RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet ID	RM0135893
RefMet name	Glutamic acid
Systematic name	(2S)-2-aminopentanedioic acid
Synonyms	PubChem Synonyms
Exact mass	147.053159 (neutral)	Calculate m/z: (Choose adduct) [M+H]+ [M+H-H2O]+ [M.]+ [M+2H]2+ [M+3H]3+ [M+4H]4+ [M+K]+ [M+2K]2+ [M+2K-H]+ [M+Na]+ [M+2Na]2+ [M+2Na-H]+ [M+Li]+ [M+2Li]2+ [M+NH4]+ [M.CH3]+ [M+Ag]+ [M+H+CH3OH]+ [M+H+CH3CN]+ [M+H+2CH3CN]+ [M+Na+CH3CN]+ [M.NaFormate+H]+ [M.NH4Formate+H]+ [M.TMSi]+ [M.tBuDMSi]+ [M+H-Hexose]+ [M+H-EtnP]+ [M+H-SerP]+ [M-H]- [M-H-H2O]- [M-CH3]- [M-2H]2- [M-3H]3- [M-4H]4- [M+Cl]- [M+OAc]- [M+Na-2H]- [M+K-2H]- [M.Formate]- [M.NaFormate-H]- [M.NH4Formate-H]- [M.F]- [M-H-Ser]- [M.HF2]- M(neutral)    View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
Formula	C5H9NO4	View other entries in RefMet with this formula
Molecular descriptors
Molfile	37101 (Download molfile/View MW Metabolite Database details)
InChI	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey	WHUUTDBJXJRKMK-VKHMYHEASA-N	View other enantiomers/diastereomers of this metabolite in RefMet
SMILES	C(CC(=O)O)[C@@H](C(=O)O)N Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super Class	Organic acids
Main Class	Amino acids and peptides
Sub Class	Amino acids
Distribution of Glutamic acid in NMDR studies
Species	Plot Species distribution
Sample source	Plot Sample source(tissue) distribution
Platform	Platform (MS/NMR) used for detection
Chromatography	Chromatography methods used for detection
Studies	NMDR Studies reporting Glutamic acid
External Links
Pubchem CID	33032
ChEBI ID	16015
KEGG ID	C00025
HMDB ID	HMDB0000148
Chemspider ID	30572
MetaCyc ID	GLT
EPA CompTox	DTXCID8026987
Spectral data for Glutamic acid standards
NP-MRD ID(NMR)	View NMR spectra
MassBank(EU)	View MS spectra
Structural annotation level
Annotation level	1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Glutamic acid

Rxn ID	KEGG Reaction	Enzyme
R00093	2 L-Glutamate + NAD+ <=> L-Glutamine + 2-Oxoglutarate + NADH + H+	L-glutamate:NAD+ oxidoreductase (transaminating)
R00114	2 L-Glutamate + NADP+ <=> L-Glutamine + 2-Oxoglutarate + NADPH + H+	L-glutamate:NADP+ oxidoreductase (transaminating)
R00239	ATP + L-Glutamate <=> ADP + L-Glutamyl 5-phosphate	ATP:L-glutamate 5-phosphotransferase
R00243	L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + Ammonia + NADH + H+	L-glutamate:NAD+ oxidoreductase (deaminating)
R00245	L-Glutamate 5-semialdehyde + NAD+ + H2O <=> L-Glutamate + NADH + H+	L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
R00248	L-Glutamate + NADP+ + H2O <=> 2-Oxoglutarate + Ammonia + NADPH + H+	L-glutamate:NADP+ oxidoreductase (deaminating)
R00251	ATP + 5-Oxoproline + 2 H2O <=> ADP + Orthophosphate + L-Glutamate	5-oxo-L-proline amidohydrolase (ATP-hydrolysing)
R00253	ATP + L-Glutamate + Ammonia <=> ADP + Orthophosphate + L-Glutamine	L-Glutamate:ammonia ligase (ADP-forming)
R00256	L-Glutamine + H2O <=> L-Glutamate + Ammonia	L-glutamine amidohydrolase
R00258	L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate	L-Alanine:2-oxoglutarate aminotransferase
R00259	Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-glutamate	acetyl-CoA:L-glutamate N-acetyltransferase
R00261	L-Glutamate <=> 4-Aminobutanoate + CO2	L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
R00355	L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate	L-Aspartate:2-oxoglutarate aminotransferase
R00707	(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+	(S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase
R00708	(S)-1-Pyrroline-5-carboxylate + NADP+ + 2 H2O <=> L-Glutamate + NADPH + H+	(S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase
R02285	N-Formimino-L-glutamate + H2O <=> L-Glutamate + Formamide	N-Formimino-L-glutamate formiminohydrolase
R02287	5-Formiminotetrahydrofolate + L-Glutamate <=> Tetrahydrofolate + N-Formimino-L-glutamate	5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
R05578	tRNA(Glu) + L-Glutamate + ATP <=> L-Glutamyl-tRNA(Glu) + Diphosphate + AMP	L-glutamate:tRNA(Glu) ligase (AMP-forming)

Table of KEGG human pathways containing Glutamic acid

Pathway ID	Human Pathway	# of reactions
hsa01100	Metabolic pathways	7
hsa00250	Alanine, aspartate and glutamate metabolism	5
hsa00330	Arginine and proline metabolism	4
hsa00220	Arginine biosynthesis	3
hsa01230	Biosynthesis of amino acids	3
hsa00260	Glycine, serine and threonine metabolism	2
hsa01200	Carbon metabolism	2
hsa01210	2-Oxocarboxylic acid metabolism	2
hsa00480	Glutathione metabolism	2
hsa00910	Nitrogen metabolism	1
hsa00970	Aminoacyl-tRNA biosynthesis	1
hsa00340	Histidine metabolism	1
hsa00650	Butanoate metabolism	1
hsa00670	One carbon pool by folate	1
hsa00860	Porphyrin and chlorophyll metabolism	1