RefMet Compound Details

MW structure	1584 (View MW Metabolite Database details)
RefMet name	Pyruvic acid
Systematic name	2-oxo-propionic acid
SMILES	CC(=O)C(=O)O   Run Tanimoto similarity search (with similarity coefficient >=0.6)
Exact mass	88.016045 (neutral)	Calculate m/z: (Choose adduct) [M+H]+ [M+H-H2O]+ [M.]+ [M+2H]2+ [M+3H]3+ [M+4H]4+ [M+K]+ [M+2K]2+ [M+2K-H]+ [M+Na]+ [M+2Na]2+ [M+2Na-H]+ [M+Li]+ [M+2Li]2+ [M+NH4]+ [M.CH3]+ [M+Ag]+ [M+H+CH3OH]+ [M+H+CH3CN]+ [M+H+2CH3CN]+ [M+Na+CH3CN]+ [M.NaFormate+H]+ [M.NH4Formate+H]+ [M.TMSi]+ [M.tBuDMSi]+ [M+H-Hexose]+ [M+H-EtnP]+ [M+H-SerP]+ [M-H]- [M-H-H2O]- [M-CH3]- [M-2H]2- [M-3H]3- [M-4H]4- [M+Cl]- [M+OAc]- [M+Na-2H]- [M+K-2H]- [M.Formate]- [M.NaFormate-H]- [M.NH4Formate-H]- [M.F]- [M-H-Ser]- [M.HF2]- M(neutral)    View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
Formula	C3H4O3	View other entries in RefMet with this formula
InChI	InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
InChIKey	LCTONWCANYUPML-UHFFFAOYSA-N	View other enantiomers/diastereomers of this metabolite in RefMet
Super Class	Organic acids
Main Class	Short-chain acids
Sub Class	Short-chain acids
Pubchem CID	1060
Annotation level	1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Pyruvic acid

Rxn ID	KEGG Reaction	Enzyme
R00209	Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+	pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating)
R00344	ATP + Pyruvate + HCO3- <=> ADP + Orthophosphate + Oxaloacetate	Pyruvate:carbon-dioxide ligase (ADP-forming)
R12212	Oxaloacetate + 2 Sodium cation <=> Pyruvate + CO2 + 2 Sodium cation	oxaloacetate carboxy-lyase (pyruvate-forming
R01447	(S)-Lactate + Oxaloacetate <=> (S)-Malate + Pyruvate	(S)-Lactate:oxaloacetate oxidoreductase
R11591	(R)-Lactate + Quinone <=> Pyruvate + Hydroquinone	(R)-lactate:quinone 2-oxidoreductase
R00200	ATP + Pyruvate <=> ADP + Phosphoenolpyruvate	ATP:pyruvate 2-O-phosphotransferase
R00216	(S)-Malate + NADP+ <=> Pyruvate + CO2 + NADPH + H+	(S)-Malate:NADP+ oxidoreductase(oxaloacetate-decarboxylating)
R10866	Pyruvate + CoA + Oxidized flavodoxin <=> Acetyl-CoA + CO2 + Reduced flavodoxin	pyruvate:flavodoxin 2-oxidoreductase (CoA-acetylating)
R00198	(R)-Lactate + 2 Ferricytochrome c-553 <=> Pyruvate + 2 Ferrocytochrome c-553 + 2 H+	(R)-Lactate:ferricytochrome-c-553 2-oxidoreductase
R00206	ATP + Pyruvate + Orthophosphate <=> AMP + Phosphoenolpyruvate + Diphosphate	ATP:pyruvate,phosphate phosphotransferase
R02320	Nucleoside triphosphate + Pyruvate <=> NDP + Phosphoenolpyruvate	NTP:pyruvate O2-phosphotransferase
R00217	Oxaloacetate <=> Pyruvate + CO2	oxaloacetate carboxy-lyase (pyruvate-forming)
R00196	(S)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c + 2 H+	(S)-Lactate:ferricytochrome-c 2-oxidoreductase
R01196	2 Reduced ferredoxin + Acetyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + Pyruvate + CoA	pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
R00199	ATP + Pyruvate + H2O <=> AMP + Phosphoenolpyruvate + Orthophosphate	ATP:pyruvate,water phosphotransferase
R00400	L-Alanine + Oxaloacetate <=> Pyruvate + L-Aspartate	L-alanine:oxaloacetate aminotransferase
R00782	L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + Ammonia	L-cysteine hydrogen-sulfide-lyase (deaminating
R00297	(R)-Lactate + Acceptor <=> Pyruvate + Reduced acceptor	(R)-2-hydroxy-acid:acceptor 2-oxidoreductase
R00369	L-Alanine + Glyoxylate <=> Pyruvate + Glycine	L-Alanine:glyoxylate aminotransferase
R00258	L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate	L-Alanine:2-oxoglutarate aminotransferase
R00703	(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+	(S)-Lactate:NAD+ oxidoreductase
R13050	(S)-Lactate + 2 NAD+ + 2 Reduced ferredoxin <=> Pyruvate + 2 NADH + 2 Oxidized ferredoxin	(S)-lactate:NAD+,ferredoxin oxidoreductase
R13049	(R)-Lactate + 2 NAD+ + 2 Reduced ferredoxin <=> Pyruvate + 2 NADH + 2 Oxidized ferredoxin	(R)-lactate:NAD+,ferredoxin oxidoreductase
R00197	(R)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c + 2 H+	(R)-Lactate:ferricytochrome-c 2-oxidoreductase
R00704	(R)-Lactate + NAD+ <=> Pyruvate + NADH + H+	(R)-Lactate:NAD+ oxidoreductase
R00396	L-Alanine + NAD+ + H2O <=> Pyruvate + Ammonia + NADH + H+	L-alanine:NAD+ oxidoreductase (deaminating)
R00214	(S)-Malate + NAD+ <=> Pyruvate + CO2 + NADH + H+	(S)-malate:NAD+ oxidoreductase (decarboxylating)
R00212	Acetyl-CoA + Formate <=> CoA + Pyruvate	Acetyl-CoA:formate C-acetyltransferase
R00220	L-Serine <=> Pyruvate + Ammonia	L-serine ammonia-lyase
R03105	Mercaptopyruvate + Thioredoxin <=> Hydrogen sulfide + Pyruvate + Thioredoxin disulfide	3-mercaptopyruvate:sulfide sulfurtransferase
R11593	Pyruvate + (R)-2-Hydroxyglutarate <=> (R)-Lactate + 2-Oxoglutarate	(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]

Table of KEGG human pathways containing Pyruvic acid

Pathway ID	Human Pathway	# of reactions
hsa01100	Metabolic pathways	19
hsa00620	Pyruvate metabolism	7
hsa01200	Carbon metabolism	5
hsa01230	Biosynthesis of amino acids	4
hsa00010	Glycolysis / Gluconeogenesis	3
hsa00250	Alanine, aspartate and glutamate metabolism	2
hsa00270	Cysteine and methionine metabolism	2
hsa00020	Citrate cycle (TCA cycle)	2
hsa00260	Glycine, serine and threonine metabolism	1
hsa00230	Purine metabolism	1
hsa00220	Arginine biosynthesis	1
hsa00350	Tyrosine metabolism	1