Data for Control of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites (Study ST001658)

(Analysis AN002708)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
11-Aminoundecanoic acid 1.7642 0.8553 0.3804
[(1,2-Dioxo-1,2-ethanediyl)bis(oxy)]diammonium 2.1728 0.2672 0.5600
1-{[(3S,4S,5R)-2,3,4-Trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}-2-pyrrolidinecarboxylic acid (non-preferred name) 0.0052 0.3147 2.6801
1-(beta-D-Ribofuranosyl)-1,2-dihydropyrimidine 0.5516 2.4229 0.0254
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide 1.0306 1.8062 0.1632
2,2,6,6-Tetramethyl-1-piperidinol (TEMPO) 2.8940 0.0551 0.0509
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide 0.0002 0.0128 2.9870
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide (2) 0.0035 2.7243 0.2722
2,4,6-triaminotoluene 2.7371 0.0113 0.2516
2,4-Dimethyloxazole 0.0216 0.0995 2.8789
2-Acetamido-2-deoxyglucose 0.0221 0.0180 2.9599
2-Acetamido-2-deoxyglucose (2) 0.0513 0.1042 2.8445
2-Amino-1H-benzimidazole 0.8230 0.8272 1.3498
2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose 0.0102 2.9452 0.0446
2-Amino-3-(1H-imidazol-4-yl)propan-1-ol 0.1682 0.0356 2.7962
2^-deamino-2^-hydroxy-6^-dehydroparomamine 0.0033 0.0043 2.9924
2^-Deoxyadenosine 0.0382 1.2770 1.6848
2^-deoxymugineic acid 0.0005 0.0033 2.9962
2^-deoxymugineic acid (2) 0.0008 0.0016 2.9976
2-(Diethylamino)ethanol 1.9758 0.5618 0.4623
2-(Diethylamino)ethanol (2) 1.6428 0.8172 0.5400
2-Hydroxyfelbamate 0.0158 2.8487 0.1355
2-Oxo-4-pentenoic acid 0.0123 0.0163 2.9714
(2S)-2-Piperazinecarboxamide 0.0039 0.0036 2.9925
(2S)-2-Piperazinecarboxamide (2) 0.9165 0.3180 1.7655
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) 0.0026 0.0032 2.9942
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (2) 0.0018 0.0041 2.9941
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (3) 0.0060 0.0060 2.9879
(2S)-3-Methyl-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (4) 0.0291 0.3415 2.6294
(2Z)-2-Aminobut-2-enoate 0.0199 0.0285 2.9516
3,4-Diaminopyridine 0.0023 0.0020 2.9957
3-Methyl-6,7,8-trihydropyrrolo[1,2-a]pyrimidin-2-one 0.3162 2.6452 0.0386
4-(2-Carboxy-1-azetidinyl)-N-(3-carboxy-3-hydroxypropyl)threonine 0.0087 0.0092 2.9821
4,6-Dimethyl-2(1H)-pyrimidinone 1.7740 0.7056 0.5205
4,6-Dimethyl-2(1H)-pyrimidinone (2) 1.5914 0.6159 0.7927
4-ACETAMIDOBUTYRIC ACID 0.2495 2.7296 0.0208
4-Aminopyridine 2.9048 0.0084 0.0868
4-Aminopyridine (2) 0.1294 0.2084 2.6621
4-Imidazolemethanol 2.2174 0.0631 0.7196
4-methylthio-2-oxobutanoic acid 0.0023 0.0016 2.9961
4-Morpholinylacetic acid 0.1237 2.8551 0.0212
4-Nitroaniline 2.8930 0.0417 0.0654
4-Nitroaniline (2) 0.1317 1.3284 1.5400
(4R)-4-{[(4R)-4-Hydroxy-1-methyl-L-prolyl]oxy}-1-methyl-L-proline 0.3015 1.7178 0.9807
5-(N,N-Dimethylcarbamimidamido)-2-oxopentanoic acid 0.0123 0.1538 2.8339
6-Oxolysine 0.0180 0.1505 2.8314
6-Oxolysine (2) 0.0101 0.3989 2.5910
6-Oxo-pipecolinic acid 0.0292 2.8094 0.1614
(±)-Abscisic acid 2.7178 0.0300 0.2521
ACPC 0.0025 0.0039 2.9936
ACPC (2) 0.0013 0.0024 2.9964
agmatine 0.0219 0.0445 2.9336
agmatine (2) 0.0446 0.0590 2.8963
ala-ser 0.0341 0.0413 2.9246
Aminolevulinic acid 0.0147 0.0521 2.9331
Aminolevulinic acid (2) 0.0270 0.0988 2.8742
Aminolevulinic acid (3) 0.1286 2.5868 0.2846
Aminolevulinic acid (4) 0.0186 0.0913 2.8901
Aminolevulinic acid (5) 0.0433 0.1959 2.7608
Aminolevulinic acid (6) 0.0574 0.0819 2.8607
APM 0.0138 2.9500 0.0362
arg-ala 0.0151 0.0175 2.9674
Arg-pro 0.0345 2.8918 0.0737
Arg-pro (2) 0.0321 0.0435 2.9244
Betaine 0.0887 2.8499 0.0614
Betaine (2) 2.6962 0.1118 0.1920
Boc-Asn-Oh 0.0483 0.0710 2.8807
Butabarbital 1.0891 1.8121 0.0988
butalbital 2.4163 0.4941 0.0897
Butoctamide semisuccinate 1.6489 0.9627 0.3883
Caprolactam 2.7537 0.2368 0.0095
Caprolactam (2) 1.3270 1.6411 0.0319
Caprolactam (3) 0.9505 1.7495 0.3000
Carbofuran 0.0259 0.4982 2.4759
Choline 2.3886 0.2831 0.3283
Choline Alfoscerate 0.0012 0.0160 2.9829
Coprine 0.0645 0.3021 2.6334
Cyclohexylamine 1.3709 0.7950 0.8341
Cyprodenate 2.1562 0.2954 0.5484
Cyprodenate (2) 0.9989 1.1112 0.8899
Daminozide 0.0149 0.1345 2.8507
Desoxymycin 2.2470 0.4850 0.2681
D-Glucosamine 0.0004 0.0014 2.9982
D-Glucosamine (2) 0.0473 2.6556 0.2971
D-Glucosamine (3) 0.0150 2.3838 0.6012
D-(-)-Glutamine 0.0001 0.0001 2.9998
Dibutyl phthalate 0.7643 1.2350 1.0007
DL-Arginine 0.0001 0.0001 2.9998
DL-Arginine (2) 0.0001 0.0000 2.9999
DL-Arginine (3) 0.0003 0.0006 2.9991
DL-Carnitine 2.3985 0.5657 0.0358
DL-Glutamine 0.0340 0.0378 2.9282
DL-Histidine 0.0004 0.0011 2.9985
DL-Histidine (2) 0.0077 0.0079 2.9844
D-Serine 0.0096 0.0101 2.9803
Dulcin 0.7272 2.1812 0.0916
Ethephon 1.9278 0.5184 0.5537
(+)-Eudesmin 1.9671 0.4552 0.5777
Fucosamine 1.9185 0.8617 0.2198
Gabapentin 1.6843 0.5358 0.7799
gaboxadol 1.0400 1.8254 0.1346
Galactosamine 0.0002 0.0003 2.9995
gamma-Aminobutyric acid 0.6726 2.2449 0.0825
g-Butyrobetaine 2.7393 0.0764 0.1842
g-Guanidinobutyrate 1.6982 0.1039 1.1979
glu-pro 0.0226 0.5134 2.4640
glu-thr 0.0794 0.0890 2.8316
glyceraldehyde 3-phosphate 2.0098 0.4681 0.5221
Glycine 0.1087 0.1761 2.7153
Glycyl-4-hydroxyproline 0.0280 0.0413 2.9307
Gly-l-pro 0.0298 0.2920 2.6781
Gly-Lys 2.9640 0.0202 0.0158
Guvacine 0.0620 2.6852 0.2528
HEPES 0.0125 0.0132 2.9743
Hexaconazole 0.0219 2.7635 0.2146
Hexaconazole (2) 0.0317 2.6494 0.3189
Histamine 0.0170 0.0205 2.9624
Homoanserine 0.0314 0.0262 2.9425
Homocitrulline 2.7172 0.2383 0.0445
Homo-L-arginine 0.0117 0.0098 2.9785
Homo-L-arginine (2) 0.0266 0.0322 2.9412
Imidazolepropionic acid 0.0030 0.0991 2.8980
Kanosamine 0.0004 0.0007 2.9990
Kanosamine (2) 0.0007 0.0012 2.9981
Kanosamine (3) 0.0393 2.8084 0.1523
L-(+)-Alanine 0.0756 0.0417 2.8827
L-Alanyl-L-proline 0.2908 2.6912 0.0180
L-Alanyl-L-proline (2) 0.7588 1.8753 0.3659
L-Alanyl-L-proline (3) 2.3976 0.5971 0.0053
L-(-)-Asparagine 0.0018 0.0014 2.9968
L-(+)-Aspartic acid 0.0457 2.7196 0.2346
L-Aspartic acid 0.0031 0.0004 2.9965
Lauramide 0.8826 1.0568 1.0606
lentiginosine 2.7363 0.1446 0.1191
L-Glutamic acid 0.0001 0.0002 2.9997
L-Glutamic acid (2) 0.0002 0.0004 2.9994
L-Glutamic acid (3) 0.0001 0.0001 2.9999
L-Glutamic acid (4) 0.2031 0.0347 2.7621
L-Glutamic acid (5) 0.0082 0.0071 2.9847
Linamarin 0.0337 0.1681 2.7981
L-Proline 0.0352 0.6050 2.3598
L-Pyroglutamic acid 0.0001 0.0002 2.9998
L-Pyroglutamic acid (2) 0.0094 0.0017 2.9889
L-Pyroglutamic acid (3) 0.0003 0.0015 2.9982
L-Pyroglutamic acid (4) 0.0004 0.0004 2.9992
L-(-)-Serine 0.0004 0.0008 2.9988
L-Theanine 0.0185 0.0245 2.9570
LU3453000 0.0061 0.0228 2.9711
LU3453000 (2) 0.0061 0.0104 2.9835
Lysylvaline 0.0108 0.0171 2.9721
MA4000000 1.1670 1.3558 0.4772
MA4000000 (2) 0.0731 0.0899 2.8370
metharbital 0.0219 0.1837 2.7944
MFCD00037215 0.0032 0.0024 2.9944
MFCD00041932 2.8428 0.1449 0.0123
MFCD00055782 0.1078 0.4096 2.4826
MFCD01664827 0.0183 2.8787 0.1030
Midodrine 0.1942 2.6783 0.1275
Miglitol 0.1653 0.0852 2.7495
Muramic acid 0.0001 0.0039 2.9960
muramic acid (2) 0.0005 0.0159 2.9836
muramic acid (3) 0.0005 0.0073 2.9922
Muramic acid (4) 0.0058 2.8864 0.1078
Muramic acid (5) 0.0072 2.2134 0.7794
N~1~-Isopropyl-2-methylpropan-1,2-diamin 1.0025 1.9523 0.0451
N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)FORMAMIDE 2.9890 0.0023 0.0087
N6-METHYLLYSINE 0.0063 0.0064 2.9873
N6-METHYLLYSINE (2) 0.0071 0.0082 2.9847
N~6~,N~6~-Dimethyllysine 0.0018 0.0023 2.9959
N-Acetyl-D-mannosaminolactone 0.0326 0.1014 2.8660
N-acetyl-LL-2,6-diaminopimelic acid 0.0285 0.1483 2.8232
N-Acetylneuraminic acid 0.0044 0.0118 2.9837
N-Acetylputrescine 2.3967 0.6016 0.0017
NI3400000 0.8610 0.1240 2.0151
nicotianamine 0.0097 0.0114 2.9789
NJ5000000 0.0046 0.0058 2.9896
NJ5000000 (2) 0.0087 0.0072 2.9841
N-methylethanolamine phosphate 2.9346 0.0628 0.0026
N-Methylglutamate 2.7487 0.1103 0.1410
N,N-diacetyllegionaminic acid 0.0012 0.0016 2.9972
N,N-diacetyllegionaminic acid (2) 0.0053 0.0064 2.9883
N,N-diacetyllegionaminic acid (3) 0.0049 0.0045 2.9905
N,N-dimethylarginine 0.0040 0.0051 2.9909
N,N-Dimethylglycine 0.0248 2.9289 0.0463
N-Nitrosoguvacoline 0.0028 0.0027 2.9945
NPYR 1.1110 0.6599 1.2291
NPYR (2) 1.1142 0.7949 1.0909
N-succinyl-LL-2,6-diaminopimelic acid 0.0314 0.0307 2.9379
N-tetracosanoylsphinganine-1-phosphocholine 2.8699 0.0102 0.1199
N-Undecanoylglycine 2.1198 0.5803 0.2999
nylon cyclic dimer 1.5835 0.7165 0.7000
Oryzalin metabolite 1.6035 1.3794 0.0171
Paracetamol 1.4434 0.0696 1.4870
PEG-4 1.8617 0.5931 0.5452
pentetrazol 0.0239 0.0199 2.9562
pentobarbital 2.1195 0.8735 0.0070
Phenylhydrazine 0.1419 2.5067 0.3514
Phenylisocyanate 2.9265 0.0286 0.0449
Picolinamide 0.0322 0.9935 1.9743
Proacacipetalin 0.0112 0.3453 2.6436
pro-gln 0.0116 0.1291 2.8592
Proline 0.0004 2.9710 0.0287
Proline (2) 1.8276 0.9999 0.1725
Pulcherriminic acid 1.3071 1.6318 0.0611
PYRIDOXAMINE 0.7320 2.2586 0.0094
Pyrogallol 0.0096 0.0125 2.9780
Reduced Glutathione 0.0195 0.0170 2.9635
RG8841500 1.0444 1.8948 0.0608
S-Allyl propanethioate 0.0018 0.0013 2.9969
spinacine 0.0056 0.0036 2.9908
Streptamine 0.0060 0.0093 2.9846
Streptamine (2) 0.0056 0.0332 2.9612
tert-Butyl 3-amino-1-methyl-2,3-dioxopropylcarbamate 0.1033 0.5731 2.3236
Tetraacetylethylenediamine 0.0079 0.3760 2.6160
THP(A) 0.0030 0.0059 2.9911
Threonine 0.0002 0.0012 2.9985
Threonylserine 0.0456 0.0472 2.9072
Tiformin 2.9532 0.0331 0.0137
tin(ii) hydride 1.0367 1.8798 0.0834
Triethanolamine 1.7341 1.0715 0.1944
Triethylamine 2.1121 0.0816 0.8063
Triethylamine (2) 2.4348 0.2427 0.3225
trimethadione 0.0024 0.0026 2.9950
trimethadione (2) 0.0038 0.0040 2.9922
trimethadione (3) 0.0066 0.0116 2.9819
trimethadione (4) 2.6594 0.1254 0.2153
trimethylglycine 2.2378 0.5602 0.2020
Tris(hydroxymethyl)aminomethane 0.0223 0.0285 2.9491
UB6600000 2.9060 0.0482 0.0457
val-arg 0.0046 0.0084 2.9870
Val-lys 0.0155 0.0204 2.9641
Veronal 2.8093 0.1728 0.0179
Veronal (2) 0.9125 0.2099 1.8776
YU0650000 0.1665 0.1594 2.6741
ZV4 2.8585 0.0434 0.0981
β-Alanine 0.0105 0.0764 2.9132
β-Alanine (2) 0.0275 0.1584 2.8141
β-Alanine (3) 0.0468 0.5373 2.4159
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Factors:

F1Treatment:HPLC fraction 4
F2Treatment:HPLC fraction 5
F3Treatment:HPLC fraction 6
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