Data for Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion (Study ST001747)

(Analysis AN002844)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7
2-3-Bisphosphoglycerate 1.0571 1.5732 0.5763 0.7306 0.8290 1.2670 0.7747
2-Deoxy-alpha-D-glucoside 1.0680 0.9949 0.9863 0.9577 0.9215 1.0281 1.0422
2-Oxo-7-methylthioheptanoic acid 0.8476 1.1741 0.7954 1.0136 1.1328 1.1347 0.7999
3-Oxalomalate 0.9870 1.3012 0.6410 0.7350 0.9839 1.4227 0.7616
4-Aminobenzoate 0.6562 0.8898 2.7447 0.8543 0.7614 0.8841 0.8971
4-Pyridoxate 1.2658 1.2050 0.6217 0.9216 0.8446 1.2376 0.7248
5-6-Dihydrothymine 1.1201 1.0096 1.3411 0.9118 0.8988 0.9631 0.8801
5-Hydroxyisourate 0.9679 1.0805 0.6656 0.6371 1.1226 1.6011 0.7683
(5-L-Glutamyl)-L-glutamine 1.0310 0.9252 0.5710 0.6648 1.3128 1.5805 0.7145
5-Oxoproline 0.9035 0.9639 0.7766 0.9103 1.1874 1.3022 0.8518
6-Hydroxykynurenic acid 1.1533 0.7632 0.2629 0.7515 1.5668 1.5716 0.5955
Acetyl phosphate 0.8394 0.9834 0.8507 1.1833 1.1327 1.1027 0.8310
Adenine 0.9097 0.9261 0.8923 0.9871 1.0883 1.1810 0.9694
Adenosine 0.5645 0.8153 1.0070 0.7102 1.0905 1.4728 1.3805
alanine 0.7730 0.8008 0.8770 0.9945 1.2836 1.1644 1.0638
Allantoate 1.2487 1.2817 0.7234 0.9458 0.7517 1.0471 0.8789
arginine 1.0049 0.9468 0.7171 0.9514 1.2357 1.1968 0.8159
asparagine 1.2540 1.2673 0.6565 0.6615 0.9133 1.2890 0.8012
aspartate 0.7013 0.6668 1.4468 1.0552 1.1813 0.8934 1.2599
cis-p-Coumarate 0.7456 0.7695 0.9704 0.9165 1.2722 1.2065 1.1194
Creatine 1.2800 0.8730 0.8170 0.7465 1.1256 1.2412 0.8261
Creatinine 2.9308 0.9893 0.6097 0.5367 0.7825 0.5828 0.3468
Cys-Gly 0.8252 0.8813 1.0950 0.7793 1.2378 1.0727 1.1629
cysteine 0.9136 0.8867 0.9227 0.8286 1.3135 1.0315 1.0805
Cytidine 0.7459 0.8634 0.7872 0.8203 1.0199 1.5070 1.1902
D-O-Phosphoserine 0.5872 0.6178 1.2086 0.8961 1.3978 1.0958 1.3113
gamma-L-Glutamyl-D-alanine 0.8800 0.6502 0.6848 0.8213 1.4542 1.4169 0.9628
glutamate 0.6738 0.7249 1.1329 1.0669 1.2403 1.0532 1.1791
glutamine 1.0025 1.1586 0.6414 0.6657 1.0988 1.5260 0.7372
Glutathione 0.7810 0.8382 1.1275 0.7588 1.2865 1.0825 1.1961
Glutathione disulfide 1.0008 0.7786 0.6120 0.6895 1.3356 1.5981 0.8114
glycine 0.9722 0.8591 0.9908 0.9517 1.1300 1.0318 1.0674
Guanidinoacetate 0.8282 1.0623 0.8976 0.7384 0.9075 1.4893 1.0397
Guanine 0.7768 0.8504 0.8658 0.8876 1.1794 1.2551 1.1457
Guanosine 0.5885 0.6726 0.7095 0.8375 1.3752 1.3850 1.3505
histidine 1.1278 1.1687 0.6665 0.7557 0.9628 1.4307 0.7271
Homocarnosine 1.2215 1.9757 0.9709 0.3973 0.5545 1.3026 0.5177
Hypotaurine 0.3923 1.1076 0.7510 0.7772 1.1144 1.3790 1.4210
Hypoxanthine 0.8326 0.8057 0.6126 0.9070 1.2691 1.4044 1.0152
Indole-3-acetaldehyde 0.3803 0.6394 0.9670 0.8499 0.7528 1.8827 1.5032
Inosine 0.7599 0.7682 0.6333 0.9637 1.1871 1.3105 1.2561
L-Adrenaline 0.5000 0.8756 1.0999 1.1571 1.0852 1.0288 1.3259
L-Carnitine 0.6204 0.8566 0.9814 1.1149 1.1168 1.1118 1.2118
L-Citrulline 1.1060 0.8520 1.2220 0.9632 0.8502 0.9446 1.1675
leucine/isoleucine 0.9771 0.9014 0.7652 0.7793 1.1301 1.4278 0.9170
L-Octanoylcarnitine 1.2685 0.8563 0.6055 1.4033 1.3816 0.7746 0.5026
lysine 0.8454 1.1391 0.6959 0.9425 1.1666 1.3151 0.7485
methionine 0.9104 0.7295 0.7385 1.0286 1.3835 1.1620 0.9366
Methylenediurea 1.2447 0.9096 0.8345 0.7751 1.0964 1.2474 0.8067
N6-Methyl-L-lysine 1.5889 0.8568 1.4768 0.7691 0.7758 0.9537 0.7440
N-Amidino-L-aspartate 2.5553 0.9189 1.4677 0.4371 0.4569 0.7963 0.4437
N-Carbamyl-L-glutamate 1.2817 0.8679 0.8885 0.7580 1.0218 1.1118 1.0286
Nicotinamide 0.8340 0.8804 0.9054 0.9286 1.1661 1.2800 0.9641
N-N-Dimethylglycine 1.1504 0.9897 0.8310 0.8497 1.0685 1.2022 0.8220
O-Butanoylcarnitine 0.7984 1.0653 1.2770 0.7450 1.0635 1.0141 1.1640
O-Propanoylcarnitine 0.5613 0.6868 1.2056 1.1015 1.0049 0.9960 1.5847
Pantothenol 1.1701 0.8112 1.6086 0.8629 1.0199 0.8403 0.9226
Peptide tryptophan 0.7788 1.4491 1.0134 0.5236 0.8070 1.6211 0.7914
phenylalanine 0.9539 1.0426 0.9098 0.8040 0.9766 1.3605 0.9072
Phosphocreatine 1.7267 0.8384 1.4222 0.8053 0.8214 0.7423 0.7917
proline 0.8694 0.8680 0.8112 0.9085 1.2810 1.2108 0.9730
Purine 1.0908 1.0794 0.9917 1.1136 0.9205 0.8965 0.8937
Putrescine 1.8685 1.1829 0.8045 0.7086 0.7255 0.9673 0.6273
Pyridoxamine 0.8597 1.1790 0.7381 0.9707 1.0704 1.2428 0.8162
S-Adenosyl-L-homocysteine 1.1907 0.8814 0.9094 0.8517 0.9963 1.1437 0.9895
S-Adenosyl-L-methionine 0.8054 0.7851 1.0073 0.8331 1.1732 1.3233 1.0840
serine 0.9074 0.9309 0.7698 0.9203 1.2679 1.1569 0.9497
Spermidine 0.9754 0.9967 0.7610 1.1780 1.0702 1.1127 0.7893
Spermine 0.7651 0.8529 1.4820 0.9821 0.7488 0.9282 1.4821
Succinyl sulfathiazole 1.0248 0.9187 0.9355 0.8936 0.9300 1.1417 1.1443
Taurine 1.0576 0.9448 1.0851 0.8617 0.9585 1.1225 1.0042
threonine 1.0100 0.9611 0.7619 0.9012 1.1024 1.1989 0.9660
trans-4-Hydroxy-L-proline 0.7989 1.0725 1.0451 0.8227 1.0134 1.3570 0.8983
trans-Homoaconitate 0.8928 1.0216 0.5849 0.8765 1.1883 1.3933 0.8628
Triacanthine 0.8571 1.0807 0.8458 0.7718 0.9689 1.3663 1.0529
Tripeptide 0.8354 1.0025 1.3405 1.1473 0.9892 0.7950 1.0293
tryptophan 0.9742 1.3031 1.2028 0.8211 0.8315 1.0161 0.9155
tyrosine 0.7256 0.7854 0.8944 0.9277 1.2719 1.2298 1.1366
Uracil 1.0008 0.9858 0.5867 1.1351 1.1193 1.2664 0.7119
valine 0.6022 1.1881 0.6330 0.9571 1.0975 1.4038 0.9684
Xanthine 0.9731 0.9302 0.6813 1.0512 1.0823 1.2448 0.8997
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Factors:

F1group:AKI | time point:24h
F2group:AKI | time point:4h
F3group:AKI | time point:7d
F4group:normal | time point:24h
F5group:sham | time point:24h
F6group:sham | time point:4h
F7group:sham | time point:7d
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