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MB Sample ID: SA216247
| Local Sample ID: | 1_034 |
| Subject ID: | SU002335 |
| Subject Type: | Mammal |
| Subject Species: | Mus musculus |
| Taxonomy ID: | 10090 |
| Genotype Strain: | C57BL/6J |
| Gender: | Male and female |
| Animal Light Cycle: | 12:12 |
| Animal Feed: | 60% high-fat diet (Research Diets Cat# D12492) |
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Treatment:
| Treatment ID: | TR002347 |
| Treatment Summary: | Male and female C57BL/6J mice were placed on 60% high-fat diet (Research Diets, Cat# D12492) for approx. 10 weeks beginning at 10 weeks of age. Mice were then counterbalanced into two treatment groups based on body weight (n = 9-11 mice/ sex/ treatment). For experiment, one dose of FGF21 (0.1 mg/kg, ip) or saline vehicle was given right before the onset of the dark cycle, then another dose (0.1 mg/kg, ip) was given the following morning after the onset of the light cycle. Mice were euthanized two hours following the AM injection, livers collected, and frozen in liquid N2. |
| Treatment Compound: | recombinant human FGF21 (ProSpecBio, Cat# CYT-474) |
| Treatment Route: | intraperitoneal injection |
| Treatment Dose: | 0.1 mg/kg |
| Treatment Dosevolume: | 0.01 mg/mL |
| Treatment Vehicle: | saline |
