Summary of Study ST003281

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002033. The data can be accessed directly via it's Project DOI: 10.21228/M8TN7J This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003281
Study TitlePhosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans
Study TypeMetabolomics and lipidomics
Study SummaryThere is a pressing need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of life-threatening meningoencephalitis in immunocompromised people. Contributing mechanisms for echinocandin tolerance are emerging with connections to calcineurin signaling, the cell wall, and membrane composition. In this context, we discovered that a defect in phosphate uptake impairs the tolerance of C. neoformans to the echinocandin caspofungin.
Institute
University of British Columbia
DepartmentLife Sciences Institute
Last NameAlcazar Magana
First NameArmando
Address2350 Health Sciences Mall
Emailarmando.alcazarmagana@ubc.ca
Phone5416097172
Submit Date2024-06-12
Num Groups8
Total Subjects28
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-06-28
Release Version1
Armando Alcazar Magana Armando Alcazar Magana
https://dx.doi.org/10.21228/M8TN7J
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR002033
Project DOI:doi: 10.21228/M8TN7J
Project Title:Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans
Project Summary:There is a pressing need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of life-threatening meningoencephalitis in immunocompromised people. Contributing mechanisms for echinocandin tolerance are emerging with connections to calcineurin signaling, the cell wall, and membrane composition. In this context, we discovered that a defect in phosphate uptake impairs the tolerance of C. neoformans to the echinocandin caspofungin.
Institute:Life Sciences Institute, The University of British Columbia
Last Name:Alcazar Magana
First Name:Armando
Address:2350 Health Sciences Mall
Email:armando.alcazarmagana@ubc.ca
Phone:5416097172
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