Summary of Study ST001319
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000896. The data can be accessed directly via it's Project DOI: 10.21228/M8VX0Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001319 |
Study Title | Pre-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Patients |
Study Type | multiple timepoints; patients with severe sepsis or septic shock treated with varying doses of L-carnitine or a saline placebo |
Study Summary | phase II study of L-carnitine infusion for the treatment of vasopressor-dependent shock |
Institute | University of Michigan |
Laboratory | Stringer NMR Metabolomics Laboratory |
Last Name | McHugh |
First Name | Cora |
Address | 428 Church St, Ann Arbor, MI, 48103, USA |
NMRmetabolomics@umich.edu | |
Phone | 7343530164 |
Submit Date | 2020-02-07 |
Num Groups | 4 |
Total Subjects | 228 |
Num Males | 128 |
Num Females | 100 |
Publications | This submission is Phase II: https://www.ncbi.nlm.nih.gov/pubmed/30646314 doi: 10.1001/jamanetworkopen.2018.6076 Earlier Phase I: Metabolomics Workbench: doi: 10.21228/M8VM2M https://www.ncbi.nlm.nih.gov/pubmed/23851424 doi: 10.1177/0148607113495414 |
Raw Data Available | Yes |
Raw Data File Type(s) | fid |
Analysis Type Detail | NMR |
Release Date | 2020-09-10 |
Release Version | 1 |
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Sample Preparation:
Sampleprep ID: | SP001401 |
Sampleprep Summary: | Methanol precipitation, ultrafiltration |
Sampleprep Protocol ID: | Methanol precipitation, Ultrafiltration |
Sampleprep Protocol Filename: | 235.01-Serum_MeOH_Precip_and_Resuspension, Expt._235.1_Filtration_of_CaPS_RACE_Serums |
Processing Method: | Methanol precipitation, dried by lyophilization, ultrafiltered |
Processing Storage Conditions: | On ice |
Extraction Method: | Methanol precipitation |
Extract Enrichment: | Lyophilization |
Sample Resuspension: | 500 uL 50mM sodium phosphate buffer in Deuterium Oxide (D2O) |
Sample Spiking: | CaFormate internal standard |