Summary of Study ST003091
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001920. The data can be accessed directly via it's Project DOI: 10.21228/M8JB09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST003091 |
Study Title | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
Study Type | Untargeted metabolomics |
Study Summary | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
Institute | Translational Genomics Research Institute |
Department | Integrated Mass Spectrometry Shared Resources |
Last Name | Pirrotte |
First Name | Patrick |
Address | 445 N 5th St Phoenix, AZ 85004 |
ppirrotte@tgen.org | |
Phone | 6023438400 |
Submit Date | 2024-01-26 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2024-03-01 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
Project ID: | PR001920 |
Project DOI: | doi: 10.21228/M8JB09 |
Project Title: | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
Project Type: | Untargeted metabolomics |
Project Summary: | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
Institute: | Translational Genomics Research Institute |
Department: | Integrated Mass Spectrometry Shared Resources |
Last Name: | Pirrotte |
First Name: | Patrick |
Address: | 445 N 5th St Phoenix, AZ 85004 |
Email: | ppirrotte@tgen.org |
Phone: | 6023438400 |
Contributors: | Bin Zhang, Khyatiben V. Pathak, Brooke Lovell, Nate Hansen, Patrick Pirrote, Le Xuan Truong Nguyen, Guido Marcucci, |