Summary of Study ST000414
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000323. The data can be accessed directly via it's Project DOI: 10.21228/M8ZS3N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000414 |
Study Title | Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action |
Study Type | Drug incubation |
Study Summary | Measuring the impact of MMV Malaria Box compounds on metabolism in Plasmodium falciparum-infected red blood cells |
Institute | Monash Institute of Pharmaceutical Sciences |
Department | Drug delivery, disposition and dynamics |
Laboratory | Creek lab |
Last Name | Creek |
First Name | Darren |
Address | 381 Royal Parade, Parkville, Melbourne, VIC3052, Australia |
Darren.Creek@monash.edu | |
Phone | N/A |
Submit Date | 2016-06-16 |
Num Groups | 126 |
Total Subjects | 18 |
Study Comments | 524 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2017-07-10 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Collection:
Collection ID: | CO000429 |
Collection Summary: | Asexual P. falciparum (3D7) were cultured with minor modifications to the method of Trager and Jensen using human RBC (Australian Red Cross Blood Service) at 3% hematocrit in modified RPMI medium containing hypoxanthine and 0.5% (w/v) albumax at 37 °C under defined atmosphere (95% N2, 4% CO2, 1% O2). Parasites were synchronized with 5% (w/v) sorbitol twice at an interval of 14 hours and cultured for a further 58 hours to ensure all experiments were performed on mid-trophozoite stage cultures (~30 h post infection) at 7-8% parasitaemia. |
Sample Type: | Cell |