oxoglutaric acid | 1.0728 | 0.7146 | 0.8540 | 1.0996 | 0.8973 | 1.2900 | 1.1439 | 0.6028 | 0.8209 | 0.7870 | 0.9619 | 1.0723 | 1.1575 | 1.1384 | 1.2135 | 0.8955 | 1.2462 | 1.1284 |
5-acetylamino-6-amino-3-methyluracil | 0.8599 | 0.5827 | 0.5852 | 0.5530 | 0.6482 | 1.6908 | 0.4561 | 0.1684 | 0.1312 | 0.3503 | 0.1312 | 3.2316 | 1.3074 | 0.4813 | 0.1721 | 1.0313 | 0.1312 | 5.5676 |
5-acetylamino-6-formylamino-3-methyluracil | 1.2227 | 0.7670 | 0.7352 | 0.8883 | 0.8020 | 2.9027 | 0.3123 | 0.1980 | 0.1980 | 0.3134 | 0.1980 | 2.7169 | 0.8299 | 0.4283 | 0.1980 | 0.7416 | 0.1980 | 4.3313 |
allantoin | 1.0784 | 0.9549 | 0.9149 | 0.9490 | 0.8452 | 1.0464 | 1.0748 | 0.9147 | 0.9490 | 0.9495 | 0.8660 | 1.0180 | 1.0685 | 1.0650 | 1.1085 | 1.0648 | 1.0982 | 1.0821 |
alpha-hydroxyisovalerate | 1.0296 | 1.0449 | 1.0312 | 0.9403 | 0.9538 | 0.9088 | 0.9646 | 0.9623 | 1.0399 | 0.9543 | 1.0236 | 1.0033 | 1.0494 | 0.9383 | 1.1365 | 1.0450 | 1.0135 | 0.9897 |
alpha-ketobutyrate | 0.7732 | 1.3705 | 1.3365 | 1.0187 | 1.3092 | 0.7068 | 0.8565 | 1.0288 | 1.2537 | 1.2752 | 1.1415 | 0.8210 | 0.8072 | 0.7939 | 0.7293 | 1.1697 | 0.8056 | 0.7355 |
alpha-ketoglutaramate* | 1.1689 | 0.8410 | 0.8250 | 0.9202 | 0.7763 | 1.1290 | 1.0856 | 0.7722 | 0.8107 | 0.8844 | 0.7939 | 1.1431 | 1.1666 | 1.1570 | 1.1539 | 1.1039 | 1.1842 | 1.1912 |
alpha-ketoglutarate | 1.0328 | 0.8861 | 0.8783 | 0.8565 | 0.9074 | 1.0095 | 1.0934 | 0.9134 | 1.0090 | 0.9275 | 0.9546 | 1.0872 | 1.1360 | 1.0402 | 0.9783 | 1.1280 | 1.0236 | 1.1581 |
arabinose | 0.9156 | 0.5986 | 0.8896 | 1.1590 | 1.3067 | 1.2233 | 1.0619 | 0.9207 | 0.8247 | 1.2355 | 0.8731 | 0.9394 | 1.1951 | 0.9596 | 1.3293 | 1.1546 | 0.6019 | 0.8142 |
arabitol/xylitol | 1.0220 | 0.8860 | 0.7657 | 0.9490 | 0.7488 | 1.0068 | 1.1026 | 0.9559 | 0.8784 | 0.9956 | 0.8822 | 1.1398 | 1.0916 | 1.2043 | 1.1517 | 1.0302 | 1.1208 | 1.1278 |
arabonate/xylonate | 0.9507 | 0.8599 | 0.6531 | 0.6515 | 0.6247 | 0.9704 | 1.2033 | 1.0216 | 0.8919 | 0.8222 | 0.9117 | 1.2802 | 1.1409 | 1.4641 | 1.1801 | 0.9163 | 1.2897 | 1.2808 |
ascorbic acid 2-sulfate | 1.0592 | 0.8660 | 0.9489 | 1.0271 | 0.9234 | 0.9958 | 0.9070 | 0.8056 | 0.8373 | 0.8738 | 0.8096 | 0.9342 | 1.1628 | 1.2113 | 1.1881 | 1.2023 | 1.2837 | 1.1348 |
ascorbic acid 3-sulfate* | 0.8368 | 1.1447 | 1.0879 | 1.3726 | 1.1554 | 0.9300 | 0.5860 | 0.7187 | 0.7035 | 0.6663 | 0.7308 | 0.6061 | 1.2379 | 1.5152 | 1.3126 | 1.2062 | 1.3684 | 1.1935 |
azelate (nonanedioate; C9) | 1.1913 | 1.1937 | 0.8593 | 0.6431 | 0.8482 | 1.0261 | 0.8008 | 0.9226 | 0.8373 | 0.6514 | 1.1346 | 0.9932 | 0.9259 | 1.1908 | 1.0121 | 1.9151 | 0.9791 | 1.0416 |
caffeic acid sulfate | 0.6615 | 1.9556 | 1.3527 | 0.1935 | 0.6568 | 0.4849 | 1.4003 | 1.6078 | 1.1936 | 0.2834 | 0.6829 | 0.8326 | 0.6629 | 3.5315 | 1.0196 | 0.2697 | 0.6388 | 1.1115 |
chiro-inositol | 0.4218 | 0.1377 | 0.4049 | 0.1835 | 2.3182 | 0.6756 | 0.5124 | 0.1377 | 0.5470 | 0.1893 | 3.3237 | 0.7985 | 0.7518 | 0.1711 | 0.5583 | 0.3703 | 5.5703 | 1.0161 |
decadienedioic acid (C10:2-DC) | 0.9841 | 0.7593 | 0.9490 | 0.3828 | 1.1434 | 0.7512 | 1.1463 | 0.8152 | 1.4694 | 0.7070 | 1.7760 | 0.9446 | 1.0999 | 0.8700 | 0.7863 | 1.3355 | 1.0326 | 1.0047 |
dihydrocaffeate sulfate (2) | 1.0030 | 0.8324 | 0.7041 | 0.1292 | 0.7310 | 1.3358 | 1.1666 | 1.2843 | 1.0106 | 0.4855 | 1.0249 | 2.2108 | 0.8804 | 1.5371 | 0.8142 | 0.1922 | 1.2807 | 1.3563 |
dihydroorotate | 0.9164 | 0.6955 | 0.5283 | 0.5623 | 0.6891 | 0.9065 | 1.1196 | 0.9778 | 0.7631 | 1.0629 | 1.1380 | 1.1529 | 1.3414 | 1.4210 | 1.2408 | 1.1968 | 1.2197 | 1.1981 |
erythritol | 0.9534 | 0.7213 | 0.6198 | 0.9683 | 0.6560 | 1.2456 | 1.2119 | 0.8773 | 0.7332 | 1.0941 | 0.8676 | 1.3678 | 1.0503 | 1.2571 | 1.0954 | 0.9853 | 1.1782 | 1.1329 |
erythronate* | 1.0359 | 0.8856 | 0.8370 | 0.9727 | 0.8481 | 1.0095 | 1.0810 | 0.8908 | 0.9046 | 1.0006 | 0.8941 | 1.0717 | 1.1059 | 1.1415 | 1.1212 | 1.0544 | 1.1239 | 1.0824 |
ethylmalonate | 1.3474 | 0.8818 | 0.8385 | 1.0356 | 0.9545 | 1.1199 | 1.1907 | 0.8046 | 0.9649 | 0.9971 | 0.9603 | 1.2020 | 0.9870 | 0.9806 | 0.9099 | 0.9386 | 0.8759 | 0.9710 |
fructose | 0.7309 | 1.2442 | 1.1314 | 1.2608 | 1.0917 | 0.6971 | 0.9685 | 1.3758 | 1.2662 | 1.0857 | 1.2532 | 0.9785 | 0.7521 | 0.7990 | 0.7642 | 0.6862 | 0.9226 | 0.8052 |
fumarate | 1.0838 | 0.9199 | 0.9977 | 0.9335 | 1.0613 | 0.9480 | 1.0008 | 0.8513 | 0.9414 | 0.8432 | 0.9321 | 0.9433 | 1.1758 | 1.1021 | 1.1042 | 1.1280 | 1.0525 | 1.0873 |
galactonate | 0.4844 | 0.5287 | 0.4086 | 0.3794 | 0.5862 | 1.1808 | 1.3549 | 0.3474 | 0.4484 | 0.5163 | 1.6784 | 1.2678 | 1.2611 | 1.3718 | 0.9181 | 1.3233 | 2.7716 | 1.3514 |
gentisate | 1.2399 | 1.2300 | 1.0945 | 0.9922 | 0.4732 | 1.3060 | 0.8914 | 1.0976 | 1.0102 | 0.6601 | 0.6003 | 1.1669 | 0.9047 | 1.6817 | 1.1064 | 0.6748 | 0.9502 | 1.0954 |
gluconate | 0.9395 | 0.8848 | 0.8889 | 1.1598 | 0.8386 | 0.9770 | 1.0216 | 1.0148 | 1.0161 | 1.1229 | 0.9126 | 1.0695 | 0.9993 | 1.0449 | 1.0256 | 0.9065 | 1.0866 | 1.0695 |
glucose | 0.9143 | 1.0545 | 1.1177 | 1.1706 | 1.0778 | 0.9270 | 0.9170 | 1.0418 | 1.0641 | 1.1508 | 1.0174 | 0.9214 | 0.9444 | 0.9662 | 0.9430 | 0.8446 | 0.9534 | 0.9446 |
glucuronate | 0.9721 | 0.9904 | 0.7455 | 1.1545 | 0.7373 | 0.8826 | 1.0201 | 0.9633 | 0.8117 | 1.0501 | 0.7858 | 0.9403 | 1.3456 | 1.1763 | 1.1294 | 1.1211 | 1.0951 | 1.1680 |
glutarate (C5-DC) | 0.8133 | 0.8198 | 0.7925 | 0.6472 | 0.8043 | 0.7346 | 1.0968 | 0.7692 | 0.8797 | 0.6524 | 1.1053 | 0.9587 | 1.4512 | 1.3202 | 1.4553 | 1.2804 | 1.4286 | 1.2290 |
glycerate | 1.1464 | 0.9925 | 0.9884 | 0.9817 | 1.0172 | 1.0876 | 0.9509 | 0.8269 | 0.9314 | 0.7587 | 0.8957 | 0.8432 | 1.1023 | 1.0054 | 1.1709 | 1.0923 | 1.2287 | 1.0925 |
glycerophosphoglycerol | 1.3573 | 0.7650 | 0.4026 | 0.7669 | 0.2050 | 0.9961 | 1.3955 | 1.4468 | 0.6749 | 0.9992 | 0.3284 | 1.2695 | 1.3627 | 1.9572 | 1.4966 | 0.6239 | 0.9759 | 1.1458 |
guanidinoacetate | 1.2016 | 0.4536 | 0.4227 | 0.8502 | 0.4856 | 1.3605 | 1.2046 | 0.4894 | 0.6064 | 0.9372 | 0.6253 | 1.3898 | 1.3190 | 1.3380 | 1.3681 | 1.2839 | 1.3239 | 1.5290 |
gulonate* | 0.9650 | 0.7518 | 0.6859 | 0.9021 | 0.6390 | 1.0349 | 1.2692 | 0.8781 | 0.9502 | 1.0052 | 0.7073 | 1.2893 | 1.1330 | 1.1849 | 1.1513 | 1.1428 | 1.1509 | 1.1931 |
heptenedioate (C7:1-DC)* | 0.9614 | 0.6209 | 0.7717 | 0.8100 | 0.8131 | 0.9497 | 1.1926 | 0.6540 | 1.1015 | 0.9854 | 1.0137 | 1.2077 | 1.2376 | 1.0093 | 1.0154 | 1.4397 | 1.0651 | 1.1784 |
homocitrulline | 0.7803 | 1.0999 | 1.5872 | 0.3929 | 1.6657 | 0.5332 | 0.8549 | 1.0285 | 1.4608 | 0.5807 | 1.2658 | 0.7435 | 1.1175 | 1.2083 | 1.1376 | 0.9427 | 0.7942 | 0.9873 |
hydantoin-5-propionate | 1.1811 | 1.2156 | 1.1260 | 1.4444 | 1.2928 | 1.0374 | 0.8385 | 0.7612 | 0.8228 | 0.8619 | 1.0343 | 0.7878 | 0.9078 | 1.2140 | 0.8050 | 0.9619 | 0.9242 | 0.8876 |
hypotaurine | 1.1291 | 0.9451 | 1.1587 | 1.1081 | 0.9875 | 0.9165 | 1.0528 | 1.0060 | 1.1376 | 0.9764 | 0.8484 | 0.9729 | 1.1092 | 0.9327 | 0.9905 | 0.8671 | 0.8921 | 0.9472 |
imidazole propionate | 1.0038 | 0.8625 | 0.8483 | 0.8345 | 0.9343 | 1.0010 | 1.2362 | 1.0079 | 0.8468 | 0.9843 | 1.0211 | 1.1781 | 0.8641 | 0.9734 | 0.9898 | 0.8980 | 1.3594 | 1.1149 |
lactate | 1.1505 | 0.8012 | 0.8666 | 1.1285 | 0.8724 | 1.1600 | 0.9453 | 0.8249 | 0.8317 | 0.9523 | 0.9136 | 1.0640 | 1.1753 | 1.1455 | 1.1352 | 0.8734 | 1.1334 | 1.1098 |
maleate | 1.0058 | 0.8042 | 0.7547 | 0.7849 | 0.7997 | 0.9035 | 1.1580 | 0.8293 | 0.9340 | 0.8879 | 0.9194 | 1.0565 | 1.2500 | 1.0506 | 1.3146 | 1.3451 | 1.1354 | 1.1620 |
maltose | 1.0381 | 1.0358 | 0.9558 | 1.2637 | 0.9269 | 1.0732 | 0.9886 | 0.8713 | 0.9434 | 0.9767 | 0.7014 | 0.8436 | 1.0628 | 1.0147 | 1.1660 | 0.9367 | 1.0839 | 1.1846 |
mannitol/sorbitol | 0.7895 | 1.8256 | 1.0493 | 1.2137 | 0.8189 | 0.7528 | 0.8747 | 1.2308 | 0.8799 | 0.8772 | 1.0425 | 0.8538 | 0.8318 | 1.8291 | 0.8774 | 0.7544 | 0.8321 | 0.8371 |
mannonate* | 0.9654 | 0.7510 | 1.0503 | 0.9073 | 1.2386 | 0.8457 | 1.1831 | 0.8050 | 1.0594 | 1.1235 | 1.2863 | 0.9179 | 0.9384 | 0.8376 | 0.9705 | 1.1597 | 0.9550 | 0.9583 |
mannose | 0.9326 | 1.0810 | 1.3480 | 0.9621 | 1.4294 | 0.8932 | 0.8235 | 1.0765 | 1.2669 | 0.9493 | 1.2883 | 0.8227 | 0.8696 | 0.8494 | 0.8409 | 0.8291 | 0.8734 | 0.8199 |
methylmalonate (MMA) | 1.0655 | 0.8508 | 0.7651 | 1.0882 | 0.7483 | 1.0723 | 0.9547 | 0.8357 | 0.9073 | 0.8804 | 0.8261 | 0.9525 | 1.2780 | 1.4117 | 1.1294 | 1.0744 | 1.1879 | 1.1360 |
methylsuccinate | 1.0388 | 1.0795 | 0.9910 | 0.8843 | 0.9920 | 1.2090 | 0.9871 | 0.9539 | 1.0326 | 0.8438 | 0.9582 | 0.9994 | 1.0139 | 1.0643 | 1.0618 | 0.9207 | 0.9896 | 1.0184 |
myo-inositol | 1.0550 | 0.9736 | 0.9732 | 0.9687 | 0.7629 | 0.8789 | 1.0934 | 0.9859 | 0.8503 | 1.0444 | 0.9051 | 1.2155 | 1.0678 | 0.9870 | 1.0908 | 1.0395 | 1.0429 | 1.0696 |
N6-acetyllysine | 1.1040 | 0.7615 | 0.6869 | 0.7476 | 0.5948 | 1.1240 | 1.3262 | 0.8493 | 0.9635 | 0.9334 | 0.8819 | 1.2589 | 1.0991 | 1.2197 | 1.0953 | 1.0582 | 1.1391 | 1.1840 |
N-acetylalanine | 1.0976 | 0.8767 | 0.7871 | 0.9561 | 0.8749 | 0.9696 | 1.1907 | 0.8940 | 0.8763 | 0.9219 | 0.9705 | 1.0810 | 1.1252 | 1.0935 | 1.1053 | 0.9959 | 1.0858 | 1.1326 |
N-acetyl-beta-alanine | 0.9091 | 1.0883 | 1.1646 | 0.9368 | 1.3284 | 0.8700 | 0.9228 | 0.9207 | 0.8706 | 0.7562 | 0.9763 | 1.0029 | 1.1007 | 1.1816 | 1.0952 | 0.8652 | 1.0266 | 1.1197 |
N-acetylglutamate | 0.9901 | 0.8566 | 0.7382 | 0.8669 | 0.6839 | 1.1329 | 1.1665 | 0.8115 | 0.8006 | 0.8216 | 0.8515 | 1.1352 | 1.2268 | 1.3936 | 1.1223 | 1.0522 | 1.1750 | 1.3092 |
N-acetylglutamine | 1.3676 | 0.6159 | 0.5029 | 0.8997 | 0.4365 | 1.4213 | 1.5417 | 0.6108 | 0.7549 | 0.9381 | 0.7437 | 1.2977 | 1.1556 | 0.9554 | 1.1607 | 1.1024 | 1.1999 | 1.2664 |
N-acetylglycine | 0.6455 | 0.7585 | 0.8524 | 0.3936 | 1.0763 | 0.5298 | 0.9051 | 1.2324 | 1.6875 | 0.6292 | 1.4033 | 0.7819 | 1.2040 | 1.0077 | 0.7314 | 1.9476 | 1.1405 | 1.0778 |
N-acetylhistidine | 1.3738 | 0.7772 | 0.7268 | 1.2021 | 0.6395 | 1.3751 | 1.2877 | 0.6930 | 0.8072 | 1.0047 | 0.8225 | 1.1586 | 1.0266 | 1.0615 | 1.0076 | 0.9750 | 1.0020 | 1.0388 |
N-acetylserine | 1.0913 | 0.8761 | 0.7582 | 0.9288 | 0.7640 | 1.1128 | 1.1157 | 0.8588 | 0.8635 | 0.9751 | 0.8711 | 1.1472 | 1.1042 | 1.1880 | 1.0524 | 1.0803 | 1.0898 | 1.1809 |
N-acetyltaurine | 1.0920 | 0.9103 | 0.8676 | 0.9908 | 0.7197 | 1.0355 | 1.2353 | 0.9561 | 0.9596 | 1.0891 | 0.8953 | 1.2439 | 1.0227 | 1.0026 | 0.9514 | 0.9956 | 0.9776 | 0.9910 |
N-delta-acetylornithine | 1.0554 | 0.4216 | 0.3690 | 0.7228 | 0.2787 | 1.0417 | 1.4852 | 0.7309 | 0.8012 | 1.2283 | 0.5619 | 1.6410 | 1.3087 | 1.4182 | 1.3171 | 1.1190 | 1.2045 | 1.3672 |
N-formylanthranilic acid | 0.9977 | 1.8024 | 1.2183 | 0.9938 | 1.6005 | 0.9321 | 0.7309 | 1.0719 | 1.0818 | 0.7833 | 1.1470 | 0.8384 | 0.7295 | 0.9766 | 0.8551 | 0.6325 | 0.7775 | 0.8733 |
orotate | 1.1108 | 0.7392 | 0.8212 | 1.3137 | 0.9105 | 1.0122 | 1.1239 | 0.8528 | 0.8285 | 1.1629 | 0.8514 | 0.9990 | 1.1342 | 0.9879 | 1.0137 | 1.0839 | 1.0399 | 1.0011 |
orotidine | 0.9312 | 0.6475 | 0.5472 | 0.8379 | 0.4981 | 1.0197 | 1.3358 | 0.7912 | 0.7689 | 1.3162 | 0.7145 | 1.1928 | 1.1950 | 1.2874 | 1.2103 | 1.3186 | 1.2123 | 1.2435 |
p-cresol glucuronide* | 1.7323 | 0.9630 | 0.7006 | 0.9071 | 0.3293 | 1.4209 | 0.5961 | 0.6329 | 0.4944 | 0.4849 | 0.4048 | 0.5005 | 1.6438 | 1.9049 | 1.3289 | 1.6833 | 1.2662 | 1.5529 |
pentose acid* | 1.1489 | 1.2889 | 0.7236 | 0.5171 | 0.4911 | 0.6565 | 1.3211 | 1.3035 | 0.9092 | 0.6554 | 0.6267 | 0.7715 | 1.3462 | 2.4934 | 1.5857 | 0.7216 | 1.0978 | 0.7608 |
perfluorooctanoate (PFOA) | 0.5927 | 0.7806 | 0.7964 | 0.7744 | 0.7307 | 0.7533 | 1.4900 | 1.4514 | 1.5413 | 1.5159 | 1.4390 | 1.4513 | 0.7363 | 0.7154 | 0.7280 | 0.6968 | 0.6988 | 0.6879 |
phenylpyruvate | 0.8162 | 1.1122 | 1.2255 | 1.1103 | 1.1323 | 0.8465 | 0.8754 | 1.4960 | 1.1168 | 1.3268 | 1.0947 | 1.0995 | 0.6808 | 0.8673 | 0.8457 | 0.6501 | 0.7229 | 0.8054 |
propionylglycine (C3) | 0.8318 | 0.3003 | 0.4560 | 0.7241 | 0.3985 | 1.1388 | 1.2951 | 0.6731 | 0.7762 | 1.0603 | 0.7344 | 1.4652 | 1.2518 | 1.6289 | 1.2908 | 0.9827 | 1.4357 | 1.7275 |
pyruvate | 1.1040 | 0.8191 | 0.9069 | 1.1093 | 0.8882 | 1.1707 | 1.0307 | 0.7908 | 0.8270 | 1.0827 | 0.9337 | 1.1559 | 1.0315 | 1.1014 | 1.0754 | 0.8936 | 1.0433 | 1.0715 |
quinate | 0.8374 | 0.5309 | 0.5822 | 0.6080 | 0.4381 | 0.7732 | 1.5159 | 0.7780 | 0.7927 | 1.1259 | 0.7670 | 3.3547 | 1.0199 | 0.8214 | 0.9039 | 0.8042 | 0.7439 | 1.3564 |
quinolinate | 1.1576 | 0.9895 | 0.7502 | 0.9731 | 0.7261 | 0.9944 | 1.1780 | 0.9237 | 0.8740 | 0.9116 | 0.8044 | 1.0280 | 1.2558 | 1.1923 | 1.1331 | 0.9337 | 1.1717 | 1.0756 |
ribitol | 1.0487 | 0.8682 | 0.8773 | 1.1424 | 0.8521 | 1.0164 | 1.1232 | 0.9242 | 0.9498 | 1.1171 | 0.9617 | 1.1312 | 1.0241 | 1.0109 | 1.0149 | 0.9139 | 0.9722 | 1.0142 |
ribonate | 0.9906 | 0.7201 | 0.7980 | 1.0178 | 0.8152 | 0.9352 | 1.1015 | 0.8995 | 1.0825 | 1.1707 | 1.0074 | 1.2626 | 0.9581 | 0.8802 | 1.0356 | 1.0204 | 1.1189 | 1.1172 |
ribulonate/xylulonate/lyxonate* | 1.0506 | 1.0612 | 0.9801 | 0.8050 | 0.9098 | 1.0697 | 0.7545 | 1.0966 | 0.9647 | 0.6874 | 0.9110 | 0.9315 | 0.9640 | 1.5200 | 1.0210 | 1.0318 | 1.3132 | 1.1268 |
salicylate | 1.1753 | 1.4515 | 1.0163 | 0.5702 | 0.8784 | 0.9573 | 1.0020 | 1.4652 | 1.3724 | 0.7764 | 0.9562 | 1.0495 | 1.5119 | 0.9836 | 0.7864 | 0.5384 | 0.7203 | 0.7024 |
sebacate (C10-DC) | 0.9458 | 1.5719 | 1.0193 | 0.4226 | 0.9300 | 0.7933 | 0.9921 | 1.2866 | 1.6098 | 0.5676 | 1.4845 | 0.9408 | 0.7669 | 1.0735 | 0.7003 | 1.4163 | 0.6834 | 0.7424 |
S-methylcysteine | 1.2039 | 0.2632 | 0.1298 | 0.8197 | 0.1834 | 2.1356 | 1.2321 | 0.3809 | 0.3020 | 0.9298 | 0.5143 | 2.2504 | 1.1420 | 1.1716 | 0.9497 | 1.0534 | 1.3265 | 2.0230 |
sphinganine-1-phosphate | 1.1091 | 0.9294 | 0.9296 | 1.1518 | 0.7101 | 1.1949 | 0.9775 | 0.9113 | 0.9656 | 0.9908 | 0.6708 | 1.0458 | 1.1572 | 0.8867 | 1.2198 | 0.9991 | 0.9555 | 1.2144 |
sphingosine 1-phosphate | 1.1371 | 0.9928 | 0.9818 | 1.1848 | 0.8455 | 1.1016 | 0.9779 | 0.8993 | 0.8951 | 1.0004 | 0.7981 | 1.0608 | 1.1411 | 0.9102 | 1.0848 | 0.9423 | 0.9394 | 1.1180 |
suberate (C8-DC) | 1.0300 | 0.9412 | 1.0282 | 0.6253 | 0.9725 | 0.8926 | 1.0027 | 1.0004 | 1.2975 | 0.7077 | 1.3633 | 1.0932 | 0.9390 | 0.9658 | 0.9836 | 1.5233 | 0.7473 | 0.8793 |
succinate | 1.2763 | 1.0366 | 0.8958 | 1.0807 | 0.9560 | 0.8195 | 1.1542 | 0.9865 | 0.9363 | 0.9623 | 1.0502 | 0.8541 | 1.1100 | 0.9665 | 1.0836 | 0.9153 | 0.8832 | 1.0361 |
succinimide | 1.0735 | 0.7487 | 0.7745 | 0.9956 | 0.8573 | 0.8510 | 1.3612 | 1.0251 | 1.0519 | 1.1533 | 1.2251 | 1.1660 | 1.0817 | 0.6999 | 0.8318 | 0.9524 | 0.9612 | 0.9911 |
threonate | 1.1513 | 1.0871 | 1.0161 | 0.9680 | 1.0735 | 1.1061 | 0.8628 | 0.9355 | 0.9005 | 0.6632 | 0.9193 | 0.8117 | 1.1783 | 1.0412 | 1.1831 | 0.9354 | 1.3036 | 0.9934 |
uracil | 1.0646 | 0.9021 | 1.3945 | 0.9658 | 1.0038 | 0.9412 | 0.8867 | 0.9868 | 1.1301 | 0.9317 | 1.0439 | 1.1032 | 1.1214 | 0.7847 | 0.7261 | 0.9909 | 1.0390 | 0.9268 |
vanillactate | 0.8813 | 1.2103 | 1.0270 | 0.8212 | 1.1022 | 1.0732 | 0.6258 | 1.2140 | 0.7720 | 0.8499 | 0.7463 | 1.3874 | 0.8828 | 1.1861 | 0.8658 | 0.7985 | 1.4410 | 1.2062 |
xanthine | 1.1813 | 1.0269 | 1.1670 | 0.8846 | 0.9892 | 1.0553 | 1.0374 | 0.9029 | 0.9982 | 0.9255 | 0.9069 | 1.0166 | 1.0945 | 0.7355 | 0.9580 | 1.1236 | 0.9324 | 1.0402 |
xylose | 0.7284 | 0.7749 | 0.6876 | 0.8653 | 1.0094 | 1.2317 | 0.9151 | 0.8192 | 0.7143 | 0.8861 | 0.8065 | 1.2854 | 0.9512 | 1.1799 | 1.3451 | 1.1520 | 0.9770 | 1.8154 |
Factors:
F1 | Group:High-Dose | TIMEPOINT:-0.5HR |
F2 | Group:High-Dose | TIMEPOINT:+23HR POST INFUSION |
F3 | Group:High-Dose | TIMEPOINT:+47HR POST INFUSION |
F4 | Group:High-Dose | TIMEPOINT:+4HR POST INFUSION |
F5 | Group:High-Dose | TIMEPOINT:+71HR POST INFUSION |
F6 | Group:High-Dose | TIMEPOINT:BASELINE |
F7 | Group:Low-Dose | TIMEPOINT:-0.5HR |
F8 | Group:Low-Dose | TIMEPOINT:+23HR POST INFUSION |
F9 | Group:Low-Dose | TIMEPOINT:+47HR POST INFUSION |
F10 | Group:Low-Dose | TIMEPOINT:+4HR POST INFUSION |
F11 | Group:Low-Dose | TIMEPOINT:+71HR POST INFUSION |
F12 | Group:Low-Dose | TIMEPOINT:BASELINE |
F13 | Group:Placebo | TIMEPOINT:-0.5HR |
F14 | Group:Placebo | TIMEPOINT:+23HR POST INFUSION |
F15 | Group:Placebo | TIMEPOINT:+47HR POST INFUSION |
F16 | Group:Placebo | TIMEPOINT:+4HR POST INFUSION |
F17 | Group:Placebo | TIMEPOINT:+71HR POST INFUSION |
F18 | Group:Placebo | TIMEPOINT:BASELINE |