Data for Control of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites (Study ST001658)
(Analysis AN002708)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 |
---|---|---|---|
11-Aminoundecanoic acid | 1.7642 | 0.8553 | 0.3804 |
[(1,2-Dioxo-1,2-ethanediyl)bis(oxy)]diammonium | 2.1728 | 0.2672 | 0.5600 |
1-{[(3S,4S,5R)-2,3,4-Trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}-2-pyrrolidinecarboxylic acid (non-preferred name) | 0.0052 | 0.3147 | 2.6801 |
1-(beta-D-Ribofuranosyl)-1,2-dihydropyrimidine | 0.5516 | 2.4229 | 0.0254 |
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide | 1.0306 | 1.8062 | 0.1632 |
2,2,6,6-Tetramethyl-1-piperidinol (TEMPO) | 2.8940 | 0.0551 | 0.0509 |
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide | 0.0002 | 0.0128 | 2.9870 |
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide (2) | 0.0035 | 2.7243 | 0.2722 |
2,4,6-triaminotoluene | 2.7371 | 0.0113 | 0.2516 |
2,4-Dimethyloxazole | 0.0216 | 0.0995 | 2.8789 |
2-Acetamido-2-deoxyglucose | 0.0221 | 0.0180 | 2.9599 |
2-Acetamido-2-deoxyglucose (2) | 0.0513 | 0.1042 | 2.8445 |
2-Amino-1H-benzimidazole | 0.8230 | 0.8272 | 1.3498 |
2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose | 0.0102 | 2.9452 | 0.0446 |
2-Amino-3-(1H-imidazol-4-yl)propan-1-ol | 0.1682 | 0.0356 | 2.7962 |
2^-deamino-2^-hydroxy-6^-dehydroparomamine | 0.0033 | 0.0043 | 2.9924 |
2^-Deoxyadenosine | 0.0382 | 1.2770 | 1.6848 |
2^-deoxymugineic acid | 0.0005 | 0.0033 | 2.9962 |
2^-deoxymugineic acid (2) | 0.0008 | 0.0016 | 2.9976 |
2-(Diethylamino)ethanol | 1.9758 | 0.5618 | 0.4623 |
2-(Diethylamino)ethanol (2) | 1.6428 | 0.8172 | 0.5400 |
2-Hydroxyfelbamate | 0.0158 | 2.8487 | 0.1355 |
2-Oxo-4-pentenoic acid | 0.0123 | 0.0163 | 2.9714 |
(2S)-2-Piperazinecarboxamide | 0.0039 | 0.0036 | 2.9925 |
(2S)-2-Piperazinecarboxamide (2) | 0.9165 | 0.3180 | 1.7655 |
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) | 0.0026 | 0.0032 | 2.9942 |
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (2) | 0.0018 | 0.0041 | 2.9941 |
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (3) | 0.0060 | 0.0060 | 2.9879 |
(2S)-3-Methyl-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) (4) | 0.0291 | 0.3415 | 2.6294 |
(2Z)-2-Aminobut-2-enoate | 0.0199 | 0.0285 | 2.9516 |
3,4-Diaminopyridine | 0.0023 | 0.0020 | 2.9957 |
3-Methyl-6,7,8-trihydropyrrolo[1,2-a]pyrimidin-2-one | 0.3162 | 2.6452 | 0.0386 |
4-(2-Carboxy-1-azetidinyl)-N-(3-carboxy-3-hydroxypropyl)threonine | 0.0087 | 0.0092 | 2.9821 |
4,6-Dimethyl-2(1H)-pyrimidinone | 1.7740 | 0.7056 | 0.5205 |
4,6-Dimethyl-2(1H)-pyrimidinone (2) | 1.5914 | 0.6159 | 0.7927 |
4-ACETAMIDOBUTYRIC ACID | 0.2495 | 2.7296 | 0.0208 |
4-Aminopyridine | 2.9048 | 0.0084 | 0.0868 |
4-Aminopyridine (2) | 0.1294 | 0.2084 | 2.6621 |
4-Imidazolemethanol | 2.2174 | 0.0631 | 0.7196 |
4-methylthio-2-oxobutanoic acid | 0.0023 | 0.0016 | 2.9961 |
4-Morpholinylacetic acid | 0.1237 | 2.8551 | 0.0212 |
4-Nitroaniline | 2.8930 | 0.0417 | 0.0654 |
4-Nitroaniline (2) | 0.1317 | 1.3284 | 1.5400 |
(4R)-4-{[(4R)-4-Hydroxy-1-methyl-L-prolyl]oxy}-1-methyl-L-proline | 0.3015 | 1.7178 | 0.9807 |
5-(N,N-Dimethylcarbamimidamido)-2-oxopentanoic acid | 0.0123 | 0.1538 | 2.8339 |
6-Oxolysine | 0.0180 | 0.1505 | 2.8314 |
6-Oxolysine (2) | 0.0101 | 0.3989 | 2.5910 |
6-Oxo-pipecolinic acid | 0.0292 | 2.8094 | 0.1614 |
(±)-Abscisic acid | 2.7178 | 0.0300 | 0.2521 |
ACPC | 0.0025 | 0.0039 | 2.9936 |
ACPC (2) | 0.0013 | 0.0024 | 2.9964 |
agmatine | 0.0219 | 0.0445 | 2.9336 |
agmatine (2) | 0.0446 | 0.0590 | 2.8963 |
ala-ser | 0.0341 | 0.0413 | 2.9246 |
Aminolevulinic acid | 0.0147 | 0.0521 | 2.9331 |
Aminolevulinic acid (2) | 0.0270 | 0.0988 | 2.8742 |
Aminolevulinic acid (3) | 0.1286 | 2.5868 | 0.2846 |
Aminolevulinic acid (4) | 0.0186 | 0.0913 | 2.8901 |
Aminolevulinic acid (5) | 0.0433 | 0.1959 | 2.7608 |
Aminolevulinic acid (6) | 0.0574 | 0.0819 | 2.8607 |
APM | 0.0138 | 2.9500 | 0.0362 |
arg-ala | 0.0151 | 0.0175 | 2.9674 |
Arg-pro | 0.0345 | 2.8918 | 0.0737 |
Arg-pro (2) | 0.0321 | 0.0435 | 2.9244 |
Betaine | 0.0887 | 2.8499 | 0.0614 |
Betaine (2) | 2.6962 | 0.1118 | 0.1920 |
Boc-Asn-Oh | 0.0483 | 0.0710 | 2.8807 |
Butabarbital | 1.0891 | 1.8121 | 0.0988 |
butalbital | 2.4163 | 0.4941 | 0.0897 |
Butoctamide semisuccinate | 1.6489 | 0.9627 | 0.3883 |
Caprolactam | 2.7537 | 0.2368 | 0.0095 |
Caprolactam (2) | 1.3270 | 1.6411 | 0.0319 |
Caprolactam (3) | 0.9505 | 1.7495 | 0.3000 |
Carbofuran | 0.0259 | 0.4982 | 2.4759 |
Choline | 2.3886 | 0.2831 | 0.3283 |
Choline Alfoscerate | 0.0012 | 0.0160 | 2.9829 |
Coprine | 0.0645 | 0.3021 | 2.6334 |
Cyclohexylamine | 1.3709 | 0.7950 | 0.8341 |
Cyprodenate | 2.1562 | 0.2954 | 0.5484 |
Cyprodenate (2) | 0.9989 | 1.1112 | 0.8899 |
Daminozide | 0.0149 | 0.1345 | 2.8507 |
Desoxymycin | 2.2470 | 0.4850 | 0.2681 |
D-Glucosamine | 0.0004 | 0.0014 | 2.9982 |
D-Glucosamine (2) | 0.0473 | 2.6556 | 0.2971 |
D-Glucosamine (3) | 0.0150 | 2.3838 | 0.6012 |
D-(-)-Glutamine | 0.0001 | 0.0001 | 2.9998 |
Dibutyl phthalate | 0.7643 | 1.2350 | 1.0007 |
DL-Arginine | 0.0001 | 0.0001 | 2.9998 |
DL-Arginine (2) | 0.0001 | 0.0000 | 2.9999 |
DL-Arginine (3) | 0.0003 | 0.0006 | 2.9991 |
DL-Carnitine | 2.3985 | 0.5657 | 0.0358 |
DL-Glutamine | 0.0340 | 0.0378 | 2.9282 |
DL-Histidine | 0.0004 | 0.0011 | 2.9985 |
DL-Histidine (2) | 0.0077 | 0.0079 | 2.9844 |
D-Serine | 0.0096 | 0.0101 | 2.9803 |
Dulcin | 0.7272 | 2.1812 | 0.0916 |
Ethephon | 1.9278 | 0.5184 | 0.5537 |
(+)-Eudesmin | 1.9671 | 0.4552 | 0.5777 |
Fucosamine | 1.9185 | 0.8617 | 0.2198 |
Gabapentin | 1.6843 | 0.5358 | 0.7799 |
gaboxadol | 1.0400 | 1.8254 | 0.1346 |
Galactosamine | 0.0002 | 0.0003 | 2.9995 |
gamma-Aminobutyric acid | 0.6726 | 2.2449 | 0.0825 |
g-Butyrobetaine | 2.7393 | 0.0764 | 0.1842 |
g-Guanidinobutyrate | 1.6982 | 0.1039 | 1.1979 |
glu-pro | 0.0226 | 0.5134 | 2.4640 |
glu-thr | 0.0794 | 0.0890 | 2.8316 |
glyceraldehyde 3-phosphate | 2.0098 | 0.4681 | 0.5221 |
Glycine | 0.1087 | 0.1761 | 2.7153 |
Glycyl-4-hydroxyproline | 0.0280 | 0.0413 | 2.9307 |
Gly-l-pro | 0.0298 | 0.2920 | 2.6781 |
Gly-Lys | 2.9640 | 0.0202 | 0.0158 |
Guvacine | 0.0620 | 2.6852 | 0.2528 |
HEPES | 0.0125 | 0.0132 | 2.9743 |
Hexaconazole | 0.0219 | 2.7635 | 0.2146 |
Hexaconazole (2) | 0.0317 | 2.6494 | 0.3189 |
Histamine | 0.0170 | 0.0205 | 2.9624 |
Homoanserine | 0.0314 | 0.0262 | 2.9425 |
Homocitrulline | 2.7172 | 0.2383 | 0.0445 |
Homo-L-arginine | 0.0117 | 0.0098 | 2.9785 |
Homo-L-arginine (2) | 0.0266 | 0.0322 | 2.9412 |
Imidazolepropionic acid | 0.0030 | 0.0991 | 2.8980 |
Kanosamine | 0.0004 | 0.0007 | 2.9990 |
Kanosamine (2) | 0.0007 | 0.0012 | 2.9981 |
Kanosamine (3) | 0.0393 | 2.8084 | 0.1523 |
L-(+)-Alanine | 0.0756 | 0.0417 | 2.8827 |
L-Alanyl-L-proline | 0.2908 | 2.6912 | 0.0180 |
L-Alanyl-L-proline (2) | 0.7588 | 1.8753 | 0.3659 |
L-Alanyl-L-proline (3) | 2.3976 | 0.5971 | 0.0053 |
L-(-)-Asparagine | 0.0018 | 0.0014 | 2.9968 |
L-(+)-Aspartic acid | 0.0457 | 2.7196 | 0.2346 |
L-Aspartic acid | 0.0031 | 0.0004 | 2.9965 |
Lauramide | 0.8826 | 1.0568 | 1.0606 |
lentiginosine | 2.7363 | 0.1446 | 0.1191 |
L-Glutamic acid | 0.0001 | 0.0002 | 2.9997 |
L-Glutamic acid (2) | 0.0002 | 0.0004 | 2.9994 |
L-Glutamic acid (3) | 0.0001 | 0.0001 | 2.9999 |
L-Glutamic acid (4) | 0.2031 | 0.0347 | 2.7621 |
L-Glutamic acid (5) | 0.0082 | 0.0071 | 2.9847 |
Linamarin | 0.0337 | 0.1681 | 2.7981 |
L-Proline | 0.0352 | 0.6050 | 2.3598 |
L-Pyroglutamic acid | 0.0001 | 0.0002 | 2.9998 |
L-Pyroglutamic acid (2) | 0.0094 | 0.0017 | 2.9889 |
L-Pyroglutamic acid (3) | 0.0003 | 0.0015 | 2.9982 |
L-Pyroglutamic acid (4) | 0.0004 | 0.0004 | 2.9992 |
L-(-)-Serine | 0.0004 | 0.0008 | 2.9988 |
L-Theanine | 0.0185 | 0.0245 | 2.9570 |
LU3453000 | 0.0061 | 0.0228 | 2.9711 |
LU3453000 (2) | 0.0061 | 0.0104 | 2.9835 |
Lysylvaline | 0.0108 | 0.0171 | 2.9721 |
MA4000000 | 1.1670 | 1.3558 | 0.4772 |
MA4000000 (2) | 0.0731 | 0.0899 | 2.8370 |
metharbital | 0.0219 | 0.1837 | 2.7944 |
MFCD00037215 | 0.0032 | 0.0024 | 2.9944 |
MFCD00041932 | 2.8428 | 0.1449 | 0.0123 |
MFCD00055782 | 0.1078 | 0.4096 | 2.4826 |
MFCD01664827 | 0.0183 | 2.8787 | 0.1030 |
Midodrine | 0.1942 | 2.6783 | 0.1275 |
Miglitol | 0.1653 | 0.0852 | 2.7495 |
Muramic acid | 0.0001 | 0.0039 | 2.9960 |
muramic acid (2) | 0.0005 | 0.0159 | 2.9836 |
muramic acid (3) | 0.0005 | 0.0073 | 2.9922 |
Muramic acid (4) | 0.0058 | 2.8864 | 0.1078 |
Muramic acid (5) | 0.0072 | 2.2134 | 0.7794 |
N~1~-Isopropyl-2-methylpropan-1,2-diamin | 1.0025 | 1.9523 | 0.0451 |
N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)FORMAMIDE | 2.9890 | 0.0023 | 0.0087 |
N6-METHYLLYSINE | 0.0063 | 0.0064 | 2.9873 |
N6-METHYLLYSINE (2) | 0.0071 | 0.0082 | 2.9847 |
N~6~,N~6~-Dimethyllysine | 0.0018 | 0.0023 | 2.9959 |
N-Acetyl-D-mannosaminolactone | 0.0326 | 0.1014 | 2.8660 |
N-acetyl-LL-2,6-diaminopimelic acid | 0.0285 | 0.1483 | 2.8232 |
N-Acetylneuraminic acid | 0.0044 | 0.0118 | 2.9837 |
N-Acetylputrescine | 2.3967 | 0.6016 | 0.0017 |
NI3400000 | 0.8610 | 0.1240 | 2.0151 |
nicotianamine | 0.0097 | 0.0114 | 2.9789 |
NJ5000000 | 0.0046 | 0.0058 | 2.9896 |
NJ5000000 (2) | 0.0087 | 0.0072 | 2.9841 |
N-methylethanolamine phosphate | 2.9346 | 0.0628 | 0.0026 |
N-Methylglutamate | 2.7487 | 0.1103 | 0.1410 |
N,N-diacetyllegionaminic acid | 0.0012 | 0.0016 | 2.9972 |
N,N-diacetyllegionaminic acid (2) | 0.0053 | 0.0064 | 2.9883 |
N,N-diacetyllegionaminic acid (3) | 0.0049 | 0.0045 | 2.9905 |
N,N-dimethylarginine | 0.0040 | 0.0051 | 2.9909 |
N,N-Dimethylglycine | 0.0248 | 2.9289 | 0.0463 |
N-Nitrosoguvacoline | 0.0028 | 0.0027 | 2.9945 |
NPYR | 1.1110 | 0.6599 | 1.2291 |
NPYR (2) | 1.1142 | 0.7949 | 1.0909 |
N-succinyl-LL-2,6-diaminopimelic acid | 0.0314 | 0.0307 | 2.9379 |
N-tetracosanoylsphinganine-1-phosphocholine | 2.8699 | 0.0102 | 0.1199 |
N-Undecanoylglycine | 2.1198 | 0.5803 | 0.2999 |
nylon cyclic dimer | 1.5835 | 0.7165 | 0.7000 |
Oryzalin metabolite | 1.6035 | 1.3794 | 0.0171 |
Paracetamol | 1.4434 | 0.0696 | 1.4870 |
PEG-4 | 1.8617 | 0.5931 | 0.5452 |
pentetrazol | 0.0239 | 0.0199 | 2.9562 |
pentobarbital | 2.1195 | 0.8735 | 0.0070 |
Phenylhydrazine | 0.1419 | 2.5067 | 0.3514 |
Phenylisocyanate | 2.9265 | 0.0286 | 0.0449 |
Picolinamide | 0.0322 | 0.9935 | 1.9743 |
Proacacipetalin | 0.0112 | 0.3453 | 2.6436 |
pro-gln | 0.0116 | 0.1291 | 2.8592 |
Proline | 0.0004 | 2.9710 | 0.0287 |
Proline (2) | 1.8276 | 0.9999 | 0.1725 |
Pulcherriminic acid | 1.3071 | 1.6318 | 0.0611 |
PYRIDOXAMINE | 0.7320 | 2.2586 | 0.0094 |
Pyrogallol | 0.0096 | 0.0125 | 2.9780 |
Reduced Glutathione | 0.0195 | 0.0170 | 2.9635 |
RG8841500 | 1.0444 | 1.8948 | 0.0608 |
S-Allyl propanethioate | 0.0018 | 0.0013 | 2.9969 |
spinacine | 0.0056 | 0.0036 | 2.9908 |
Streptamine | 0.0060 | 0.0093 | 2.9846 |
Streptamine (2) | 0.0056 | 0.0332 | 2.9612 |
tert-Butyl 3-amino-1-methyl-2,3-dioxopropylcarbamate | 0.1033 | 0.5731 | 2.3236 |
Tetraacetylethylenediamine | 0.0079 | 0.3760 | 2.6160 |
THP(A) | 0.0030 | 0.0059 | 2.9911 |
Threonine | 0.0002 | 0.0012 | 2.9985 |
Threonylserine | 0.0456 | 0.0472 | 2.9072 |
Tiformin | 2.9532 | 0.0331 | 0.0137 |
tin(ii) hydride | 1.0367 | 1.8798 | 0.0834 |
Triethanolamine | 1.7341 | 1.0715 | 0.1944 |
Triethylamine | 2.1121 | 0.0816 | 0.8063 |
Triethylamine (2) | 2.4348 | 0.2427 | 0.3225 |
trimethadione | 0.0024 | 0.0026 | 2.9950 |
trimethadione (2) | 0.0038 | 0.0040 | 2.9922 |
trimethadione (3) | 0.0066 | 0.0116 | 2.9819 |
trimethadione (4) | 2.6594 | 0.1254 | 0.2153 |
trimethylglycine | 2.2378 | 0.5602 | 0.2020 |
Tris(hydroxymethyl)aminomethane | 0.0223 | 0.0285 | 2.9491 |
UB6600000 | 2.9060 | 0.0482 | 0.0457 |
val-arg | 0.0046 | 0.0084 | 2.9870 |
Val-lys | 0.0155 | 0.0204 | 2.9641 |
Veronal | 2.8093 | 0.1728 | 0.0179 |
Veronal (2) | 0.9125 | 0.2099 | 1.8776 |
YU0650000 | 0.1665 | 0.1594 | 2.6741 |
ZV4 | 2.8585 | 0.0434 | 0.0981 |
β-Alanine | 0.0105 | 0.0764 | 2.9132 |
β-Alanine (2) | 0.0275 | 0.1584 | 2.8141 |
β-Alanine (3) | 0.0468 | 0.5373 | 2.4159 |
Factors:
F1 | Treatment:HPLC fraction 4 |
F2 | Treatment:HPLC fraction 5 |
F3 | Treatment:HPLC fraction 6 |