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MGP002986

UniProt Annotations

Entry Information
Gene Namesignal recognition particle receptor (docking protein)
Protein EntrySRPR_HUMAN
UniProt IDP08240
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08240-1; Sequence=Displayed; Name=2; IsoId=P08240-2; Sequence=VSP_046055; Note=No experimental confirmation available.;
FunctionComponent of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
SimilarityBelongs to the GTP-binding SRP family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
SubunitHeterodimer with SRPRB. {ECO:0000269|PubMed:16439358}.
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